• Proceedings of the KSPS conference
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• 1994.02a
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• pp.45-53
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• 1994

음 변화 규칙을 음성규칙(A)와 음운규칙(B)와 기타(C)로 분류한다면, A.음성규칙의 발생 총계는 B.음운규칙의 발생 총계보다 2배 이상 더 많다. 여기에 가장 발생 빈도가 높은 규칙부터 순서대로 10개만 정리하면 다음과 같다. 순위 규칙부류 명칭 백분율 1 A 음절 말 유성자음의 불파화 31.84, 2 A 유성음화 19.37 3 B 장모음화 10.00, 4 A 설측음화 9.78, 5 B 경음화 6.43, 6 B 음절말 장애음 중화 5.16, 7 A ㅅ 구개음화 3.71, 8 C 음절 조정 규칙 3.10, 9 B 단모음화 1.60, 10 A ㄴ 구개음화 1.42 별도로 진행한 총체적 연구(이상억에 의하면, 음성규칙, 즉 A가 총 6개 있는데 그 중 5규칙이 10위 내에 나타나 상위 쪽에 3번이나 포함되어 있는 점이 주목된다. 특히 규칙 1과 2의 합계는 전체 중 51.2%를 넘는다. 규칙 10위까지의 합계는 전체 중 92.4%를 차지한다. 13.장모음화(10%)는 12.단모음화(1.6%)보다 훨씬 높은 출현빈도를 보인다. 또 각종 구개음화 규칙의 순위는 ㅅ(7위), ㄴ(10위), ㄹ(17위), ㄷ(26위) 구개음화로 분포되어 있음이 밝혀졌다. 한편 삭제규칙(음운탈락 및 단순화) 계열이 14, 15, 19, 21, 25, 28위에 널리 나열되어 있는 데 반해, 삽입규칙은 23위에 ㄴ삽입 하나가 보일 뿐이다.

• Toxicological Research
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• v.8 no.2
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• pp.331-342
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• 1992

The chicken major histocompatibility complex (MHC), the B complex, is beginning to be analyzed at the DNA level. Inbred lines of chickens have been reported to possess 3~5 MHC class II genes. To further analyzed the molecular structure of the chicken MHC class II genes, cDNA clones coding for chicken MHC class II (B-L) ${\beta}$ chain molecules were isolated from chicken spleen and liver. Tissue-specific transcription of B-L ${\beta}$genes was studied by Northern blot analysis. A high level of expression was detected for spleen poly(A)$^+$ RNA whereas a faint signal was detected for liver poly(A)$^+$ RNA. Twenty-nine cDNA clones were isolated from the spleen and eight cDNA clones were isolated from the liver. Based on restriction maps, most clones could be clustered into one family of genes. Four cDNA clones were sequenced (S7, S10 and S19 from the spleen and L1, which was identical to S19, from the liver). Complete amino acid sequences of B-L ${\beta}$ chain molecules were predicated from the nucleotide sequences of the cDNA clones. Although both the nature and the location of the conserved residues were similar in chicken and mammalian sequences, some species-specific differences were found, suggesting that the structures of the B-L molecules are similar, but not identical to their mammalian counterparts.

• The Journal of the Korean Society for Microbiology
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• v.19 no.1
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• pp.79-83
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• 1984

To determine the existence of anti-HLA antibodies finally in 220 human placental extracts to be proved negative antiserum by previous anti-HLA A,B,C antibody screening procedure, the present study was performed by fractionation of immunoglobulins using saturated ammonium sulfate and by simple batch method on DEAE cellulose. Thereafter using known 150 T-lymphocyte panels, complement-dependent microlymphocytotoxicity test was performed to observe the existence of anti-HLA antibodies and the degree of the antibody response of the concentrates. The following results were obtained: 1. Of total 141 placental sera concentrated 45 cases(31.9%) were showed significant anti-HLA A,B,C antibody response after concentration(Excellent, 19(13.5%), Good, 3(2.1%), Weak, 23(16.3%)). 2. Anti-HLA specificities of placental sera obtained after concentration were A2, A24, B13, B27, B44, B51, CN1, C7. 3. A new type C new-1 anti-HLA antibody that is only expressed in Korean people, was obtained. 4. 79 placental sera purrified by simple batch method using DEAE cellulose were showed negative anti-HLA antibody responses.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.19 no.11
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• pp.1000-1004
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• 2006

In this paper, thermal stability of Ni-silicide formed on the SOI substrate with $B_{11}$ has been characterized. The sheet resistance of Ni-silicide on un-doped SOI and $B_{11}$ implanted bulk substrate was increased after the post-silicidation annealing at $700^{\circ}C$ for 30 min. However, in case of $B_{11}$ implanted SOI substrate, the sheet resistance showed stable characteristics after the post-silicidation annealing up to $700^{\circ}C$ for 30 min. The main reason of the excellent property of $B_{11}$ sample is believed to be the retardation of Ni diffusion by the boron and bottom oxide layer of SOI. Therefore, retardation of Ni diffusion is highly desirable lot high performance Ni silicide technology.

• Korean Journal of Optics and Photonics
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• v.19 no.3
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• pp.169-174
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• 2008

In this paper, we have presented techniques to reduce the splicing loss between standard single mode fiber and high ${\Delta}$ single mode fiber based on the mode expanding and mode evolution induced by thermal treatment of the fibers. The experimental results show that mechanical splicing loss can be reduced from 2.3 dB to 0.1 dB through proper thermal treatment of the high ${\Delta}$ fiber. Meanwhile, we achieved $0.2{\sim}0.4dB$ of low splicing loss between two fibers by heating the splicing region using electric arcing or an oxygen flame.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.37 no.3
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• pp.49-57
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• 2000

In this paper, lumped-element isolator is analyzed and designed using the scattering matrix approach. Using the designed parameters, compact isolator with 7.0x7.0x2.3 mm$^3$ dimensions is fabricated and tested in 1.765GHz PCS phone band. Implemented isolator shows 29.95dB isolation characteristic at center frequency and has 0.35dB insertion loss in overall 30MHz operating bandwidth. Return losses of input and output port are measured below -19 dB. Experimental results show that the implemented isolator has better performances than the conventional one.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.19 no.2
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• pp.265-271
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• 2015

In this paper, Dualband meander microstrip antenna is proposed for Wireless Body Area Network application. Designed antenna is mounted on the phantom to maintain a constant distance of the substrate, and studied the characteristics related to change in several meaningful parameters to improve performance. Characteristics of antenna, returnloss, radiation pattern, gain, bandwidth, are analyzed using Computer Simulation Technologes(CST) software. The proposed antenna operates at 4.33Ghz and 6.09GHz ~ 9.88GHz for UWB. The antenna showed that returnloss and -10dB bandwidth are -42.30dB and 410Mhz at 4.33GHz, maximum -29.11dB and 3.75GHz at 6.1GHz ~ 9.8GHz.

• Journal of Medicine and Life Science
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• v.19 no.3
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• pp.130-133
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• 2022

Several studies have reported a possible link between anti-aquaporin-4 antibody and vitamin B12 deficiency in neuromyelitis optica spectrum disorder (NMOSD). Bilaterally symmetric hyperintense signals on magnetic resonance imaging (MRI) of the posterior columns, called the inverted V sign, are a characteristic feature of subacute combined degeneration associated with vitamin B12 deficiency. We report a patient with anti-aquaporin-4 antibody-positive NMOSD and an inverted V sign on MRI of the spinal cord and address the association between anti-aquaporin-4 antibody and functional vitamin B12 deficiency.

• IMMUNE NETWORK
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• v.19 no.1
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• pp.1.1-1.13
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• 2019

Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disease characterized by production of autoantibodies to various nuclear antigens and overexpression of genes regulated by IFN-I called IFN signature. Genetic studies on SLE patients and mutational analyses of mouse models demonstrate crucial roles of nucleic acid (NA) sensors in development of SLE. Although NA sensors are involved in induction of antimicrobial immune responses by recognizing microbial NAs, recognition of self NAs by NA sensors induces production of autoantibodies to NAs in B cells and production of IFN-I in plasmacytoid dendritic cells. Among various NA sensors, the endosomal RNA sensor TLR7 plays an essential role in development of SLE at least in mouse models. CD72 is an inhibitory B cell co-receptor containing an immunoreceptor tyrosine-based inhibition motif (ITIM) in the cytoplasmic region and a C-type lectin like-domain (CTLD) in the extracellular region. CD72 is known to regulate development of SLE because CD72 polymorphisms associate with SLE in both human and mice and CD72^-/- mice develop relatively severe lupus-like disease. CD72 specifically recognizes the RNA-containing endogenous TLR7 ligand Sm/RNP by its extracellular CTLD, and inhibits B cell responses to Sm/RNP by ITIM-mediated signal inhibition. These findings indicate that CD72 inhibits development of SLE by suppressing TLR7-dependent B cell response to self NAs. CD72 is thus involved in discrimination of self-NAs from microbial NAs by specifically suppressing autoimmune responses to self-NAs.

• Childhood Kidney Diseases
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• v.19 no.2
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• pp.176-179
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• 2015

Rituximab (RTX), a monoclonal antibody against the B-cell marker CD20, is commonly used as a treatment for antibody-mediated diseases or B-lymphocyte-mediated diseases. Destruction of B cells may reverse the disease course in many conditions; however, patients who are treated with RTX cannot respond appropriately to de novo infection due to lack of B lymphocytes. Here, we report one such case. A 7-year-old renal allograft recipient presented with severe anemia due to parvovirus infection after RTX treatment. The patient had focal segmental glomerulosclerosis and had received cadaveric kidney transplantation 6 months previously. She was treated with high-dose steroid for acute rejection and RTX for Epstein Barr Virus infection 3 months previously. At presentation, her hemoglobin level was 5.4 g/dL and leukocyte and platelet counts were normal. She had microcytic normochromic anemia and high viral load of parvovirus B19(70,578 copies/mL). Intravenous immunoglobulin ($200mg/kg{\cdot}d$) treatment controlled the progression of anemia and parvovirus infection. De novo parvovirus infection during the B lymphocyte-depletion period may have precipitated the severe anemia in this case. Close monitoring of infection is required after RTX therapy.