• Computers and Concrete
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• 제4권3호
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• pp.167-186
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• 2007

Ductility based design of reinforced concrete structures implicitly assumes certain damage under the action of a design basis earthquake. The damage undergone by a structure needs to be quantified, so as to assess the post-seismic reparability and functionality of the structure. The paper presents an analytical method of quantification and location of seismic damage, through system identification methods. It may be noted that soft ground storied buildings are the major casualties in any earthquake and hence the example structure is a soft or weak first storied one, whose seismic response and temporal variation of damage are computed using a non-linear dynamic analysis program (IDARC) and compared with a normal structure. Time period based damage identification model is used and suitably calibrated with classic damage models. Regenerated stiffness of the three degrees of freedom model (for the three storied frame) is used to locate the damage, both on-line as well as after the seismic event. Multi resolution analysis using wavelets is also used for localized damage identification for soft storey columns.

• 대한전기학회논문지:시스템및제어부문D
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• 제54권10호
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• pp.587-594
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• 2005

An adaptive observer for rotor resistance is designed to estimate rotor flux for the a-b model of an induction motor assuming that rotor speed and stator currents are measurable. A singularly perturbed model of the motor is used to design an Adaptive sliding mode observer which drives the estimated stator currents to their true values in the fast time scale. The adaptive observer on the sliding surface is based on the equivalent switching vector and both the estimated fluxes and the estimated rotor resistance converge to their true values. A speed controller considering the effects of parameter variations and external disturbance is proposed in this paper. First, induction motor dynamic model at nominal case is estimated. based on the estimated model, speed controller is designed to match the prescribed speed tracking specifications. Then a dead-time compensator and a robust controller are designed to reduce the effects of parameter variations and external disturbances. the desired speed tracking control performance can be preserved under wide operating range, and good speed load regulating performance. Some simulated results are provided to demonstrate the effectiveness of the Proposed controller.

• BMB Reports
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• 제40권6호
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• pp.944-951
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• 2007

3-Hydrogenkwadaphnin (3-HK) is a daphnane-type diterpene ester isolated from Dendrostellera lessertii (Thymelaeaceae) with high differentiation and apoptotic potency in leukemic cells without any measurable adverse effects on normal cells (Moosavi et al., 2005b). In this study, we report that 3-HK (12 nM) has the ability to cease proliferation, induce differentiation and apoptosis in chronic myelogenous leukemia (CML) K562 cell line. The treated cells lost erythroid properties and differentiated along the megakaryocytic lineage based on the morphological features apparent after Wright-Giemsa staining, DNA content analysis and the expression of cell surface marker glycoprotein IIb as analyzed by flow cytometry. Moreover, using Hoechst 33258 and Annexin V double staining indicated the occurrence of apoptosis among the treated cells. On the other hand, restoration of the depleted GTP pool size by exogenous addition of guanosine ($50{\mu}M$) reduced the effect of the drug regarding the extent of differentiation while no further enhancement of 3-HK effect was obtained by addition of exogenous hypoxanthine ($100{\mu}M$). These interesting results necessitate further investigation regarding the mechanism of action of this unique anti-leukemic agent.

• 대한수학회지
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• 제60권3호
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• pp.565-586
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• 2023

We study the Dirichlet problem for the degenerate nonlocal parabolic equation u_t - a(||∇u||²_L²(Ω))∆u = C_b ||u||^β_L²(Ω) |u|^q(x,t)-2 u log |u| + f in Q_T, where Q_T := Ω × (0, T), T > 0, Ω ⊂ ℝ^N, N ≥ 2, is a bounded domain with a sufficiently smooth boundary, q(x, t) is a measurable function in Q_T with values in an interval [q^-, q⁺] ⊂ (1, ∞) and the diffusion coefficient a(·) is a continuous function defined on ℝ₊. It is assumed that a(s) → 0 or a(s) → ∞ as s → 0⁺, therefore the equation degenerates or becomes singular as ||∇u(t)||2 → 0. For both cases, we show that under appropriate conditions on a, β, q, f the problem has a global in time strong solution which possesses the following global regularity property: ∆u ∈ L²(Q_T) and a(||∇u||²_L²(Ω))∆u ∈ L²(Q_T ).

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6249-6256
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• 2013

One-carbon metabolism plays an important role in colorectal carcinogenesis. Meta-analyses have suggested protective associations of folate and vitamin $B_6$ intakes with colorectal cancer primarily based on studies in Caucasians, and genetic polymorphisms pertaining to the folate metabolism have been a matter of interest. Less investigated are the roles of methionine synthase (MTR) and thymidylate synthetase (TS) polymorphisms in colorectal carcinogenesis. In a study of 816 cases and 815 community controls in Japan, we investigated associations of dietary intakes of folate, methionine, vitamin $B_2$, vitamin $B_6$, and vitamin $B_{12}$ with colorectal cancer risk. The associations with MTR 2756A>G, MTRR 66A>G, and TSER repeat polymorphism were examined in 685 cases and 778 controls. Methionine and vitamin $B_{12}$ intakes were inversely associated with colorectal cancer risk, but the associations were totally confounded by dietary calcium and n-3 fatty acids. The other nutrients showed no association with the risk even without adjustment for calcium and n-3 fatty acids. The TSER 2R allele was dose-dependently associated with an increased risk. The MTR and MTRR polymorphisms were unrelated to colorectal cancer risk. There was no measurable gene-gene or gene-nutrient interaction, but increased risk associated with the TSER 2R allele seemed to be confined to individuals with high folate status. This study does not support protective associations for folate and vitamin $B_6$. The TSER 2R allele may confer an increased risk of colorectal cancer. The role of the TSER polymorphism in colorectal carcinogenesis may differ by ethnicity.

• 대한치과보철학회지
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• 제34권3호
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• pp.438-447
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• 1996

This study was performed to determine the failure strength and pattern of implant prosthesis luted with resin cement between gold cylinder and superstructure, and to evaluate the bonding strength of resin cement. To evaluate failure strength and pattern, the groups were divided into 2. Group 1 : Casted gold cylinder Group 2 : Luted with resin cement between gold cylinder ans superstructure. To evaluate effects of the bonding strength of the implant prosthesis luted with resin cement according to storage condition, the groups were divided into 3 : Group A : Stored in waste at $37^{\circ}C$ for 24 hours. Group B : 1000 cycles thermocycled between $5^{\circ}C\;and\;55^{\circ}C$ in water. Group C : Stored in water at $37^{\circ}C$ for 30 days. The results were as follows. 1. Failure was found at gold screw in all specimens of group 1 & 2. 2. The bond strength in group 1 and 2 was 189.86 and 188.14kgf. There was no statistically significant difference between group 1 and 2(P>0.05). 3. The bond strength of group A, B and C was 53.28, 45,86 and 39.29Kgf. There result suggest the advantage of an improved fit of superstructure to the abutment and a simple procedure. But there was a measurable decrease of the bond strength according to storage condition. So, Further research is necessary to evaluate of the implant prosthesis luted with resin cement between gold cylinder and superstructure.

• 한국수산과학회지
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• 제12권3호
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• pp.125-130
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• 1979

1978년 8월 23일 부터 동년 10월 20일 사이에 우리 나라의 남부와 싱가폴 북부 해상에서 새바다호의 순항, 예망, 표박시의 선박소음에 관하여 실험한 결과를 요약하면 다음과 같다. 1. 외부 갑판상의 가장 높은 소음원은 연돌로 돌출하는 배기소음이고, 연돌뒤(No.9)에서 순항, 예망, 표박시 92,90,87dB로 가장 높았으며, 선수(No. 1)에서 65,63,53dB로 가장 낮았다. 2. 학생 거주구역에서는 주기소음보다 통풍기나 에이콘의 가동소음이 주소음원을 이루었는데 통풍기를 가동하면 표박할때와 에이콘을 가동하면서 순항때를 비교하면, 출입구(No. 14)에서 85,69dB로 가장 높았고 학생실(No. 22)에서 45,40dB로 가장 낮았다. 3. 중앙부의 선원거주구역에서는 순항소음압이 예망소음압보다 2dBwjd도로 선원식당(No. 30)까지는 높게 나타났고, 급냉실(No. 31)로 부터는 반대로 낮게 측정 되었다. 또 이 구역에서는 출입문을 닫았을 때 선장실(No, 25)에서 13dB, 선원식당(No, 30)에서 3dB씩 낮아졌다. 4. 순항시 주기소음압은 Pitch $8^{\circ}$와 $12^{\circ}$때 103, 105dB 였는데, Pitch $8^{\circ}$로 예망시는 106dB로서 3dB의 증가를 보였다. 5. 선형과 기관이 같은 오대산호와 소음을 비교 하면 식당, 싸롱, 학생식에서 $4\~6dB$씩 낮았고 작업갑판상에서는 14dB나 높은 음압이였다.

• 한국축산식품학회지
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• 제30권1호
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• pp.73-86
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• 2010

The current study was designed to optimize solid phase microextraction (SPME)-GC-MS conditions for extraction and analysis of volatile components for Hanwoo beef and to establish a tentative database of flavor components. Samples were taken from Hanwoo longissimus muscle (30 mon old steer, $1^+B$ carcass grade) at 24 h postmortem. Results indicated that the optimum adsorption time for $75{\mu}m$ CAR/PDMS fiber was 60 min at $60^{\circ}C$. Thermal cleaning at $250^{\circ}C$ for 60 min was the best practice for decontamination of the fiber. A short analysis program with a sharp oven temperature ramp resulted in a better resolution and higher number of measurable volatile components. With these conditions, 96 volatile compounds were identified with little variation including 22 aldehydes, 8 ketones, 31 hydrocarbons, 12 alcohols, 8 nitrogen- and sulfurcontaining compounds, 5 pyrazines and 10 furans. A noticeable observation was the high number of hydrocarbons, aldehydes, ketones, alcohols and 2-alkylfurans which were generated from lipid decomposition especially the oxidation and degradation of unsaturated and saturate fatty acids. This implies that these compounds can be candidates for flavor specification of highly marbled beef such as Hanwoo flavor.

• 대한의용생체공학회:의공학회지
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• 제28권1호
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• pp.84-94
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• 2007

In order to collect information on local distribution of conductivity and permittivity underneath a scan probe, we developed a multi-frequency trans-admittance scanner (TAS). Applying a sinusoidal voltage with variable frequency on a chosen distal part of a human body, we measure exit currents from 320 grounded electrodes placed on a chosen surface of the subject. The electrodes are packaged inside a small and light scan probe. The system includes one voltage source and 17 digital ammeters. Front-end of each ammeter is a current-to-voltage converter with virtual grounding of a chosen electrode. The rest of the ammeter is a voltmeter performing digital phase-sensitive demodulation. Using resistor loads, we calibrate the system including the scan probe to compensate frequency-dependent variability of current measurements and also inter-channel variability among multiple. We found that SNR of each ammeter is about 85dB and the minimal measurable current is 5nA. Using saline phantoms with objects made from TX-151, we verified the performance of the lesion estimation algorithm. The error rate of the depth estimation was about 19.7%. For the size estimate, the error rate was about 15.3%. The results suggest improvement in lesion estimation algorithm based on multi-frequency trans-admittance data.

• Asian-Australasian Journal of Animal Sciences
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• 제16권3호
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• pp.384-388
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• 2003

Twenty yearling lambs of Southeast Nigeria dwarf, liveweight ($18{\pm}1.9 kg$) were grouped into 5 treatments. Dry brewer's grain was substituted for maize offal in the experiment diets namely A to E at 0%, 15%, 30%, 45% and 60% respectively, as supplement to low quality, dry season cassava leaf top and Andropogan gayanus hay at 1:1 ratio that lasted for 56 days. After which 5 of the lambs (average bodyweight=$24.3{\pm}1.5kg$) were transferred to metabolism crates to determine the digestibility and nitrogen/protein balance studies. While the mean group intakes were (945.9, 996.1, 1,040.5, 1,148.5 and 1,037.7 g conc. DM/day), the growth rates were (115.1, 124.1, 152.5, 168.5 and 123.1 g liveweight gain/day), respectively. There was a recorded decline in both intake (p>0.05) and growth rate (p<0.05) as the level of dry brewer's grain was increased beyond 45% of the supplement. Similar trend was observed on the protein and organic matter efficiency ratios (p>0.05) together with the organic matter intake. The urine nitrogen output was also significant (p>0.05). The work further revealed that, at a certain critical level of intake, dry brewer's grain is able to support growth rates measurable to or better than those noted when feeding maize offal to lambs, and went on to prove dry brewer's grain as an attractive supplementary feed for the drier months of the year, in the Southeast of Nigeria.