• Journal of Society of Preventive Korean Medicine
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• v.19 no.1
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• pp.145-159
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• 2015

Objective : In the previous study, co-administration of Gongjindan-gamibang (GJD) with sorafenib increased oral bioavailability of sorafenib through augment the absorption, therefore, the effects of GJD co-administration on the pharmacokinetics of sorafenib were observed after single and 7-day repeated oral co-administration with 3.5 hr-intervals in the present study. Method : After 50 mg/kg of sorafenib treatment, GJD 100 mg/kg was administered with 3.5 hr-intervals. The plasma were collected at 30 min before administration, 30 min, 1, 2, 3, 4, 6, 8 and 24 hrs after end of first and last 7th sorafenib treatment, and plasma concentrations of sorafenib were analyzed using LC-MS/MS methods. PK parameters of sorafenib ($T_{max}$, $C_{max}$, AUC, $t_{1/2}$ and $MRT_{inf}$) were analysis as compared with sorafenib single administered rats. Results : GJD markedly inhibited the absorption of sorafenib, from 1 hr to 24 hrs after end of first 3.5 hr-interval co-administration, the $C_{max}$ (-43.27%), $AUC_{0-t}$ (-56.29%) and $AUC_{0-inf}$ (-66.70%) of sorafenib in co-administered rats were dramatically decreased as compared with sorafenib single treated rats. However, GJD significantly increased the absorption of sorafenib, from 4 hr to 8 hrs after end of last 7th 3.5 hr-interval co-administration, the $AUC_{0-t}$ (34.08%) and $AUC_{0-inf}$ (37.31%) of sorafenib in co-administered rats were dramatically increased as compared with sorafenib single treated rats. Conclusion : Although GJD decreased the oral bioavailability of sorafenib through inhibition of gastrointestinal absorptions after end of first 3.5 hr-interval co-administration, it is observed that GJD increases the oral bioavailability of sorafenib as facilitated the absorption after end of last 7th repeated co-administration. Hence, the co-administration of GJD and sorafenib should be avoided in the combination therapy of sorafenib with GJD on anticancer therapy.

• The Korean Journal of Pharmacology
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• v.12 no.1
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• pp.63-67
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• 1976

The purpose of the present study was to see the Panax Ginseng has any influence upon the acquisition of the conditioned avoidance response(CAR) in rats. Sixty male rats of Holtsman strain were used. The animal weighed between 20 and 300 gm at the beginning of the experiment. Training of avoidance conditioning was done in a two-way shuttle box which was separated into two compartments by a guilotine door. The conditioned stimulus (CS) was a light beam and the unconditioned stimulus (UCS) was an electric shock. The shock was presented 10 sec. after onset of the CS and continued until the subject crossed to the opposite safety compartment within 20 sec. after onset of UCS. Each S was received 30 trials a day (one session) for 6 consecutive sessions. The number of CR which avoided successfully without having shock and the number of fecal balls during the conditioning were served as an index of learning performance and emotionality. The results obtained as follows. All doses of Ginseng saponin treated animals showed more CR than control, but did not differ significantly from control. Ginseng saponin treated animals with the doses of $50{\sim}100\;mg/kg$ defecated the fecal balls significantly less frequent than the placebo control during CAR.

• Journal of Nutrition and Health
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• v.25 no.6
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• pp.468-475
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• 1992

This study was carried out to observe the effects of dietaryn-6, n-3 fatty acids and vitamin A levels on humoral immunity in rat. Sixty eight male Sprague-Dawley rats were fed 6 different experimental diets for 6 weeks. The diets were composed of 10% of either corn oil or fish oil with various levels of vitamin A ; deficient(12450 IU/kg diet) adequate(4000IU/kg diet) and excess(400,000 IU/kg diet) The weight of spleen from the excess vitamin A-fish oil group showed the lowest value of all the groups when spleen weight was expressed/100g body weight. The number of PFC to SRBC was not affected by dietary at type and vitamin A levels. Hemagglutination titers were significantly lower in fish oil groups compared to corn oil groups and the values of vitamin A deficient groups were lower than the ones of adequate and excess vitamin A groups. IgM contents is serum were significantly lower in fish oil groups than in corn oil groups. IgG contents were higher in fish oil groups than in corn oil groups and the highest levels was recorded in excess vitamin A-fish oil group which showed the smallest speen size. Light microscopical examination showed that spleen tissues of fish oil groups were well developed than those of the corn oil groups and vitamin A deficient and excessive groups showed poor development than the adequate groups. Therefore it is suggested that adequate amounts of vitamin A consumption is necessary for healthy individuals and fish oil intake along with excess vitamin A should be avoided in order to maintain immune function properly.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.10
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• pp.2959-2965
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• 2009

This research is based on the medical information record of a university hospital on analysis of outpatients, inpatients and delivery related information in gynecology area. The result of application having analysis of patients as basic material for hospital management is as follows. The number of new patients in average was 140.9, and as the year passes by, it seemed to decrease noticeably(p=0.000). In the first year (2001) the number was only 212.6, but increased to 140 by the year of 2007, showing increase of 80.9. The actual number of patients in the hospital was 124.6 in average and it showed noticeable decrease after each year (p=0.000), from 144.6 patients on the first year 2001, to 104.8 patients in 2007, showing approximately 40 patients decreased. Multiple regression analysis was performed having independent variables as characteristics of patients and cause of delivery related factors, and dependent variables as the number of patients in the hospital. According to analysis, the cause of affecting the number of patients in the hospital was selected as the number of new patients, the number of delivery per year. The reliability rate was recorded as 62.8%. Therefore, apart from the services on marketing and patient management which must come first, the effect of inviting them cannot be avoided, which directly links to trust resulting from the consideration to patients.

• Journal of Pharmaceutical Investigation
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• v.37 no.4
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• pp.237-242
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• 2007

The chemical formula of indapamide is 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-l-yl)-benzamide, Indapamide is an oral antipertensive diuretic agent indicated for the treatment of hypertensive and edema. Indapamide inhibits carbonic anhydrase enzyme. Transdermal drug delivery systems, as compared to their corresponding classical oral or injectable dosage form counterparts, offer many advantages. The most important advantages are improved systemic bioavailability of the pharmaceutical active ingredients (PAI), because the first-pass metabolism by the liver and digestive system are avoided; and the controlled, constant drug delivery profile (that is, controlled zero-order absorption). Also of importance is the reduced dose frequency compared to the conventional oral dosage forms (that is, once-a-day, twice-a-week or once-a-week). Other benefits include longer duration of therapeutic action from a single application, and reversible action. For example, patches can be removed to reverse any adverse effects that may be caused by overdosing. In order to evaluate the effects of vehicles and penetration enhancers on skin permeation of Indapamide, the skin permeation rates of Indapamide from vehicles of different composition were determined using Franz cells fitted with excised hairless skins. Solubility of Indapamide in various solvents was investigated to select a vehicle suitable for the percutaneous absorption of Indapamide, The solvents used were Tween80, Tween20, Labrasol, Lauroglycol90 (LG90) and Peceol. Lauroglycol90 increase the permeability of indapamide approximately 3.75-fold compared with the control. Tween80, Tween20, Labrasol, Lauroglycol90 (LG90) and Peceol showed flux of $0.06ug/cm^2/hr,\;0.4ug/cm^2/hr,\;0.21ug/cm^2/hr,\;0.72ug/cm^2/hr,\;0.29ug/cm^2/hr$, respectively.

• The Journal of the Korea Contents Association
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• v.13 no.8
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• pp.152-159
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• 2013

Delinquency young people committed society as evolves is also increasing rapidly. Juvenile delinquency that occurred recently is serious. As a result, young people are feeling fear of delinquency. Fear of delinquency young people feel, a major impact on the personality development of the youth of the period of growth. In particular, the violent delinquency, to give a physical impact, damage youth receives is large. As well as physical damage to people in and around the juvenile victims, given the damage mental serious form, fear violent delinquency has been shown in many previous studies. Therefore, in this study you have the purpose to study the effects on the reaction of juvenile victims for fear of delinquency caused by the delinquency of violence. Set randomly on campus and external experience and damage directly or indirectly, are classified into action evasive action defensive reaction of fear by delinquency, factors that affect the risk caused by violent delinquency, Daegu after conducting a survey of high school students in general in the areas in which we tested the hypothesis. As a result of the verification, exerting a significant influence in order to act defensive becomes clear, experience of direct damage and experience of damage indirect fear of delinquency, avoided experience of direct damage it was found to exert a significant effect on to the action manner.

• The Journal of the Korea Contents Association
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• v.18 no.7
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• pp.84-94
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• 2018

This study analyzed domestic media articles from 1920 to 2017 using R 3.4, a big data analysis tool. In addition, it examines the sexual minority discourse reproduced through the media for about 100 years, focused on the role of the film as an art of struggling with the projective aversion to sexual minorities. sexual minorities in movies are not abominable. They are people we already know in our daily lives, and they are just different in sexual orientation. In general, sexual minorities are less likely to encounter in everyday life, so they are experienced and perceived through what the media present. It is noteworthy that the representation of sexual minorities in the media is formed as a major agenda of our society by publicizing the problems underlying society on the surface. It causes social issues to be raised by revealing and highlighting the problems that are regarded as alienated and avoided from the mainstream's gaze. The content provided by the media enables a three-dimensional experience of subjects who have not experienced it by themselves, and has a decisive influence in correctly recognizing and judging society. Media content suggests that it can be a powerful weapon of recognition struggle that can naturally fight against social hatred without using methods such as demonstrations or protests.

• Journal of Korea Water Resources Association
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• v.39 no.7 s.168
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• pp.593-603
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• 2006

The basin response to storm is regarded as nonlinearity inherently. In addition, the consistent nonlinearity of hydrologic system response to rainfall has been very tough and cumbersome to be treated analytically. The thing is that such nonlinear models have been avoided because of computational difficulties in identifying the model parameters from recorded data. The parameters of nonlinear system considered as dynamic effects in the conceptual model are optimized as the sum of errors between the observed and computed runoff is minimized. For obtaining the optimal parameters of functions, the historical data for the Bocheong watershed in the Geum river basin were tested by applying the numerical methods, such as quasi-linearization technique, Runge-Kutta procedure, and pattern-search method. The estimated runoff carried through from the storage function with dynamic effects was compared with the one of 1st-order differential equation model expressing just nonlinearity, and also done with Nash model. It was found that the 2nd-order model yields a better prediction of the hydrograph from each storm than the 1st-order model. However, the 2nd-order model was shown to be equivalent to Nash model when it comes to results. As a result, the parameters of nonlinear 2nd-order differential equation model performed from the present study provided not only a considerable physical meaning but also a applicability to Korean watersheds.

• The Journal of Advanced Prosthodontics
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• v.5 no.3
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• pp.287-295
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• 2013

PURPOSE. This study investigated the effect of laser parameters and air-abrasion on the peel strength of silicon-based soft denture liner to different denture resins. MATERIALS AND METHODS. Specimens (N=180) were prepared out of three different denture base resins (Rodex, cross-linked denture base acrylic resin; Paladent, heat-cured acrylic resin; Deflex, Polyamide resin) ($75mm{\times}25mm{\times}3mm$). A silicon-based soft denture liner (Molloplast B) was applied to the denture resins after the following conditioning methods: a) Air-abrasion ($50{\mu}m$), b) Er,Cr:YSGG laser (Waterlase MD Turbo, Biolase Technology) at 2 W-20 Hz, c) Er,Cr:YSGG laser at 2 W-30 Hz, d) Er,Cr:YSGG laser at 3 W-20 Hz, e) Er,Cr:YSGG laser at 3 W-30 Hz. Non-conditioned group acted as the control group. Peel test was performed in a universal testing machine. Failure modes were evaluated visually. Data were analyzed using two-way ANOVA and Tukey's test (${\alpha}$=.05). RESULTS. Denture liner tested showed increased peel strength after laser treatment with different parameters ($3.9{\pm}0.4-5.58{\pm}0.6$ MPa) compared to the control ($3.64{\pm}0.5-4.58{\pm}0.5$ MPa) and air-abraded groups ($3.1{\pm}0.6-4.46{\pm}0.3$ MPa), but the results were not statistically significant except for Paladent, with the pretreatment of Er,Cr:YSGG laser at 3 W-20 Hz. Polyamide resin after air-abrasion showed significantly lower peel strength than those of other groups ($3.1{\pm}0.6$ MPa). CONCLUSION. Heat-cured acrylic resin, PMMA, may benefit from Er,Cr:YSGG laser treatment at 3 W-20 Hz irradiation. Air-abrasion of polyamide resins should be avoided not to impair their peel bond strengths to silicon-based soft denture liners.

• Ecology and Resilient Infrastructure
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• v.7 no.3
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• pp.160-170
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• 2020

Railroads and roads are typical linear projects, and their networks are expanding nationwide. To minimize the impact of their development on the environment, ecological disconnection due to the parallel lines of railroads and roads is to be avoided as much as possible. In this study, to examine the environmental impact of railroad and road development, the characteristics of railroads and roads and the differences between them were examined through a comparative analysis of key evaluation items. Based on the result, the road development, unlike the railroad project, suggests items for establishing an efficient land use plan and soil protection as the key evaluation items. There are no specific evaluation items and criteria that can be used to examine the environmental impact of railroad lines located adjacent to roads. In this study, eight evaluation items were suggested by reviewing the relevant literature. In particular, in the strategic environmental impact assessment stage, which examines the adequacy and location feasibility of the plan, the minimum separation distance criteria were proposed to examine in advance the environmental impact of railroads located adjacent to the existing roads. The distances were examined for the previously operated routes, and a distance of less than 200 m was suggested to minimize the environmental impact. The results were compared with those in other studies and analyzed. The results of this study can be used as a basis for examining alternative routes that can minimize the environmental impact of adjacent railroads and roads.