• 동의신경정신과학회지
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• 제17권1호
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• pp.107-120
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• 2006

Objective : The purpose of this study is to learn the effects of Musimgigong supine position Doyin-therapy (MGSDT) on the autonomous nervous system (ANS) and musculoskeletal system (MSS), and to know how much MGSDT is useful for relaxing the human body. Methods : Eight oriental medical doctors participated in the experiment, who have trained Musimgigong for 6 years or more. Before and after applying MGSDT, we measured BVP/HR, respiration rate, peripheral temperatures, skin conductance, and EMG, using Procomp Infinity and Biograph Infinity of Thought Technology Ltd Results and Conclusions : 1. After the treatment, the participants in MGSDT group reported that they felt refreshed and relaxed. 2 By analyzing the measured data, we observed significant difference in respiration rate(p=.026<.05) and SC(p=.013<.05) before and after applying MGSDT. We also observed relaxing effect in BVP/HR, EMG, but was not significant. On the other hand Temp was stressed but was not significant. Conclusion is that MGSDT can be considered to have an effect on relaxing ANS. Therefore MGSDT could have useful clinical effect to autonomic imbalance.

• 사상체질의학회지
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• 제16권3호
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• pp.76-84
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• 2004

1. Objectives This paper is intended to find out Sasang Constitutional difference on Autonomous Function after Acupuncture stimulation in healthy subjects. 2. Methods of Research Nineteen healthy volunteers(Soyangin 6, Taeumin 7, Soeumin 6) had acupunctured perpendicularly into the Hapkok point(LI4) and the Taechung point(Liv3). Heart Rate Variability, Mean Heart Rate and Blood Pressure were checked 4 times(before and after Acupuncture stimulation) to evaluate Autonomous Function. 3. Results & Conclusions The conclusions were as follows 1. There was no statistically significant Sasang Constitutional difference on sympathetic activity and parasympathetic activity before Acupuncture stimulation. 2. Acupuncture stimulation caused a statistically significant increase in the parasympathetic activity in the whole subject. 3. After Acupuncture stimulation, there was a statistically significant increase in the parasympathetic activity in Soeumin and a tendency of increase in the parasympathetic activity in Soyangin. But there was a tendency of increase in the Sympathetic activity in Taeumin.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2006년도 추계학술대회 논문집
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• pp.565-566
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• 2006

• 한국지능시스템학회논문지
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• 제14권5호
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• pp.610-616
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• 2004

생체 공학이나 신경생리학, 로봇공학에서는 인간의 2족 보행 메커니즘을 알아내는 것이 중요한 연구과제이며 그에 대한 연구 성과는 재활도구나 컴퓨터 애니메이션 및 인간형 로봇과 같은 다양한 응용분야에 있어서의 기초 기술로서 제공되어질 것을 기대하고 있다. 반면에 인간의 2보행 운동은 신경계와 역학계에 의한 복잡한 상호작용으로, 그 실현 메커니즘에 있어 신경계의 구체적인 제어방법에 관해서는 그 복잡성 때문에 아직 많은 부분이 불명확하게 남겨져 있다. 따라서 전문가에 의한, 매번 시행착오를 통해 신경계의 상세한 설계를 할 필요가 있다. 이 논문은 유전자 프로그래밍을 이용하여 신경계의 구조와 Parameter를 자동적으로 최적화하는 모델을 제안하고 시뮬레이션을 통해 타당성을 확인하였다.

• 대한한방내과학회지
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• 제26권4호
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• pp.844-852
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• 2005

Objectives : Through spectral analysis of heart rate variability(HRV) to study autonomic nervous system dysfunction of Hwabyung, culture related disease in Korea. Methods : HRV of 18 patients diagnosed as Hwabyung was measured against 13 healthy controls. HRV was measured by SA-2000p(Mediocre, Korea) for five minutes after 5 minutes resting. Results : 1. In time domain analysis, mean pulse rate(PRT) of in Hwabyung group was significantly higher than healthy controls. Standard deviation of all normal P-P intervals(SDNN), the square root of the mean of the sum of the squares of differences between adjacent normal P-P intervals(RMS-SD) in Hwabyung group was lower than healthy controls, but not significant. 2. As for frequency domain analysis, In TP(logarithmic total power), In VLF(logarithmic very low frequency), and In LF(logarithmic low frequency )in Hwabyung group was significantly lower than healthy controls. Ln HF(logarithmic high frequency), LF/HF ratio in Hwabyung group was also lower but not significant. Conclusions : This study suggests tile activity and imbalance of cardiac autonomous nervous system in Hwabyung patient is significantly lower than healthy individuals.

• 한국방사선학회논문지
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• 제15권4호
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• pp.499-505
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• 2021

본 연구는 HRV 신호를 분석하여 비임산부와 임산부의 시기별 자율신경계 활성도를 비교하였다. W병원의 질병이 없는 임산부 99명과 비임산부 27명을 연구대상으로 하였다. 획득한 HRV 신호는 프로그램을 이용해 시간영역 분석, 주파수 영역 분석을 실시하였다. 측정된 값은 일원배치 분산 분석을 통해 임신 시기별 간의 차이를 통계 분석 하였다. 결과에서, 시간 영역 분석에서 SDNN과 RMSSD는 임신 초기와 비임신 여성의 결과값이 임신 중기, 말기와 비교했을 때 유의하게 높았다. 주파수 영역 분석에서 LF와 HF는 임신 초기와 비임신의 값이 중기, 말기에 비하여 유의하게 높았으나 VLF와 LF/HF에서는 유의한 차이가 없었다. 이는 임신이 진행될수록 비임신 상태와 임신 초기보다 중기 및 말기에 자율신경 조절 능력이 저하되고 신체적 피로도와 정신적 피로도가 증가하게 되는 것을 의미한다. 따라서 임신 기간이 길어질수록 임산부의 심신 안정을 유지하기 위해 각별한 관리가 필요할 것으로 사료된다.

• 대한한의진단학회지
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• 제9권2호
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• pp.94-109
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• 2005

Objectives: This paper investigated the effects of 8 Constitution Acupuncture on Heart Rate Variability(HRV) and is intended to find out 8 Constitutional difference on Autonomous Function after 8 Constitution Acupuncture stimulation. Methods: The subjects were comprised of 42 volunteers(11 men and 31 women). The volunteers had acupunctured by 8 Constitution Acupuncture Therapy. HRV and Mean Heart Rate(MHR) were measured by TAS9v2.0(IEMBIO & Saerom, Korea) on two times: before and immediately after acupuncture stimulation. The SPSS 13.0 for windows was used for statistical analysis: Mann-Whitney U-test, Paired Samples T -test and Wilcoxon signed rank test were used to verify the results. Results: 1. There was no statistically significant difference on HRV and MHR between Sympathicotonia and Vagotonia before acupuncture. 2. In the whole subject, immediately after acupuncture stimulation, MHR showed a significant decrease(p<0.01) and Ln(TP), Ln(LF) and Ln(HF) showed a significant increase(p<0.05). But there was no significant difference in LHR. 3. Immediately after acupuncture stimulation, MHR showed a significant decrease and Ln(TP), Ln(HF), showed a significant increase in Pulmotonia(p<0.05), Ln(TP) showed a significant increase in Pancretonia(p<0.05),MHR showed a significant decrease and Ln(TP) showed a significant increase in Hepatonia(p<0.05), and MHR showed a significant decrease and Ln(TP), Ln(HF), showed a significant increase in cholecystonia(p<0.05). But there were no significant difference on HRV and MHR in Colonotonia and vesicotonia. Conclusion: The results suggest that 8 Constitution Acupuncture is associated with changed activity in sympathetic and parasympathetic nervous system. Further study is needed for investigating the effects of 8 Constitution Acupuncture on HRV and autonomic nervous system.

• 한국전자통신학회논문지
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• 제10권1호
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• pp.125-132
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• 2015

본 논문은 인지능력이 저하된 노인들에게 침과 뜸 요법을 시행하고 HRV 측정값을 통하여 그 효과를 분석한다. 인지능력이 저하되거나 상실된 사람들에게 자주 사용되었던 주요한 경혈을 고문헌에서 조사하였다. 인지능력이 저하된 노인들에게 침과 뜸을 시술한 후 HRV 측정기를 이용하여 여러 가지 변화를 측정하였다. 측정된 값들을 상호 비교하여 자율신경계와 심박동수의 변화에 침과 뜸이 어떤 영향을 주는지 효능을 측정하였다. 연구 결과 침과 뜸이 인지능력의 개선에 긍정적이 효과가 있다는 것을 HRV 분석을 통해 확인할 수 있었다.

• Journal of Korean Neurosurgical Society
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• 제47권5호
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• pp.345-351
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• 2010

Objective : In this study, the Mindfulness Based Stress Reduction (MBSR) program was applied to patients presenting with depression and anxiety after surgery from spontaneous subarachnoid hemorrhage (SAH) and the effects were assessed. Methods : The subjects were patients admitted for cerebral aneurysm rupture and treated by means of surgery from March to December, 2007. More than 6 months had passed after surgery, without any special lesions showing up on computed tomography (CT), and the Glasgow outcome scale (GOS) was 5 points. Among patients with anxiety and depression symptoms, 11 patients completed the program. The MBSR program was conducted once a week, 2.5 hours each, for 8 weeks. The evaluation criteria were : 1) the Beck Depression Inventory (BDI): it measures the type and level of depression, 2) the State-Trait Anxiety Inventory : the anxiety state of normal adults without mental disorder, and 3) Heart Rate Variability (HRV) : the influence of the autonomous nervous system on the sinoarterial node varies continuously in response to the change of the internal/external environment. Results : The BDI value was decreased from 18.5 ${\pm}$ 10.9 to 9.5 ${\pm}$ 7.1 (p = 0.013) : it was statistically significant, and the depression level of patients was lowered. The state anxiety was decreased from 51.3 ${\pm}$ 13.9 to 42.3 ${\pm}$ 15.2; the trait anxiety was reduced from 50.9 ${\pm}$ 12.3 to 41.3 ${\pm}$ 12.8, and a borderline significant difference was shown (p = 0.091, p = 0.056). In other words, after the treatment, although it was not statistically significant, a decreased tendency in anxiety was shown. In the HRV measurement, standard deviation normal to normal (SDNN), square root of the square root of the mean sum of squared differences between adjacent normal to normal intervals (RMSSD), and total power (TP) showed significant increase, Physical Stress Index (PSI) showed a significant reduction, and thus an improvement in the homeostatic control mechanism of the autonomic nervous system was ween. Conclusion : The MBSR program was applied to the patients showing anxiety and depression reaction after SAH treatment, and a reduction in depression symptoms and physiological reactions were observed. The application of the MBSR program may be considered as a new tool in improving the quality of life for patients after surgery.

• Molecules and Cells
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• 제45권11호
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• pp.846-854
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• 2022

Neurons make long-distance connections via their axons, and the accuracy and stability of these connections are crucial for brain function. Research using various animal models showed that the molecular and cellular mechanisms underlying the assembly and maintenance of neuronal circuitry are highly conserved in vertebrates. Therefore, to gain a deeper understanding of brain development and maintenance, an efficient vertebrate model is required, where the axons of a defined neuronal cell type can be genetically manipulated and selectively visualized in vivo. Placental mammals pose an experimental challenge, as time-consuming breeding of genetically modified animals is required due to their in utero development. Xenopus laevis, the most commonly used amphibian model, offers comparative advantages, since their embryos ex utero during which embryological manipulations can be performed. However, the tetraploidy of the X. laevis genome makes them not ideal for genetic studies. Here, we use Xenopus tropicalis, a diploid amphibian species, to visualize axonal pathfinding and degeneration of a single central nervous system neuronal cell type, the retinal ganglion cell (RGC). First, we show that RGC axons follow the developmental trajectory previously described in X. laevis with a slightly different timeline. Second, we demonstrate that co-electroporation of DNA and/or oligonucleotides enables the visualization of gene function-altered RGC axons in an intact brain. Finally, using this method, we show that the axon-autonomous, Sarm1-dependent axon destruction program operates in X. tropicalis. Taken together, the present study demonstrates that the visual system of X. tropicalis is a highly efficient model to identify new molecular mechanisms underlying axon guidance and survival.