• 대한약침학회지
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• 제11권1호
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• pp.41-54
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• 2008

Objective : In this study, we investigated the effects of Sweet Bee Venom(SBV) and Bee Venom(BV) at a acupoint, HT7(Shinmun) on the Heart Rate Variability(HRV) in the healthy man. And we tried to observe how Sweet Bee Venom and Bee Venom affects on the balance of the autonomic nervous system. Methods : We investigated on 22 heathy volunteers consisted of 10 subjects in SBV group and 12 subjects in BV group. Study form was a randomized, placebo-controlled, double-blind clinical trial. 22 subjects of each group were injected SBV and BV at HT7(Shinmun). And we measured HRV by QECG-3:LXC3203 (LAXTHA Inc. Korea) on 7 times : before and after injection per 5minutes during 30minutes. Results : 1. After SBV injection, Mean-RR was significantly high from 0 to 10 minutes, Mean-HRV was significantly low from to 10 minutes, SDNN was significantly high after 25minutes, Complexity was significantly high from 5 to 10 minutes and RMSSD was significantly high from 5 to 10minutes. 2. Complexity of SBV Group significantly decreased from 20 to 25minutes, RMSSD of SBV Group significantly increased from 10 to 15minute and from $20{\sim}25$minutes, SDSD of SBV Group significantly increased from 10 to 15 minute and from $20{\sim}25$minutes compared with that of BV group. 3. After SBV injection, Ln(VLF) was significantly from 25 to 30minutes. Conclusions : The results suggest that SBV in heathy adult man tend to activate the autonomic nervous system compared to BV within normal range.

• 대한한방부인과학회지
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• 제24권3호
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• pp.98-108
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• 2011

Objectives: The purpose of this study is to investigate the relationship between granulocyte/lymphocyte ratio and dysmenorrhea, history of gynecological disease, heart rate varibility(HRV). Methods: From May 1st 2011 to July 10th 2011, a total of 40 female subjects (age 20-39) were recruited. We evaluated the menstruation condition by questionnaires including VAS(Visual Analog Scale), VRS(Verbal Rating Scale) and MVRS (Multidimensional Verbal Rating Scale), also measured subject's WBC differential count and HRV. Results: 1. There was no statistically significant difference in granulocyte/lymphocyte ratio according to menstruation cycle, duration, amount, color, and blood clot. 2. There was no statistically significant difference in VAS, VRS, MVRS mean scores between normal group and abnormal group according to granulocyte/ lymphocyte ratio. 3. The past prevalence of gynecological disease of abnormal group showed significantly higher compared with that of normal group($x^2$=6.578, p=0.010). 4. LF/HF ratio and granulocyte ratio significantly showed positive correlation ($r_s$=0.311 p=0.048) and LF/HF ratio and lymphocyte ratio significantly showed negative correlation($r_s$=-0.319 p=0.045). Conclusion: These findings suggest that the gynecologic diseases are related to disorder of autonomic nervous system, but not dysmenorrhea. And the balance state of sympathetic/parasympathetic nerve infered through granulocyte/lymphocyte ratio and HRV seems to be consistent. However, reconfirmation through further studies is needed.

• Journal of Acupuncture Research
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• 제29권3호
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• pp.89-99
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• 2012

Objectives : This study was performed to investigate the effect of simple acupuncture and electroacupuncture at Bai Hui($GV_{20}$) on heart rate variability in healthy adults with stress task. Methods : 40 healthy volunteers participated in this study. HRV was recorded before and after stress. And then simple acupuncture(SA group) was applied at $GV_{20}$ or electroacupuncture(EA group) was applied at the same spot in each treatment group for 20 minutes. No treatment was performed in control group for 20 minutes. Then HRV was recorded. Results : 1. In all groups, LF norm, LF/HF, HF norm showed significant changes after mental stress. 2. Control group showed no significant change. In SA group, HF norm LF, LF norm and LF/HF showed a significant change after treatment. In EA group, Mean HR, HF, LF norm, HF norm and LF/HF showed a significant change after treatment. In both treatment groups, there were significant differences after treatment compared to control group. 3. In EA group, HF and HF norm decreased significantly after treatment compared to SA group. Conclusions : These results suggest that simple acupuncture and electroacupuncture at $GV_{20}$ affect the balance of the autonomic nervous system and that electroacupuncture at $GV_{20}$ enhances parasympathetic activation more than simple acupuncture.

• 대한한의학회지
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• 제29권2호
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• pp.107-115
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• 2008

Objectives: The objective of this study was to assess the effects of acupuncture applied at PC6 and SP4 points on heart rate variability (HRV) in normal subjects under mental stress Methods: 24 healthy male subjects were recruited and randomized to a treatment group (12 subjects) or a control group (12 subjects). Both groups performed a mental arithmetic stress test and then acupuncture needles were inserted on PC6 and SP4 for the study group. In the control group, they took sham acupuncture as a control. Heart rate variability (HRV) was measured during the whole study period by FM-150 (digital Holter ECG recorder). Results: In the both groups, low frequency (LF) power and ratio of low frequency to high frequency (LF/HF) was significantly increased after mental stress. Acupuncture induced significant decrease in low frequency (LF) power and ratio of low frequency to high frequency (LF/HF) which were increased after mental stress test. But sham acupuncture induced no changes. Results: In both groups, low frequency (LF) power and ratio of low frequency to high frequency (LF/HF) significantly increased after mental stress. Acupuncture induced significant decrease in low frequency (LF) power and ratio of low frequency to high frequency (LF/HF) which increased after mental stress test. In contrast, sham acupuncture induced no changes. Conclusions: Acupuncture on PC6 and SP4 could be useful to decrease sympathetic activity and balance autonomic nervous system for those who are under stress.

• 감성과학
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• 제18권2호
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• pp.19-30
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• 2015

본 연구는 라벤더 향과 레몬 향을 포함하는 방향성 의류소재에 힐링효과가 있는지 알아보고자 신체 반응인 자율신경계 반응을 평가하였다. 이를 위해 라벤더와 레몬향의 마이크로캡슐과 수성 아크릴 바인더를 사용하여 면직물에 코팅처리 하여 각각 2%, 5%의 농도로 처리 된 라벤더와 레몬향의 방향성 의류소재 총 4종을 만들었다. 심전도, 피부전도수준, 혈류량의 실험 참여자는 10명 이었으며, 안정 상태에서 30초, 스트레스 상태 (working memory task) 30초, 향 자극 상태(방향성 섬유를 비벼 향을 나게 한 후) 30초를 측정하였다. 그리고 주관적 감성 평가도 함께 실시하였다. 데이터를 분석하기 위해 표준화를 해주었으며, 표준화 값에 대하여 안정 상태와 자극 상태의 생리신호 차이와, 스트레스 상태와 자극 상태의 생리신호 차이를 알아보기 위해 비모수검정 Friedman 검증을 통해 그 경향을 분석 하였다. 자율신경 발란스 지수(LF/HF)는 스트레스 유발 후 향 자극 상태와 유의한 차이가 있어 사후검증 하였다. 그 결과 레몬 5%의 향 자극은 라벤더 2%, 라벤더 5%, 레몬 2%의 향 자극과 유의한 차이가 있었다. 스트레스 유발 후 레몬 5%의 향 자극은 스트레스를 증가 시켰으나 라벤더 2%, 라벤더 5%, 레몬 2%의 향 자극은 심리적 안정을 유발하여 스트레스를 감소시켰으며 본 논문에서 힐링효과를 나타냈다.

• 동의신경정신과학회지
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• 제20권1호
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• pp.165-176
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• 2009

Objectives : The purpose of this study was to assess the effects of mental stress stimulation and acupucnture applied at HT7 point on heart rate variability (HRV) in normal subjects. Methods : Thirty seven healthy volunteers participated in this study. The volunteers were randomly allocated into two groups. Both groups performed a mental arithmetic stress test and stroop color-word test for 10 minute. Then, acupuncture needles were inserted on HT7 for the study group and on non-acupucnture point for the control group. HRV was recorded three times at test time and before and after acupuncture stimulation. Results : After giving mental stress stimulation to both groups, LF and LF!HF ratio were increased and HF was decreased significantly. After giving acupuncture to study group, LF and LF/HF ratio were decreased and HF was increased, but it was not significant. After giving acupuncture to control group, LF and LF/HF ratio were increased and HF was decreased, but it was not significant. Conclusions : This results show that mental arithmetic stress test and stroop color-word test contribute to activation of the sympathetic nervous system Acupuncture at HT7 could be relatively useful to decrease sympathetic activity and balance autonomic nervous system for those who are under stress.

• 동의생리병리학회지
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• 제26권5호
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• pp.745-752
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• 2012

This study aims to show the change of Heart Rate Variability(HRV) and Pulse wave velocity(PWV) on menstruation in women at college. Heart Rate Variability(HRV) and Pulse wave velocity(PWV) of 122 women at college were measured at their menstruation and ordinary period. SDNN, RMSSD, SDSD, HRV Index(%), stress resistance and cardiac activity were significantly higher at their menstruation than ordinary period, but Total Power and pNN50(%) were opposite. The automatic nervous system balance and physical stress were decreased in groups without dysmenorrhea than with one. PWV(E-R) and PWV(E-L) were much higher at menstruation than ordinary period. PTT(F-R) and PTT(F-L) were decreased in groups without dysmenorrhea than with severe one. We demonstrated that menstruation can effect on Heart Rate Variability and Pulse wave velocity and dysmenorrhea can cause the imbalance of autonomic nervous system.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 제37회 하계학술대회 논문집 D
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• pp.2157-2158
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• 2006

Heart Rate Variability (HRV) system is useful for evaluating the balance in homeostasis of autonomic nervous system. In this study, we implement HRV monitoring system by performing real time FFT spectrum analysis on R-R intervals data acquired from Electrocardiogram (ECG) acquisition and transmitting the data by RF communication module.

• 대한통합의학회지
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• 제1권1호
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• pp.11-22
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• 2013

Purpose : The purpose of this study was to investigate the effects of music intervention upon lighting on stress. Method : The participants 60 college students, were divided three groups. Two groups were apply each music and bright lighting(bright lighting groups) and music and dark lighting(dark lighting groups) during 13minutes at Snozelen and the other group was control group. Each groups were assessed stress resistance, activity of parasympathetic nerve, activity of sympathetic nerve, balance of ANS, physical arousal by EKG of CANS 3000, at before and after other each intervention. The analyses were performed using version of SPSS 17. Result : The change rate of bright lighting group was showed statistically significant decrease in stress resistance compared to control group. And the change rate of dark lighting group was showed statistically significant decrease in resistance stress, activity of parasympathetic nerve, and balance of ANS compared to control group and statistically significant increase in stress resistance and activity of parasympathetic nerve compared to bright lighting group. Conclusion : The results of this study indicate that music intervention on dark lighting is more effective on decrease of stress than application of bright lighting and general lighting.

• 감성과학
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• 제22권1호
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• pp.55-64
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• 2019

스트레스는 자율신경계 반응의 변화를 수반하며, 특히 심박변이도 지표는 스트레스에 의한 자율신경계의 활동을 반영하는 양적 지표로 사용된다. 본 연구에서는 스트레스 완화를 위한 산소와 색채 조명의 복합 자극이 제시되는 동안 자율신경계 반응의 변화를 확인하였다. 42명의 실험참가자는 지난 2주 동안 경험한 스트레스에 대한 증상들을 스트레스 반응 척도에 평가하였다. 스트레스 평가 후, 실험참가자는 복합 자극을 제시받았고, 자극 제시 전과 후, 그리고 자극이 제시되는 동안 심전도 신호가 기록되었다. 자극 조건은 30% 농도의 산소와 백색 조명, 산소와 주황색 조명과 산소와 파란색 조명의 조합의 세 가지로 구성되었다. 심박률(HR), R-R간격의 표준편차(SDNN), 연속한 R-R 간격 차이 값의 평균제곱근(RMSSD)과 심박변이도의 저주파 성분(LF), 고주파 성분(HF), 그리고 LF와 HF의 비율을 심박변이도 지표로 추출하였다. 이들 지표는 자극 제시 전과 후의 평균을 비교하는데 활용되었다. 결과는 자극 조건이 제시되고 난 후, HR과 LF/HF ratio의 유의한 감소를 보여주었다. 특히, 산소와 파란색 조명이 제시된 조건에서 다른 두 조건보다 유의하게 큰 RMSSD와 HF의 증가 및 LF/HF ratio의 감소가 나타났다. 이는 30% 농도의 산소와 파란색 조명의 조건이 부교감신경의 활성화에 의한 자율신경의 균형을 유발하여 스트레스 이완에 가장 효과적임을 보여주었다.