• 한국생물공학회:학술대회논문집
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• 2000.11a
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• pp.147-150
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• 2000

Bioprocess chromatography is probably the most widely used unit operation in biopharmaceutics manufacturing. To obtain a good quality product reproducibly, the chromatography process validation should be performed carefully. We developed a miniaturized automatic chromatography system, MiniValChrom, for column performance validation.

• Journal of Institute of Control, Robotics and Systems
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• v.15 no.2
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• pp.240-248
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• 2009

Modem version of supersonic jet fighter aircraft must have been guaranteed appropriate controllability and stability in HAoA(High Angle of Attack). The HAoA flight control law have two parts, one is control law of departure prevention and the other is control law of departure recovery support. The control laws of departure prevention for advanced jet trainer consist of HAoA limiter, roll command limiter and rudder fader. The control laws of departure recovery support are consist of yaw-rate limiter and MPO(Manual Pitch Override) mode. The guideline of pitch rocking using MPO mode is simple, but operating skill of pitch rocking is very difficult by the pilot with inexperience of departure situation. Therefore, automatic deep stall recovery system is necessary. The system called the "Automatic Pitch Rocker System" or APRS, provided a pilot initiated automatic maneuver capable of an aircraft recoveries in situations of deep stall, speed and altitude. This paper addresses the design and validation for APRS to recovery of an deep stall without manual pitch rocking by the pilot. Also, this system is designed to recovery of speed, attitude and altitude after deep stall recovery using ATCS (Automatic Thrust Control System) and autopilot. Finally, this system is verified by real-time pilot evaluation using HQS (Handling Quality Simulator).

• Proceedings of the KSR Conference
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• 2007.05a
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• pp.126-131
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• 2007

Design for automatic coupler system of Korean Tilting Train eXpress is described. In order to carry out validation & verification activities for system design, test condition is taken into account at collision speed of 10km/h, which is required in Safety Notice for rolling stock vehicle. The study aims at safety validation between a coupler and car body including design verification for a coupler through the identifying of system design and the evaluating of test results.

• KSBB Journal
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• v.17 no.4
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• pp.326-332
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• 2002

The quality of biopharmaceutical proteins is strongly affected by a manufacturing process employed to produce Et, and thus validation of the manufacturing bioprocess is a very important issue. Chromatography is probably the most widely used bioprocess unit operation for protein purification. In this study, a miniaturized automatic chromatography system was designed and constructed for scale-down studies for process chromatography validation. This system, named MiniValChrom, has the following features: automatic and repeated operation, flexible sequences and intervals among the steps, on-line and real-time monitoring and control, method files savings, etc. Using the MiniValChrom, we peformed a case study of an abbreviated experiment to estimate chromatographic resin lifetime. BSA (bovine serum albumin) and Cibacron Blue 3G-A were used as the model protein and the resin, respectively. The resin deterioration was evaluated by determining and monitoring the HETP and NTP values from the chromatograms every 5 cycles. It was observed that the HETP and the NTP values were changed by 9% after 15 cycles. The resin lifetime validation could be completed by repeating this experiment until the HETP value reached a predetermined value. The MiniValChrom's concept and the protocol suggested in this study can serve as a rapid and economical tool for the validation studies of bioprocess chromatography system.

• Journal of applied mathematics & informatics
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• v.3 no.2
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• pp.183-192
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• 1996

The least squares cross validated bandwidth is the mini-mizer of the corss validation function for choosing the smooth parame-ter of a kernel density estimator. It is a completely automatic method but it requires inordinate amounts of computational time. We present a convenient formula for calculation of the cross validation function when the kernel function is a symmetric polynomial with finite sup-port. Also we suggest an algorithm for finding global minima of the crass validation function.

• Journal of electromagnetic engineering and science
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• v.15 no.3
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• pp.181-184
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• 2015

Evaluation of radiating radiofrequency fields from hand-held and body-mounted wireless communication devices to human bodies are conducted by measuring the specific absorption rate (SAR). The uncertainty of system validation and probe calibration in SAR measurement depend on the variation of RF power used for the validation and calibration. RF input power for system validation or probe calibration is controlled manually during the test process of the existing systems in the laboratories. Consequently, a long time is required to reach the stable power needed for testing that will cause less uncertainty. The standard uncertainty due to this power drift is typically 2.89%, which can be obtained by applying IEC 62209 in a normal operating condition. The principle of the Automatic Input Power Level Control System (AIPLC), which controls the equipment by a program that maintains a stable input power level, is suggested in this paper. The power drift is reduced to less than ${\pm}1.16dB$ by AIPLC, which reduces the standard uncertainty of power drift to 0.67%.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.14 no.2
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• pp.9-16
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• 2006

FAA AC120-40B Level D flight dynamics model for T-50 Full Mission Trainer was successfully developed. Since AC120-40B Level D requires the quantitative validation tests for simulation model compared with flight test data, T-50 flight test data for each validation test item was gathered, and also automatic test environments which include AFT (Automatic Fidelity Tester) and STA (Simulation Test Analyzer) were developed. The final test results after the iterative test-tuning processes were all within the tolerances specified in AC120-40B Level D. Qualification Test Guide, QTG contains the detail test processes and results.

• Journal of Korea Society of Industrial Information Systems
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• v.25 no.4
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• pp.17-27
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• 2020

In this paper, we proposed verification methods to prove the effectiveness of automatic test equipment (ATE) for weapon systems. Since the test results from the unproven ATE is not reliable and its use is limited as objective data, it is essential to verify the test equipment in order to guarantee the quality level of the unit under test (UUT). Through the suggested methods, it is applied to the ATE of the tactical information communications network (TICN) system to confirm the verification results and to describe the validation results.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.9
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• pp.144-150
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• 2020

This study examined the current status of ATE in the development stage of the domestic guided weapons field, including the re-establishment of automatic test equipment (ATE), and attempted to develop methods to verify the validity of ATE in the defense sector. This study includes methods for confirming the repeatability and reproducibility of newly manufactured or replaced ATE. An error injection test is required for validation in the development phase. And pre-inspection steps are required for validation. When developing ATE, the use of an international standard testing script language ensures efficient validation and SW reliability. This ensures interoperability between the main and test equipment, and the tester can secure a test system platform that supports standardized testing methods, which is considered to be effective in validating specific ATE for each weapon system.

• Biotechnology and Bioprocess Engineering:BBE
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• v.10 no.2
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• pp.142-148
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• 2005

This paper proposes a cell age model for Penicillium chrysogenum fed-batch cultivation to supply a qualitative insight into morphology-associated dynamics. The average ages of the segregated cell populations, such as growing cells, non-growing cells and intact productive cells, were estimated by this model. A combined model was obtained by incorporating the aver-age ages of the cell sub-populations into a known but modified segregated kinetic model from literature. For simulations, no additional effort was needed for parameter identification since the cell age model has no internal parameters. Validation of the combined model was per-formed by 20 charges of industrial-scale penicillin cultivation. Meanwhile, only two charge-dependent parameters were required in the combined model among approximately 20 parameters in total. The model is thus easily transformed into an adaptive model for a further application in on-line state variables prediction and optimal scheduling.