• 한국감성과학회:학술대회논문집
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• 한국감성과학회 2002년도 추계학술대회 논문집
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• pp.148-152
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• 2002

This study is to develop the Alzheimers disease (AD) detection and analysis system using event-related potential (ERP) of AD patients. We recorded ERP in an auditory oddball paradigm in mild AD (n=25), severe AD (n=12), age-matched normal aged controls (n=17), and young controls (n=7). The amplitude and latency of target P300 components were compared among 4 groups. The relationship between P300 measures and neuro psychological test (K-DRS) scores were evaluated by correlations. The latency of P300 was prolonged in AD and the effects were correlated with the severity of dementia. The P300 amplitude was not affected significantly in AD. Theres no difference between normal aged group and young group. These results suggest that the P300 component is specifically affected by Alzheimer type dementia.

• 한국멀티미디어학회논문지
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• 제20권12호
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• pp.1856-1864
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• 2017

The ultimate goal of multimedia in bio-signal research is to approach multimedia contents through bio-signal. Hence it is important to interpret user's emotions by analyzing his or her bio-signals. In this paper, we construct ERP task of oddball component to analyze EEG signal between normal stimuli and fear stimuli and measure EEG during ERP task. The results from extracted ERP component show that there is a difference in N200 in visual stimuli, P300 in auditory stimuli, and N100 and P300. Moreover, there are larger changes in audiovisual stimuli, indicating that users recognize greater fear of crime when visual and auditory stimuli are simultaneously presented.

• Annals of Clinical Neurophysiology
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• 제3권2호
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• pp.136-142
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• 2001

Background : Nervous system dysfunction is a major complication of end stage renal disease. Although severe neurologic symptoms are partially or completely reversed by adequate hemodialysis, even optimally dialyzed patients will usually not return to normal neurocognitive function. To investigate the influence of chronic renal failure and hemodialysis on higher cognitive function electrophysiologically, we studied auditory P300 event-related potentials in 14 hemodialysis patients and 14 age- and sex-matched normal healthy controls. Methods : The subjects consisted of 14 patients(M: 6, F: 8) with chronic renal failure(CRF) for 1 to 10 years and 14 age- and sex-matched healthy controls(M: 5, F: 9). For the reliability of study, patients with diabetes mellitus, abnormal brain CT findings, or low mini-mental state score(below 20) were excluded. Event related potentials(ERPs) for hemodialysis patients were performed at pre- and post-hemodialysis. To obtain ERPs, subjects underwent 2-tone auditory discrimination test(oddball paradigm). Results : Although the age(control: $48.79{\pm}10.31years$, CRF: $51.21{\pm}7.61years$) and mini-mental state score(control: $27.00{\pm}1.71points$, predialysis CRF: $25.07{\pm}3.58points$) were not different in normal control and CRF groups significantly(P>0.05), P300 latencies at Cz(control: $288.11{\pm}17.36msec$, predialysis CRF: $332.35{\pm}42.34msec$) were significantly delayed(P<0.05)and the duration of Trail making test A was significantly prolonged(control: $64.2{\pm}24.2sec$, CRF: $118.9{\pm}101sec$) in CRF group. P300 latencies between pre- and post-hemodialysis CRF patients(predialysis CRF: $332.35{\pm}42.34msec$, postdialysis CRF: $325.82{\pm}38.69msec$) were not significantly different. The P300 latency was not related with the duration of CRF(Spearman's correlation test, r=0.25, P>0.05) and the frequency of hemodialysis(Spearman's correlation test, r=0.28, P>0.05). Conclusions : From these results, we suggest that P300 latency is valuable in evaluating cognitive brain dysfunction in patients with CRF and hemodialysis does not have a significant effect on cognitive brain dysfunction in patients with CRF.

• The Journal of Korean Physical Therapy
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• 제26권4호
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• pp.234-239
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• 2014

Purpose: The purpose of this study is to use P300 latency to determine whether methods of motor learning in terms of massed and distributed practice can affect motor sequential learning in healthy adults. Methods: Twenty-four healthy subjects participated in this study. They were randomly allocated into three groups: a 10 minute, a 12 hour, and a 24 hour group. In the SRT task, eight numbers were adopted as auditory stimuli. During an experiment, participants were instructed to press the matching key as quickly and accurately as possible when one of the eight numbers was presented randomly. The subjects practiced for three sessions, each of which comprised five blocks of 40 serial reaction time tasks. While they practiced during these three sessions, P300 latency was measured. The data were analyzed using ANCOVA. Results: The P300 latency of Fz, Cz, and Pz decreased in all groups except for the Fz area of the 10 min group. Overall, the P300 latency of the 10 min group showed a smaller decrease compared with the 12 hr and 24 hr groups. Statistically, no significant differences in the Fz and Cz areas were observed among the three groups. The P300 latency in the Pz area of the 10 min group showed a significantly smaller decrease compared with the other groups. Conclusion: These findings suggest that short-term sequential motor training can alter brain functions such as the P300 latency. We also found that better acquisition of a motor skill was obtained with distributed practice of a task than with massed practice.

• 동의신경정신과학회지
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• 제14권2호
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• pp.43-59
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• 2003

Object : This study was designed to assess the protective effects of Jowiseungchungtang on cognitive decline of the patients with early DAT[Dementia of Alzheimer Type]. Method : 15 patients with early DAT and 10 healthy elderly subjects were measured by using auditory ERP and K-DRS, and after 9 months again. During 9 months the patients with early DAT were administered with Jowiseungchungtang. Result : 1. The score of K-DRS increased in two group but it was not significant. 2. The latency of ERP P300 component increased in 2nd test of the normal group, but did not increase in 2nd test of patients group. 3. The amplitude of ERP P300 component showed the significant difference in electrode location in patients group, but it did not show any typical property. Conclusion : The results suggest that Jowiseungchungtang may have protective effects on cognitive decline in the patients with early DAT.

• 동의신경정신과학회지
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• 제16권1호
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• pp.43-66
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• 2005

Object : This study was designed to asses the protective effects of Kunneo tang on cognitive decline of the patients with early DAT. Method : Before administered with Kunneotang, 16 patients with early DAT were measured by auditory ERP, MMSE-K and K-DRS. During 12 months the patients with early DAT were administered with Kunneotang. After 12months the patients were measured by the same examinations again. Result : 1. The total score of MMSE-K decreased but it was not significant. 2. The total score of K-DRS increased but it was not significant. Among the five criteria(attention, memory, initiation/perseveration, construction, conceptualization), Initiation/perseveration score signifcantly decreased and there were no significant differences in the other scores. But, memory mean score had a tendency to increase. 3. The latency of ERP P300 component increased but it was not significant and the amplitude of ERP P300 component showed the significant difference. Conclusion : The results suggest that Kunneotang may have protective effects on cognitive decline in the patients with early DAT.

• Annals of Clinical Neurophysiology
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• 제1권1호
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• pp.26-30
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• 1999

본 연구에서는 ERP검사 중에는 중뇌동맥의 MFV가 검사전후와 비교하여 유의하게 증가힌 소견을 보였다. 비록 중뇌동맥의 혈류속도의 변화가 뇌활동정도를 직접 반영할 수는 없다고 생각이 되지만 이 연구의 결과로 P300의 생성에 중뇌동맥에 의해서 영양받는 전두엽, 측두엽 및 두정엽이나 다른 대뇌부위가 관여할 것으로 사료된다. 경두개도플러검사는 다른 뇌기능활동을 반영할 수 있는 양전자방출단층촬영이나 단일광자방출단층촬영과 같이 혈류역학을 볼 수 있는 검사와 병행하여 연구하면 P300의 발생부위를 규명하는데 도움을 줄 것으로 사료되며 뇌활동을 역동적으로 평가하는데 도움을 줄 것으로 생각된다.

• 인지과학
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• 제28권1호
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• pp.1-26
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• 2017

본 연구는 청각 oddball 방안, 사건관련전위와 sLORETA를 사용하여 조현형 인격 성향을 가지는 대학생의 P300 신호원을 조사하였다. 또한 P300 신호원의 전류밀도와 조현병 증상간의 관계를 조사하였다. Schizotypal personality questionnaire(SPQ)의 점수에 근거하여 조현형 인격성향군(n=37)과 정상통제군(n=42)을 선정하였다. P300은 자주 제시되는 표준 자극(1000Hz)과 드물게 제시되는 목표 자극(1500Hz)으로 구성되는 청각 oddball 과제를 사용하여 측정하였으며, 참여자들은 목표 자극이 몇 번 제시되었는지 횟수를 세어 실험 후 보고하는 것이 요구되었다. 행동분석 결과, Oddball 과제의 정확률에서는 두 집단 간 유의한 차이가 관찰되지 않았다. 사건관련전위를 분석한 결과, 조현형 인격성향군이 정상통제군에 비해 유의하게 감소된 P300 진폭을 보였다. P300의 신호원을 추정하기 위하여 sLORETA를 사용하여 분석한 결과, 두 집단 모두에서 좌우반구 전두엽, 두정엽, 측두엽, 후두엽에 분포되어 관찰되었다. 두 집단의 P300 신호원의 전류밀도를 비교한 결과, 조현형 인격성향군이 정상통제군에 비해 좌반구 상측두회와 우반구 중측두회에서 감소된 활성화를 보인 반면 좌반구 하전두회와 우반구 상전두회에서는 활성화 증가를 보였다. 이에 덧붙여, 조현형 인격성향군에서 우반구 상전두회의 전류밀도와 SPQ의 와해 점수 사이에 부적 상관이 관찰되었다. 이러한 결과는 P300 신호 원인 전두 및 측두 영역의 이상을 조현병 환자뿐만 아니라 경미한 증상을 가지고 있는 조현형 인격성향군도 가지고 있음을 시사한다. 이에 덧붙여 본 연구 결과는 조현병 고위험군의 선별에 사용되는 SPQ의 경우 총점보다는 와해 점수가 고위험군의 선별에 더 유용하게 사용될 수 있음을 시사한다.

• 대한전기학회논문지:시스템및제어부문D
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• 제49권6호
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• pp.334-338
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• 2000

Even though it is not practical, yet there is a trend of the researches related to the anesthesia on the determination of depth of anesthesia and level of consciousness in the view point of neurophysiological aspects. That is, quantification of physiological signals which represent human brain function and pharmacological response could be used to find the level of consciousness based on the changes in physiological signals. This research was performed to analyze the relationship between parameters extracted from LAEP(long latency auditory evoked potential) and the amount of sedatives injected to the patients. Seventeen patients were participated for the experiment. Two different sedatives, midazolam and diazepam, were injected intramuscularly, and LAEPs caused by 1KHz and 2KHz auditory tone bust were obtained. It was found that amplitude of extracted parameters from LAEP, N100 and P300, were reduced as dose of sedatives were increased. Results of this study could be used for extracting more meaningful index and establishing algorithm for predicting changes of level of consciousness induced by sedatives.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 2002년도 추계학술대회 논문집
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• pp.132-139
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• 2002

본 실험은 청각 사상관련전위(ERP)를 이용하여 다양한 성격 특질 모형들의 생물학적 근거와, 구조의 공통점과 차이점을 명확히 하기 위해서 설계되었다. 48명의 대학생 피험자들에게 4가지 성격 측정 검사(NEO-PI-R, EPQ-R, BIS/BAS 척도, IVE)를 시행하고, 이어 두 종류의 청각 자극 세트(50ms와 300ms)를 이용한 오드볼 과제를 통해 ERP를 측정하였다. 설문지 간의 상관과, 설문지와 ERP 내외생적 구성 요소 간의 상관, 그리고 그 상관의 두피 분포 양상을 통합적으로 고려하여 해석하였다. 각 성격 검사의 외향성 척도에 해당한다 할 수 있는 E, E, BAS-FUN은 양성 모두에서 높은 수준의 설문지 척도 간 정적 상관을 보였으나, 50ms 자극으로 유발된 P3 진폭은 E와 BAS-FUN에 대해서만 유의하게 높은 상관을 나타내었다. 이 결과는 Eysenck의 모델과 일견 일치하는 결과이지만, 그가 개발한 EPQ-R의 외향성 척도(E) 보다는 오히려 다른 척도들이 뇌파에 반영된 성격의 생물학적 기제를 측정하기 위한 적절한 도구일 수도 있음을 시사한다. 신경증적 경향성을 반영하는 N과 N 척도는 50ms 자극에 대한 여성 피험자의 N1, P2 진폭과 유의한 상관을 보였다. 그러나 이론적으로 두 척도에 등가적인 것으로 예상되었던 BIS 척도는 설문지 간 상관이나 ERP 요소와의 상관에서 모두 유의한 결과를 보이지 않았다. Eysenck가 성격의 세 번째 축(차원)으로 제시했던 P(정신병적 경향성) 역시 여성 피험자들에게서 두드러지는 설문지 간 상관을 보였으나, 300ms 자극에 대한 P2 진폭과의 정적인 상관은 양성을 합한 자료에서만 발견되었다. 여성의 상관 분포는 비록 통계적으로 유의한 수준에는 이르지 못하였으나, 양성 자료의 분포와 유사함이 확인되었다. 이 실험의 결과는 P3 진폭과 외향성 간의 부적인 상관 관계를 보고하였던 기존 연구들을 지지한다. 또한 본 실험에서 확인된 Eysenck 모델의 신경증적 경향성이나 정신병적 경향성이 ERP의 비교적 초기에 나타나는 외생적 구성 요소들(N1, P2)과의 상관 양상은, P3 요소에 집중하였던 기존 연구들이 외향성 이외의 차원으로 일관된 결과를 얻어내지 못했던 이유를 설명해줄 수 있을 것이다. 또한 성격 차원과 그것을 지표 하는 ERP 구성 요소 간의 관계를 해석할 때에 성별이나 유발 자극의 속성을 고려해야 함을 보여준다.