• Journal of Pharmaceutical Investigation
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• 제20권3호spc1호
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• pp.51-76
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• 1990

It is sometimes said lately that the pH of the human gastric juice is significantly different among individuals. Thus, the dissolution behavior of coated solid dosage forms should preferably be independent of the pH of the test solution. With these points as a background, the effect of pH on the dissolution velocity of coated tablets was studied to compare that of Pharmacoat with other gastric soluble film coating materials. Three viscosity types of Pharmacoat have been available(3, 6 and 15cP) until now. the 6cP type has been considered to be the most suitable for a tablet coating amongst the three types. The 3 cP type with a low degree of polymerization, is capable of providing high concentration, but the film strength is so inferior that sometimes cracking of the film may occur. On the other hand, in the case of the 15cP type, high polymer concentration cannot be achieved because of the high dgree of polymerization, and thus it is uneconomical for coating. Now, there is a strong demand to reduce the coating time even when HPMC is used in the 6cP type in order to reduce the coating cost. In order to improve this problem, we have concentrated our attention on reducing the viscosity value of HPMC to an allowable lower limit from 6cP. As a result of this study, it was found that the reduction of the viscosity value to around 4.5cP enabled the use of a higher solution concentration and an incidental shorter coating time without giving any substantial adverse effects on the properties of coated preparations. These experiment results are presented in the later part of this presentation. Based on this study, we have added the viscosity type of 4.5cP as one of the Pharmacoat products as Pharmacoat-645.

• 대한약리학회지
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• 제9권2호
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• pp.47-53
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• 1973

Chinae Rhizoma is dried crude roots and rhizomes obtained from Smilax china Linne which belongs to Smilax Genus of Liliaceae Familia, and it has been in wife use as a folk remedy for a long time. But very little systemic studies on its pharmacological actions have been made until now. Furthermore, the effective components except saponin of Chinae Rhizoma have been not known yet. It came to the attention of the authors that Chinae Rhizoma are used as antidiarrhetics in Chinese herb medicine, therefore they attempted to observe the effects of Chinae Rhizoma Alcoholic Extracts (Chinae Rhizoma Ethanol Extract=CREE, Chinae Rhizoma Methanol Extract=CRME) from Smilax china Linne on motility of the isolated rabbit duodenum in this experiment. The results of the study were as follow: 1. The movement of the isolated rabbit duodenum was slowed down and its tonus was relaxed in proportion to the concentration of Chinae Rhizoma Alcoholic Extracts (CREE & CRME). 2. With a concentration of CREE $10^{-4}g/ml$, the contractile effects of acetylcholine $10^{-6}g/ml$, pilocarpine $10^{-5}g/ml$ and physostigmine $10^{-5}g/ml$ were remarkably blocked in the movement of isolated rabbit duodenum. 3. The concentration of the isolated rabbit duodenum induced by barium chloride $10^{-4}g/ml$ was significantly inhibited by CREE $10^{-4}g/ml$. 4. With the administrations of histamine $10^{-5}g/ml$, serotonin $10^{-6}g/ml$ and prostaglandin $A_2\;10^{-6}g/ml$ respectively, contractions were observed in the rabbit duodenum. But, treatment of CREE $10^{-4}g/ml$ inhibited markedly the tonus and motility of the duodenum pretreated with the above drugs. 5. The effects of CREE and CRME were very much alike in this experiment. From the above results, it is concluded that the mechanism of action of Chinae Rhizoma on motility of isolated rabbit duodenum was partially due to cholinergic blocking effect.

• Asian Journal of Atmospheric Environment
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• 제8권1호
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• pp.25-34
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• 2014

In winter 2013, extreme air pollution by fine particulate matter ($PM_{2.5}$) in China attracted much public attention. In order to simulate the $PM_{2.5}$ pollution, the Community Multiscale Air Quality model driven by the Weather Research and Forecasting model was applied to East Asia in a period from 1 January 2013 to 5 February 2013. The model generally reproduced $PM_{2.5}$ concentration in China with emission data in the year 2006. Therefore, the extreme $PM_{2.5}$ pollution seems to be mainly attributed to meteorological (weak wind and stable) conditions rather than emission increases in the past several years. The model well simulated temporal and spatial variations in $PM_{2.5}$ concentrations in Japan as well as China, indicating that the model well captured characteristics of the $PM_{2.5}$ pollutions in both areas on the windward and leeward sides in East Asia in the study period. In addition, contribution rates of four anthropogenic emission sectors (power generation, industrial, residential and transportation) in China to $PM_{2.5}$ concentration were estimated by conducting zero-out emission sensitivity runs. Among the four sectors, the residential sector had the highest contribution to $PM_{2.5}$ concentration. Therefore, the extreme $PM_{2.5}$ pollution may be also attributed to large emissions from combustion for heating in cold regions in China.

• 한국재료학회지
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• 제21권4호
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• pp.192-195
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• 2011

The electro-deposition of compound semiconductors has been attracting more attention because of its ability to rapidly deposit nanostructured materials and thin films with controlled morphology, dimensions, and crystallinity in a costeffective manner (1). In particular, low band-gap $A_2B_3$-type chalcogenides, such as $Sb_2Te_3$ and $Bi_2Te_3$, have been extensively studied because of their potential applications in thermoelectric power generator and cooler and phase change memory. Thermoelectric $Sb_xTe_y$ films were potentiostatically electrodeposited in aqueous nitric acid electrolyte solutions containing different ratios of $TeO_2$ to $Sb_2O_3$. The stoichiometric $Sb_xTe_y$ films were obtained at an applied voltage of -0.15V vs. SCE using a solution consisting of 2.4 mM $TeO_2$, 0.8 mM $Sb_2O_3$, 33 mM tartaric acid, and 1M $HNO_3$. The stoichiometric $Sb_xTe_y$ films had the rhombohedral structure with a preferred orientation along the [015] direction. The films featured hole concentration and mobility of $5.8{\times}10^{18}/cm^3$ and $54.8\;cm^2/V{\cdot}s$, respectively. More negative applied potential yielded more Sb content in the deposited $Sb_xTe_y$ films. In addition, the hole concentration and mobility decreased with more negative deposition potential and finally showed insulating property, possibly due to more defect formation. The Seebeck coefficient of as-deposited $Sb_2Te_3$ thin film deposited at -0.15V vs. SCE at room temperature was approximately 118 ${\mu}V/K$ at room temperature, which is similar to bulk counterparts.

• 한국잡초학회지
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• 제32권3호
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• pp.230-239
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• 2012

Coconut (Cocos nucifera L) is one of the predominant plantation crops in Sri Lankan economy which is known to have existed for over thousands of years. During the past decades coconut production had been reduced by a significant quantity. The usage of poor quality planting materials is a major reason for the low coconut production. Thus much attention needs to be paid in coconut nurseries. Weed management is a critical management practice in the nursery. Though glyphosate application is becoming popular in nurseries it can affect weeds as well as coconut seedlings growth. Therefore the effects of glyphosate were evaluated by determining the growth of shoot and root of coconut seedlings. Poly bag nursery was prepared and three treatments were used. Treatments were no glyphosate and manual weeding ($T_1$), application of glyphosate 1.08 ai kg $ha^{-1}$ at 2 monthly interval ($T_2$) and application of glyphosate 1.44 ai kg $ha^{-1}$ at 2 monthly interval ($T_3$). Application of glyphosate at early stage of seedling growth had a no significant effect on growth parameters tested. However, the concentrations of glyphosate negatively affected numbers, volumes and dry weights of secondary, tertiary and quaternary roots at the latter stage of seedling growth. The leaf area and the height of seedling were significantly reduced by the highest concentration of glyphosate. Among the growth parameters tested, seedling girth and shoot dry weight were not affected by the application of glyphosate. These results revealed that the usage of glyphosate at both concentrations negatively affected root growth of coconut seedlings. Based on these results, the both concentration levels of glyphosate should be applied to coconut nurseries before sprouting the seed nuts.

• 환경위생공학
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• 제24권2호
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• pp.40-48
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• 2009

Unusual bloom of toxic cyanobacteria in water bodies have drawn attention of environmentalists world over. Major bloom of Anabaena, Microcystis in water storage reservoir, rivers and lake leading to adverse health effects have been reported from Australia, England and many part of the world. These cyanobacterial cells can release intercellular matter like toxin in water and these intercellular matter can increase the concentration of organic matter. Cellysis can occur when algal cells meet the disinfectants like chlorine in water treatment plant and the resultant rising up of DOC(Dissolved Organic Carbon) or TOC(Total Organic Carbon) can increase the formation of disinfection by products. Disinfectants that kill microorganisms react with the organic or inorganic matter in raw water. In general disinfectants oxidize the matter in raw water and the resultant products can be harmful to human. There are always conflict about which is more important, disinfection or minimizing disinfection by products. The best treatment process for raw water is the process of the lowest disinfection by products and also the the lowest microorganism. In this study the cultured cells, Microcytis Aeruginosa(MA), Anabaena Flos-aquae(AF), Anabaena Cylindrica(AC), and the cells obtained in Daechung Dam(DC) whose dominant species was Anabaena Cylindrica were subjected to chlorination. Chlorination oxidizes inorganic and organic compounds and destruct live cells in raw water. Chloroform was analyzed for the cultured cells which were treated with $20mg/\ell$ dose of chlorine. In general chloroform is easily formed when dissolved organic matter react with chlorine. The cultured cells contributes the concentration of dissolved organic carbon and also that of total organic carbon which might be potent precusors of chloroform formed. The correlations of the concentration of chloroform, DOC and TOC were investigate in this study.

• Nuclear Engineering and Technology
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• 제48권4호
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• pp.881-892
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• 2016

Following the Fukushima accident and its extended station blackout, attention was brought to the importance of the spent fuel pools' (SFPs) behavior in case of a prolonged loss of the cooling system. Since then, many analytical works have been performed to estimate the timing of hypothetical fuel uncovery for various SFP types. Experimentally, however, little was done to investigate issues related to the formation of a flammable gas mixture, distribution, and stratification in the SFP building itself and to some extent assess the capability for the code to correctly predict it. This paper presents the main outcomes of the Experiments on Spent Fuel Pool (ESFP) project carried out under the auspices of Swissnuclear (Framework 2012-2013) in the PANDA facility at the Paul Scherrer Institut in Switzerland. It consists of an experimental investigation focused on hydrogen concentration build-up into a SFP building during a predefined scaled scenario for different venting positions. Tests follow a two-phase scenario. Initially steam is released to mimic the boiling of the pool followed by a helium/steam mixture release to simulate the deterioration of the oxidizing spent fuel. Results shows that while the SFP building would mainly be inerted by the presence of a high concentration of steam, the volume located below the level of the pool in adjacent rooms would maintain a high air content. The interface of the two-gas mixture presents the highest risk of flammability. Additionally, it was observed that the gas mixture could become stagnant leading locally to high hydrogen concentration while steam condenses. Overall, the experiments provide relevant information for the potentially hazardous gas distribution formed in the SFP building and hints on accident management and on eventual retrofitting measures to be implemented in the SFP building.

• 대한의용생체공학회:의공학회지
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• 제36권6호
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• pp.291-295
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• 2015

Various types of implantable drug delivery devices have attracted significant attention for several decades to improve drug bioavailability and reduce side effects, thus enhancing therapeutic efficacy and patients' compliance. However, when implanted into the body, the devices may be influenced by the changes in physiological condition, such as temperature, pH or ionic concentration. Thus, the drug release rates could be also altered concurrently. Therefore, in this work, we employed an implantable ALZET$^{(R)}$ Osmotic Pump, which has been widely used to locally deliver various therapeutic agents and examined the effect of pH, temperature and ionic concentration on its drug release rate. For this, we performed in vitro cell tests to simulate the condition of local tissues influenced by the altered drug release rates, where we used diclofenac sodium as a model drug.

• 한국산학기술학회논문지
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• 제20권3호
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• pp.483-490
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• 2019

화재 발생으로 인한 피해 및 영향에 관해 국내에서의 연구는 미비한 상태이다. 따라서 화재 발생에 따른 연기 농도를 측정하기 위한 기기를 개발함으로 연기가 주변 지역으로 확산될 경우의 농도를 측정하고자 한다. 본 논문에서 제안한 공기질 측정 시스템은 기존의 측정기와는 달리 CO, CO2, NOx VOCs, NH3 등 총 5가지의 가스를 동시에 측정할 수 있고, 센서보호 알고리즘을 통해 높은 내구 수명을 갖는다. 또한, 모니터링 프로그램을 통해 실시간 가스 변화량을 측정하는 시스템을 구성하였다. 상용 가스 분석기와의 비교를 통해 가스농도 측정의 신뢰성을 확보하였으며, 실내 및 실외 화재실험을 통해 발화점 주변에 존재하는 가스농도 평가를 실시하여 신뢰성이 높은 데이터를 얻을 수 있음을 확인하였다.

• Biotechnology and Bioprocess Engineering:BBE
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• 제7권5호
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• pp.252-262
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• 2002

The growing interest in the application of arachidonic acid (ARA) in various fields of health and dietary requirements has elicited much attention on the industrial production of ARA-containing oil by the cultivation of Mortierella fungi. For the industrial production of ARA, various studies, such as isolation of a high-potential strain and optimization of culture conditions, have been conducted. Studies including the investigation of morphology are important because ARA is accumulated in the mycelia, and thus cultivation with high biomass concentration is essential for obtaining a high ARA yield. Combining the results derived from various studies, a high ARA yield was attained in an industrial fermentor. These ARA production techniques are applicable to the production of other polyunsaturated fatty acids (PUFAs), and will contribute to the improvement of fermentation technology especially in the field of fungal cultivation.