• Journal of Life Science
• /
• v.22 no.10
• /
• pp.1339-1343
• /
• 2012

Atopic dermatitis is characterized by chronically pruritic and inflammatory dermatitis. In this study, we investigated the effect of Platycodon grandiflorum including platycodin D (PG-Platycodin D) in an atopic dermatitis-like mouse model. An atopic dermatitis-like skin lesion was induced by repeated treatment of 2,4-dinitrochlorobenzene (DNCB) on the dorsal skin of ICR mice. The efficacy of PG-Platycodin D was tested by observing scratching behavior, the skin severity score, and histopathologic analysis. PG-Platycodin D reduced the DNCB-induced increase in scratching behavior and the skin severity score. In addition, histopathologic analysis revealed a reduction in the thickening of the epidermis in the PG-Platycodin D group. These results may contribute to the development of a therapeutic drug for the treatment of atopic dermatitis.

• Child Health Nursing Research
• /
• v.15 no.4
• /
• pp.401-408
• /
• 2009

Purpose: This study was done to assess the home nursing and quality of life of parents caring for preschool children with atopic dermatitis and to identify the factors which influence quality of life. Methods: Participants in the study were 149 parents of preschool children with atopic dermatitis attending a kindergarten and a nursery school in S city. Parent completed a set of questionnaires (assessing demographic factors, home nursing, quality of life). Descriptive analysis, t-test, ANOVA and multiple regression were used to analyze the data. Results: The mean score for home nursing was $3.06{\pm}0.38$ and for quality of life, $4.18{\pm}0.74$. The lowest scored question in the 13 question on quality of life was that of frustration related to itching sensation. Significant factors that affect quality of life were severity and home care. These variables explained 21% of variance in quality of life (F=21.17, p<.001). Conclusion: The results indicate that severity of childhood atopic dermatitis and home nursing impact on the quality of life of parents. Using the above findings, health professionals who work with children with atopic dermatitis and their parents need to develop specific nursing interventions that will promote health of children with atopic dermatitis and quality of life in their parents.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.29 no.3
• /
• pp.208-216
• /
• 2016

Objectives : The purpose of this study is to report the effectiveness of Soshiho-tang on the patients who suffered from atopic dermatitis with gastrointestinal disorders.Methods : We diagnosed the symptoms and the signs of the patients who suffered from atopic dermatitis with gastrointestinal disorders as Soshiho-tang syndrome(嘔而發熱) according to 'Treatise on Cold Damage Disease(傷寒論)'. Patients are treated only with Soshiho-tang. The severity of Atopic dermatitis was evaluated by SCORAD index, visual analogue scale(VAS) and pictures. Gastrointestinal disorders(mainly food allergy, indigestion) were evaluated by patients' subjective complaint.Results : After the treatment, not only the severity of atopic dermatitis but gastrointestinal disorders were also improved.Conclusions : Soshiho-tang has improved the symptoms of Atopic dermatitis with gastrointestinal disorders in this study.

• Journal of Sasang Constitutional Medicine
• /
• v.27 no.4
• /
• pp.404-418
• /
• 2015

Objectives This study investigated the effect of camping style Hospitalization program for atopic dermatitis female adolescent patients. 6 patients, 12-14 year old female adolescent, admitted for camping style hospitalization program.Methods 6 patients were admitted for camping style hospitalization program (2014.08.13~2014.08.16). The program included acupuncture, herbal medicine, examination, education, psychotherapy, dressing, exercise. The patients were analyzed by Severity Scoring Atopic Dermatitis(SCORAD) index and measured skin pH value(pH). Also, patients evaluated themselves by writing an atopic dermatitis diary which consists of diet, emotion, severity of pruritus, and sleep loss, and checked questionnaires which consist of atopic dermatitis, self treatment methods and degree of satisfaction of each program.Results Most of subjective symptoms which patients complained were improved and also SCORAD index total scores were decreased by sasang constitutional medication.Conclusions We expect that the camping style hospitalization program based on sasang constitutional medicine could be helpful for female adolescent patient of atopic dermatitis.

• The Journal of Pediatrics of Korean Medicine
• /
• v.28 no.2
• /
• pp.40-55
• /
• 2014

Objectives This study investigated the effect of camping style Hospitalization program for atopic dermatitis children patients. Methods 6 patients were admitted for camping style hospitalization program. The program includes acupuncture, herbal medicine, examination, education, psychotherapy, dressing, exercise. The patients were analyzed by Severity Scoring Atopic Dermatitis (SCORAD) index and measured skin pH value (pH). Also, patients evaluated themselves by writing an atopic dermatitis diary which consists of diet, emotion, severity of pruritus, and sleep loss. Checked questionnaires which consists of atopic dermatitis, self treatment methods and each program satisfaction. Results After 7 days of hospitalization program, the patient's SCORAD index scores were decreased and most of the patient's symptoms were improved. Conclusions The hospitalization program could be helpful for atopic dermatitis children patients.

• Toxicological Research
• /
• v.31 no.2
• /
• pp.89-96
• /
• 2015

Atopic dermatitis is a chronic inflammatory skin condition including severe pruritus, xerosis, visible eczematous skin lesions that mainly begin early in life. Atopic dermatitis exerts a profound impact on the quality of life of patients and their families. The estimated lifetime prevalence of atopic dermatitis has increased 2~3 fold during over the past 30 years, especially in urban areas in industrialized countries, emphasizing the importance of life-style and environment in the pathogenesis of atopic diseases. While the interplay of individual genetic predisposition and environmental factors contribute to the development of atopic dermatitis, the recent increase in the prevalence of atopic dermatitis might be attributed to increased exposure to various environmental factors rather than alterations in human genome. In recent decades, there has been an increasing exposure to chemicals from a variety of sources. In this study, the effects of various environmental chemicals we face in everyday life - air pollutants, contact allergens and skin irritants, ingredients in cosmetics and personal care products, and food additives - on the prevalence and severity of atopic dermatitis are reviewed.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.20 no.2 s.33
• /
• pp.247-255
• /
• 2007

Objective : Atopic dermatitis is a chronic, inflammatory skin disease which was characterized by intense pruritus and the course marked by exacerbation and remission. The purpose of this study is to report the effect of oriental treatment. Especially new oriental prescription to atopic dermatitis Methods : We treated children patients who had atopic dermatitis and visited oriental hospital of Semyung University. Children patients in this case are two person. The first one is fourteen-years-old female, Other one is seven-years-old boy. And I create a new oriental prescription that named 'Allergy 1' thinking about oriental theory. After then I treated them with 'Allergy 1' herb medication and used two index to assess the severity in atopic dermatitis. Results : Each index show us approximately 70% improvement in atopic dermatitis symptom. Conclusion : On the basis of this cases, It may be considered that treatment of atopic dermatitis should be improved by the treatment of herb medication "Allergy 1"

• Korean Parent-Child Health Journal
• /
• v.19 no.1
• /
• pp.9-16
• /
• 2016

Purpose: The disease specific self-efficacy of mothers caring children with atopic dermatitis is a crucial factor for adherence to recommended treatments. This study investigated factors associated with disease specific self-efficacy of mothers of atopic dermatitis children. Methods: A cross-sectional study was used. One hundred twenty five mothers recruited from the out-patient clinic of three hospitals completed self-administrative questionnaires, including the disease specific self-efficacy, general parenting efficacy, and severity of atopic dermatitis. Descriptive statistics, ANOVA, and multiple regression analysis were performed. Results: The degree of disease specific self-efficacy of mothers was significantly different according to the disease severity, and parenting efficacy. 26.0% of the variance of disease specific self-efficacy was explained by the severity of disease and parenting efficacy. Conclusions: Future studies need to focus on the development of educational programs that will help to improve mothers' disease specific self-efficacy as well as parenting efficacy.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.17 no.3
• /
• pp.114-119
• /
• 2004

Background: Atopic dermatitis is chronic exzemaous dermatosis characterized by severe itching, licalized eruption and chronic relapsing progress and has familu history of atopic diseases and hereditary disposition. This Study is attempted in order to estimate of possibility of oriental treatment on atopic dermatitis. Objective: We studied 24 years old women with atopic dermatitis from June 2004 to July 2004 Method: We treated her with herb medication and used three index to assess the severity of atopic dermatitis. Results: Each index show us about 50-60$\%$ of improvement Conclusion: On the basis of this study, It should be considered that treatment of atopic dermatitis should be focused on fever of yang-ming.

• Journal of Ginseng Research
• /
• v.35 no.2
• /
• pp.149-154
• /
• 2011

In order to determine the efficacy of functional foods, objective measurement of the severity of atopic dermatitis (AD) after taking foods is important. The aim of this study was to conduct an objective evaluation of whether Korean red ginseng (KRG) might be helpful for improvement of skin condition and serum IgE in patients with AD. Thirty atopic patients (18 females and 12 males) participated in this study. Patients took KRG for 16 weeks. Bioengineering methods, including the corneometer and evaporimeter, were used at the start of the study and after 8 weeks and 16 weeks. In addition, we assessed serum IgE levels and the severity scoring of the atopic dermatitis (SCORAD) index. Transepidermal water loss and skin hydration showed significant improvement after 16 weeks. A significant decrease in the SCORAD index, as well as in serum IgE level, was observed after 16 weeks. Our results demonstrated that KRG may be helpful as a functional food for patients with AD.