• Korean Journal of Veterinary Research
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• v.36 no.1
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• pp.151-159
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• 1996

This study was carried out to evaluate the effects of all-trans retinoic acid(RA) on the development of cholangiocarcinoma in hamsters. Eighty six female Syrian golden hamsters were divided into four groups. Group I was for the induction of the cholangiocarcinoma, which was infected orally with C sinensis and given dimethylnitrosamine(DMN, 15ppm) in drinking water for 4 weeks. Group II was for evaluating the effect of all-trans RA treatment on the cholangiocarcinogenesis, which was treated the same as group I and orally given RA(1mg/kg, 5 times per week) for 15 weeks. Group III was given only RA hr 15 weeks. Control group IV was given only soybean oil which was solvent for RA treatment. More than 5 heads of hamsters in each group were sacrificed at 4, 7, 11 and 15 weeks after the begining of the experiment. The livers were examined grossly, histopathologically, and immunohistochemically. The results obtained were as follows : 1. Death of animals started from the 11 weeks after the begining of the experiment. One of the total 22 animals(5%) and 7 of the total 24 animals(29%) died in group I and group II, respectively. 2. Proliferation of oval cell was peaked at 11 weeks in group I and at 7 weeks in group II, and decreased gradually after those periods of the time. 3. Cholangiocarcinomas were found in 1 of 6 animals(17%) at 11 weeks and in 4 of 6 animals(67%) at 15 weeks in group I, respectively. But in group II, the cholangiocarcinomas occured in 1 of 5 animals(20%) at 7 weeks, in 7 of 12 animals(58%) at 11 weeks and in 2 of the rest animals(100%) at 15 weeks, respectively. 4. Expression of $\alpha$-fetoprotein(AFP) of the oval cells in the group II showed the same degree of positive reaction at that of group I at 4 weeks. But AFP postive oval cells decreased gradually and AFP negative oval cells(ductlike oval cells) increased gradually. 5. Expression of cytokeratin of the oval cells in group II was shown slightly at 4 weeks and the degree of expression increased moderately from the 7 weeks. But the expression of the oval cells in group I was shown slightly after the 7 weeks. These results suggested that all-trans RA promoted the occurrence and the rate of cholangiocarcinoma by inducing differentiation of small cells and oval cells in the liver of hamsters infected with C sinensis and treated with DMN.

• Journal of Oral Medicine and Pain
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• v.41 no.4
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• pp.169-179
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• 2016

Purpose: This study is designed to analyse etiology and bone pattern at the first visit using cone-beam computed tomography (CBCT) and to evaluate the treatment outcome of conservative treatment in temporomandibular disorder (TMD) patients with rheumatoid arthritis (RA). Methods: One hundred condyles in 50 subjects with RA were chosen among the patients who presented to the Department of Oral Medicine of Pusan National University Dental Hospital, diagnosed as TMD. Condylar bone changes were classified by normal, erosive bony change, proliferative bony change and combined group (erosive bony change+proliferative bony change). They were treated conservatively with physical therapy, medication, behavioral therapy and/or occlusal stabilizing splint therapy. After 3 months on average, patients were re-evaluated with regards to subjective symptoms and the clinical findings were investigated. Results: TMD patients with RA have behavioral contributing factors such as parafunctional habit. The results that analyse bone pattern at the first visit using CBCT proliferative bony changes group (32.6%) were more common than erosive bony changes group (15.2%). In comparison between unilateral and bilateral bony change in temporomandibular joint, the ratio showed no significant differences. After 3 months of conservative treatments, pain, noise, limitation of motion (LOM) were markedly improved regardless of occlusal splint therapy. However only LOM was significantly improved through occlusal splint therapy during 3 months. Conclusions: TMD patients with RA had similar behavioral contributing factors and characteristics of CBCT images shown in general TMD patients and also similar response to conservative treatment so it is difficult to differentiate. Therefore when TMD patients show symptoms corresponding to clinical diagnostic criteria of RA at the first visit, serological testing should be conducted and through this, early diagnosis and treatment of RA should be initiated.

• Journal of Sensor Science and Technology
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• v.31 no.1
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• pp.64-68
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• 2022

Herein, we propose a LoRaWAN-based small draft system that can measure the ocean current flow (speed, direction, and distance) in real time at the request of the Coast Guard to develop a device that can promptly find survivors at sea. This system has been implemented and verified in the early stages of rescue after maritime vessel accidents, which are frequent. GPS signals often transmit considerable errors, so correction algorithms using the improved triangulation method algorithm are required to accurately indicate the direction of currents in real time. This paper is structured in the following manner. The introduction section elucidates rescue activities in the case of a maritime accident. Chapter 2 explains the characteristics and main parameters of the GPS surveying technique and LoRaWAN communication, which are related studies. It explains and expands on the critical distance error correction algorithm for GPS signals and its improvement. Chapter 3 discusses the design and analysis of small draft buoys. Chapter 4 presents the testing and validation of the implemented system in both onshore and offshore environments. Finally, Section 5 concludes the study with the expected impact and effects in the future.

• Journal of Korea Multimedia Society
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• v.23 no.2
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• pp.282-292
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• 2020

In order to minimize casualties from marine vessel accidents that occur frequently at home and abroad, it is important to ensure the safety of the passengers aboard the vessel in the event of an accident. There is an EPIRB system as a system for disaster preparedness in the marine situation currently on the market, but there is a problem that the price is very expensive. In order to overcome the cost problem, which is a disadvantage of previous system, LoRaWAN-based communication is used. LoRaWAN communication-based vessel positioning and risk detection system based on LoRaWAN communication transmits measurement data of each module using two Beacon and GPS modules to stably perform position measurement for both indoor and outdoor situations. The rider danger situation detection system can detect the safety status of the rider using the 3-axis acceleration sensor, collect data from the rider positioning system and the rider safety status detection system, and send to server using LoRa communication. When conducting communication experiments in the long-distance maritime situation and actual communication experiments using the implemented system, it was found that the two experiments showed over 90% communication success rate on average.

• Korean Journal of Clinical Pharmacy
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• v.29 no.2
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• pp.109-114
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• 2019

Background: Rheumatoid arthritis (RA) is a systemic inflammatory disease that manifests as joint damage or athletic disability via sustained inflammation of the synovial membrane. The risk of cardiovascular disease (CVD) is higher in RA patients. This study aimed at evaluating the association between CVD comorbidities and RA by comparing a pharmacotherapy group with a non-pharmacotherapy group. Methods: Patient sample data from the Health Insurance Review and Assessment Service (HIRA-NPS-2016) were used. Inverse probability of treatment weighting (IPTW) using the propensity score was used to minimize the differences in patient characteristics. Logistic regression analysis was used to evaluate the risk of CVD comorbidities. Results: The analyses included 1,207,213 patients, of which 33,122 (2.8%) had RA. The odds ratios (OR) of CVD comorbidities were increased in RA patients; ischemic heart disease (IHD: OR 1.75; 95% CI 1.73, 1.77), cerebral infarction (CERI: OR 1.28; 95% CI 1.26, 1.30), hypertension (HTN: OR 1.44; 95% CI 1.43, 1.45), diabetes mellitus (DM: OR 2.04; 95% CI 2.03, 2.06), and dyslipidemia (DL: OR 3.49; 95% CI 3.47, 3.51). The ORs of IHD, CERI, HTN, and DM in the traditional DMARD and biologic treatment groups were decreased, compared with those in the non-pharmacotherapy group. Conclusions: Thus, CVD risk was higher in RA patients, considering age, sex, and socioeconomic status. Appropriate pharmacotherapy could decrease the risk of CVD comorbidities in RA patients.

• The Journal of the Convergence on Culture Technology
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• v.7 no.1
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• pp.608-614
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• 2021

Currently, blockchain-based public cryptocurrency (hereinafter referred to as cryptocurrency) cannot acquire status as a currency for transaction due to the economic policies of each country, but it is used as an alternative currency transaction method due to individual circumstances of some Internet users. With this trend, it is predicted that such cryptocurrency can be used in real life beyond the Internet in the near future. In this paper, a technical method for designing a cryptocurrency payment system based on LoRaWAN that can easily build a wireless Internet network infrastructure at low cost as a way to activate the use of cryptocurrency in real life is presented based on the LoRaWAN standard.

• Journal of the Korean Ceramic Society
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• v.47 no.6
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• pp.583-589
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• 2010

In this paper, the properties of reclaimed ash(RA) from various domestic thermal power plants(S, D and H) were analyzed, and the possibility of fabricating the artificial lightweight aggregate(ALA) using RA was studied. The chemical compositions of RA are similar to the clay, but it had higher concentrations of alkali earth metal oxides(CaO, MgO) and unburned-carbon. The TCLP(Toxicity Characteristic Leaching Procedure) results showed that the dissolution concentrations of heavy metal ions of RA were below the limitation defined by the enforcement regulation of wastes management law in Korea. The results of IC analysis showed that leaching concentration of $Cl^-$ ion was 124 ppm for RA of HN and ${SO_4}^{2-}$ ion was leached a few hundreds ppm for all RA in this study. The ALAs with various mass ratio of clay to reclaimed ash(RA:Clay = 7:3, 6:4, 5:5, 4:6, 3:7) were sintered with a electric muffle furnace at the temperature of $1050{\sim}1200^{\circ}C$. The specific gravity and water absorption(%) of the sintered ALAs were 1.1~1.8 and 10~30% respectively. The ALA sintered in the rotary kiln at $1125^{\circ}C$ showed a bulk density of 1.7 and water absorption of 15.2%.

• Journal of Applied Biological Chemistry
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• v.49 no.4
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• pp.131-134
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• 2006

The in vitro anti-fungal activity of hydroxylated fatty acids obtained from microbial conversion by Psuedomonas aeruginosa PR3 using ricinoleic acid(RA), eicosadienoic acid(EDA) and conjugated linoleic acid(CLA) as substrates, was investigated. Bioconverted hydroxylated fatty acids showed different anti-fungal activities potentials against the range of phytopathogenic fungi such as Botrytis cinerea, Rhizoctonia solani, Fusarium oxysporum, Sclerotonia sclerotiorum, Colletotricum capsici, Fusarium solani and Phytophthora capsici. RA and EDA showed up to 50% fungal mycelial inhibition at the concentration of $5{\mu}l\;ml^{-1}$. RA, EDA and CLA also exhibited anti-fungal activities with minimum inhibitory concentration(MIC), ranging from 500 to $1000{\mu}g\;ml^{-1}$. Screening was also carried out using varied concentrations of bioconverted RA and EDA for determining the anti-fungal effect on the spore germination of different fungi. Bioconverted RA and EDA showed a considerable degree of spore germination inhibition.

• Journal of Korean Physical Therapy Science
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• v.5 no.4
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• pp.845-850
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• 1998

The purpose of those study is to estimate grip and hand activity of RA patients and find that the evaluation is very a valuable to the RA patients. The term of the evaluation was from June 25. 1998.. to July 30. 1998 and researched at Hanyang university Rheumatic Hospital. This study researched 100 normal people and 85 RA patients and analyzed the results and averaged those with t-test by Excel data. The results of those study are as follows. 1. The highest percent of those results of the dynamometer, pinch research was the people who are on 40s. 2. The results of all RA patients marked lower than those of normal people. 3. It's difficult to do hard work such as washing, opening can, transferring boxes to the patients. 4. The above research is effective to RA patients.

• Smart Media Journal
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• v.13 no.1
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• pp.45-51
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• 2024

Long Range Wide Area Network (LoRaWAN) is a widely adopted Internet of Things (IoT) protocol due to its high range and lower energy consumption. LoRaWAN utilizes Adaptive Data Rate (ADR) for efficient resource (e.g., spreading factor and transmission power) management. The ADR manages these two resource parameters on the network server side and end device side. This paper focuses on analyzing the ADR and Gaussian ADR performance of LoRaWAN. We have performed NS3 simulation under a static scenario by varying the antenna height. The simulation results showed that antenna height has a significant impact on the packet delivery ratio. Higher antenna height (e.g., 50 m) has shown an improved packet success ratio when compared with lower antenna height (e.g., 10 m) in static and mobility scenarios. Based on the results, it is suggested to use the antenna at higher allevation for successful packet delivery.