• Title/Summary/Keyword: Asymmetric alkylation

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Diastereoselective Synthesis of (+)-Frontalin

  • Jung, Jung-Hwa;Kim, Hee-Doo
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.345.3-346
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    • 2002
  • In connection with the asymmetric synthesis of chiral l.2-diol. we report here the total synthesis of (+)-frontalin using diastereoselective alkylation featuring tridentate chelation-controlled asymmetric alkylation of a-hydroxyketone, in which the chiral auxiliary is attached to the hydroxyl group as ether linkage. The starting D-glyceraldehyde acetonide was converted (S)- [(4R)-2.2-dimethyH,3-dioxolan-4-yl] (4-methoxyphenyl) methanol. (omitted)

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