• The Korean Journal of Pharmacology
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• v.29 no.1
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• pp.149-156
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• 1993

Intramolecular excimerization of 1,3-di(1-pyrenyl)propane (Py-3-Py) and fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene (DPH) were used to examine the effects of ethanol on the rate and range of lateral diffusion of bulk bilayer structures of plasma membrane vesicles isolated from cultured mouse myeloma cell line Sp2/0-Ag14 (Sp2/0-PMV). In a concentration-dependent manner, ethanol increased the excimer to monomer fluorescence intensity ratio (I'/I) of Py-3-Py in the Sp2/0-PMV and decreased the anisotropy (r), limiting anisotropy $(r_{\infty})$, and order parameter (S) of DPH in the Sp2/0-PMV. This indicates that ethanol increased both the lateral and rotational diffusion of the probes in the Sp2/0-PMV. Selective quenching of DPH by trinitrophenyl groups was utilized to examine the transbilayer asymmetric rotational diffusion of the Sp2/0-PMV. The anisotropy (r), limiting anisotropy $(r_{\infty})$, and order parameter (S) of DPH in the inner monolayer were 0.022, 0.029, and 0.063, respectively, greater than calculated for the outer monolayer of the Sp2/0-PMV. Selective quenching of DPH by trinitrophenyl groups was also utilized to examine the transbilayer asymmetric effects of ethanol on the range of rotational diffusion of the Sp2/0-PMV. Ethanol had a greater fluidizing effect on the outer monolayer as compared to the inner monolayer of the Sp2/0-PMV. It has been proven that ethanol exhibits a selective rather than nonselective fluidizing effect within transbilayer domains of the Sp2/0-PMV.

• Journal of Digital Convergence
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• v.17 no.12
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• pp.109-115
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• 2019

The purpose of this study is to analyze the effect of Prior Sales change on R&D Costs and each detail item, and to analyze what decision managers make when changing sales. In order to conduct a more in-depth analysis as well as a one-period model of Anderson et al. (2003), which was used in previous studies, the two-period model of Banker et al.(2014) And analyzed the detailed items. As a result of the analysis, it is possible to confirm cost stickiness behavior only in the depreciation cost and others due to the limit of the model in the one period model. For a more in-depth analysis, the analysis of two-period model showed that labor costs and other items showed cost stickiness behavior when prior sales increased, but total R&D costs showed a anti-cost stickiness behavior. When prior sales decline, consigned service costs showed a cost stickiness behavior. This study is meaningful because it analyzed the effect of prior sales change on R&D cost behavior which were not performed in previous studies. Furthermore, we expect to be able to conduct more detailed research by sales and industry in future studies.

• Bulletin of the Korean Chemical Society
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• v.27 no.9
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• pp.1297-1304
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• 2006

A systematic study of the structure, energetics and spectral characteristics of substituted aminoketenes $R(NH_2)$C=C=O (R = H, $CH_3$, $NH_2$, OH, $OCH_3$, CH=$CH_2$, C$\equiv$CH, CN, CHO, NO, $NO_2$) which are highly reactive and transient intermediates in synthesis has been conducted by ab initio calculations at the MP2/6- 31G*//MP2/6-31G* level. Twenty four stable isomers of the eleven substituted aminoketenes having dihedral angles $\phi NH_2\sim120{^{\circ}}$ and $60^{\circ}$ have been identified and their optimized geometries and energies obtained. Electrostatic and steric effects on the molecular geometries have been analyzed. While the $\pi$-acceptor groups lead to planar conformations, the electron-donor groups give rise to non-planar conformations. Isodesmic substituent stabilization energies relative to alkenes have been calculated and correlation with group electronegativities established. Role of induction effect by the substituent groups and resonance effects in charge distribution in the molecules has been analyzed. An analysis of the asymmetric stretching frequencies and intensities of the C=C=O group shows that affect of non-$\pi$ acceptor substituents on the frequency is determined by the field effect (F) and resonance effect (R) parameters, the calculated intensities I (km/mol.) are correlated to group electronegativities $x$ of the substituents by the relationship I = 640.2–100.1 $x$ (r = 0.92). The $\pi$-acceptor substituents increase the intensity which may be explained in terms of their delocalizing effect on the negative charge at the $C_{\beta}$ atom.

• Nuclear Engineering and Technology
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• v.49 no.7
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• pp.1537-1546
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• 2017

Many thermal-hydraulic tests have been conducted at the Korea Atomic Energy Research Institute for verification of the SMART (System-integrated Modular Advanced ReacTor) design, the standard design approval of which was issued by the Korean regulatory body. In this paper, the contributions of these tests to the standard design approval of SMART are discussed. First, an integral effect test facility named VISTA-ITL (Experimental Verification by Integral Simulation of Transients and Accidents-Integral Test Loop) has been utilized to assess the TASS/SMR-S (Transient and Set-point Simulation/Small and Medium) safety analysis code and confirm its conservatism, to support standard design approval, and to construct a database for the SMART design optimization. In addition, many separate effect tests have been performed. The reactor internal flow test has been conducted using the SCOP (SMART COre flow distribution and Pressure drop test) facility to evaluate the reactor internal flow and pressure distributions. An ECC (Emergency Core Coolant) performance test has been carried out using the SWAT (SMART ECC Water Asymmetric Two-phase choking test) facility to evaluate the safety injection performance and to validate the thermal-hydraulic model used in the safety analysis code. The Freon CHF (Critical Heat Flux) test has been performed using the FTHEL (Freon Thermal Hydraulic Experimental Loop) facility to construct a database from the $5{\times}5$ rod bundle Freon CHF tests and to evaluate the DNBR (Departure from Nucleate Boiling Ratio) model in the safety analysis and core design codes. These test results were used for standard design approval of SMART to verify its design bases, design tools, and analysis methodology.

• Knowledge Management Research
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• v.16 no.4
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• pp.109-132
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• 2015

We examine offline and online channel sales of experience goods, and compare and contrast the sales patterns of existing products and new products between channels. To this end, we obtain the channel-specific time-series sales data from the leading company selling beauty products, both offline and online. By applying the Vector Autoregressive Model, we empirically find out how the relationship between existing products and new products changes between the shopping channels. Our empirical findings are as follows. First, the sales effects from existing products to new products are significantly positive at both offline and online channels, and this positive effect is greater in the offline channel than in the online channel. Second, the influence of new products on existing products is more positive in the offline channel than in the online channel. Third, the impact of existing products sales on new products sales is greater than that of new products on existing products. Lastly, the inertia effect, the effect within the same shopping channel and the same selling product, is significantly positive in the offline channel but not in the online channel, and this asymmetric inertia effect emerges as we focus on experience goods. Moreover, the impulse response function analysis provides the three important implications. First, companies should pay attention to the same channel but different types of products. Second, the offline channel is more vulnerable to market shock than the online channel. Third, new products sales vary by existing products sales to the greater extent, compared to the opposite relationship. We believe our study contributes theoretically and practically to the fields of marketing and knowledge management.

• Earthquakes and Structures
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• v.17 no.6
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• pp.635-647
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• 2019

Tests and theoretical studies for seismic responses of a transmission tower-line system under coupled horizontal and tilt (CHT) ground motion were conducted. The method of obtaining the tilt component from seismic motion was based on comparisons from the Fourier spectrum of uncorrected seismic waves. The collected data were then applied in testing and theoretical analysis. Taking an actual transmission tower-line system as the prototype, shaking table tests of the scale model of a single transmission tower and towers-line systems under horizontal, tilt, and CHT ground motions were carried out. Dynamic equations under CHT ground motion were also derived. The additional P-∆ effect caused by tilt motion was considered as an equivalent horizontal lateral force, and it was added into the equations as the excitation. Test results were compared with the theoretical analysis and indicated some useful conclusions. First, the shaking table test results are consistent with the theoretical analysis from improved dynamic equations and proved its correctness. Second, the tilt component of ground motion has great influence on the seismic response of the transmission tower-line system, and the additional P-∆effect caused by the foundation tilt, not only increases the seismic response of the transmission tower-line system, but also leads to a remarkable asymmetric displacement effect. Third, for the tower-line system, transmission lines under ground motion weaken the horizontal displacement and acceleration responses of transmission towers. This weakening effect of transmission lines to the main structure, however, will be decreased with consideration of tilt component.

• Journal of the Society of Naval Architects of Korea
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• v.48 no.3
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• pp.222-232
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• 2011

This article examines the scale effect of the flow characteristics, resistance and propulsion performance on a 317k VLCC. The turbulent flows around a ship in both towing and self-propulsion conditions are analyzed by solving the Reynolds-averaged Navier-Stokes equation together with the application of Reynolds stress turbulence model. The computations are carried out in both model- and full-scale. A double-body model is applied for the treatment of free surface. An asymmetric body-force propeller is used. The speed performances including resistance and propulsion factors are obtained from two kinds of methods. One is to analyze the computational results in model scale through the revised ITTC' 78 method. The other is directly to analyze the computational results in full scale. Based on the computational predictions, scale effects of the resistance and the self-propulsion factors including form factor, thrust deduction fraction, effective wake fraction and various efficiencies are investigated. Scale effects of the streamline pattern, hull pressure and local flow characteristics including x-constant sections, propeller and center plane, and transom region are also investigated. This study presents a useful tool to hull-form and propeller designers, and towing-tank experimenters to take the scale effect into consideration.

• Journal of Korean Physical Therapy Science
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• v.9 no.1
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• pp.53-59
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• 2002

This study is research for effect of the involved lower limb weight bearing training on symmetrical weight supporting rate improvement by practicing involved lower limb weight bearing training of three weeks period to improve standing equilibrium problem with asymmetric weight supporting rate of hemiplegia. In result of the study, it has shown that P-value incase of involved supporting rate is lower than level of significance $\alpha$<.05 and mean improvement rate of experienced group is higher in comparison with controlled group and experienced group. In changing quantity of involved maximum supporting rate, P-value is .26 and higher than level of significance $\alpha$<.05, and so it did not show significant difference statistically. But in case of experienced group between pre and post-test, involved side supporting rate and involved side maximum supporting rate showed significant improvement in all. In comparison of relative characteristic training effect difference, it was shown that train-learning effect on case of 40-60 years old, hemorrhagic patient and standard body bun of patient is valuable, which showed significant improvement in case of paralytic side and disease period, it did not show significant difference on excercise learning effect in two above cases. In the above result, we can say that continuous weight bearing training on the involved lower limb for three weeks period help improve the involved side supporting rate of hemiplegia. Accordingly, the weight bearing training on the involved lower limb is training method that patient can easily train with simple guidance of therapists, without being special expensive equipment. Furthermore it can be helpful to establish home therapeutic plan for hemiplegia through education of a patron.

• Korea Real Estate Review
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• v.28 no.2
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• pp.21-34
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• 2018

The purpose of this study is to investigate the effect of macro-finance variables on the correlation between the housing and stock markets because understanding the nature of time-varying correlations between different assets has important implications on portfolio allocation and risk management. Thus, we adopted the AG-DCC GARCH model to obtain time-varying, conditional correlations. Our sample ranged from January 2004 to November 2017. Our empirical result showed that the coefficients on asymmetric correlation were significantly positive, implying that correlations between the housing and stock markets were significantly higher when changes in the housing price and stock returns were negative. This finding suggested that the housing market has less hedging potential during a stock market downturn, when such a hedging strategy might be necessary. Based on the regression analysis, we found that the term spread had a significantly negative effect on correlations, while the credit spread had a significantly positive effect. This result could be interpreted by the risk premium effect.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.37 no.5
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• pp.449-457
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• 2013

In this study, we performed a numerical analysis to investigate the effect of rotation on the blood flow and arterial wall behavior by using the FSI (fluid-structure interaction) technique. The geometry of the artery included 50% stenosis at the center. To simulate the rotational effect, 2-6 rps of axial velocity was applied to the arterial model. A spiral wave and asymmetric flow occurred due to the stenosis and axial rotation both in the rigid body model and in the FSI model. However, the arterial wall motion caused periodic and transient blood flow changes in the FSI model. The FRZ (fluid recirculation zone) decreased in the FSI model, which is a known predictor for the formation and vulnerability of plaque. Therefore, it is observed that arterial wall motion also influences the generation of the FRZ.