• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제36권4호
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• pp.320-324
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• 2010

Introduction: The placement of a single miniplate is not sufficient to achieve rigid fixation in mandibular angle fractures. It often causes difficulties in reducing the intermaxillary fixation (IMF) period. Consequently, the placement of 2 miniplates is preferable. The intraoral approach in an open reduction and internal fixation (ORIF) of a mandibular angle fracture with 2 miniplates is often challenging. Accordingly, an alternative of transbuccal approach is performed. However, this method leaves a scar on the face and can result in facial nerve injury. This clinical study suggests a protocol that can maintain rigid fixation without a transbuccal approach in mandibular angle fractures. Materials and Methods: The subjects were 7 patients who sustained fractures of the mandibular angle and treated at Department of Oral and maxillofacial surgery, Sacred Heart Hospital, Hallym University. ORIF under general anesthesia was done using the intraoral approach. One miniplate was inserted on external oblique ridge of the mandible, and the other was placed on lateral surface of the mandibular body with contra-angle drill and driver. A radiographic assessment and occlusal contact point examination was carried out before surgery, and 2, 4 and 6 weeks after surgery. Results: The mean operation time was 80 minutes. Regarding the occlusion state, the number of contact points increased after surgery. Paresthesia and infection were reported to be complications before surgery. Conclusion: The placement of 2 miniplates using contra-angle drill for ORIF of mandibular angle fractures allows early movement of the mandible without IMF. We propose this approach to reduce the patients’discomfort and simplify the surgical procedure.

• 생물정신의학
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• 제15권1호
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• pp.5-13
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• 2008

Objectives : It was the aim of the present paper to examine the impact of the apolipoprotein E(APOE) ${\varepsilon}4$ on cognitive performance in community-dwelling elderly samples with 'questionable dementia'. Methods : Total 295 samples who were diagnosed with 'questionable dementia' in the recent year and completed the Korean version of the Consortium Establish a Registry for Alzheimer's Disease(CERAD-K) neuropsychological assessment protocol, were recruited. The CDR test established score of 0.5. Genomic DNA was extracted from the venous blood and APOE genotyping was done in this group. Their cognitive performance was compared by the occurrence of the APOE ${\varepsilon}4$ allele. Results : The impact of ${\varepsilon}4$ allele was significant in the Word List Recall Test(WLRT, F=4.511, df=1, p=0.035). The 'young-old' group aged 75 years and under had a significantly lower performance on the Word List Recall Test(WLRT, F=5.090, df=1, p=0.015), but the 'old-old' group over 75 years of age had not significantly different performance on the all the item of tests in ${\varepsilon}4$+ allele group. Conclusion : The conclusion to be drawn here is that community-dwelling elderly samples with ${\varepsilon}4$ allele in 'questionable dementia' had a significantly lower performance on the Word List Recall Test in the CERAD-K neuropsychological test batteries and the effect was prominent in the 'young-old' age group.

• Asian Pacific Journal of Cancer Prevention
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• 제17권9호
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• pp.4259-4265
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• 2016

Background: Colorectal malignancies with high microsatellite instability (MSI-H), either hereditary (Lynch syndrome) or sporadic, demonstrate better prognosis and altered response to 5FU chemotherapy. It is now recommended to perform MSI testing for all new cases of colorectal cancer regardless of being categorized as hereditary or sporadic. For MSI detection, immunohistochemistry or PCR-based protocols using a cohort of various sets of STR markers are recommended. Here we aimed to evaluate a simplified protocol using just a single STR marker, MT1XT20 mononucleotide repeat, for detection of MSI in Lynch syndrome patients. A Promega five-marker MSI testing panel and immunohistochemistry (IHC) were used as the gold standard in conjunction with MT1XT20. Materials and Methods: Colorectal patients with a positive history of familial cancers were selected by evaluating medical records. Based on Amsterdam II criteria for Lynch syndrome 20 families were short listed. DNA was extracted from formalin fixed paraffin embedded tumour and adjacent normal tissues resected from the index case in each family. Extracted DNA was subjected to MT1XT20 mononucleotide marker analysis and assessment with a commercially available five marker MSI testing kit (Promega, USA). IHC also was performed on tissue sections and the results were compared with PCR based data. Results: Eight (40%), seven (35%) and five (25%) cases were MSI positive using with the Promega kit, IHC and MT1XT20, respectively. Among the markers included in Promega kit, BAT26 marker showed instability in all 8 samples. NR24 and NR21 markers showed instability in 7 (87.5%), and BAT25 and MONO 27 in 6 (75%) and 5 (62.5%). Conclusions: Although MT1XT20 was earlier reported as a valid standalone marker for MSI testing in CRC patients, we could not verify this in our Iranian patients. Instead BAT26 among the markers included in Promega MSI testing kit showed instability in all 8 MSI-H CRC samples. Therefore, it seems BAT26 could act well as a single marker for MSI testing in Iranian CRC patients.

• 한국산림과학회지
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• 제101권4호
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• pp.547-557
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• 2012

본 연구는 강원대학교 학술림을 대상으로 현장조사자료와 Landsat TM-5 위성영상 정보를 이용하여 k-NN기법을 통해 산림바이오매스를 추정하는 것을 목적으로 하였다. 임상 층화 및 최소수평 참조거리(HRA)와 공간필터링의 조건변화에 따른 최적의 참조표본점 개수(k)를 검토하였으며, 이에 따른 산림바이오매스량 추정과 정확도를 비교 분석하였다. 침엽수는 $5{\times}5$ 필터링을 적용한 HRA 4 km와 k=8를 적용하였을 때 최소의 RMSE를 나타냈으며, 편차는 1.8 t/ha으로 과대추정되었다. 한편, 잣나무와 활엽수는 필터링을 적용하지 않은 HRA 4km의 k=8과 HRA 10 km의 k=6을 적용하였을 때 최소의 RMSE가 나타났으며, 편차는 각각 -1.6 t/ha, -5.2 t/ha로 과소추정되었다. k-NN기법에 의하여 추정된 총 바이오매스량은 799천t이며, ha당 평균 산림바이오매스량은 237 t/ha로서 표본점자료를 이용한 추정치보다 약 1 t/ha 높게 나타났다.

• 한국산림과학회지
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• 제96권6호
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• pp.644-651
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• 2007

본 연구는 교토의정서 제 2차 공약기간(2013~2017년) 이후 교섭에 있어서 국가별 탄소배출 흡수 인벤토리에 유력하게 포함될 전망인 HWP 탄소축적 변화량 및 배출량을 평가하기 위하여 우리나라 HWP 생산 수입 수출량에 대한 FAO통계와 국내통계를 적용하여 비교 추정하였다. 그 결과, 2005년 현재 HWP 탄소축적 변화량은 FAO 통계 적용의 경우 축적변화 접근법(SCA)이 1.434 Tg C, 대기유출입 접근법(AFA)이 -1.330 Tg C, 생산 접근법(PA)이 0.597 Tg C, 국내통계 적용은 SCA가 1.246 Tg C, AFA가 -1.520 Tg C, PA가 0.444 Tg C로 추정되었다. HWP으로 부터의 $CO_2$ 배출량 흡수량은 FAO통계 적용의 경우 SCA가 $-5,258Gg\;CO_2$ (흡수), AFA가 $4,877Gg\;CO_2$ (배출), PA가 $-2,189Gg\;CO_2$ (흡수), 국내통계 적용은 SCA가 $-4,569Gg\;CO_2$ (흡수), AFA가 $5,573Gg\;CO_2$ (배출), PA가 $-1,628Gg\;CO_2$ (흡수)로 FAO통계 적용이 국내통계 적용보다 모든 방법별 HWP 탄소축적 변화량 및 배출량 추정에서 유리한 것으로 나타났다.

• 한국콘텐츠학회논문지
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• 제15권6호
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• pp.290-296
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• 2015

본 연구는 일개병원에서 시행된 년간 소아 두부 CT 검사에 대한 CT 선량지표(CTDI)를 국내 진단참고 준위와 비교하여 분석함으로써 제안점을 도출하고 피폭 방사선량 저감화 방안을 제시하고자 하였다. 이를 위하여 2014년 1월부터 12월까지 두부 손상으로 소아 두부 CT 검사를 의뢰 받은 10세 미만의 소아 231명을 후향적으로 조사하였다. 조사 방법은 선량 보고서와 의료전자차트를 참조하여 일반적 특성, 관전압(kVp), 관전류(mA), 검사 범위, $CTDI_{vol}$, DLP를 조사하여 분석하였다. 결과적으로 $CTDI_{vol}$은 전체 연구대상자의 7.4%(17명)가 국내 진단참고준위를 초과한 것으로 나타났으며 DLP의 경우 41.6%(96명)가 초과 되어 $CTDI_{vol}$ 보다 비교적 높게 나타났다. DLP는 한국식품의약품안전처에서 제시한 CT 선량 지표보다 대부분 약 60% 이상 초과되었으며 건강보험심사평가원에서 제시한 기준 검사 범위보다 약 30%이상 증가된 검사 범위가 DLP가 높게 나타난 원인으로 분석되었다. 결론적으로 임상에서 CT 검사 시 건강보험심사 평가원에서 제시하는 소아 두부 CT 검사의 기준 검사 범위를 준수하여 검사하고 프로토콜을 적절히 조절한다면 피폭선량을 상당히 낮출 수 있을 것으로 판단된다.

• 재활치료과학
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• 제6권1호
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• pp.35-43
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• 2017

목적 : 양측성 상지 활동의 대칭적, 비대칭적 양측성 상지훈련이 상지기능회복에 미치는 영향을 알아보고자 하였다. 연구방법 : 원주에 소재한 ${\bigcirc}{\bigcirc}$병원의 연구 뇌졸중 환자 15명을 무작위로 대칭적 움직임훈련 그룹과 비대칭적 움직임 훈련 그룹으로 나누었다. 중재는 하루 30분, 주5회, 4주 동안, 총 20회기를 받았다. 결과 : 양측 상지의 실제 사용량은 대칭적 움직임 훈련은 건측, 환측 모두 유의한 변화를 보였으며, 비대칭 움직임 훈련도 환측에서 유의한 변화를 보였다. 또한 환측에서 그룹 간 유의한 변화차이가 있었다. 두 훈련 그룹 모두 수행도와 만족도, 상지기능 변화는 그룹 내 유의미한 변화가 있었지만 그룹 간 차이는 없었다. 결론 : 대칭적 움직임 훈련은 비대칭 움직임 훈련보다 대칭적 움직임은 비대칭적 움직임 보다 운동수행에서의 향상을 보였지만, 보다 명확한 차이를 얻기 위해서는 fMRI와 같은 뇌신경학적 평가도구를 사용하는 것이 필요할 것이라 판단되며, 보다 명확한 훈련 프로토콜이 필요하고, 보다 많은 뇌졸중 환자를 대상으로 한 후속연구의 필요성이 제시된다.

• Korean Journal of Acupuncture
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• 제31권1호
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• pp.33-39
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• 2014

목적 : 본 연구는 복강신경총 차단술을 시행한 상복부 암성통증 환자들을 대상으로 침치료가 암관련 통증을 감소시키는 효과적이고 안전한 치료법임을 증명하기에 적합한지를 알아보기 위한 예비연구이다. 방법 : 본 연구는 3주간 진행되는 무작위배정 대조군 예비임상연구이며, 총14명의 피험자들은 시험군 (복강신경총차단술+침치료)과 대조군 (복강신경총차단술)으로 무작위배정된다. 모든 피험자들은 복강신경총 차단술을 1회 시술 받으며, 오직 시험군의 경우에만 주 3회, 2주간 총 6회의 추가적인 침치료를 시술받을 예정이다. 1차 유효성 평가변수는 통증에 대한 VAS를, 2차 유효성 평가변수는 Painvison과 추가 진통제 소비량을 측정한다. 평가는 시험시작 전, 시험 1주, 2주 및 3주후에 이루어지게 된다. 결론 : 본 연구는 추후 본격적인 무작위배정 대조군 임상시험을 위한 예비연구로서, 본 연구를 통해 상복부 암성 통증치료에 있어서 침치료가 복강신경총차단술과 같이 병행치료 했을 때 임상적으로 유효함을 증명할 수 있는 근거를 마련해 줄 것이라 사료된다.

• Korean Journal of Acupuncture
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• 제32권3호
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• pp.99-107
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• 2015

Objectives : This study was designed to obtain basic data for a further large-scale trial as evaluating the efficacy and safety of Geochangmanryeung-dan(GMD) and acupuncture on patient with spinal stenosis treated by epidural steroid injection. Methods: The study is a randomized controlled pilot clinical trial, conducted over 8 weeks. Twenty participants will be recruited and randomly allocated to 2 groups: an experimental(GMD and acupuncture with epidural steroid injection) group and a control(only epidural steroid injection) group. The epidural steroid injection will be administered once per 2 weeks for 6 weeks(3 times in total). GMD will be administered as a dose of 5 pills, 3 times per day, for 6 weeks. Acupuncture will be performed 2 times per week for 6 weeks(12 times in total). The primary outcome will be measured by visual analogue scale and self-rated walking distance. The secondary outcome will be measured by PainVision, short-form McGill Pain Questionnaire, and Oswestry Disability Index. Both primary and secondary outcomes will be measured at baseline, 2, 4, 6, and 8 weeks. The last assessment(at 8 weeks) will be performed 2 weeks after treatment cessation. Conclusions : This clinical trial, as the pilot study for a future large-scale trial, will provide clinical information for evaluating the efficacy and safety of GMD and acupuncture treatment in combination with epidural steroid injection for the treatment of spinal stenosis.

• 대한한의학회지
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• 제30권1호
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• pp.83-94
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• 2009

Background and Objectives: The skin barrier protects skin against a harmful environment. Its function includes an antimicrobial barrier as well as a physical barrier. Stress is harmful to the skin barrier and there are many studies on this, but there are few about the effect of stress during pregnancy on the skin barrier of offspring. The aim of this study was to investigate the effect of stress during pregnancy on the skin barrier of offspring by examination with the naked eye, cortisol, weight, TEWL and histologic tests. Materials and Methods: Male hairless mice ten weeks old were coupled with females for three days. After twelve days the females were divided into two groups. We stressed one group and not the other group. The offspring from the non-stressed (N group) and stressed (S group) grew up until four weeks. The S group was exposed to chronic mild stress using the chronic stress model protocol modified method of Wilner and Towell for a week. We made examinations with the naked eye, assessment of cortisol, weight, TEWL, and histologic test to contrast the S group with the N group. Statistical analysis was performed by using Mann-Whitney and Friedman test. Statistical significance was achieved if the probability was less than 5% (p<0.05). Results: 1. By making an examination with the naked eye, S group showed papules, creases and dryness on their skin, but N showed no change compared with normal skin. 2. There was no statistically significant difference between S group and N group in cortisol (p>0.05). 3. There was no statistically significant difference between S group and N group in weight. N group had less weight than S group (p<0.05). 4. There was no statistically significant difference between S group and N group in TEWL (p>0.05). 5. There was no statistically significant difference between S group and N group in TEWL recovery (p>0.05). 6. In TEWL and TEWL recovery, there was statistically significant difference by time between S group and N group (p<0.005). Histologically, S group showed a thicker epidermis and epidermal crest than N group. Conclusions: We found that stress during pregnancy has negative effects on the skin barrier of offspring. Though there were no statistically significant differences between S group and N group in TEWL recovery, we found evidence that the recovery of skin barrier function is interrupted by stress during pregnancy by examination with both the naked eye and histology.