• Journal of Veterinary Science
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• v.22 no.2
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• pp.26.1-26.6
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• 2021

Fourteen African swine fever (ASF) outbreaks occurred in the pig farms in the northwestern region of South Korea, near the border with North Korea, from September 16, 2019 to October 9, 2019. Active and passive surveillance on the ASF-infected farms indicated that the infection was limited only to pigsties where the infected pigs were detected on the farm for the first time before further transmission to other pigsties and farms. This early detection could be one of the pivotal factors for the prompt eradication of ASF in domestic pig farms within 1 month in the northwestern region of South Korea.

• BMB Reports
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• v.42 no.4
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• pp.227-231
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• 2009

The eukaryotic genome forms a chromatin structure that contains repeating nucleosome structures. Nucleosome packaging is regulated by chromatin remodeling factors such as histone chaperones. The Saccharomyces cerevisiae H3/H4 histone chaperones, CAF-1 and Asf1, regulate DNA replication and chromatin assembly. CAF-1 function is largely restricted to non-transcriptional processes in heterochromatin, whereas Asf1 regulates transcription together with another H3/H4 chaperone, HIR. This study examined the role of the yeast H3/H4 histone chaperones, Asf1, HIR, and CAF-1 in chromatin dynamics during transcription. Unexpectedly, CAF-1 was recruited to the actively transcribed region in a similar way to HIR and Asf1. In addition, the three histone chaperones genetically interacted with Set2-dependent H3 K36 methylation. Similar to histone chaperones, Set2 was required for tolerance to excess histone H3 but not to excess H2A, suggesting that CAF-1, Asf1, HIR, and Set2 function in a related pathway and target chromatin during transcription.

• Archives of Plastic Surgery
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• v.46 no.1
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• pp.75-78
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• 2019

It is difficult to differentiate acute skin failure (ASF) from pressure ulcer (PU). ASF is defined as unavoidable injury resulting from hypoperfusion caused by severe dysfunction of another organ system. We describe a case of ASF mistaken as PU that resulted in a legal dispute. A 74-year-old male patient was admitted to our intensive care unit with sepsis due to bacterial pneumonia. Despite the use of air cushions and regular position changes, skin ulcerations occurred over his occiput, back, buttock, elbow, and ankle. After improvement in his general condition, he was transferred to the department of plastic and reconstructive surgery. Debridement was performed immediately, followed by conservative treatment (including a vacuum-assisted closure device) for 6 weeks. The buttock and occiput wounds were treated surgically. Despite complete healing, his caregivers sued the hospital for failing to prevent PU formation. ASF is a pressure-related injury resulting from hemodynamic instability due to organ system failure. Unlike PU, ASF may occur despite the implementation of all appropriate preventive measures. Furthermore, misdiagnosis of ASF as PU can lead to litigation. Therefore, it is critical for the proper diagnosis to be made quickly, and for physicians to explain that ASF occurs despite proper preventative treatment.

• Transactions of the Korean Society of Automotive Engineers
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• v.16 no.1
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• pp.175-180
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• 2008

Due to the global environment problems and the consumer's need for higher vehicle performance, it becomes very important for the global car makers to reduce vehicle weight. To reduce vehicle weight, many car makers have tried to use lightweight materials, for example, aluminum, magnesium, and plastics, for the vehicle structures and components. Especially, the ASF(aluminum space frame) is known for the excellent concept of the vehicle to satisfy structural rigidity, safety performance and weight reduction. In this research, the design of experiments and the multi-disciplinary optimization technique were utilized to meet the weight and structural rigidity target of the ASF. For the structural performance of the ASF, the locations and the size of aluminum extruded frames, aluminum cast nodes, and the aluminum sheets were optimized. As a result, the optimization design procedure has been set up to meet both structural and weight target of the ASF, and the assembled ASF showed good structural performance and weight reduction.

• The Journal of Internal Korean Medicine
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• v.43 no.4
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• pp.529-541
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• 2022

Objectives: Acanthopanax senticosus is a tree used in traditional medicine for various diseases. In this study, we investigated the anti-cancer effects of a water extract of Acanthopanax senticocus fruit (ASF) on 2 human breast cancer cell lines (MCF-7 and MDA-MB-231). Methods: The MTT assay was used to assess cell proliferation. The expression of apoptosis-related genes was assessed by quantitative real-time PCR. Results: ASF treatment caused a dose-dependent inhibition of cell growth in both estrogen-independent MDA-MB-231 and estrogen-dependent MCF-7 breast cancer cells. ASF decreased mRNA expression of the apoptotic suppressor gene Bcl-xL, and increased mRNA expression of proapoptotic genes. ASF increased the mRNA expression of p21 and RIP-1 in both cell types. ASF decreased the mRNA expression of survivin in the MCF-7 cell line. Conclusions: ASF exhibits anti-cancer activity involving apoptotic cell death.

• Journal of Advanced Navigation Technology
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• v.11 no.1
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• pp.1-8
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• 2007

Loran-C of ground transmitting station base that can prevent confusion of country navigation system and give BACK-UP function about electric wave navigation comparing utilization incapability state about GPS(Global Positioning System) infra that user is spreading rapidly over our society whole such as sea/aviation safety, vehicles navigation, minuteness agriculture, minuteness measurement in this treatise practical use of Loran-C navigation propose. Executed ASF(Additional Secondary Phase Factor) production and an application experiment Loran-C by location error improvement way to enhance practical use value. By the result Loran-C in conclusion that can improve location error 100~400m remarkably by 10~65m reach. Also, production extent is latitude when go composition medium and bends cotton at ASF revision table utilization of land area, this smell is judged to be suitable hardness 10 minutes. And notable location error improvement and numeric of GPS BACK-UP function are judged to be possible at a ASF revision table application to Korea Peninsula whole area hereafter.

• Journal of Veterinary Science
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• v.22 no.5
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• pp.71.1-71.12
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• 2021

Background: African swine fever (ASF) is a hemorrhagic fever occurring in wild boars (Sus scrofa) and domestic pigs. The epidemic situation of ASF in South Korean wild boars has increased the risk of ASF in domestic pig farms. Although basic reproduction number (R₀) can be applied for control policies, it is challenging to estimate the R₀ for ASF in wild boars due to surveillance bias, lack of wild boar population data, and the effect of ASF-positive wild boar carcass on disease dynamics. Objectives: This study was undertaken to estimate the R₀ of ASF in wild boars in South Korea, and subsequently analyze the spatiotemporal heterogeneity. Methods: We detected the local transmission clusters using the spatiotemporal clustering algorithm, which was modified to incorporate the effect of ASF-positive wild boar carcass. With the assumption of exponential growth, R₀ was estimated for each cluster. The temporal change of the estimates and its association with the habitat suitability of wild boar were analyzed. Results: Totally, 22 local transmission clusters were detected, showing seasonal patterns occurring in winter and spring. Mean value of R₀ of each cluster was 1.54. The estimates showed a temporal increasing trend and positive association with habitat suitability of wild boar. Conclusions: The disease dynamics among wild boars seems to have worsened over time. Thus, in areas with a high elevation and suitable for wild boars, practical methods need to be contrived to ratify the control policies for wild boars.

• Journal of Positioning, Navigation, and Timing
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• v.2 no.1
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• pp.75-80
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• 2013

This article presents the design of long range navigation (LORAN)-disciplined oscillator (LDO), employing the timing information of the LORAN system, which was developed as a backup system that corrects the vulnerability of the global positioning system (GPS)-based timing information utilization. The LDO designed on the basis of hardware generates a timing source synchronized with reference to the timing information of the LORAN-C receiver. As for the LDO-based timing information measurement, the Kalman filter was applied to estimate the measurement of which variance was minimized so that the stability performance could be improved. The oven-controlled crystal oscillator (OCXO) was employed as the local oscillator of the LDO. The controller was operated by digital proportional-integral-derivative (PID) controlling method. The LDO performance evaluation environment that takes into account the additional secondary factor (ASF) of the LORAN signals allows for the relative ASF observation and data collection using the coordinated universal time (UTC). The collected observation data are used to analyze the effect of ASF on propagation delay. The LDO stability performance was presented by the results of the LDO frequency measurements from which the ASF was excluded.

• Journal of Veterinary Science
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• v.21 no.2
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• pp.14.1-14.10
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• 2020

African swine fever (ASF) is a highly contagious disease of domestic pigs and wild boars (WBs). Without a vaccine, early antibody and antigen detection and rapid diagnosis are crucial for the effective prevention of the disease and the employment of control measures. In Sardinia, where 3 different suid populations coexisted closely for a long time, the disease persists since 1978. The recent ASF eradication plan involves more stringent measures to combat free-ranging pigs and any kind of illegality in the pig industry. However, critical issues such as the low level of hunter cooperation with veterinary services and the time required for ASF detection in the WBs killed during the hunting season still remain. Considering the need to deliver true ASF negative carcasses as early as possible, this study focuses on the evaluation and validation of a duplex pen-side test that simultaneously detects antibodies and antigens specific to ASF virus, to improve molecular diagnosis under field conditions. The main goal was to establish the specificity of the two pen-side tests performed simultaneously and to determine their ability to detect the true ASF negative carcasses among the hunted WBs. Blood and organ samples of the WBs hunted during the 2018/2019 hunting seasons were obtained. A total of 160 animals were tested using the pen-side kit test; samples were collected for virological and serological analyses. A specificity of 98% was observed considering the official laboratory tests as gold standards. The new diagnostic techniques could facilitate faster and cost-effective control of the disease.

• Journal of Veterinary Science
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• v.21 no.2
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• pp.38.1-38.24
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• 2020

African swine fever (ASF), caused by the ASF virus, a member of the Asfarviridae family, is one of the most important diseases in the swine industry due to its clinical and economic impacts. Since the first report of ASF a century ago, ample information has become available, but prevention and treatment measures are still inadequate. Two waves of epizootic outbreaks have occurred worldwide. While the first wave of the epizootic outbreak was controlled in most of the infected areas, the second wave is currently active in the European and Asian continents, causing severe economic losses to the pig industry. There are different patterns of spreading in the outbreaks between those in European and Asian countries. Prevention and control of ASF are very difficult due to the lack of available vaccines and effective therapeutic measures. However, recent outbreaks in South Korea have been successfully controlled on swine farms, although feral pigs are periodically being found to be positive for the ASF virus. Therefore, we would like to share our story regarding the preparation and application of control measures. The success in controlling ASF on farms in South Korea is largely due to the awareness and education of swine farmers and practitioners, the early detection of infected animals, the implementation of strict control policies by the government, and widespread sharing of information among stakeholders. Based on the experience gained from the outbreaks in South Korea, this review describes the current understanding of the ASF virus and its pathogenic mechanisms, epidemiology, and control.