• 한국임상수의학회지
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• 제12권1호
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• pp.839-847
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• 1995

In this study, ultrasonographic evaluations were made after experimentally induced ascites in dogs. Ultrasonographic evaluation allowed to identify the earliest fluid accumulation between the spleen and the left kidney after the administration of 0.9% normal saline at 8 ml/kg into the abdominal cavity in dogs. Ultrasonographic finding were observed in order between the spleen and the left kidney, the liver, the pelvic cavity. It is considered that the most adequate pare f3r the early detection of ascites is between the spleen and the left kidney, and the least amount of detection fluid is 8 ml/kg in dogs.

• Journal of Chest Surgery
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• 제55권1호
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• pp.81-84
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• 2022

Esophagectomy and esophageal reconstruction are commonly chosen as surgical options for esophageal cancer. However, prolonged untreated chyle leakage is associated with a poor prognosis. We report the case of a patient with refractory chylous ascites. To limit the ongoing fluid loss, we utilized the chylous ascites as an additional fluid source in a renal replacement therapy system. A continuous renal replacement therapy (CRRT) drainage system was modified to drain both the chylous ascites and venous blood. The ascites drainage rate was determined empirically and regulated by a dial-flow extension set. The CRRT mode was set to continuous venovenous hemodiafiltration and maintained for 7 days. After the patient was weaned from CRRT, ascites did not reaccumulate, and the patient's general condition improved dramatically. No infections related to the system occurred. This procedure temporarily alleviates symptoms and provides more time for alternative treatment strategies.

• 한국임상수의학회지
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• 제21권2호
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• pp.194-196
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• 2004

A 12-year old neutered male Yorkshire terrier dog was presented to the Veterinary Medical Teaching Hospital of Seoul National University with a history of chronic intermittent diarrhea, vomiting, anorexia and weight loss of 2-months duration. On presentation, he was very cachexic and had ascites. Abnormal findings on a complete blood count and chemistry profile included mild anemia, leukocytosis, panhypoproteinemia, hypocholesterolemia, decreased blood urea nitrogen (BUN) and increased serum bile acids. Radiographic findings indicated microhepatica. Peritoneal fluid analysis was consistent with transudates (total protein < 2.5 g/dl, total nucleated cell count = 2,200/ul) and cytologic examination of the fluid revealed neoplastic lymphoblasts. From these findings hepatic dysfunction and protein-losing enteropathy were attributable to abdominal lymphoma. This case suggests that cytologic examination is important in diagnosing underlying diseases of ascites, even if it is transudative effusion.

• Journal of Korean Neurosurgical Society
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• 제50권4호
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• pp.385-387
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• 2011

Leptomeningeal metastasis is a devastating complication of advanced stage cancer. It is frequently accompanied by hydrocephalus and intracranial hypertension that must be treated by ventriculoperitoneal shunts. However, there are actual risks of peritoneal seeding or accumulation of malignant ascites after the cerebrospinal fluid diversion procedure, though it has not been reported. Here, we present the case of a patient with non-small cell lung cancer with leptomeningeal metastasis in whom malignant ascites developed after a subduroperitoneal shunt.

• 한국미생물·생명공학회지
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• 제17권3호
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• pp.269-272
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• 1989

In order to obtain monoclonal antibody from ascites fluid at sufficiently high purity using a single hydroxylapatite chromatography (HA) a further optimization on its operating variables was carried out. By adjusting the pH of the eluent, the sodium phosphate buffer, to 6.0 from 6.8 and adding CaCl$_2$to 1 mM at the column inlet, the elution molarities (M$_{elu}$) for the desired monoclonal antibody and contaminating proteins can be distinguished from each other with enough resolution. Previously these two groups of proteins co-eluted at the same time at pH 6.8 and without CaCl$_2$. This sin81e step hydroxylapatite chromatography yields the desired antibody pure enough for diagnostic use.

• 한국식품영양학회지
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• 제3권1호
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• pp.9-12
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• 1990

Toxohormone-L is a lipolytic factor, found in ascites fluid of sarcoma 180-bearing mice and of patients with hepatoma. A substance that inhibited the lipolytic action of toxohormone-L was isolated from white ginseng powder. This substance was an acidic polysaccharides It inhibited toxohormone-L-induced lipolysis in a dose dependent manner at concentrations higher than 100g/ml.

• 한국식품영양학회지
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• 제2권2호
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• pp.27-30
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• 1989

This study was devised to observe an inhibitory reaction toward an lipolytic action of toxohormone-L from KEUMSUNYEON powder. Toxohormone-L is known to be a lipolytic factor that was purified from the ascites fluid of sarcoma 180-bearing mice and of patients with hepatoma. KEUMSUNYEON powder was found to inhibit toxohormone-L induced lipolysis at its concentration of 0.5 mg/ml.

• Asian Pacific Journal of Cancer Prevention
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• 제17권12호
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• pp.5315-5320
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• 2016

Purpose: Tumor cell growth and sensitivity to chemotherapy depend on many factors, among which insulin-like growth factors (IGFs) may play important roles. The aim of the present study was to evaluate the levels of insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) in primary tumors and ascites as predictors of response to neoadjuvant chemotherapy in ovarian cancer (OC) patients. Materials and Methods: Tumor tissue samples and ascitic fluid were obtained from 59 patients with advanced OC. The levels of IGF-I, IGF-II, IGFBP-3, IGFBP-4 and PAPP-A were determined using ELISA kits. Taking into account the data on expression of these IGF-related proteins and outcome, logistic regression was performed to identify predictors of response to neoajuvant chemotherapy. Results: Human ovarian tumors expressed IGFs, IGFBP-3, IGFBP-4 and PAPP-A and these proteins were also present in ascites fluid and associated with its volume. IGFs and IGFBPs in ascites and soluble PAPP-A might play a key role in ovarian cancer progression. However, levels of proteins of the IGF system in tumors were not significant predictors of objective clinical response (oCR). Univariate analysis showed that the level of IGF-I in ascites was the only independent predictor for oCR. Conclusion: The level of IGF-I in ascites was shown to be an independent predictor of objective clinical response to chemotherapy for OC patients treated with neoadjuvant chemotherapy and debulking surgery.

• Neonatal Medicine
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• 제25권4호
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• pp.196-201
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• 2018

Umbilical venous catheterization (UVC) is a common practice in intensive neonatal care. However, a malpositioned UVC and its prolonged use may lead to various problems, including mechanical, infectious, and thrombotic complications in various organs such as the liver, lungs, and heart. Congenital chylous ascites is characterized by abnormally high levels of triglycerides in the peritoneal fluid of newborns, which originate from refluxed lymph within the abdominal cavity. Herein, we report a case of an UVC complication presenting as chyloperitoneum simulating congenital chylous ascites in a preterm neonate that resulted from total parenteral nutrition (TPN) extravasation from a malpositioned UVC. Biochemical analysis of intraperitoneal chylous fluid and TPN infusate could help confirm the origin of chyloperitoneum. This case suggests that TPN extravasation from UVC should be considered when chyloperitoneum develops in newborns with an indwelling catheter. UVC positions must also be carefully monitored at regular intervals to recognize associated complications early, particularly in cases with an inevitably malpositioned catheter related to the anatomy of the vessel course.

• Journal of Yeungnam Medical Science
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• 제16권1호
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• pp.76-84
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• 1999

악성 복수와 비악성 복수의 감별 진단은 진단과 치료 과정에서 매우 중요한 역할을 한다. 많은 계측치들이 감별을 위하여 사용되어져 왔는데 어느 것도 단독 사용시 두 군을 완벽히 구분짓지는 못한다. 이에 본 연구자들은 악성복수와 비악성 복수의 감별에 있어서 여러 계측치들을 비교하여 민감도와 특이도가 높은 계측치를 찾고 이 결과를 토대로 악성복수와 비악성 복수의 구분에서 간단하면서도 효과적인 진단방법을 찾고자 하였다. 1995년 1월부터 1997년 12월까지 영남대학교 의과대학 부속병원 내과에 복수를 주소로 내원하여 복수 천자를 시행한 80명을 대상으로 이들 환자들을 악성 복수 환자군과 비악성 복수 환자군으로 나누어 조사하였다. 악성 복수군은 다시 암종증이 동반된 21명의 환자와 암종증의 증거가 없는 6명의 환자로 구분하였고 비악성 복수군은 다시 52명의 간경변증 환자군과, 1명의 간경변증이 없는 군으로 구분하였다. 모든 환자에게서 복수와 혈액에서 동시에 검체가 얻어졌고 계측치로 복수액의 콜레스테롤, CEA, LDH, 단백치, 세포진 검사, 복수액과 혈청의 LDH 비, 단백비, 혈청-복수액 알부민 차를 구하였고, 각 계측치의 평균을 구하여 두 군을 비교하였는데, 모든 계측치가 통계적으로 유의한 차이를 보여 주었다. 저자는 각 계측치마다 각 측정치를 적용하여 가장 높은 민감도와 특이도를 보이는, 즉 가장 높은 진단 능력을 나타내는 측정치를 절단치로 정한 후각 계측치에 적용하여 진 양성, 진 음성, 가 양성, 가 음성으로 분류한 후 민감도, 특이도, 양성 기대도, 음성 기대도, 진단 능력을 산출하였고, 연구된 계측치 중 민감도가 높은 계측치인 복수액의 콜레스테롤을 선별검사의 단계에 적용하고, 특이도가 높은 계측치인 세포진 검사와 복수와 혈청의 단백비를 악성 복수로 분류된 군에 적용하여 악성 복수를 확진하는 2단계 진단 과정을 80명의 환자들에게 적용하여 다음 결과를 얻었다. 1) 복수액 분석 결과 복수액의 콜레스테롤치가(절단치: 30 mg/dl) 93%의 가장 높은 민감도를 보였고, 복수액의 세포진 검사와 복수액과 혈청의 단백비가(절단치: 0.5) 100%, 98%의 가장 높은 특이도를 나타내었다. 2) 2단계의 진단 과정을 통하여 복강내 암종 전이가 확인된 21명 모두 악성 복수군으로 분류되었다. 3) 광범위한 간전이가 있는 악성 복수 모두 비악성군으로 분류되었다. 4) 간 경변증으로 인한 52례에서 모두 비악성군으로 분류되었다. 5) 전체 진단 과정을 통해 총 27명의 악성 복수 중 81.5%인 22명이 악성 복수군으로 진단되었다. 이상의 결과를 토대로 본 연구자들이 제시한 진단 과정은 악성 복수와 비악성 복수의 감별 진단에 효과적인 방법으로 생각되며 더욱 정확한 진단을 위해서는 임상 양상, 방사선학적 검사, 기타 검사 등을 토대로 종합적인 판단이 필요하리라 생각된다.