• 한방안이비인후피부과학회지
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• 제30권3호
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• pp.201-210
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• 2017

만성 비소 중독으로 의심되는 피부염 환자를 양방 치료 없이 평혈음을 기본으로 한 한약과 침 치료 등 한방 단독 치료를 통하여 제반 증상을 호전시켰음을 관찰하여 보고한다.

• 셀메드
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• 제4권3호
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• pp.20.1-20.7
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• 2014

Ethanolic leaf extract of Bauhinia variegata has been tested for its possible antioxidant potentials against sodium arsenite induced toxicity in mice. Mice were randomized into two groups of five and fifty mice. Group I consisting of 5 mice without any treatment with food and water ad libitum which served as normal control. Group II mice were fed with sodium arsenite in drinking water at 100 ppm concentration for two monthsthen they were segregated into five groups which were treated differently. Group II a mice received only arsenic as sodium arsenite with drinking water, Group II b were fed chronically 1 : 20 alcohol to distilled water (vehicle), Group II c, d, e mice were orally fed 50 mg/kg, 150 mg/kg and 250 mg/kg of B. variegata leaf extract of once daily for 15 and 30 days respectively along with arsenic. Several toxicity marker enzymes such as gamma glutamyl transferase, lactate dehydrogenase, aspartate and alanine aminotransferase, acid and alkaline phosphatase, catalase and superoxide dismutase along with haematological variables such as glucose 6-phosphate dehydrogenase, creatinine, bilirubin, haemoglobin and sugar in different groups of treated and control mice were studied. Results obtained from the in vivo experiment revealed that administration of sodium arsenite caused a significant increase in some enzymes while decrease in some. A similar trend was also observed with haematological variables. In contrast B. variegata treatment at 150 mg/kg favourably modulated these alterations and maintained the antioxidant status than other two doses i.e. 50 mg/kg and 250 mg/kg thereby making it a good candidate to be used as supportive palliating measures in arsenic induced toxicity.

• Advances in Traditional Medicine
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• 제10권4호
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• pp.294-303
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• 2010

We determined arsenic, lead, mercury and cadmium concentrations in Chinese herbal medicines sold in the United States by medical use parts. 54 kinds of herbal products including 9 medical use parts (radix, rhizoma, cortex, pericarpium, fructus, lignum, semen, folium, and herba) were analyzed using inductively coupled plasma-mass spectrometry for arsenic, lead and cadmium, and using mercury analyzer for mercury. Arsenic (median concentration, 0.25 mg/g), mercury (0.20 mg/g), lead (3.78 mg/g) and cadmium (0.39 mg/g) were detected in 71%, 54%, 35%, and 18% of 143 herbal medicine samples, respectively. A total of 27% and 12% of 143 products analyzed contained mercury and cadmium above the regulatory standards. Herba and folium (leaves of herbal plants) were the most contaminated parts from metals, whereas pericarpium, lignum and semen (outer layers and seeds) were less contaminated. This study suggests that metal contamination is different by medical use parts. Our findings provide further evidence that efforts to protect people using traditional remedies from metal intoxication should be made to enforce the regulatory standards.

• Journal of Yeungnam Medical Science
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• 제40권3호
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• pp.311-314
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• 2023

Thallium poisoning is usually accidental. We present a case of a 51-year-old woman who was evaluated in June 2018 for myalgia, vertigo, asthenia, and abdominal pain. Physical examination revealed temporal-spatial disorientation, jaundice, and asterixis. The laboratory reported the following: bilirubin, 10.3 mg/dL; aspartate transaminase, 78 U/L; alanine transaminase, 194 U/L; albumin, 2.3 g/dL; prothrombin time, 40%; and platelet count, 60,000/mm³. Serology performed for hepatitis A, B, and C; Epstein-Barr virus; cytomegalovirus; and human immunodeficiency virus was negative, and a collagenogram was negative. Physical reevaluation revealed alopecia on the scalp, armpits, and eyebrows; macules on the face; plantar hyperkeratosis; and ulcers on the lower limbs. Tests for lead, arsenic, copper, and mercury were carried out, which were normal; however, elevated urinary thallium (540 ㎍/g; range, 0.4-10 ㎍/g) was observed. The patient was treated with D-penicillamine 1,000 mg/day and recovered her urinary thallium levels were within normal range at annual follow-up. Thallium poisoning is extremely rare and can be fatal in small doses. An adequate clinical approach can facilitate early diagnosis.

• Safety and Health at Work
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• 제3권4호
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• pp.257-267
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• 2012

Occupational neurotoxic diseases have become increasingly common in Taiwan due to industrialization. Over the past 40 years, Taiwan has transformed from an agricultural society to an industrial society. The most common neurotoxic diseases also changed from organophosphate poisoning to heavy metal intoxication, and then to organic solvent and semiconductor agent poisoning. The nervous system is particularly vulnerable to toxic agents because of its high metabolic rate. Neurological manifestations may be transient or permanent, and may range from cognitive dysfunction, cerebellar ataxia, Parkinsonism, sensorimotor neuropathy and autonomic dysfunction to neuromuscular junction disorders. This study attempts to provide a review of the major outbreaks of occupational neurotoxins from 1968 to 2012. A total of 16 occupational neurotoxins, including organophosphates, toxic gases, heavy metals, organic solvents, and other toxic chemicals, were reviewed. Peer-reviewed articles related to the electrophysiology, neuroimaging, treatment and long-term follow up of these neurotoxic diseases were also obtained. The heavy metals involved consisted of lead, manganese, organic tin, mercury, arsenic, and thallium. The organic solvents included n-hexane, toluene, mixed solvents and carbon disulfide. Toxic gases such as carbon monoxide, and hydrogen sulfide were also included, along with toxic chemicals including polychlorinated biphenyls, tetramethylammonium hydroxide, organophosphates, and dimethylamine borane. In addition we attempted to correlate these events to the timeline of industrial development in Taiwan. By researching this topic, the hope is that it may help other developing countries to improve industrial hygiene and promote occupational safety and health care during the process of industrialization.

• 대한화학회지
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• 제51권6호
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• pp.560-568
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• 2007

이 연구의 목적은 한국 중등학교 과학 교과서에 기술된 화학적으로 불분명한 ‘중금속' 용어에 대해 정의, 종류 및 의미의 항목으로 알아보았다. 예비 결과에 의하면 교과서중에서 ‘화학 I' 교과서 8종 중 6종에 서 비중을 근거로 중금속을 정의하고 있으며 또 인체에 유해하고 지속적으로 축적되는 금속으로 묘사하고 있 다. 특히 8종의 모든 교과서에서 중금속의 예로 카드뮴, 납 그리고 수은을 제시하고 있으나 비소와 같은 비금 속이나 크롬, 망간, 철, 코발트, 니켈 그리고 구리 같은 인체 필수 미량 금속도 들어 있었다. 금속의 독작용을 이해함에 있어서 금속의 산화상태, 생체 내 존재량, 생체 성분과의 반응성을 고려해야 하지만 교과서에서 이에 대한 단편적인 예만 제시하고 있었다. 화학적으로 정의되지 못한 용어는 학생들로 하여금 중금속은 독소와 동 일할 수 있다는 대안 개념을 유발시킬 수 있으므로 이러한 모호한 정의와 설명은 교과서에서 지양되어야 한다.