• Fisheries and Aquatic Sciences
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• v.24 no.1
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• pp.1-9
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• 2021

Human prostate cancer is the second most frequently diagnosed cancer worldwide, and its incidence rate continues to increase. Advanced prostate cancer is more difficult to treat than early forms due to its chemotherapy resistance. There is need for more effective agents that can inhibit the progression of advanced prostate cancer. Demethoxyfumitremorgin C (DMFTC) was isolated from the fermentation extract of the marine fungus Aspergillus fumigatus. Antiproliferative activity of DMFTC against human prostate cancer PC3 cells was examined through cell cycle analysis by flow cytometry, the fluorescent nuclear imaging analysis with propidium iodide (PI), and proteins expression related to cell cycle arrest and apoptosis were investigated via Western blotting. DMFTC inhibited PC3 cells growth through G1 phase cell cycle arrest and apoptosis induction. It activated the tumor suppressor p53 and the Cdk inhibitor p21, which regulate the cell progression into the G1 phase. Additionally, PI-positive late apoptotic non-viable cells were increased and the expression levels of the G1-positive downstream regulators cyclin D, cyclin E, Cdk2, and Cdk4 were decreased by DMFTC treatment. These results suggest that DMFTC induces G1 arrest and apoptosis induction through regulation of p53/p21-dependent cyclin-Cdk complexes, and it may be a useful therapeutic agent for the treatment of human advanced prostate cancer.

• International Journal of Internet, Broadcasting and Communication
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• v.13 no.1
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• pp.116-122
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• 2021

This study evaluated the effect of simulation training on cardiac arrest in hospitals for inactive nurses with 360 VR content, and attempted to prepare basic data for simulation training for inactiv nurses in the future. The design of this study is an experiment study before and after a single group. The study period was from October 13, 2020 to December 17, 2020. The subjects of the study were a total of 21 nurses who participated in the education program for inactive nurses. For simulation training for inactive nurses, Microsoft Powerpoint, hybrid simulation, high-fidelity simulation, and 360 VR content were applied for theories education and practical education. As a result of the study, the satisfaction level of the curriculum for the cardiac arrest situation in the hospital for inactive nurses was 4.78±0.36 points out of 5 points. Understanding of education was 4.71±0.46 points out of 5 points. Usefulness of education was 4.80±0.40 points out of 5 points. Confidence in airway maintenance before and after training, BLS review, manual defibrillator, emergency medication administration, airway maintenance, emergency situation simulation, and debriefing were all significant. According to the results of this study, simulation training of the situation of cardiac arrest in the hospitals for inactive nurses was effective. In future studies, it will be necessary to develope and verify specific teaching and learning methods by applying various cases of cardiac arrest situations in consideration of the type of hospitals.

• International Journal of Internet, Broadcasting and Communication
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• v.13 no.1
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• pp.229-237
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• 2021

This study aimed to help build a quality control program to improve cardiac arrest treatment via analysis of medical records in a local tertiary general hospital to evaluate factors that influence clinical outcomes of in-hospital cardiac arrest. At first, the medical records of in-hospital cardiac arrest were analyzed, and targeted surveys about functional and structural factors associated with cardiopulmonary resuscitation (CPR) were conducted amongst the workforce in charge of cardiac arrest treatment. From January 2012 through June 2013, a total of 486 adult cases of in-hospital cardiac arrests, except for those occurring in the emergency room, were enrolled in this study. Among the patients, those of recovery of spontaneous circulation were 57.8%; 13.8% of patients were discharged alive; 8.9% of patients were discharged without significant neurologic sequela. Despite CPR is usually successful when administered as quickly as possible, in this analysis showed that prompt reaction after initial recognition was significantly lower in nurses compared with doctors. Analysis of survey results showed that confidence in performing CPR was significantly associated with the experience of CPR in doctors, while in nurses educational experience showed a correlation. In order to improve quality of in-hospital CPR system maintaining and increasing confidence of CPR performance is the most important factor. Therefore it can be helpful to develop and apply a phased, customized education program using training simulators as well as personalizing them to increase the personnel's confidence in CPR performance.

• Journal of Korean Neurosurgical Society
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• v.56 no.6
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• pp.534-536
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• 2014

Due to improvements in emergency resuscitation provided by rescue teams, more trauma victims who could have died due to sudden heart failure at the scene are brought to the hospital following resuscitation. Most of these patients present with major organ injuries and hypovolemic shock at the time of trauma. However, head trauma associated with sudden heart arrest is rare. Here, we report a case of ring fracture with pontomedullary laceration that led to sudden heart arrest.

• BMB Reports
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• v.40 no.6
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• pp.895-898
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• 2007

The oxygen dependent regulation of DNA replication is an essential property of proliferating mammalian cells. In human T24 bladder cancer cells, several hours of hypoxia leads to reversible DNA replication arrest and re-entry of oxygen induces a burst of replication initiation. This short communication provides strong evidence that PD184352 initiates DNA replication in living hypoxic cells without elevating the oxygen level. PD184352 releases the regular hypoxic replicon arrest, however, at a low intensity compared to the effect of reoxygenation. Moreover, PD184352 shows no effect on normoxically incubated as well as reoxygenated T24 cells.

• Clinical and Experimental Reproductive Medicine
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• v.23 no.1
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• pp.7-9
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• 1996

Here, A forty year old patient is presented, showing azoospermia following vasovasostomy. The bilateral testicular biopsies were performed to confirm whether ductal obstruction due to vasovasostomy or testicular failure existed. The finding of biopsy was spermatogenic arrest. After completion of medical testicular stimulation with clomiphene citrate and pentoxifilline for 3 months, repeat vasovasostomy was performed. Semenanaylsis revealed normal sperm parameters after operation. Necessity of testicular biopsy before deciding repeat vasovasostomy, accuracy of testicular biopsy, efficacy of testicular stimulation in the patient with spermatogenic arrest and effect of testicular biopsy on testicular fuction are discussed.

• Journal of Chest Surgery
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• v.27 no.10
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• pp.854-857
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• 1994

Hypothermia and circulatory arrest is efficatious adjunct in the surgical treatment of conventionally difficult or otherwise inoperable lesion. This technique was utilized in 5 patients, 3 with membraneous obstruction of inferior vena cava[MOVC] and 1 with giant middle cerebral artery aneurysm and 1 with renal cell carcinoma invading inferior vena cava. All membraneous obstruction of inferior vena cava patients had excellent results but the others died of operative complications. The rationale for the use of complete cardiac arrest with hypothermia is reviewed and the use of these technique in selected patients is warrented.

• Journal of Chest Surgery
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• v.32 no.1
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• pp.80-83
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• 1999

Complete circulatory arrest with profound hypothermia has been an indispensable adjunct to the safe management of selected giant intracranial aneurysms. For the conduct of cardiopulmonary bypass, there are usually two kinds of methods, open and closed chest methods. We could manage one case of huge intracranial aneurysm that was successfully operated under circulatory arrest using the closed chest method, especially with percutaneous insertion of arterial and venous cannulas for cardiopulmonary bypass.

• Journal of the Korean Society of Safety
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• v.11 no.3
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• pp.3-9
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• 1996

Dynamic fracture characteristics of Polycarbonate WL-RDCB specimen were investigated. The dynamic crack propagation velocities in these specimens were measured by using both high speed camera system and silver paint grid method developed and justified in the INHA Fracture Mechanics Laboratory. The measured crack propagation velocities were fed into the INSAMCR code(a dynamic finite element code which has been developed in the INBA Fracture Mechanics Laboratory) to extract the dynamic stress intensity factors. It has been confirmed that both dynamic crack arrest toughness and the static crack arrest toughness depend on both the geometry and the dynamic crack propagation velocity of specimens. The maximum dynamic crack propagation velocity of Polycarbonate WL-RDCB specimen was found to be dependent on the material property, geometry and the type of loading. The dynamic cracks in these Polycarbonate WL-RDCB specimens seemed to propagate in a successive manner, involving distinguished 'propagation-arrest-propagation-arrest' steps on the microsecond time scale. It was also found that the relat-ionship between dynamic stress intensity factor and dynamic crack propagation velocities might be represented by the typical '$\Gamma$'shape.

• The Korean Journal of Emergency Medical Services
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• v.15 no.3
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• pp.57-70
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• 2011

Purpose : The purpose of this study was to reveal some factors of ROSC & survival for cardiac arrests from sport & leisure activities(CASLs). Methods : A retrospective study of the 1,341 out of hospital cardiac arrests(OHCAs) treated by EMS in Gyeonggi Provincial Fire and Disaster Headquarters from January to December in 2008 was conducted. The primary end-point was admission to emergency room. To clarify the factors through comparison of CASLs(n=58) with ROSCs & survivals(n=58), Answer Tree analysis for data mining with the CHAID algorithm was performed and alpha was set at .05. Mean, median, and percentile of time intervals, distances, and age on the 58 CASLs, 75 ROSCs, and 27 survivals(patients admitted to emergency room) were analysed. Results : Fourteen CASLs(24.1%), 41 ROSCs(54.7%), 16 survivals(59.3%) were treated with CPR within 5 min., and only 2 CASLs(3.4%), 11 ROSCs(14.7%), 10 survivals(37.0%) were treated with defilbrillation within 10 min. from arrest. If time recording from arrest to defilbrillation, the patients were classified 81.0%($X^2=9.83$, p=.005) into ROSCs & survivals. And the patients with no history, 100.0%($X^2=5.44$, p=.020). The other patients with no intention, 87.5%($X^2=7.00$, p=.024). Whereas the other patients with intention, treated with CPR after 4 min. from arrest were classified 67.2%($X^2=3.99$, p=.046) into CASLs. Conclusion : CPR within 4 minutes was the most important factor that discriminates between CASLs and ROSCs & survivals to record cardiac arrests-defilbrillation time. CPR within 4 min. from arrest, no history, and no intention were factors for improved ROSC & survival.