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Effects of Anemarrhena asphodeloides Extract on Atopic-Dermatitis like Skin Lesions in DNCB-induced Balb/c Mice (DNCB로 유도한 아토피 유사 피부염에 지모 추출물이 미치는 영향)

  • Yumi Jang;Yong-Ung Kim;Mi Ryeo Kim;Hye-Sun Lim;Gunhyuk Park
    • Journal of Environmental Science International
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    • v.32 no.1
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    • pp.67-76
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    • 2023
  • Under constant environmental pollution, the incidence of Atopic Dermatitis (AD) caused by air pollutants and allergens has increased. AD is an allergy inflammatory skin disease characterized by pruritus, eczema, and skin dryness. In herbal medicine, Anemarrhena asphodeloides (Anemarrhenae Rhizoma; AR) has been utilized to treat Alzheimer's disease, osteoporosis, hypertension, and inflammation. The purpose of study evaluated the effect of AR in a mouse model of 2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin lesions. After acclimatization for 5 days, the mice (6-week-old, male Balb/c) were divided into five groups (n=6/group): NC (normal control), DNCB (control), Dex (5 mg·kg-1, p.o.), AR100 (100 mg·kg-1, p.o.), and AR300 (300 mg·kg-1, p.o.). On days 1 and 3, 1% DNCB was applied to the skin and ears. After 4 days, 0.5% DNCB was applied once every 2 days for 2 weeks. Then, skin and ears eczema area and severity index (EASI); skin nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) levels; and plasma immunoglobulin E (IgE) levels were examined. The AR groups showed lower EASI, skin and ear thickness, mast cell count, and IgE levels than the control groups. Moreover, AR reduced iNOS, COX-2, and PGE2 levels. Therefore, AR possesses anti-inflammatory properties and can improve skin damage, indicating its therapeutic potential against AD.

Risk Factors for Cervical Cancer in Rural Areas of Wuhan China: a Matched Case-control Study

  • Zhang, Bin;Zhou, Ai-Fen;Zhu, Chang-Cai;Zhang, Ling;Xiang, Bing;Chen, Zhong;Hu, Rong-Hua;Zhang, Ya-Qi;Qiu, Lin;Zhang, Yi-Ming;Xiong, Chao-Du;Du, Yu-Kai;Shi, Yu-Qin
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.12
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    • pp.7595-7600
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    • 2013
  • Cervical cancer is a serious public health problem in developing countries. We investigated possible risk factors for cervical cancer in rural areas of Wuhan China using a matched case-control study with 33 women diagnosed with cervical cancer and 132 healthy women selected from the same area as matched controls. A questionnaire, which included questions about general demography conditions, environmental and genetic factors, the first sexual intercourse, first marriage age, age at first pregnancy, pregnancy first child's age, female personal health history, social psychological factors, dietary habits, smoking and alcohol status and other living habits was presented to all participants. At the same time, HPV infection of every participant was examined in laboratory testing. Results showed HPV infection (P<0.000, OR=23.4) and pregnancy first child's age (P<0.000, OR=13.1) to be risk factors for cervical cancer. Menopause (P=0.003, OR=0.073) was a protective factor against cervical cancer. However, there was no indication of associations of environmental (drinking water, insecticide, disinfectant) genetic (cancer family history), or life-style factors (smoking status, alcohol status, physical training, sleep quality), including dietary habits (intake of fruit and vegetable, meat, fried food, bean products and pickled food) or social psychological factors with cervical cancer. The results suggest that the risk of cervical cancer in Chinese rural women may be associated with HPV infection, menopause and the pregnancy first child's age.

Actual Analysis of the Interrelationship between Evaluation Indicators of Communicable Disease Control and Prevention Activities and Communicable Disease Incidence Data (법정감염병 발생자료와 감염병관리사업 평가지표와의 관계 실증분석)

  • Kim, Min-Jun;Hong, Jee-Young;Lee, Moo-Sik
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.15 no.12
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    • pp.7179-7186
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    • 2014
  • This study examined the interrelationship between the evaluation indicators of communicable disease control and prevention activities, and the communicable disease incidence data. This study analyzed the incidence data of communicable disease in local governments of south Korea and evaluated the data of communicable disease control and prevention activities by the Ministry of Health of the central government in South Korea during 2004-2005. Frequency analysis was carried out to understand the character of the participant, t-test to compare the mean value between the two groups and stepwise multiple regression analysis to understand the significance between the dependent and independent variables. In this study, the finance related to communicable diseases (group I diseases in both city and rural center), keep rate of periodic reports on notifiable communicable diseases based on the law for communicable disease control and prevention (group II in city), the level of education on personal hygiene (group II in rural center), level of education on AIDS prevention and the reporting rate of cases of tuberculosis (group III in city), and reporting rate of incident cases of tuberculosis (tuberculosis and Hansen disease in both rural and city) were significant indicators. The level of education on AIDS prevention and the reporting rate of the cases of tuberculosis (in city), and number of adverse reactions after immunization (in rural area), reporting rate of cases of tuberculosis (in total center) were significant indicators in total communicable disease and all types of public health centers. The authors verified core evaluation indicators as actual proof. This study provides useful data for a summative evaluation, standardization, and guidelines on communicable disease control and prevention activities of public health centers and local government.

Development of Pine Wilt Disease (Bursaphelenchus Xylophilus) Prevention System (소나무재선충병 방제관제시스템 개발에 관한 연구)

  • Seo, Bong-Sang;Jeon, Hyeong-Seob;Kim, Jun-Beom;Cho, Gi-Sung
    • Proceedings of the Korean Society of Surveying, Geodesy, Photogrammetry, and Cartography Conference
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    • 2007.04a
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    • pp.283-287
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    • 2007
  • Pine Wilt Disease (Bursaphelenchus Xylophilus) has been attacked since 1988, then it becomes very serious problem of the all over the country. Government has been invested a lot of money to prevent but it is hard to survey the damaged area and ineffectively control the process of prevention. Therefore, this study is focused on development of Pine Wilt Disease (Bursaphelenchus Xylophilus) Prevention System using GIS and GPS through constructiong database of digital map, satellite imagery and attribute data and development component for desktop PC, internet and mobile system to realtime data transmission between project manager and field worker. Especially, we developed the mobile system that can transmit field conditions in realtime using GPS, GIS and CCD camera, the telecommunication control server that transmit received field condition data to web connecting module and system manager, the web system for end user to notify prevention details, the control system lot manager to recognize filed conditions and to control field workers and the wireless telecommunication module to connect in realtime between field and control center.

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Implementation of an Auto-Steering System for Recreational Marine Crafts Using Android Platform and NMEA Network

  • Beirami, Mohammadamin;Lee, Hee Yong;Yu, Yung-Ho
    • Journal of Advanced Marine Engineering and Technology
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    • v.39 no.5
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    • pp.577-585
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    • 2015
  • This paper deals with development of an autopilot system for leisure yacht based on NMEA 2000 network and android platform. The developed system can operate both for manual steering and automatic navigation mode. In automatic steering mode, after manipulation of commands which are NMEA 0183 sentences by android platform, the developed system translates and sends the packets through NMEA 2000 network. Then the controller which is connected to NMEA 2000 network receives the commands and controls the boat's rudder system automatically. The automatic steering mode is achieved by cooperation of two controllers; one for controlling the rudder system, and the other for controlling the vessel's heading. To control the vessel's rudder and heading angle two PID controllers are developed with an adjustable dead-band gain. Also, in order to eliminate the steady-state error occurred by applying dead-band, an integral controller which specifically supervises the system's behavior inside the dead-band area is developed. In this paper, at the first stage, simulations are accomplished using computer in order to examine the feasibility of the proposed based on simulation results. In the next step, the system on a real hydraulic steering model is implemented and at the end the performance examination by implementing it on a real boat and doing test navigation is executed.

The Status and Future Challenges of Tobacco Control Policy in Korea

  • Cho, Hong-Jun
    • Journal of Preventive Medicine and Public Health
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    • v.47 no.3
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    • pp.129-135
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    • 2014
  • Tobacco use is the most important preventable risk factor for premature death. The World Health Organization (WHO) Framework Convention on Tobacco Control (FCTC), the first international public health treaty, came into force in 2005. This paper reviews the present status of tobacco control policies in Korea according to the WHO FCTC recommendations. In Korea, cigarette use is high among adult males (48.2% in 2010), and cigarette prices are the lowest among the Organization for Economic Cooperation and Development countries with no tax increases since 2004. Smoke-free policies have shown incremental progress since 1995, but smoking is still permitted in many indoor public places. More than 30% of non-smoking adults and adolescents are exposed to second-hand smoke. Public education on the harmful effects of tobacco is currently insufficient and the current policies have not been adequately evaluated. There is no comprehensive ban on tobacco advertising, promotion, or sponsorship in Korea. Cigarette packages have text health warnings on only 30% of the main packaging area, and misleading terms such as "mild" and "light" are permitted. There are nationwide smoking cessation clinics and a Quitline service, but cessation services are not covered by public insurance schemes and there are no national treatment guidelines. The sale of tobacco to minors is prohibited by law, but is poorly enforced. The socioeconomic inequality of smoking prevalence has widened, although the government considers inequality reduction to be a national goal. The tobacco control policies in Korea have faltered recently and priority should be given to the development of comprehensive tobacco control policies.

A Novel Seamless Direct Torque Control for Electric Drive Vehicles

  • Ghaderi, Ahmad;Umeno, Takaji;Amano, Yasushi;Masaru, Sugai
    • Journal of Power Electronics
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    • v.11 no.4
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    • pp.449-455
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    • 2011
  • Electric drive vehicles (EDV) have received much attention recently because of their environmental and energy benefits. In an EDV, the motor drive system directly influences the performance of the propulsion system. However, the available DC voltage is limited, which limits the maximum speed of the motors. At high speeds, the inverter voltage increases if the square wave (SW) voltage (six-step operation) is used. Although conventional direct torque control (DTC) has several advantages, it cannot work in the six-step mode required in high-speed applications. In this paper, a single-mode seamless DTC for AC motors is proposed. In this scheme, the trajectory of the reference flux changes continuously between circular and hexagonal paths. Therefore, the armature voltage changes smoothly from a high-frequency switching pattern to a square wave pattern without torque discontinuity. In addition, because multi-mode controllers are not used, implementation is more straightforward. Simulation results show the voltage pattern changes smoothly when the motor speed changes, and consequently, torque control without torque discontinuity is possible in the field weakening area even with a six-step voltage pattern.

A Study on Dynamic Walking Control of Biped Robot (이족 보행로봇의 동적 보행 제어에 관한 연구)

  • Shim, Byoung-Kyun;Jeong, Yang-Keun;Shim, Hyun-Seok;Lee, Woo-Song
    • Journal of the Korean Society of Industry Convergence
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    • v.17 no.4
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    • pp.245-254
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    • 2014
  • In this paper, stable and robust dynamic walking for a biped motion is proposed. To success this objective, the following structures are processed. In this paper, the proposed control method is one that adjusts actual zero moment position to move to the closest possible point in the stable area instead of following desired zero moment position. This minimizes energy consumption with the smallest joint movements. The proposed control method makes mechanical energy that drives lower limb of the bipedal robot efficient. In this paper, walking experiment is carried out with the three control structures mentioned above. The trajectory generated by off-line is illustrated by performing to walking on flat ground. experiment with an obstacle whose height is lower than that of trajectory is executed to validate dynamic motion.

Interrelationship between Diabetic Control and Related Factors of Dietary Compliance in Diabetic Patients (당뇨병 환자의 당뇨병 조절과 식사요법 실천 관련요인과의 상관성)

  • Choe, Ji-Eun;Seo, Jeong-Suk
    • Journal of the Korean Dietetic Association
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    • v.11 no.2
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    • pp.137-146
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    • 2005
  • This study was carried out to investigate the relationship between diabetic control and related factors of the practice of diet therapy which affects mostly diabetic patients’ dietary compliance. A questionnaire survey was conducted on 128 diabetic patients who had visited Internal medicine endocrinology clinic at University Medical Center of Daegu area. The questionnaires including clinical characteristics, meal regularity and food intake which shows dietary compliance, intrinsic barriers to the practice of diet therapy and knowledge of diet therapy were asked and analyzed. The factor which affects HbA1c was intrinsic barriers and HbA1c became higher as the level of intrinsic barriers was increasing. The education on diet therapy had no influence on the intrinsic barriers, but the level of knowledge on diet therapy was shown higher in the educated patients. The above results suggest that the practice of diet therapy should be leaded to develop behavioral aspects through resonable motivation on dietary compliance along with removing intrinsic barriers rather than simply providing information.

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Wake Flow Characteristics around the Side Mirror of a Passenger Car (승용차 외장측면거울 주위의 유동 특성)

  • Han, Yong-Oun;Kim, Jung-Hyun;Hwang, In-Ho;Seo, Jung-Bok;Lim, Byung-Hoon;Jung, Ui-Hyun
    • Proceedings of the KSME Conference
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    • 2007.05b
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    • pp.2573-2578
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    • 2007
  • In order to investigate the vortex body frame interaction around the side mirror of a passenger car, velocity vector fields in the wake, pressure distributions and boundary layer flows over both the mirror surface and the mirror housing, have been measured by several experimental tools. It was resulted that only within an half downstream distance of the mirror span there appears the recirculation zone, and also found that vortex trail towards to the driver side window between A and B pillars, making the acoustic noise and vibration. Wake vortex rolls up after this recirculating zone and makes the trail of the vortex center towards the driver side window, which was also confirmed by measurements of wake velocity vectors in the vertical sections of the trail and visualization over the side mirror surfaces as well. It was also observed that total pressure distribution over the mirror surface has the minimum peak near the lower tip region which can be considered as the origin of the vortex center. It can be concluded that the geometrical modification of the lower tip and the upper root area of the mirror housing is the key to control the wake vortex.

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