• 대한인간공학회지
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• 제33권4호
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• pp.289-297
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• 2014

Objective: The purpose of this study is to identify the incidence risk of cardiovascular disease (CVD) in the workplace, and to suggest the prediction models for level of CVD incidence risk. Background: CVD can be caused by various factors related to personal habits such as diet and exercise, or genetics. However it can also be caused and aggravated by work, making the elimination of such risk factors at work crucial disease (KOSHA, 2013). Method: The distribution of CVD risk assessment levels of 162 workers was compared with the acquired medical examination data to discuss the necessity of assigning additional risk factors. Two alternative risk assessment models were given to enhance the accuracy of the evaluation; adjusting risk scores given in the KOSHA GUIDE H-1-2013 (alternative 1) and building a matrix of KOSHA GUIDE H-1-2013 and risk assessment results based on work condition levels (alternative 2). To verify the suggested models, medical examination results of 12 workers approved of convalescence were referred to. Results: The second alternative showed more relevance between the results and workers approved of convalescence in predicting the risk group when applied to actual heath examination data from the approved workers. The power of description of the new method for determining the risk of CVD incidence, 83.3%, is higher than that of KOSHA GUIDE H-1-2013, 25%. Conclusion: Results of this study imply that more approved workers had been from unmanaged normal groups than managed risk groups, raising the importance of CVD management. Application: The new prediction model considering working time and shift work developed in this study is expected to be a fundamental data for risk analysis and management of CVD in the workplace.

• 한국항행학회논문지
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• 제28권1호
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• pp.51-59
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• 2024

현재 항공 산업 분야에 우수한 조종사를 공급하기 위해 전 세계적으로 전문교육기관 제도 (ATO; approved training organization)를 활용하고 있다. 세계적으로 활용되는 이 제도는 각 국가에 맞는 실정으로 변형되어 활용되고 있다. 본 연구에서는 우리나라 조종사 양성 전문교육기관의 운영방식 및 교육 환경을 자세히 살펴보고, 국제민간항공기구의 국제표준, 미국, 유럽, 캐나다 등과 일본, 중국, 싱가포르 등 주변국의 비행 교육기관 운영방식 및 비행교육 환경을 비교하여 차이점을 도출함으로써 우리나라 전문교육기관 제도와 어떠한 차이를 보이는지를 비교하였다. 이러한 비교자료를 기반으로 해당 업무 종사자들의 설문 조사를 통해 국내 항공안전법 전문교육기관 지정기준에서 설정하고 있는 학과 수업 양에 대한 만족도가 설문대상의 특성에 따라 큰 차이가 있었고 학과 수업과목에 따라 중요도의 차이가 발생하였다.

• 한국직업건강간호학회지
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• 제22권2호
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• pp.102-111
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• 2013

Purpose: This study was conducted to analyze the characteristics of work-related musculoskeletal diseases (MSD) and the factors for approving MSD by the parts of the body. Methods: The analysis was done using the data which were drawn from the Industrial Accident Compensation Insurance that is operated by the Korea Worker's Compensation & Welfare Service. The data were composed of total cases related to the work-related diseases from 2006 to 2009. In addition, MSD data input by an investigator were collected. The factors associated with MSD were analyzed using ${\times}2$ and multiple logistic regression. Results: MSD approved cases have increased since 2006 and the proportion of the approved work-related MSD cases in the workers with work-related diseases in 2009 were 33.4%. Spinal approved cases were the highest percentage and upper and lower extremities cases gradually increased. The factors for approving upper extremity were found to be age, company size, type of industry, working duration, and in the case of spine to be company size and heavy lifting. Conclusion: Work-related MSD have increased and the factors that affected MSD by the parts of the body varied. Management strategy must be established to prevent MSD by the parts of the body.

• Translational and Clinical Pharmacology
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• 제26권4호
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• pp.155-159
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• 2018

For regulatory approval of a new drug, the most preferred and reliable source of evidence would be randomized controlled trials (RCT). However, a great number of drugs, being developed as well as already marketed and being used, usually lack proper indications for children. It is imperative to develop properly evaluated drugs for children. And expanding the use of already approved drugs for other indications will benefit patients and the society. Nevertheless, to get an approval for expansion of indications, most often with off-label experiences, for drugs that have been approved or for the development of pediatric indications, either during or after completing the main drug development, conducting RCTs may not be the only, if not right, way to take. Extrapolation strategies and modelling & simulation for pediatric drug development are paving the road to the better approval scheme. Making the use of data sources other than RCT such as EHR and claims data in ways that improve the efficiency and validity of the results (e.g., randomized pragmatic trial and randomized registry trial) has been the topic of great interest all around the world. Regulatory authorities should adopt new methodologies for regulatory approval processes to adapt to the changes brought by increasing availability of big and real world data utilizing new tools of technological advancement.

• Nuclear Medicine and Molecular Imaging
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• 제40권2호
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• pp.66-73
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• 2006

Monoclonal antibodies are designed to bind specifically to certain antigen, give therapeutic effect to the target and to be produced in large scale with homogeneity. The monoclonal antibodies conjugated with radionuclide can deliver therapeutic irradiation to the target, and showed successful results in certain malignancies, which is known as radioimmunotherapy. The target-to-background ratio depends on the antigen expression in the target and normal tissues, which is related to the therapeutic efficacy and toxicity in radioimmunotherapy. For the solid tumor beta-ray energy should be high, but lower beta energy is better for the hematological malignancies. I-l31 is widely used in thyroid cancer with low cost and high availability. Labeling monoclonal antibody with I-131 is relatively simple and reproducible. Some preclinical data for the I-131 labeled monoclonal antibodies including acute toxicity and efficacy are available from already published literatures in KIRAMS, physician sponsored clinical trial protocols using Rituximab, KFDA approved anti-CD20 chimeric monoclonal antibody and I-131 were approved by KFDA and currently are ongoing.

• 한국안전학회지
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• 제35권3호
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• pp.79-85
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• 2020

Ahn-heung Proving Ground(APG) of Agency for Defense Development(ADD) is the only weapon test site which has been performing firing tests for many kinds of missile, artillery and ammunition. APG has been performing the firing tests of so many times every year. The tests related to missiles, artillery and ammunitions cover 80% among the quantity of annual test events. The target area of many kinds of missile, artillery and ammunition is on the sea. Therefore, APG has its marine firing ranges which were approved by the ministry of Defense. Both weapons and ships can run into each other on the sea. APG has to monitor and detect the positions of the ships in the specific dangerous zone on the sea. The positions of the ships are detected by Scanter 2001 radar and GPS100 detection radar. Evading the time period when the ships appear very often on the sea may be a good solution to keep the maritime safety. And evading the place where the ships appear very often on the sea may be a good solution as well. This paper is to analyze the ships' distribution characteristics of marine firing range, which are to raise the efficiency of many kinds firing tests which have been performed in APG of ADD. Ship distribution data from February 2014 to December 2016 were used in this paper. Ship distribution was analyzed with monthly data, seasonal data and etc. The number of the ships in approved sea area is higher in the morning than in the afternoon, and in fall than other seasons, and from August to November, and below 0.5 m in the hight of wave. Using the these conditions, we can raise the test efficiency of many kinds firing tests and guarantee maritime safety. The number of the ships in approved sea area is entirely unrelated to visibility of the sea. The time period when the number of the ships are high on the sea is morning. The season when the number of the ships are comparatively high on the sea is fall. APG of ADD could raise the efficiency of the firing tests and improve the maritime safety, using the analysis results of the characteristics on the ship distribution.

• 의학교육논단
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• 제25권2호
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• pp.109-113
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• 2023

An educational outcome cohort has been established at Keimyung University School of Medicine to help make educational policy decisions and improve educational programs based on data. The purpose of the educational outcome cohort is to support educational policy decisions for achieving graduation outcomes smoothly and to accomplish the intended human resources development of the university through objective analyses and regular monitoring, providing continuous feedback. The data collected for the educational outcome cohort include the student identifications of freshmen, entrance exam scores, premedical and medical school grades, titles and forms of student academic research, the results of psychological testing, scholarship recipient lists, volunteer clubs, and so forth. The data are collected using an information utilization agreement approved by the Institutional Review Board, and the collected data are encrypted and stored on a dedicated computer for enhanced personal information security. Proposals to access and utilize the educational outcome cohort data must be discussed and approved by the Educational Outcome Cohort Committee, which decides on the scope and method of utilization. The collected and managed educational outcome cohort data have been used to develop comparative programs to improve students' competency and to support admission policy decisions through an analysis of the characteristics and performance of medical school students. The establishment and utilization of the educational outcome cohort will play an important role in determining the School of Medicine's educational policies and suggesting new directions for educational policies in the future.

• 한국임상약학회지
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• 제25권3호
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• pp.171-177
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• 2015

Background: Androgenetic alopecia (AGA), one of alopecias, requires continuous treatment in order to prevent or stop it, and patient's compliance is very important. Currently, only two drugs (finasteride, minoxidil) have been approved for AGA by Food and Drug Administration of United States (US FDA). However, another ${\alpha}-2$ reductase inhibitor, dutasteride, is approved by Korea Ministry of Food and Drug Safety (MFDS) through a phase III trial. For treatment, pharmacotherapy of AGA usually combines topical minoxidil 7% with one of oral <${\alpha}-2$ reductase inhibitor. Objectives: We evaluated the comparative efficacy and adverse effect between topical minoxidil 7%/finasteride 1 mg and topical minoxidil 7%/dutasteride 0.5 mg pharmacotherapy for outpatients with AGA. Also we evaluated the relationship between therapeutic effect and regular hospital visit. Method: This study was performed retrospectively based on electronic medical record (EMR) data of total 98 patients (topical minoxidil 7% with dutasteride 0.5 mg ($Avodart^{(R)}$) or finasteride 1 mg ($Alopecia^{(R)}$, $Propecia^{(R)}$) with diagnosis of AGA from department of dermatology at a secondary hospital from January $1^{st}$, to May $31^{st}$, 2014. Results: The efficacy and adverse event of topical minoxidil 7%/dutasteride 0.5 mg (DUTA group) were 100% and 45.7%, and of topical minoxidil 7%/finasteride 1 mg (FINA group) were 92.1% and 33.3%, respectively. The mean onset time of responses and adverse events in the FINA group were 3.86 months and 4.43 months. Those in the DUTA group were 3.97 months and 5.06 months. Conclusion: Both FINA and DUTA group were highly effective, but the DUTA group showed higher efficacy and adverse effects than those in the FINA group. Dutasteride may be another alternative in AGA treatment.

• 한국산업보건학회지
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• 제30권4호
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• pp.353-363
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• 2020

Objectives: Occupational diseases that occur due to or aggravated by work have commonly been recognized in the manufacturing industry, but there are now more incidences happening in the service industry due to changes in the industrial structure. Health workers are exposed to direct factors and various other causes of occupational disease at work, such as physical, chemical, biological, and psyco-social factors. This study aims to identify work-related diseases affecting health workers that are recognized as occupational diseases. Methods: The research is based on the data of workers whose diseases were accepted as work-related by the Industrial Accidents Compensation Insurance, and filed by the Korean Occupational Safety and Health Agency. Amongst the approved claims during 2011 to 2015, we focused on healthcare workers and health-related workers of the Korean Standard Classification of Occupations. Descriptive statistics were performed. Results: The number of health workers(HWs) with approved work-related disease was 1,707 over 5 years. The number of healthcare workers(HCWs) excluding caregivers was 370 (21.7%) and of health-related workers (HRWs) it was 736 (43.1%). Out of HWs who were approved for their illnesses, females were 80% of HCWs and 88% of HRWs. The most common occupational disease in HWs was musculoskeletal diseases, while that of nurses was infectious disease. Conclusions: HWs are exposed to various risks from their profession and are affected by occupational diseases. It is necessary to focus on this issue and provide preventive measures.

• 한국가금학회지
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• 제44권1호
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• pp.11-18
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• 2017

본 연구는 국내 산란계 동물복지 인증농가의 사육시설 및 사육형태에 따른 기초 사료를 수집하기 위해 수행하였다. 조사를 위하여 동물복지 인증을 받은 64농가에 설문지를 발송하였으며, 이 중 20농가(31.3%)에서 설문지가 회수되었다. 20농가의 사육시설별 현황은 보온덮개계사, 자연농법계사, 판넬철골조계사가 각각 4농가(20%), 7농가(35%), 9농가(45%)였으며, 사육밀도별 현황은 2~3수/$m^2$ 2농가, 4~5수/$m^2$ 10농가, 6~7수/$m^2$ 8농가였다. 사육형태별 현황은 평사 14농가(70%), 방사 3농가(15%), 평사+방사 3농가(15%)였다. 보온덮개계사와 자연농법계사의 사육밀도는 대부분의 농가에서 4~6수/$m^2$ 로 사육하였고, 판넬철골조계사는 9농가 중 7농가에서 6~7수/$m^2$로 사육하였다. 사료섭취량은 20농가 중 11농가(55%)에서 120~130 g을 섭취하였으며, 보온덮개, 자연농법, 판넬철골조계사의 농가 수가 각각 3농가(15%), 3농가(15%), 5농가(25%)이었다. 사육시설별 산란피크는 보통 24~28주령이었고, 산란율 80% 이상의 농가는 보온덮개 75%, 자연농법 56.2%, 판넬철골조계사 67%이었다. 호흡기 질병 발병률이 55%로 가장 높았으며, 보온덮개계사 75%, 자연농법계사 70%, 판넬철골조계사 33%가 발병하였다. 대장균증은 판넬철골조계사에서만 나타났으며, 발병률은 44%였다. 동물복지 인증을 받은 계란(특히 판넬철골조계사) 중 70%가 대형마트나 지역판매장으로 유통되었다. 사육형태에 따른 계란가격은 평사 14농가 중 6농가(42.9%)가 계란 1개당 200~250원으로 계산되었다. 이런 결과들은 현재 동물복지 인증농가의 생산실태를 보여주고 있다.