• Journal of the Korean Geotechnical Society
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• v.25 no.12
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• pp.57-67
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• 2009

Along with the advanced construction technologies, the maximum size of coarse aggregate used for dam construction ranges from several cm to 1m. Testing the original gradation samples is not only expensive but also causes many technical difficulties. Generally, indoor tests are performed on the samples with the parallel grading method after which the results are applied to the design and interpretation of the actual geotechnical structure. In order to anticipate the exact behavior characteristics for the geotechnical structure, it is necessary to understand the changes in the shear behavior. In this study, the Large Triaxial Test was performed on the parallel grading method samples that were restructured with river bed sand-gravel, with a different maximum size, which is the material that was used to construct Dam B in Korea. And the Stress - Strain characteristics of the parallel grading method samples and the characteristics of the shear strength were compared and analyzed. In the test results, the coarse-grained showed strain softening and expansion behavior of the volume, which became more obvious as the maximum size increased. The internal angle of friction and the shear strength appeared to increase as the maximum size of the parallel grading method sample increased.

• Journal of the Korean Geotechnical Society
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• v.23 no.6
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• pp.97-102
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• 2007

Though the stability analysis of soil slopes widely employs the limit equilibrium method, the study on the jointed rock slopes must consider the direction of joint and the characteristics of Joint at the same time. This study analyzes the result of the change in the factors which show the characteristics of discontinuity and the shape factor of rock slopes, and so on, in an attempt to validate the propriety as to the interpretation of jointed rock slope stability which uses the general finite element program. First, the difference depending on the flow rules was compared, and the factor effect study was conducted. The selected independent variables included the direction of joint which displays the mechanical characteristics of discontinuity, adhesive cohesion, friction angle, the inclination and height of rock slope which reveal the shape of slope and surcharge load. And the horizontal displacement was numerically interpreted at the 1/3 point below the slope, a dependent variable, to compare the relative degree of factor effects. The findings of study on factor effects led to the validation that the result of horizontal displacement for each factor satisfied various engineering characteristics, making it possible to be applied to stability interpretation of jointed rock slope. A modelling is possible, which considers the application of the result of real geotechnical surveys & laboratory studies and the non-linear characteristics when designing the rock slope. In addition, the stress change which may result from the natural disaster, such as precipitation, and the construction, can be expressed. Furthermore, as the complicated rock condition and the ground supporting effect can be considered through FEM, it is considered to be very useful in making an engineering decision on the cut-slope, reinforcement and so on.

• Journal of the Korean Geotechnical Society
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• v.25 no.11
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• pp.27-38
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• 2009

In this study, a series of 1 g shaking table model pile tests were carried out in saturated dense and loose sand to evaluate dynamic p-y curves for various conditions of flexural stiffness of a pile shaft, acceleration frequency and acceleration amplitude for input loads. Dynamic p-y backbone curve which can be applied to pseudo static analysis for saturated dense sand was proposed as a hyperbolic function by connecting the peak points of the experimental p-y curves, which corresponded to maximum soil resistances. In order to represent the backbone curve numerically, empirical equations were developed for the initial stiffness ($k_{ini}$) and the ultimate capacity ($p_u$) of soils as a function of a friction angle and a confining stress. The applicability of a p-y backbone curve was evaluated based on the centrifuge test results of other researchers cited in literature, and this suggested backbone curve was also compared with the currently available p-y curves. And also, the scaling factor ($S_F$) to account for the degradation of soil resistance according to the excess pore pressure was developed from the results of saturated loose sand.

• Journal of the Korean Institute of Gas
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• v.27 no.2
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• pp.39-48
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• 2023

This study presents the experimental results to measure the adsorption amount of methane gas by coal according to the conditions of a coalbed methane (CBM) reservoir. Adsorbed gas to coal seam particles was measured under reservoir conditions (normal pressure ~ 1,200 psi pressure range, temperature range15 ~ 45℃) using coal samples obtained from random mines in Kalimantan Island, North Indonesia. The obtained amount of absolute adsorbed gas was applied to triangular with linear interpolation to calculate the maximum amount of adsorbed gas according to temperature and pressure change, at which no experiment was performed. As a result, it was revealed that the amount of adsorbed gas to coal particles increased as the pressure increased and temperature decreased, but the increase of the amount of adsorbed gas decreased at more than an appropriate depth(1,000 ft). In the cleat permeability and cleat porosity for each depth of the coal bed considering the effective stress, the cleat permeability was 28.86 ~ 46.81 md, and the cleat porosity was 0.83 ~ 0.98%. This means that the gas productivity varies significantly with the depth because the reduction of the permeability according to the depth in the coal seam is significant. Therefore, a coalbed depth should be considered essential when designing the spacing of production wells in a coalbed methane reservoir in further study.

• Biomolecules & Therapeutics
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• v.31 no.4
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• pp.446-455
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• 2023

The mechanistic functions of 3-deoxysappanchalcone (3-DSC), a chalcone compound known to have many pharmacological effects on lung cancer, have not yet been elucidated. In this study, we identified the comprehensive anti-cancer mechanism of 3-DSC, which targets EGFR and MET kinase in drug-resistant lung cancer cells. 3-DSC directly targets both EGFR and MET, thereby inhibiting the growth of drug-resistant lung cancer cells. Mechanistically, 3-DSC induced cell cycle arrest by modulating cell cycle regulatory proteins, including cyclin B1, cdc2, and p27. In addition, concomitant EGFR downstream signaling proteins such as MET, AKT, and ERK were affected by 3-DSC and contributed to the inhibition of cancer cell growth. Furthermore, our results show that 3-DSC increased redox homeostasis disruption, ER stress, mitochondrial depolarization, and caspase activation in gefitinib-resistant lung cancer cells, thereby abrogating cancer cell growth. 3-DSC induced apoptotic cell death which is regulated by Mcl-1, Bax, Apaf-1, and PARP in gefitinib-resistant lung cancer cells. 3-DSC also initiated the activation of caspases, and the pan-caspase inhibitor, Z-VAD-FMK, abrogated 3-DSC induced-apoptosis in lung cancer cells. These data imply that 3-DSC mainly increased mitochondria-associated intrinsic apoptosis in lung cancer cells to reduce lung cancer cell growth. Overall, 3-DSC inhibited the growth of drug-resistant lung cancer cells by simultaneously targeting EGFR and MET, which exerted anti-cancer effects through cell cycle arrest, mitochondrial homeostasis collapse, and increased ROS generation, eventually triggering anti-cancer mechanisms. 3-DSC could potentially be used as an effective anti-cancer strategy to overcome EGFR and MET target drug-resistant lung cancer.

• Journal of Marine Life Science
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• v.3 no.2
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• pp.51-58
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• 2018

Variations in water temperature are known to affect almost every part of fish physiology. The rise in water temperature due to climate change can physically damage fish. This study was conducted to evaluate the health status of the Atlantic salmon (Salmo salar) at high water temperature (20℃) than the optimum water temperature (15℃). Liver tissue exerts important metabolic functions in thermal adaptation. Therefore, liver tissue was used in this study. The evaluation method is to develop the biomarker gene using NGS RNAseq analysis and to examine the expression pattern using RT-qPCR analysis. The NGS RNAseq analysis revealed 1,366 differentially expressed genes, among which 880 genes were increase expressed and 486 genes were decrease expressed. The biomarker genes are such as heat shock protein 90 alpha (Hsp90α), heat shock protein 90 beta (Hsp90β) and cytochrome P450 1A (CYP1A). The selected genes are sensitive to changes in water temperature through NGS RNAseq analysis. Expression patterns of these genes through RT-qPCR were similar to those of NGS RNAseq analysis. The results of this study can be applied to other fish species and it is considered to be useful industrially.

• Journal of Korean Tunnelling and Underground Space Association
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• v.12 no.6
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• pp.407-416
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• 2010

A new tunnel auxiliary method is proposed in this paper which utilizes the concept of cavity expansion for tuunel reinforcement by forming an umbrella arch on the roof of tunnel. When an inflatable pipe is inserted and expanded by pressure in the bore hole of umbrella arch, the ground around the bore hole can be compacted so that the stress condition above the tunnel perimeter is favorably changed. In order to verify the reinforcement effect of new concept, pilot-scale chamber test, trapdoor test and numerical analysis were performed and compared. In pilot-scale chamber test, three types of inflatable pipes are tested to verify the capability of expansion, and the results arc compared with analytical results obtained by applying cavity expansion theory and with results obtained from finite clement analysis, and the experimental results showed agreeable matches with analytical and numerical ones. Numerical analysis of a tunnel and trapdoor test applied with the inflatable pipes are also performed to figure out the reinforcement effect of the proposed techniques, and the results implied that the new method with 3 directional inflatable pipe (no pressure to downward direction) can contribute to reduce tunnel convergence and face settlement.

• The Journal of the Korea Contents Association
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• v.22 no.5
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• pp.518-526
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• 2022

The extension of life expectancy due to modernization means an extension of the benefit time for elderly care and disease. However, compared to the increase in the elderly, the attitude of children toward parental responsibility is gradually weakening. These social phenomena bring alienation, hopelessness, and stress to life in old age, and the resulting sense of helplessness leads to suicidal thoughts or intentional death (suicide), becoming a social problem. The intentional death (suicide) of the elderly is a social phenomenon that often occurs around them, and the reality can be seen through the movie. In this study, the main character 'Soyoung' in the movie 'The Woman Who Kills' and the surrounding characters 'Song Old Man', 'Jongsu', and 'Jaewoo' in conversations with the elderly problem and death factors were analyzed in the Matrix. ), and then applied to the 'flow chart of problems in the elderly due to modernization' compiled by Byeong-Woo Lim (2019), to explore the factors of intentional death (suicide). As a result of the analysis, the four elderly were exposed to problems of the elderly such as disease, alienation and loneliness, poverty, and loss. (Suicide) was analyzed.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.3C
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• pp.179-186
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• 2008

Pressuremeter test estimates the deformational properties of soil from the relationship between applied pressure and the displacement of cavity wall. It is general to utilize the reloading curve for the estimation of deformational properties of soil because the initial loading curve can be affected by the disturbance caused by boring. On the other hand, the instrumental resolution or the variation of measured data makes it hard to estimate the maximum shear modulus from pressuremeter test results. This study suggested the methodology estimating the maximum shear modulus from pressuremeter test directly, based on the curve fitting of reloading curve. In addition, the difference was taken into account between the stress state around the probe in reloading and that of the in-situ state. Pressuremeter tests were conducted for 15 cases using a large calibration chamber, together with a number of reference tests. The maximum shear moduli taken from suggested method were compared with those from empirical correlation and bender element test.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.5A
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• pp.841-848
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• 2006

There is a complex variation of stress in PSC anchorage zones and box girder diaphragms because of large concentrated load by prestress. According to the AASHTO LFRD design code, three-dimensional effects due to concentrated jacking loads shall be investigated using three-dimensional analysis procedures or may be approximated by considering separate submodels for two or more planes. In this case, the interaction of the submodels should be considered, and the model loads and results should be consistent. However, box girder diaphragms are 3-dimensional disturbed region which requires a fully three-dimensional model, and two-dimensional models are not satisfactory to model the flow of forces in diaphragms. In this study, the strengths of the prestressed box girder diaphragms are predicted using the 3-dimensional grid strut-tie model approach, which were tested to failure in University of Texas. According to the analysis results, the 3-dimensional strut-tie model approach can be possibly applied to the analysis and design of PSC box girder anchorage zones as a reasonable computer-aided approach with satisfied accuracy.