• Korean Journal of Soil Science and Fertilizer
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• v.20 no.3
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• pp.285-299
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• 1987

Timing and placement of fertilizer applications are two managerial means to improve the fertilizer use efficiency. The relative importance of these two means is determined by the application rate. With the realistic rate of N application recommended to the small farmers in the tropics, at present and in the near future, basal application in right manner, seems to be more important than split application at different times. In wetland rice soils, deep placement by whatever available means is desirable. But in the situations where perfect deep placement is very difficult to implement, the whole-layer application may be worth trying, until better methods become available. In rainfed uplands, N fertilizer application plans should be contingent upon the amount and distribution of rainfall: apply a less risky rate as subsurface banding near the crop rows to start with; then, depending upon the rainfall prospects in the season, apply or omit the additional dose. Because the patterns of crop response to N fertilizer can be significantly different between the research farms and farmers' fields, it seems imperative to have information on the patterns of crop response to N under farmers' management conditions, for the development of realistic fertilizer application recommendations. To enable the farmers to adopt improved fertilizer application technologies, it is essential to develop and make available to farmers convenient fertilizer applicators. Past experience with the improved fertilizer use technologies indicates that, in the long run, the development of fertilizers that are not only effective and convenient for farmers to use but also easy to produce without major modifications of existing fertilizer production systems is the ultimate solution to the problem of low N fertilizer use efficiency.

• Journal of Microbiology and Biotechnology
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• v.26 no.1
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• pp.1-8
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• 2016

The new movement towards green chemistry and renewable feedstocks makes microbial production of chemicals more competitive. Among the numerous chemicals, organic acids are more attractive targets for process development efforts in the renewable-based biorefinery industry. However, most of the production costs in microbial processes are higher than that in chemical processes, among which over 60% are generated by separation processes. Therefore, the research of separation and purification processes is important for a promising biorefinery industry. This review highlights the progress of recovery processes in the separation and purification of organic acids, including their advantages and disadvantages, current situation, and future prospects in terms of recovery yields and industrial application.

• Journal of the Korean Society of Radiology
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• v.8 no.3
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• pp.123-136
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• 2014

In this paper, we study to classify molecular imaging and applications to predict future. Molecular imaging in vivo at the cellular level and the molecular level changes taking place to be imaged, that is molecular cell biology and imaging technology combined with the development of the new field. Molecular imaging is used fluorescence, bioluminescence, SPECT, PET, MRI, Ultrasound and other imaging technologies. That is applied to monitoring of gene therapy, cell tracking and monitoring of cell therapy, antibody imaging, drug development, molecular interaction picture, the near-infrared fluorescence imaging of cancer using fluorescence, bacteria using tumor-targeting imaging, therapeutic early assessment, prediction and therapy. The future of molecular imaging would be developed through fused interdisciplinary research and mutual cooperation, which molecular cell biology, genetics, chemistry, physics, computer science, biomedical engineering, nuclear medicine, radiology, clinical medicine, etc. The advent of molecular imaging will be possible to early diagnosis and personalized treatment of disease in the future.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.11
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• pp.4663-4670
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• 2014

Trichostatin A (TSA) is a histone deacetylase (HDAC) inhibitor. We here investigated its effects on proliferation and apoptosis of the CNE2 carcinoma cell line, and attempted to establish genome-wide DNA methylation alteration due to differentially histone acetylation status. After cells were treated by TSA, the inhibitory rate of cell proliferation was examined with a CCK8 kit, and cell apoptosis was determined by flow cytometry. Compared to control, TSA inhibited CNE2 cell growth and induced apoptosis. Furthermore, TSA was found to induce genome-wide methylation alteration as assessed by genome-wide methylation array. Overall DNA methylation level of cells treated with TSA was higher than in controls. Function and pathway analysis revealed that many genes with methylation alteration were involved in key biological roles, such as apoptosis and cell proliferation. Three genes (DAP3, HSPB1 and CLDN) were independently confirmed by quantitative real-time PCR. Finally, we conclude that TSA inhibits CNE2 cell growth and induces apoptosis in vitro involving genome-wide DNA methylation alteration, so that it has promising application prospects in treatment of NPC in vivo. Although many unreported hypermethylated/hypomethylated genes should be further analyzed and validated, the pointers to new biomarkers and therapeutic strategies in the treatment of NPC should be stressed.

• Journal of the Korean Ceramic Society
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• v.56 no.6
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• pp.526-533
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• 2019

Indialite/cordierite glass-ceramics demonstrate excellent microwave dielectric properties such as a low dielectric constant of 4.7 and an extremely high quality factor Qf of more than 200 × 10³ GHz when crystallized at 1300℃/20 h, which are essential criteria for application to 5G/6G mobile communication systems. The glass-ceramics applied to dielectric resonators, low-temperature co-fired ceramic (LTCC) substrates, and direct casting glass substrates are reviewed in this paper. The glass-ceramics are fabricated by the crystallization of glass with cordierite composition melted at 1550℃. The dielectric resonators are composed of crystallized glass pellets made from glass rods cast in a graphite mold. The LTCC substrates are made from indialite glass-ceramic powder crystallized at a low temperature of 1000℃/1 h, and the direct casting glass-ceramic substrates are composed of crystallized glass plates cast on a graphite plate. All these materials exhibit excellent microwave dielectric properties.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.35 no.3
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• pp.331-336
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• 2011

The three-dimensional complex curvature of the airfoil complicates the manufacture and repair of gas-turbine components. As a result of the developments in computer technology since the early 1990s, CNC-based technologies for machine tools and related programs have been increasingly applied in the gas turbine industry. In particular, fiveaxis simultaneous machines with adaptive functions have proven its excellent flexibility and productivity due to the capability in determining the 3D data from the unknown curvature. A well-organized robot system with eight-axis simultaneous control can lead to powerful standardization and high productivity. We summarize and review CNC technologies and their applications in the gas turbine industry, with a discussion of the manufacture and repair of gas turbine parts.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.14 no.1
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• pp.77-92
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• 2020

When automatic speech recognition (ASR) is provided as a cloud service, it is easy to collect voice and application domain data from users. Harnessing these data will facilitate the provision of more personalized services. In this paper, we demonstrate our transfer learning-based knowledge service that built with the user-generated data collected through our novel system that deliveries personalized ASR service. First, we discuss the motivation, challenges, and prospects of building up such a knowledge-based service-oriented system. Second, we present a Quadruple Transfer Learning (QTL) method that can learn a classification model from a source domain and transfer it to a target domain. Third, we provide an overview architecture of our novel system that collects voice data from mobile users, labels the data via crowdsourcing, utilises these collected user-generated data to train different machine learning models, and delivers the personalised real-time cloud services. Finally, we use the E-Book data collected from our system to train classification models and apply them in the smart TV domain, and the experimental results show that our QTL method is effective in two classification tasks, which confirms that the knowledge transfer provides a value-added service for the upper-layer mobile applications in different domains.

• Tunnel and Underground Space
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• v.10 no.4
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• pp.516-525
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• 2000

Recently, the demand for pollution-free demolition work of old reinforced concrete and steel structure has rapidly increased as the redevelopment of urban area has been accelerated. This study deals with linear shape charges for explosive jet cutting on steel structure. We have tested material and shape of steel structure, characteristics of thickness and strength, shape of linear shape charges, type of shape charges, cumulative charges, type of liner, stand-off distance, detonation method. effect of sound and vibration by air blast in explosive jet cutting method. So, We developed linear shape charges in order to take advantage of optimum explosive jet cutting condition. Shape charges were made of PETN explosives. We obtained the experimental formula to decide the amount of explosive needed for thickness of steel structure plate. There are prospects for application of the explosion curving technology under the open space conditions for dismantling the steel structure and steel bridge, scrapped old boats, which are going out of service.

• Journal of Broadcast Engineering
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• v.23 no.5
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• pp.701-713
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• 2018

The purpose of this paper is to analyze the changes of the digital music platforms and digital profit distribution issues which are considered to be the most important part of the application to the Global music industry based on the block chain system. This attempt is not to reveal the success of the block chain and the value judgment in the societies that will come in the future. How to apply the original function of the block chain in the field of the music industry, which has changed a lot in the digital era, this paper focused on what we need to work on. First, I will briefly review the structure and major functions of the block chain system and the crypto-currency, and examine the link between the blockchain and the music industry. In addition, I will focus on some overseas' cases that are actually applied, and examine the possibility of applying them in the domestic music industry. Through this, I expect that this article will become a cornerstone for discussing the development direction of the music industry, especially the Korean music industry, which is constantly changing due to the technological advancement process.

• Development and Reproduction
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• v.14 no.2
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• pp.43-50
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• 2010

Recently induced pluripotent stem (iPS) cells are derived from somatic cells by ectopic expression of several transcription factors (reprogramming factors) using technology of somatic cell reprogramming. iPS cells are able to selfrenew and differentiate into all type of cells in the body similarly to embryonic stem cells. Because iPS cells have advantages that can avoid immune rejection after transplantation and ethical issues unlike embryonic stem cells, research on iPS has made significant progress since the first report by Yamanaka in 2006. Nevertheless of many advantages of iPS, safer methods to introduce reprogramming factors into somatic cells must be developed due to safety concerns regarding viral vectors, and safer reprogramming factors to substitute the oncogenes should be evaluated for clinical application of iPS. Here we discuss the recent progress in reprogramming factors in embryonic stem cells, oocytes, and embryos, and discuss further research for finding new, more reliable and safer reprogramming factors.