• Advances in nano research
• /
• v.12 no.5
• /
• pp.501-514
• /
• 2022

This study aimed to investigate the effects and potential mechanisms of Chikusetsusaponin V (CsV) on endothelial nitric oxide synthase (eNOS) and vascular endothelial cell functions. Different concentrations of CsV were added to animal models, bovine aorta endothelial cells (BAECs) and human umbilical vein endothelial cells (HUVECs) cultured in vitro. qPCR, Western blotting (WB), and B ultrasound were performed to explore the effects of CsV on mouse endothelial cell functions, vascular stiffness and cellular eNOS mRNA, protein expression and NO release. Bioinformatics analysis, network pharmacology, molecular docking and protein mass spectrometry analysis were conducted to jointly predict the upstream transcription factors of eNOS. Furthermore, pulldown and ChIP and dual luciferase assays were employed for subsequent verification. At the presence or absence of CsV stimulation, either overexpression or knockdown of purine rich element binding protein A (PURA) was conducted, and PCR assay was employed to detect PURA and eNOS mRNA expressions, Western blot was used to detect PURA and eNOS protein expressions, cell NO release and serum NO levels. Tube formation experiment was conducted to detect the tube forming capability of HUVECs cells. The animal vasodilation function test detected the vasodilation functions. Ultrasonic detection was performed to determine the mouse aortic arch pulse wave velocity to identify aortic stiffness. CsV stimulus on bovine aortic cells revealed that CsV could upregulate eNOS protein levels in vascular endothelial cells in a concentration and time dependent manner. The expression levels of eNOS mRNA and phosphorylation sites Ser1177, Ser633 and Thr495 increased significantly after CsV stimulation. Meanwhile, CsV could also enhance the tube forming capability of HUVECs cells. Following the mice were gavaged using CsV, the eNOS protein level of mouse aortic endothelial cells was upregulated in a concentration- and time-dependent manner, and serum NO release and vasodilation ability were simultaneously elevated whereas arterial stiffness was alleviated. The pulldown, ChIP and dual luciferase assays demonstrated that PURA could bind to the eNOS promoter and facilitate the transcription of eNOS. Under the conditions of presence or absence of CsV stimulation, overexpression or knockdown of PURA indicated that the effect of CsV on vascular endothelial function and eNOS was weakened following PURA gene silence, whereas overexpression of PURA gene could enhance the effect of CsV upregulating eNOS expression. CsV could promote NO release from endothelial cells by upregulating the expression of PURA/eNOS pathway, improve endothelial cell functions, enhance vasodilation capability, and alleviate vessel stiffness. The present study plays a role in offering a theoretical basis for the development and application of CsV in vascular function improvement, and it also provides a more comprehensive understanding of the pharmacodynamics of CsV.

• Journal of Conservation Science
• /
• v.38 no.2
• /
• pp.154-165
• /
• 2022

The color appearance of cultural heritage are essential factors for manufacturing technique interpretation, conservation treatment usage, and condition monitoring. Therefore, this study systematically established color reproduction procedures based on the digital color management system for the portrait of Gwon Eungsu. Moreover, various application strategies for recording and conserving the cultural heritage were proposed. Overall color reproduction processes were conducted in the following order: photography condition setting, standard color measurements, digital photography, color correction, and color space creation. Therefore, compared with the color appearance, the digital image applied to a camera maker profile indicated an average color difference of 𝜟10.1. However, the digital reproduction result based on the color management system exhibits an average color difference of 𝜟1.1, which is close to the color appearance. This means that although digital photography conditions are optimized, recording the color appearance is difficult when relying on the correction algorithm developed by the camera maker. Therefore, the digital color reproduction of cultural heritage is required through color correction and color space creation based on the raw digital image, which is a crucial process for documenting the color appearance. Additionally, the recording of color appearance through digital color reproduction is important for condition evaluation, conservation treatment, and restoration of cultural heritage. Furthermore, standard data of imaging analysis are available for discoloration monitoring.

• Journal of the Korean Society of Environmental Restoration Technology
• /
• v.25 no.6
• /
• pp.51-64
• /
• 2022

Along with the urbanization, the risk of urban flooding due to climate change is increasing. Flood regulation, one of the ecosystem services, is implemented in the different level of function of flood risk mitigation by the type of ecosystem such as forests, arable land, wetlands etc. Land use changes due to development pressures have become an important factor in increasing the vulnerability by flash flood. This study has conducted evaluating the urban flood regulation service using InVEST UFRM(Urban Flood Risk Model). As a result of the simulation, the potential water retention by ecosystem type in the event of a flash flood according to RCP 4.5(10 year frequency) scenario was 1,569,611 tons in urbanized/dried areas, 907,706 tons in agricultural areas, 1,496,105 tons in forested areas, 831,705 tons in grasslands, 1,021,742 tons in wetlands, and 206,709 tons in bare areas, the water bodies was estimated to be 38,087 tons. In the case of more severe 100-year rainfall, 1,808,376 tons in urbanized/dried areas, 1,172,505 tons in agricultural areas, 2,076,019 tons in forests, 1,021,742 tons in grasslands, 47,603 tons in wetlands, 238,363 tons in bare lands, and 52,985 tons in water bodies. The potential economic damage from flood runoff(100 years frequency) is 122,512,524 thousand won in residential areas, 512,382,410 thousand won in commercial areas, 50,414,646 thousand won in industrial areas, 2,927,508 thousand won in Infrastructure(road), 8,907 thousand won in agriculture, Total of assuming a runoff of 50 mm(100 year frequency) was estimated at 688,245,997 thousand won. In a conclusion. these results provided an overview of ecosystem functions and services in terms of flood control, and indirectly demonstrated the possibility of using the model as a tool for policy decision-making. Nevertheless, in future research, related issues such as application of models according to various spatial scales, verification of difference in result values due to differences in spatial resolution, improvement of CN(Curved Number) suitable for the research site conditions based on actual data, and development of flood damage factors suitable for domestic condition for the calculation of economic loss.

• KIPS Transactions on Computer and Communication Systems
• /
• v.12 no.1
• /
• pp.17-24
• /
• 2023

Mobile apps frequently request permission to access sensitive data for user convenience. However, while using mobile applications, sensitive and personal data has been leaked even if users do not allow it. To deal with this problem, Google App Store has required developers to disclose how the mobile app handles user data in a privacy policy. However, users are not certain that the privacy policy describes all the app's behavior. They have no choice but to rely on the privacy policy to confirm how the app uses data. This study designed a system that checks the reliability of privacy policies by analyzing the privacy policy texts and mobile apps. First, the system extracts and analyzes the privacy policy texts to check which personal data the privacy policy discloses that the mobile apps can collect. After analyzing which data apps can access using android static analysis, we compare both results to analyze the reliability of privacy policies. For the experiment, we collected the APK files and metadata of about 13K android apps registered in the Google Play Store and preprocessed the apps by four conditions. According to the comparison between privacy policies and mobile app behavior, many apps can access more personal data than disclosed in the privacy policy.

• Journal of Digital Convergence
• /
• v.20 no.2
• /
• pp.289-297
• /
• 2022

The purpose of this study was to investigate the perception of dental students based on their experiences of online classes after taking non-face-to-face education courses for all the school semesters in 2020. For the research method, an online survey was conducted on A survey was conducted on 161 dental students enrolled in A University. The analytical method was conducted through frequency analysis, correlation analysis, and multiple regression analysis. The survey analysis findings showed that the satisfaction of dental students' about the non-face-to-face education course was above 4.2, and the detailed items were in the order of the appropriateness of the attendance processing method, satisfaction with recorded video lectures, and the assessment method of the course grade. In the case of the factors that affect the satisfaction of non-face-to-face education courses, the learning system and assessment method were statistically significant. The online class type that is most preferred by the students is recorded video lectures, and the highest number of participants chose 21~30 minutes as the appropriate time for the class content. It is considered that the application of the online system will continue to be used together with face-to-face education courses in the education site and various university-level efforts like systematic support are required to achieve effective learning achievements. This study only investigated the non-face-to-face education operation conditions of A University, so it cannot be generalized to all universities, but it can be used as basic data to provide education curriculum design and supportive measures for the compatibility of face-to-face and non-face-to-face courses.

• International Journal of Computer Science & Network Security
• /
• v.22 no.9
• /
• pp.251-257
• /
• 2022

Nowadays, the issues of comprehensive formation of a person capable of self-education, self-development and creative self-realization in the conditions of distance education are relevant. There is a need to solve this problem, which is due to social, cultural, and pedagogical factors. This makes it necessary to find effective means of personality formation. In this matter, great importance is attached to the modern method of forming a creative personality - art therapy. Various approaches to the definition of art therapy have been clarified. They consider various forms of art therapy when working with children, adolescents and adults in the context of distance education. The most relevant are the two main forms of work - individual and group art therapy. Art therapy develops the individual's creativity. Therefore, during art therapy, attention is focused on the inner world, experiences, and feelings. Therefore, we believe that in the context of distance education, art therapy has everything for the powerful potential of personality formation. Scientists consider this therapy as therapy by means of art, which is based on experiences, conflicts that can be expressed in the visual arts and music. Art therapy helps to get rid of conflicts and experiences. This happens in the context of distance education through the development of attention to feelings, strengthening one's own personal value and increasing artistic competence. The article describes the signs that characterize art therapy. Art-therapeutic technologies in the context of distance education, which are now actively used by psychologists, teachers and art therapists themselves, are highlighted. The advantages of distance learning are considered. The characteristic features of distance learning and features of the use of art therapy by means of distance education in the process of professional training of specialists are determined.

• KIPS Transactions on Computer and Communication Systems
• /
• v.11 no.2
• /
• pp.67-72
• /
• 2022

Recently, various intelligent application services using artificial intelligence are being actively developed. In particular, research on artificial intelligence-based real-time prediction services is being actively conducted in the manufacturing industry, and the demand for artificial intelligence services that can detect and predict fire and odors is very high. However, most of the existing detection and prediction systems do not predict the occurrence of fires and odors, but rather provide detection services after occurrence. This is because AI-based prediction service technology is not applied in existing systems. In addition, fire prediction, odor detection and odor level prediction services are services with ultra-low delay characteristics. Therefore, in order to provide ultra-low-latency prediction service, edge computing technology is combined with artificial intelligence models, so that faster inference results can be applied to the field faster than the cloud is being developed. Therefore, in this paper, we propose an LSTM algorithm-based learning model that can be used for fire prediction and odor detection/prediction, which are most required in the manufacturing industry. In addition, the proposed learning model is designed to be implemented in edge devices, and it is proposed to receive real-time sensor data from the IoT terminal and apply this data to the inference model to predict fire and odor conditions in real time. The proposed model evaluated the prediction accuracy of the learning model through three performance indicators, and the evaluation result showed an average performance of over 90%.

• Journal of the Korean Society of Radiology
• /
• v.16 no.4
• /
• pp.387-394
• /
• 2022

120 kVp FBP reconstruction image standard by using raw data after scanning by changing tube voltage among the NECK CT protocols that are broad applied in clinical practice using a human phantom including thyroid gland The usefulness of the DLIR reconstruction technique was investigated. As a result, CTDIvol decreased when the DLIR reconstruction technique was applied, and in particular, the image quality obtained under the same standard scanning conditions at a lower dose for ASIR-V and DLIR reconstruction was reached than when FBP was applied at the same kVp In addition, as a result of SNR and CNR analysis, the DLIR reconstructed image was analyzed with high SNR and CNR values, and SSIM analysis, the SSIM index of the 100 kVp, DLIR reconstructed image was measured to be close to 1, and it was analyzed that the similarity of the reconstructed image to the original image was high (p>0.05). If the results of this study are used to supplement clinical image evaluation and further develop an algorithm applicable to various anatomical structures, it is thought that it will be useful for clinical application as it is possible to maintain the image quality while lowering the examination dose.

• International Journal of Computer Science & Network Security
• /
• v.22 no.7
• /
• pp.57-64
• /
• 2022

This scientific article is devoted to the study of the legal significance of such a category of legal status of the purchaser of another's thing, as its good faith. The essence of this phenomenon has been studied, it has been established that the criterion of good faith attaches significant importance to the claims of the participants of these relations for the acquisition or preservation of private property rights. The paper emphasizes that, in addition to the importance of good conscience at the time of possession of another's thing, which gives legal certainty the possibility of registration of the title and is part of the actual composition for the acquisition of property or the right of ancient possession, bona fides also characterizes the behavior of the occupier. In this case, good conscience only has some legal consequences when it is opposed to subjective law. Under such conditions, it acquires direct legal significance, including as a condition for the acquisition and protection of rights. Good faith possession of another's property is an internal indicator of the subject's awareness of a certain property status. This sense, the article assesses this status from the standpoint of the scientific concept of the visibility of law. According to this theory, prescription is also considered as a consequence of the appearance of law, however, because it arises and lasts against the will of the parties and despite their awareness of this fact. Therefore, bona fide continuous and open possession of property as one's own, during the acquisition period, was most significantly associated with the appearance of property. Therefore, the concept of good faith, in the sense of personal perception of real values, is closely related to the principle of protection of the appearance of law, as it is aimed at understanding it by third parties. The paper notes certain differences in the application of the theory of the appearance of the right in the acquisition of property by a bona fide purchaser from an unauthorized alienator and the acquisitive prescription. It is emphasized that such a mechanism must be used in presuming the attitude to the thing as its own, by the holder of movable property. But there should be exceptions to the rule, in particular, if the owner has grounds for vindication of the thing.

• Structural Monitoring and Maintenance
• /
• v.9 no.4
• /
• pp.323-336
• /
• 2022

Steel truss bridge is one of the most widely used bridge types in Indonesia. Out of all Indonesia's national roads, the number of steel truss bridges reaches 12% of the total 17,160 bridges. The application of steel truss bridges is relatively high considering this type of bridge provides advantages in the standardization of design and fabrication of structural elements for typical bridge spans, as well as ease of mobilization. Directorate of Road and Bridge Engineering, Ministry of Works and Housing, has issued a standard design for steel truss bridges commonly used in Indonesia, which is designed against the design load in SNI 1725-2016 Bridge Loading Standards. Along with the development of actual traffic load measurement technology using Bridge Weigh-in-Motion (B-WIM), traffic loading data can be utilized to evaluate the reliability of standard bridges, such as standard steel truss bridges which are commonly used in Indonesia. The result of the B-WIM measurement on the Central Java Pantura National Road, Batang - Kendal undertaken in 2018, which supports the heaviest load and traffic conditions on the national road, is used in this study. In this study, simulation of a sequences of traffic was carried out based on B-WIM data as a moving load on the Australian type Steel Truss Bridge (i.e., Rangka Baja Australia -RBA) structure model with 60 m class A span. The reliability evaluation was then carried out by calculating the reliability index or the probability of structural failure. Based on the analysis conducted in this study, it was found that the reliability index of the 60 m class Aspan for RBA bridge is 3.04 or the probability of structural failure is 1.18 × 10^-3, which describes the level of reliability of the RBA bridge structure due to the loads from B-WIM measurement in Indonesia. For this RBA Bridge 60 m span class A, it was found that the calibrated nominal live load that met the target reliability is increased by 13% than stated in the code, so the uniform distributed load will be 7.60 kN/m² and the axle line equivalent load will be 55.15 kN/m.