• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2201-2205
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• 2013

Colorectal cancer (CRC) is one of the most common cancers in many parts of the world. Its development is a multi-step process involving three distinct stages, initiation that alters the molecular message of a normal cell, followed by promotion and progression that ultimately generates a phenotypically altered transformed malignant cell. Reports have suggested an association of the phosphoinositide-3-kinase (PI3K)/Akt pathway with colon tumorigenesis. Activation of Akt signaling and impaired expression of phosphatase and tensin homolog (PTEN) (a negative regulator of Akt) has been reported in 60-70% of human colon cancers and inhibitors of PI3K/Akt signaling have been suggested as potential therapeutic agents. Around 80% of human colon tumors possess mutations in the APC gene and half of the remainder feature ${\beta}$-catenin gene mutations which affect downstream signaling of the PI3K/Akt pathway. In recent years, there has been a great focus in targeting these signaling pathways, with natural and synthetic drugs reducing the tumor burden in different experiment models. In this review we survey the role of PI3K/Akt/mTOR and Wnt signaling in CRC.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2015년도 제49회 하계 정기학술대회 초록집
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• pp.132-132
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• 2015

Virtual metrology (VM) model based on plasma information (PI) parameter for C4F8 plasma-assisted oxide etching processes is developed to predict and monitor the process results such as an etching rate with improved performance. To apply fault detection and classification (FDC) or advanced process control (APC) models on to the real mass production lines efficiently, high performance VM model is certainly required and principal component regression (PCR) is preferred technique for VM modeling despite this method requires many number of data set to obtain statistically guaranteed accuracy. In this study, as an effective method to include the 'good information' representing parameter into the VM model, PI parameters are introduced and applied for the etch rate prediction. By the adoption of PI parameters of b-, q-factors and surface passivation parameters as PCs into the PCR based VM model, information about the reactions in the plasma volume, surface, and sheath regions can be efficiently included into the VM model; thus, the performance of VM is secured even for insufficient data set provided cases. For mass production data of 350 wafers, developed PI based VM (PI-VM) model was satisfied required prediction accuracy of industry in C4F8 plasma-assisted oxide etching process.

• BMB Reports
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• 제30권6호
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• pp.415-420
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• 1997

Although $CD4^+$ T cell responses to protein-derived antigen have well been understood, the epitopes recognized by hapten-specific $CD4^+$ T cells have not been fully defined. In this study, we characterized the response of a T cell hybridoma (5Di0.1B8) which is specific for a hapten. N-hydroxysuccinimidyl-4-azidobenzoate (HSAB) restricted by MHC class II $I-A^d$. Using three different antigen presenting cells (APCs) expressing $I-A^d$, the role of class II MHC proteins in haptenic antigen presentation and subsequent activation of 5D10.1B8 has been examined. Activation of 5D10.1B8 T cells by HSAB analogs was also performed. Our results show that each APC activated T cells differentially and that interleukin-2 (IL-2) augmented antigen-presenting ability of all the APCs, suggesting that increased expression of class II MHC protein by IL-2 played an important role in HSAB presentation and T cell activation. Finally, early T cell receptor-dependent signals induced by HSAB or its analogs were examined by phosphotyrosine immunoblot analysis, and showed that tyrosine phosphorylation level of a 18-20 kD protein increased upon stimulation.

• Journal of Microbiology and Biotechnology
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• 제15권4호
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• pp.694-700
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• 2005

Defects in the mitotic spindle or in the attachment of chromosomes to the spindle are believed to release an activated form of spindle checkpoint complex that inhibits APC-dependent ubiquitination and subsequently arrests the cell cycle at metaphase. When the spindle assembly is disrupted, the fission yeast mitotic arrest deficient (mad) mutants fail to arrest and rapidly lose viability. To enhance our understanding of the molecular mechanisms for the pathway of checkpoint function, the functional characterizations of Mad 1 p from Schizosaccharomyces pombe involved in this process have been carried out. Yeast two-hybrid and various deletion analyses of S. pombe Mad1 p reveal that the C terminus of Mad1p is critical for the binding of Mad2p and maintenance of Mad 1 p-Mad2p interaction. In addition, it was found. that the Mad1p region (residues 206-356) is essential for Mad1p-other checkpoint components. Mad1p truncating this region is sufficient to bind Mad2p but abolishes the checkpoint function, indicating that the checkpoint function is necessary for interaction of Mad 1 p-other checkpoint components. The possible functions of S. pombe Mad1p at the cell cycle checkpoint are discussed.

• Steel and Composite Structures
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• 제15권2호
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• pp.203-220
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• 2013

The study of the tensile strength of composite materials is far more complex than analysis of the properties of elasticity and plasticity. Indeed, during mechanical loading, micro-cracks in the matrix, the fibers break, debonding of the interfaces are created. The failure process of composites is of great diversity and cannot be described if even we know: the strength criterion of each individual component, the state of stress and strain in the material, the propagation phenomena cracks in the structure and nature of the interface between the matrix and the reinforcement. This information is only partially known and the obtained by the analysis of a stress limit beyond which there is destruction of the material is almost impossible. To partially process the issue, a solution lies in a mesoscopic approach of seeking a law to locate the ultimate strength of the material for a plane stress state. Tests on rectangular plates in bending PEEK/APC2 and T300/914 three were made and this in order to validate our approach, the calculation has been implemented in a nonlinear finite element code (Castem 2000), in order to make comparison with the numerical results. The results show good agreement between numerical simulation and the two materials; however, it would be interesting to consider other phenomena in the criterion.

• 정보처리학회논문지A
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• 제10A권1호
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• pp.69-74
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• 2003

경쟁적인 시장에서 살아남기 위해서는 공장의 공정제어를 정확하게 하는 것이 필수적이다. SPC(Statistical Process Control) 시스템은 품질 향상의 욕구를 충족시키기 위해 광범위하게 사용되어지고 있다. 하지만 대부분의 기존 상업제품들은 유연성이 떨어지고, 반자동적으로 운영되며, 다른 툴과의 접목에 어려움이 있다. 본 논문이 제안하는 rSPC(Real-Time SPC) 시스템은 웹을 기반으로 하고, XML을 입력/출력 프로토콜로 이용한다. 또한 강력한 그래픽 표현기능과 효율적인 파일 시스템으로 실시간 제어를 가능하게 한다. 새로운 SPC시스템은 어떤 생산체제에도 사용 가능하지만, 특히 반도체, TFT/LCD 산업에 최적화되어 있다. 시스템의 구현은 C++과 COM/DCOM을 사용하며, 기존의 제품보다 향상된 성능을 보인다.

• 한국식품과학회지
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• 제31권5호
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• pp.1345-1348
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• 1999

고등어의 저장중 표피 오염 미생물 수를 신속하게 측정하여 신선도 판정을 위한 자료로 활용하고자 ATP bioluminescence assay에 의한 측정가능성을 파악하고자 하였다. 고등어를 $1^{\circ}C$에 저장하면서 표피를 swabbing 방법에 의해 미생물을 분리하여 총균수의 변화와 ATP bioluminescence assay에 의한 RLU 값을 측정하여 상관관계를 측정하여 본 결과 0.90 이상의 regression coefficient를 나타내어 유의적인 관계가 있음을 알 수 있었다. 따라서 ATP bioluminescence assay는 고등어 표피 오염 미생물의 신속 측정 방법으로 적합함을 알 수 있었으며 이 방법을 사용하였을 경우 기존의 48시간 이상 소요되는 전통적인 plate count 방법에 비하여 전처리를 포함하여 30분 이내에 결과를 알 수 있는 매우 신속하고 정확한 측정방법임을 알 수 있었다.

• 대한전자공학회논문지TC
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• 제37권1호
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• pp.32-43
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• 2000

본 논문에서는 패킹 방식 CDMA 망에서 기존에 제시되었던 음성과 데이터 통합 서비스를 위한 매체 접근 제어(Medium Access Control: MAC) 프로토콜들이 갖는 문제점들을 고찰하고 이를 극복할 수 있는 새로운 접근 방법을 제시하였다. 본 논문에서는 동기식 다중코드 CDMA 시스템에서 중앙의 기지국이 모든 단말의 트래픽 상태를 우선권(priority)에 의해 파악하고 이에 따라 패킷 단위로 채널을 할당함으로써 음성과 데이터 서비스를 효율적으로 통합할 수 있는 Prioritized Packet Reservation CDMA ($P^2R$-CDMA) 프로토콜을 제안하고, 모의 실험을 통해 음성과 데이터 트래픽이 요구하는 서비스 품질을 보장하면서 다중화 이득을 극대화함으로써 전송 허가 확률의 제어를 기반으로 하는 기존의 방식보다 시스템 용량을 향상시킬 수 있음을 확인하였다.

• Journal of international Conference on Electrical Machines and Systems
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• 제2권1호
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• pp.120-126
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• 2013

The main aim of this paper is to expound high-efficiency operation of Switched Reluctance Generator (SRG) based on the current waveform. For this purpose, theoretical analysis of the copper loss and iron loss of the system is done first. Then, necessary simulation is done to find the variation trend of the copper loss and iron loss with the variation of the current waveform at the same output power. Finally, the best current waveform which can make the system operate with high efficiency is obtained by considering the influence of these two kinds of loss. In order to verity the simulation results, the experimental platform of DC motor-SRG is built and the modified angle position control (APC) method which can specify the current shape optionally is presented. By comparing the system efficiency at the three kinds of typical current waveform, the correctness and feasibility of the theory is verified. The proposed method is simple, reliable, and easy to achieve.

• 한국가금학회지
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• 제27권3호
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• pp.189-195
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• 2000

Microbiological and sensory evaluations of chicken wings treated with acetic acid and trisodium phosphate(TSP) during retail(1${\pm}$2$^{\circ}C$) and refrigerated storage(4$^{\circ}C$). Chicken wings(average weight of 15${\pm}$2g per leg) were treated with 0.5∼2% aerobic plate counts(APC) on the surface of chicken wings for storage of 16 days at 4$^{\circ}C$. During storage of 12 days at retail store(1${\pm}$2$^{\circ}C$), the treating chicken wings with 7.5∼10% TSP solutions for 10 min showed significantly inhibitory effect in preventing the growth of aerobic microbes. For odor and appearance scores, chicken wings treated with 0.5∼2% acetic solutions resembled untreated wings for storage of 16 days at 4$^{\circ}C$. However, both odor and appearance scores of chicken wings treated with 2.5∼10% TSP solutions were similar to those of untreated wings for storage of 4 days, and a higher in the storage of beyond 8 to 12 days at retail store.