• 대한한의학회지
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• 제32권6호
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• pp.54-66
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• 2011

Objectives: The purpose of the present study was to investigate the antidiarrheal effects of Anjang-san in mice and rats. Methods: We measured the content of condensed tannin in Anjang-san extract, and observed the effects of Anjang-san on the small intestinal and colonic transport of mice, as well as on mice models of diarrhea induced by castor oil and $MgSO_4$, and on rat models of castor oil-induced enteropooling. Results: Anjang-san showed significant inhibitory effects on abnormally increased small intestinal transit induced by pyridostigmine and neostigmine, and inhibitory effects on large intestinal transit. Anjang-san also exhibited antidiarrheal effects on diarrhea induced by $MgSO_4$, and inhibitory effects on castor oil-induced enteropooling. Anjang-san also improved castor oil-induced diarrhea based on simple numbers without statistical significance. Conclusion: These results demonstrate that Anjang-san has significant antidiarrheal properties and attests to its possible utility in functional diarrheas, irritable bowel syndrome and other gastrointestinal disorders based upon further studies.

• Natural Product Sciences
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• 제3권2호
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• pp.100-103
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• 1997

A study was undertaken to evaluate the effect of petroleum ether extract of leaves of Ficus racemosa Linn. for its antidiarrheal potential against several experimental models of diarrhea in rats. Ficus racemosa leaves extract (FRLE) treated animals showed significant inhibitory activity against castor oil induced diarrhea and inhibited significantly $PGE_2$ induced enteropooling in rats. It also showed significant reduction in gastrointestinal motility following charcoal meal in rats. The results obtained establish the efficacy of FRLE as an antidiarrheal agent.

• 약학회지
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• 제28권4호
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• pp.237-241
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• 1984

The effect of lofexidine, clonidine, and other drugs on castor oilinduced diarrhea in rats was investigated. Castor oil was administered orally and drugs were administered intraperitoneally. The results were as follows. 1. Lofexidine(0.1-43{\mu}mol$/kg) blocked dose dependently caster oil-induced diarrhea like clonidine, but its potency was weaker than that of clonidine, 1. Yohimbine (1-10{\mu}mol/kg$) antagonized the antidiarrheal action of lofexidine and clonidine. 3. Prazosin (3-30{\mu}mol/kg$) did not antagonize the antidiarrheal action of lofexidine and clonidine. 4. Metoclopramide, bromocriptine mesylate, and nadolol did not affect antidiarrheal action of lofexidine significantly. 5. Loperamid prolonged the antidiarrheal action of lofexidine.

• 한국식품과학회지
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• 제31권2호
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• pp.547-552
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• 1999

저자 등이 건강한 한국사람으로부터 장내유해효소를 억제할 수 있은 장내환경개선효과가 우수한 한국형 유산균을 분리하여 소장수송능 효과, castor oil을 이용한 설사모델 동물에서 지사효과 및 항돌연변이 효과를 측정한 결과 소장의 수송능에는 아무런 영향을 미치지 못했으나 대장의 소송능은 현저한 수송능 촉진효과를 나타냈으며 특히 Bifidobacterium breve K-110의 균주가 우수하였다. Castor oil로 유도된 설사에 대한 지사 효과는 대부분의 균주에서 억제효과가 인정되지 않았으나, K-111의 균주는 유의한 지사효과를 나타냈다. 아울러 유산균은 항돌연변이 효과는 Bifidobacterium breve K-100 균주가 가장 우수한 효과를 나타내었으며 이러한 효과는 유산균의 세포벽 성분이 peptidoglycan에 의한 효과였다. 이러한 결과들로 볼 때 한국형유산균은 장내세균이 생산하는 유해효소의 생산성을 억제하는 것외에도 설사와 변비를 개선할 수 있으며 발암물질에 의한 항돌연변이 효과을 통해서 장내환경개선 효과를 기대할 수 있을 것으로 생각된다.

• Biomolecules & Therapeutics
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• 제10권4호
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• pp.236-239
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• 2002

The goal of this study was to evaluate the antidiarrheal efficacy of $Lacteol^{TM}$-loperamide combination against the mouse model of secretory diarrhea. Secretory dirrhea was induced in mice by p.o. administration of castor oil (0.3 ml). Antidirrheal effects of $Lacteol^{TM}$-loperamide combination were compared with each individual component. $Lacteol^{TM}$-loperamide combination was the most potent among these agents, eliminating diarrhea in 100% of mice at a dose 1360/4 mg/kg (Lacteol/loperamide, respectively). In this study, we also measured changes of bodyweight as another indicator of the dirrhea, based on the assumption that lower bodyweight loss represented reduced fecal passage. The bodyweight loss of $Lacteol^{TM}$-loperamide combination administered group was 4 times lower than that of vehicle control. These findings indicate that $Lacteol^{TM}$-loperamide combination may be more potent than individual component in its antidiarrheal action, so we are going to challenge this combination for further study and clinical evaluation.

• 한국임상수의학회지
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• 제14권2호
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• pp.168-171
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• 1997

The present experiment was conducted to compare the therapeutic effects of laser irradiation on Kyo-So Hyul with those of antidisrrheal drugs gentamycin, berberine and sulfisomidine for 173 piglets with diarrhea as major symptoms. The results obtained were as follows; antidiarrheal drugs were effective in fifty nine (78%) of seventy six piglets and ineffective in seventeen (22%) of seventy six piglets. Laser irradiation on the Kyo-So Hyul were proved as effective in eighty eight (91%) of ninety seven piglets and invalid in nine (9%) of ninety seven piglets.

• Journal of Pharmaceutical Investigation
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• 제16권2호
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• pp.76-84
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• 1986

Berberine is one of alkaloids extracted from Phellodendri Cortex or Coptidis Rhizoma and has extensively used as an antibacterial and antidiarrheal drug. In order to increase the bioavailability of berberine preparation, berberine pamoate was synthesized and investigated on its usage in vitro and in vivo. Berberine was more rapidly extracted from herbal plants by hot water extraction method than soxhlet extraction method. Berberine pamoate was easily synthesized from berberine hydrochloride and potassium pamoate solution and identified using the infrared spectrum. Quantitative analysis of berberine was possible in methanol solution by fluorometric determination. The dissolution rate of berberine pamoate was more decreased than that of berberine hydrochloride in simulated gastric fluid and simulated intestinal fluid. The remaining proportion of berberine pamoate in the small intestine of rat was maintained at high concentration for a long time as compared with that of berberine hydrochloride.

• 한국임상수의학회지
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• 제17권1호
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• pp.57-61
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• 2000

This study was designed to examine therapeutic effect of bee(Apis mellifera L.) venom in calves with bacterial diarrhea. Calves with bacterial diarrhea were administered with bee venom and therapeutic drug, respectively. In the bee venom-treated group, 69 calves were acupunctured once a day for 3 conseutive days. Two local acupoints of Jiao-chao(GV-1, at the indentation between the base of tail and the anus) and Bai-hui(GV -20, in the dorsal midline of the lumbo-sacral space) were stung by the bee. In the therapeutic drug-treated group, 55 claves were intramuscularly injected with a standard dosage of antibiotic (ciprofloxacin, 2.5 mg/kg of body weight) and antidiarrheal drug (berberine cholride, 10mg/head) once a day for 3 consecutive days. At post-treatment, 81.2% of the bee venom-treated calves and 76.4% of the therapeutic drugtreated calves were recovered from bacterial diarrhea. Bee acupuncture therapy showed in calves without side effects such as allergy hemorrhage, or infection. It might be concluded that apitherapy was affective in controlling of calves with bacterial diarrhea.

• Child Health Nursing Research
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• 제7권4호
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• pp.519-529
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• 2001

Recurrent abdominal pain(RAP) occurs in 8-10％ of elementary school children. It is suspected that functional causes are about 90％ and organic causes about 10％ for the recurrent abdominal pain. RAP is treated by antispasmodics or analgesics or antidiarrheal drugs in school health rooms. The purpose of this study was to verify the effect of Koryo-Hand-Acupuncture on recurrent abdominal pain of children. The duration of this study was from April to July, 2001. The subjects were the grade 4th-6th elementary students complaining recurrent abdominal pain. Total subjects were 46 cases; 23 cases of which were placed in experimental and the others in control group. The results of this study were as follows; 1. Numeric-pain-intensity of experimental group received Koryo-Hand-Acupuncture was decreased more than that of control group received mock Koryo-Hand-Acupuncture significantly. 2. Probed current in stomach corresponding point (A12) of experimental received Koryo-Hand-Acupuncture was decreased more than that of control group received mock Koryo-Hand-Acupuncture significantly. 3. Medication requirement rate of experimental group received Koryo-Hand-Acupuncture was decreased more than that of control group received mock Koryo-Hand-Acupuncture significantly. The following suggestions with the results of the study would be made like these; 1. Stimulation implement of Koryo-Hand- Acupuncture should be used independently and each effect should be investigated. 2. With repeated studies for various signs and diseases, the effect of Koryo-Hand- Acupuncture must be verified.

• The Korean Journal of Pain
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• 제18권1호
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• pp.74-77
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• 2005

A neurolytic celiac plexus block produces long-lasting pain relief in upper abdominal cancer patients. Unwanted side effects such as local pain, hypotension, and diarrhea are common but the durations of these side effects are usually transient. Chronic diarrhea induced by a neurolytic celiac plexus block is rarely reported and is considered to be an autonomic neuropathy due to sympathetic denervation. A 73-year-old Klatskin tumor patient developed chronic diarrhea after a neurolytic celiac plexus block and the diarrhea was sustained for 3 months despite the use of conventional antidiarrheal treatments. We report a case of chronic diarrhea that was induced by a neurolytic celiac plexus block.