• Bulletin of the Korean Chemical Society
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• 제33권8호
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• pp.2603-2608
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• 2012

A novel mononuclear supramolecule of copper(II) has been synthesized with Ippyt ligand (Ippyt=3-(4'-imidazole phenyl)-5-(pyrid-2''-yl)-1,2,4-triazole) (1). Compound 1, namely [$Cu(Ippyt)_2(H_2O)_2$], has been characterized by single-crystal X-ray diffraction, IR spectrum, elemental analysis and thermogravimetric analysis. Structure determination reveals that the elongated-octahedral geometry is formed in the vicinity of the copper (II) atom being coordinated by four nitrogen atoms from two Ippyt ligands occupying the equatorial position and two oxygen atoms from two coordinated water molecules in the axial position, which together form the $N_4O_2$ donor set. Hydrogen bonding interactions between nitrogen and oxygen atoms result in the set up of a supramolecular network architecture. Biological properties including antibacterial activity and superoxide dismutase (SOD) mimetic activity of compound 1 have been investigated by agar diffusion method and the modified Marklund method, respectively. The results indicate that compound 1 exhibits a stronger antibacterial efficiency than the parent ligand and it also has a certain radical-scavenging activity.

• 융합정보논문지
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• 제12권5호
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• pp.126-132
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• 2022

데크재, 산책로 등 옥외용도로 대부분 사용되고 있는 합성목재(Wood Plastic Compound;WPC)를 실내 용도의 건축용 내장재로 사용하기 위하여, 항균성, 총 휘발성 유기화합물 배출량(TVOC), 난연성 등이 개선된 WPC 패널을 제조하였다. 고밀도 폴리에틸렌(HDPE)과 편백나무 목분(Chamacyparis obtusa wood flour), 항균제 및 난연제 등의 첨가제를 혼합한 후 압출 성형하여 합성목재(Wood Plastic Composite) 컴파운드 펠렛을 제조하였다. 이 WPC 컴파운드 펠렛을 이축압출기를 사용하여 제조한 합성목재 패널(303mm×606mm×10mm)은 우수한 항균 및 항진균 특성을 나타냈다. 또한 패널의 총 휘발성 유기화합물 배출량(TVOC)은 0.062mg/m2·h 였으며, KS F 2271의 난연성 2등급 표준을 달성하였다.

• Natural Product Sciences
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• 제3권1호
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• pp.75-80
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• 1997

Preliminary antibacterial assay data that the Tectona grandis callus extract showed more antibacterial activity against E. coli and B. subtilis than the leaf extract led the authors to isolate the following antibacterial compounds from the callus. A mixture (3) of $2{\alpha},3{\beta}-dihydroxy-olean-12-en-28-oic$ acid (3a) and $2{\alpha},3{\beta}-dihydroxy-urs-12-en-28-oic$ acid (3b) exhibited the most potent antibacterial activity against both bacteria. The other 3 compounds, in the decreasing order of the activity, were identified as $2{\alpha},3{\beta}-dihydroxy-urs-12-en-28-oic$ acid (2), betulinic acid (1), and $2{\alpha},3{\alpha}$,23-trihydroxy-urs-12-en-28-oic acid (4). The antibacterial compounds (2, 3a, 3b and 4) were not detected or occurring in small quantities in the intact tissue, while they were observed in the callus. Only the less active compound 1 was present more abundantly in intact tissues than the callus.

• Natural Product Sciences
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• 제20권2호
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• pp.107-112
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• 2014

This research aimed to investigate the antibacterial activity of Lycoris radiata. The methanol extract and solvent fractions from L. radiata exhibited antibacterial activities against Escherichia coli, Staphylococcus aureus, and Helicobactor pylori. Open-column chromatography was used to isolate phytochemical constituents from L. radiata; spectroscopic analysis elucidated their structures as ${\beta}$-sitosterol (1), daucosterol (2), O-methyllycorenine (3), lycorenine (4), lycoricidinol (5), lycorine (6), and lycoricidine (7). Further testing of compounds 1 - 7 revealed antibacterial effects against E. coli, S. aureus, and H. pylori, which suggested the potential of these substances as antibacterial agents. We determined that compounds 1 and 2, isolated from the n-hexane fraction, were more effective against S. aureus and H. pylori. Compound 4, isolated from the methylene chloride fraction, exhibited noticeable antibacterial effects against E. coli. This study is the first report on the antibacterial activities of phytochemical constituents from L. radiata against E. coli, S. aureus, and H. pylori.

• 한국환경보건학회지
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• 제17권1호
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• pp.104-109
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• 1991

Carbamates are generally used as insecticide, thus 8-hydroxy-5-chloroquinolinyl-N-ethylcarbamate was newly synthesized. Its physical properties were determined and chemical structure was identified by means of IR, nmr in addition to elemental analysis. The effect of the compound on rat's ileum, and antibacterial activity against Staphylococcus aureus, Salmonella typhi, E. coli, and Pseudomonas aeruginosa were examined. It was observed that the dosage over 100 $\mu$g/ml of the compound relaxed rat's ileum and the same dosage of the compound inhibited growth of the above strains of bacteria.

• Mycobiology
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• 제37권1호
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• pp.31-36
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• 2009

A phytochemical study on the flower of Calotropis gigantea (Linn.) using silica gel column chromatography and preparative thin layer chromatography, led to the first time isolation of Di-(2-ethylhexyl) phthalate (compound 1) and anhydrosophoradiol-3-acetate (compound 2). The structures of these compounds were confirmed by spectroscopic analyses (IR, HRTOFMS and NMR). The antibacterial and antifungal activities of ethyl acetate extract, compound 1 and compound 2 were measured using the disc diffusion method. Ethyl acetate extract and compound 1 presented better results than compound 2. The minimum inhibitory concentrations (MICs) of the extract and compounds were found to be in the range of $16{\sim}128{\mu}g/ml$. The cytotoxicity ($LC_{50}$) against brine shrimp nauplii (Artemia salina) were also evaluated and found to be 14.61 ${\mu}g/ml$ for ethyl acetate, 9.19 ${\mu}g/ml$ for compound 1 and 15.55 ${\mu}g/ml$ for compound 2.

• Bulletin of the Korean Chemical Society
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• 제27권5호
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• pp.705-712
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• 2006

The synthesis of a new series of 1 $\beta$-methylcarbapenems having 5-(1,2-disubstituted ethyl)pyrrolidine moiety are described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. Among them, compound (IIIc) having 1-methoxyimino-2-hydroxyethyl moiety showed the most potent antibacterial activity.

• 생약학회지
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• 제39권3호
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• pp.246-248
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• 2008

Six prenylated xanthones, cudraxanthone B (1), isocudraxanthone K (2), cudraxanthone H (3), cudratricusxanthone A (4), cudraxanthone L (5) and macluraxanthone B (6), have been isolated from the MeOH extract of Cudrania tricuspidata root barks. The evaluation for antibacterial effect of compounds 1-6 against the pathogenic microorganisms concerning with public health or zoonosis was conducted. Of these, compound 4 showed significant antibacterial effect in disk diffusion method.

• 대한수의학회지
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• 제13권1호
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• pp.35-38
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• 1973

It was discovered that furamizole, one of the nitrofuran derivatives, possesses a strong antibacterial activity upon various organisms. Since then, a number of nitrofuran derivatives have been examined for antibacterial activity. This experiment was carried in vitro to evaluate with regard to antibacterial activity upon Mycoplasma gallisepticum. As a result, furamizole was found to be a good effective compound upon Mycoplasma gallisepticum. Furamizole inhibited the growths of the three strains of Mycoplasma gallisepticum and two strains of the same species at a concentration of $0.064{\mu}g/mI$. and $0.016{\mu}g/mI$. In short, there were not great differences in sensitivity to furamizole among the five strains tested.

• 한국염색가공학회지
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• 제25권4호
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• pp.247-253
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• 2013

The enzyme-like catalytic functions of metal complex phthalocyanine derivatives those containing carboxylic acid groups could be applied as odor-removing systems and antibacterial systems. Pyromellitic dianhydride and 4-nitrophthalimide were used as starting material for synthesizing dinitro-tetracarboxylic acid iron phthalocyanine(compound 1). Then diamino-tetracarboxylic phthalocyanine(compound 2) was obtained by reduction of compound 1. For the formation of covalent bond with cellulose fiber, cyanuric chloride was introduced to the amino group of compound 2 by condensation reaction compound 3. The exhaustion method was employed for adsorbing compound 3 on cotton fiber. K/S values of each fabrics were measured by a CCM system and deodorizing rates were tested by a detector tube method for ammonia gas. K/S values of treated cotton fiber with compound 3 were arranged from 2.1 to 4.2 at $90^{\circ}C$ of exhaustion temperature. Deodorizing rates provided result of 81%, 84%, 88%, 91%, by passing time of 30 min, 60 min, 90 min, 120 min, respectively.