• East Asian mathematical journal
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• v.38 no.3
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• pp.357-363
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• 2022

Immunological imbalance eventually results in the development of various diseases. A typical example is an imbalance of cytokines with immunomodulatory abilities. In this paper, we propose a two-variable delay model to anti-pro-inflammatory cytokine therapy for autoimmune diseases, which are caused by an imbalance between the pro and anti-inflammatory cytokines. The interaction between pro- and anti-inflammatory cytokines were modeled mathematically to investigate the relevance of cytokines in disease processes. The delay time was estimated to maintain the stability of a biologically important steady state. In particular, the effects of delay with anti-pro-inflammatory cytokines therapy in autoinflammatory diseases were studied.

• Proceedings of the Korean Society of Organic Agriculture Conference
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• 2009.12a
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• pp.103-113
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• 2009

This present study was carried out to investigate the biological effects of soybean extracts comparing organic and conventional cultivation. Cellular and molecular analysis was performed to determine anti-oxidative, anti-inflammatory, anti-apoptotic, and anti-inflammatory effects of both soybean extracts. First, we obtained various solvent extracts of soybeans such as water, ethanol, and methanol. Molecular and cellular analysis were performed with 0.1 mg/ml concentration of each solvent extracts. The results of anti-oxidative, anti-inflammatory and anti-apoptotic effects of organic cultivated soybean extracts were prominent than conventional cultivated soybean extracts. However, discrepancy between organic and conventional cultivated soybean extracts was not observed in anti-allergic effects determined by releasing histamine from rat mast cell line, RBL-2H3. Conclusively, organic cultivated soybeans have stronger effects than conventional cultivated soybeans in suppression of inflammation. In addition, organic soybeans could be applied as a functional food ingredient for treatment of chronic inflammation, asthma, and atopic dermatitis with enhanced anti-inflammatory activities.

• Journal of the Society of Naval Architects of Korea
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• v.57 no.3
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• pp.124-132
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• 2020

The purpose of this paper is to establish the basic procedure and method for selection of preferred anti-fouling paint considering economic analysis according to ship's speed loss based on ISO 19030 that has been published in 2016 to prescribe practical methods for measuring changes in ship specific hull and propeller performance. In this study, six (6) anti-fouling paint products have been assumed for alternatives with each target maximum average speed loss and carried out comparison of the alternatives and sensitivity analysis in assumed conditions for selection of the preferred alternative.

• Journal of the Korea Institute of Military Science and Technology
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• v.23 no.4
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• pp.426-434
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• 2020

This paper studies the impact of the maintenance time of anti-ship missile Harpoon on operational availability with real field data. The Harpoon maintenance simulation model is developed as a testbed for identifying the optimal inventory levels on operational availability. Using multiple linear regression analysis and integer programming, the optimal inventory levels of essential assemblies are suggested. Finally, the result of sensitivity analysis shows the quantitative impact of maintenance time on operational availability and inventory costs. The authors believe that this quantitative analysis can support policy decisions to decrease maintenance time of missiles.

• Structural Engineering and Mechanics
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• v.20 no.2
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• pp.225-239
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• 2005

Applications of the Trefftz boundary element method (BEM) to anti-plane electroelastic problems are presented in this paper. Both direct and indirect methods with domain decomposition are discussed in details. Each crack is treated as semi-infinite thin slit defined in a subregion, for which a particular solution of the anti-plane problem, satisfying exactly the crack-face condition, is derived. The stress intensity factors defined at each crack tip can be directly computed from the coefficients of the particular solution. The performance of the proposed formulation is assessed by two examples and comparison is made with results obtained by other approaches. The Trefftz boundary element approach is demonstrated to be suitable for the analysis of the anti-plane problem of piezoelectric materials.

• International Journal of Oral Biology
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• v.32 no.3
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• pp.113-118
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• 2007

Treatment of oral cancers with chemotherapeutic agents become evaluated as an effective method to reduce cancer cell proliferation. Anti-proliferative and anti-oral cancer activities of momordin I on oral cancer cells were evaluated in this study. Momordin I was originally purified from a natural product, Ampelopsis radix and showed the antiproliferative activity against oral carcinoma, KB cells. Obtained $IC_{50}$ value was approximately $10.4{\mu}g/ml$. Time-and dose-dependent chromosomal DNA fragmentations were observed in momordin I-treated KB cells. Flow cytometry analysis showed time-dependent apoptotic cell appearance after treatment of momordin I. Approximately 18.6% apoptotic cells were observed at 72 hours after $20{\mu}g/ml$ of momordin I treatment. These observation were consistent with the results obtained in DNA fragmentation analysis. These data suggest that momordin I has anti-proliferative effect and induces cell death in KB cells through apoptosis.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.33 no.2
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• pp.169-178
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• 2009

The presence of low adhesion at the wheel-rail contact point can result in skid of train wheels, and the skid, in turn, results in flats appearing on the wheels. Thus, anti-skid control has a crucial role for safe braking and prevention from flats that could cause a disastrous train accident. This paper presents dynamic modeling of a tilting train and the brake system of the tilting train, and analyzes the anti-skid logic used in the tilting train. The validity of the analysis is demonstrated via simulation study using Simulink for skid and re-adhesion circumstances of the tilting train.

• Journal of the Korea Institute of Military Science and Technology
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• v.16 no.5
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• pp.590-597
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• 2013

For a lower tier defense, the distance between a launcher and an engagement control station is quite important to estimate the proper defense area and to effectively arrange missile launchers. In this paper, we have analyzed an effectiveness of anti-ballistic missile launcher arrangement for the lower tier defense against the ballistic missile. The operation concept, specific configuration and aerodynamic characteristics of the ballistic missile such as SCUD-B/C, Nodong are considered in order to develop a realistic engagement simulation. The diverse engagement results through numerical simulations are provided to conduct the effectiveness analysis of anti-ballistic missiles.

• Journal of Korean Association for Spatial Structures
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• v.20 no.3
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• pp.99-106
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• 2020

If an excessive displacement occurs in the base isolation system, the structure will be damaged due to overturning of the upper structure. In this study, we analyze the behavior of base isolation by applying earthquake to base isolation with anti-uplift device. In the case of structures that generate horizontal reaction forces such as arch structures, horizontal reaction forces must be considered in the design of the base isolation and structural members. And anti-uplift device for preventing the excessive displacement of the base isolation system is needed.

• Environmental Analysis Health and Toxicology
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• v.30
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• pp.6.1-6.7
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• 2015

Objectives This study aimed to estimate the effects of 4-nonylphenol (NP), a ubiquitously present surfactant in aquatic environments, on the anti-oxidant systems of the liver in the Far Eastern catfish Silurus asotus. Methods Changes in biochemical parameters involved in glutathione (GSH)-related and other anti-oxidant systems were analyzed following 4 weeks of 4-NP administration (0.1 and 1.0 mg/kg diet) via a formulated diet to catfish. Results 4-NP exposure induced an elevation in hepatic lipid peroxide levels and an accompanying decrease in reduced state GSH after 2 weeks, suggesting pro-oxidant effects of the chemical in catfish. This oxidative stress was associated with an inhibition of the GSH-utilizing enzyme glutathione peroxidase at the same time point. This inhibition was restored after 4 weeks. The activities of other anti-oxidant enzymes, i.e., glutathione reductase, superoxide dismutase and catalase were increased after 4 weeks. These enzyme increases occurred more strongly at the higher 4-NP concentration (1.0 mg/kg diet). Conclusions 4-NP given to catfish at 0.1 to 1.0 mg/kg diet, concentrations relevant to environmental levels, depletes the endogenous anti-oxidant molecule GSH and temporarily inhibits GSH-related anti-oxidant enzymes. Such declines in anti-oxidant capacity and elevated oxidative stress seem to be compensated eventually by subsequent activation of various anti-oxidant enzyme systems.