• 척추신경추나의학회지
• /
• 제15권2호
• /
• pp.9-18
• /
• 2020

Objectives This study verified the clinical effectiveness of Qigong exercise therapy for individuals with hypertension. Methods Ten electronic databases were used for information retrieval. Only randomized controlled trials (RCTs) using Qigong exercise therapy as a treatment for hypertension were included in this study. Cochrane risk of bias tool was used to assess the methodological quality of each RCT. Results After a thorough review, six RCTs were deemed eligible. These studies were divided into two groups: Qigong vs. no intervention and Qigong plus anti-hypertensive drug vs. anti-hypertensive drug alone. Among the six RCTs, four studies were Qigong vs. no intervention, and two studies were Qigong plus anti-hypertensive drug vs. anti-hypertensive drug alone. The meta-analysis demonstrated that adding Qigong exercise to anti-hypertensive drug treatment lowers diastolic blood pressure more than the anti-hypertensive drug alone. Conclusions Although Qigong exercise is not widely used in the Korean medical field, the results of this study demonstrated the necessity of exercise while controlling hypertension. However, the number of included studies was small, with their high risk of bias. In conclusion, although it is difficult to determine whether Qigong exercise lowers blood pressure in hypertensive patients, exercise including Qigong must be parallel with the intake of anti-hypertensive drugs.

• 대한본초학회지
• /
• 제33권6호
• /
• pp.29-34
• /
• 2018

Objectives : It is necessary to manage herbal medicines based on effectiveness by comparing the efficacy of herbal medicines by region. In this study, we compared anti-oxidative activity and marker compounds of Eucommiae Cortex by regional groups. Methods : Eucommiae Cortex grown and harvested in Gangjin, Sancheong, Yeongwol, Jangsu, and Jecheon were used. Eucommiae Cortex was extracted in distilled water at $100^{\circ}C$ for 3 hours, and filtered. filtered. Extract samples were freeze-dried at $-80^{\circ}C$. Comparison of anti-oxidant activity in Eucommiae Cortex samples from regional groups was measured in 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) free radical scavenging, and ferric reducing antioxidant power (FRAP) between regional groups of Eucommiae Cortex. In addition, high-performance liquid chromatography (HPLC) analysis was conducted to compare pinoresinol diglucoside concentration by regional groups. Results : HPLC analysis found that pinoresinol diglucoside concentration, widely known as the marker compound of Eucommiae Cortex, was the highest in Gangwon Yeongwol. There was a significant difference in anti-oxidative activity of Eucommiae Cortex between regional groups as discovered in DPPH, ABTS and FRAP assays. DPPH free radical scavenging was the highest in Jeonbuk Jangsu. ABTS free radical scavenging was the highest in Jeonbuk Jangsu and Chungbuck Jecheon. FRAP was the highest in Jeonbuk Jangsu. Conclusions : Although pinoresinol diglucoside concentration was high, anti-oxidative activity was not proportionately high. Pinoresinol diglucoside concentration was the highest in Gangwon Yeongwol. Anti-oxidative activity was the highest in Jeonbuk Jangsu.

• 융합보안논문지
• /
• 제23권1호
• /
• pp.97-107
• /
• 2023

4차 산업혁명 시대에 디지털기기 보급의 대중화와 함께 이를 대상으로 한 사이버 범죄가 증가함에 따라 디지털 데이터 증거 확보의 중요성이 대두되고 있다. 하지만 디지털 데이터 증거 확보의 어려움은 디지털 데이터를 조작, 삭제, 난독화 등 분석 시간을 증가시키거나 불가능하게 만드는 안티 포렌식 기법을 활용하기 때문이다. 이러한 안티 포렌식은 디지털 포렌식 측면에서 증거물의 회손 및 차단하는 일련의 행위로 정의하며, 안티 포렌식 기법으로 데이터 파괴, 데이터 암호화, 데이터 은닉, 데이터 변조 등으로 분류된다. 따라서 본 연구에서는 안티포렌식 기법을 데이터 은닉 및 삭제 (난독화 및 암호화)로 분류하여 최근 연구동향을 조사 및 분석하고 향후 안티포렌식의 연구 방향을 제안하고자 한다.

• 대한임상검사과학회지
• /
• 제54권4호
• /
• pp.279-284
• /
• 2022

환자의 긴급 상황에서 수혈 시 일부 수혈 전 검사를 수행하지 않는다. 수혈 후 항체 선별검사를 실시하여 용혈성 수혈 반응을 일으키는 비예기 항체의 실태를 조사를 비교평가하기 위해 국내·외에 보고된 공시자료를 포함하여 조사하였다. 2014~2016년 P병원에서 항체 선별 검사 68,602건과 항체 동정검사 528건을 선정하였다. 68,602건 중 1,198건(1.74%)이 양성이며 Rh계열 161건(30.49%), Lewis계열 67건(12.69%), 기타(Di (a)등) 28건(5.30%)으로 나타났다. Anti-E는 93건(17.61%), c는 13건(2.46%)이다. 국내·외 공시자료 중 국내 경우는 2007년 이전에는 Anti-E 196건(22.45%), Anti-Le(a) 82건(9.39%) Anti-E+c 60건(6.87%)으로 조사되었지만 2008년 이후에는 Anti-E 107건(17.12%), Anti-E+c 56건(8.96%), Anti-Di (a) 28건(4.48%)으로 조사되었다. 한편 다른 국내의 경우는 S병원(2012~2015년)에는 Anti-E, Anti-Le (a), Anti-E+c이며Anti-E+c이며 D병원(2016~2017년)에는 Anti-E, Anti-D Anti-E+c,Anti-E+c, Anti-C+e로 조사되었다. Saudi의 경우는 Anti-D, Anti-E, Anti-Jk (a)순이며, India 경우는 Anti-M, Anti-N, Anti-Le (a), Anti-D로 조사되었다. 권역별 외상센터 개설 전후시기에 응급수혈요청의 빈도 비교에서는 1.8배 이상이 증가한 것으로 조사되었다. 결론적으로 장기간의 항체분포로 효율성을 검증할 수는 없었지만 수혈의 안전성을 높이고 응급 수혈 상황에서 용혈성 수혈 부작용을 줄일 수 있는 대안을 위해 기초 정보를 제공하고 추가적인 검증연구가 필요할것으로 사료된다.

• 대한본초학회지
• /
• 제22권4호
• /
• pp.101-108
• /
• 2007

Objectives : To compare the anti-oxidant effects of Ligusticum chuanxiang and Cnidium officinale extracts and their mixture with Angelica gigas, we investigated the anti-oxidative activities using rat liver tissues. Methods : We investigated the anti-oxidative activities by analysis of lipid peroxidation, xanthine oxidase activity, aldehyde oxidase activity, hydroxyl radical scavenging activity, superoxide dismutase activity and catalase activity in rat liver tissues. Results : Both Ligusticum chuanxing and Cnidium offieinale inhibited the lipid peroxidation compared to the control, there is no significant differences between two groups. Cnidium officinale showed strong inhibitory effects on xanthine oxidase and aldehyde oxidase activities compared with that of Ligusticum chuanxing. Ligusticum chuanxing and Cnidium officinale were scavenged the hydroxy radicals, and increased SOD and catalase activities. These results suggested that Ligusticum chuanxing and Cnidium officinale were showed antioxidant activity, especially Cnidium officinale showed higher activity than Ligusticum chuanxing. Conclusions: These results suggest that Ligusticum chuanxing could be replaced by Cmdium afficinale in clinical trial.

• Natural Product Sciences
• /
• 제14권3호
• /
• pp.196-201
• /
• 2008

Five neolignans (1 - 4, 8), two sesquiterpene-lignans (5 - 6), and two phenylpropanoids (7, 9) were isolated from the stem bark of Magnolia obovata Thunberg (Magnoliaceae) by repeated column chromatography. The structures of isolated compounds were identified as 4-methoxyhonokiol (1), obovatol (2), magnolol (3), honokiol (4), eudeshonokiol B (5), eudesobovatol B (6), coumaric acid (7), magnaldehyde B (8), and ${\rho}-coumaric$ acid (9) on the basis of spectroscopic analysis including 2D-NMR and MS data. Compounds 1 - 9 were evaluated for their anti-complement activities against the classical pathway of the complement system. Of them, compound 8 showed significant anti-complement activity on the classical pathway with $IC_{50}$ value of 102.7 ${\mu}M$, whereas compounds 1 - 7 and 9 were inactive. This result indicated that an aldehyde group in the neolignan is important for the anti-complement activity against the classical pathway.

• Journal of Positioning, Navigation, and Timing
• /
• 제9권2호
• /
• pp.59-63
• /
• 2020

The antenna arrays are known to be effective for GPS anti-jamming and the performance can be improved further if a dual-polarized antenna array is used. However, when the Minimum Variance Distortionless Response (MVDR) beamformer is used as a signal processing algorithm for the dual-polarized antenna array, the anti-jamming performance can degrade in the presence of errors in the steering vector that is a key factor of the MVDR beamformer. Therefore, in this paper, the effect of the steering vector error on the anti-jamming performance of the dual-polarized antenna array is analyzed by simulations and the result is compared to that of the single-polarized antenna array.

• 생약학회지
• /
• 제47권2호
• /
• pp.165-171
• /
• 2016

Corylopsis gotoana (Hamamelidaceae) has been used as a traditional medicine for the treatment various diseases including cold, edema and vomiting. However, previous studies regarding component analysis and pharmacological actions of C. gotoana are extremely limited until now. In this study, we investigated anti-inflammatory activities of the methanolic extract of the twigs of Corylopsis gotoana (MCG) both in vitro and in vivo. MCG effectively inhibited excessive NO production in IFN-${\gamma}$ and LPS-stimulated mouse peritoneal macrophages without notable cytotoxicity. In addition, we also found that MCG could attenuate the expression of inflammatory mediators such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). We further tested in vivo anti-inflammatory activity of MCG using paw edema mouse model. Herein, MCG demonstrated significant suppression on the paw edema induced by both of trypsin and carrageenan. These results indicated that MCG has potent anti-inflammatory potential and may be useful for prevention and treatments of inflammatory diseases.

• 동의생리병리학회지
• /
• 제25권3호
• /
• pp.533-539
• /
• 2011

Sulfuretin is one of the main flavonoids produced by Rhusverniciflua. Sulfuretin has been shown to exhibit many pharmacological activities including anti-oxidant, anti-obesity, anti-inflammatory and anti-mutagenic activities. However, the anti-skin photoaging effects of sulfuretin has not yet been reported. In the present study, we investigated the inhibitory effect of sulfuretin on the expression levels of MMP-1 and -3 in the human dermal fibroblast cells. Western blot analysis and real-time PCR revealed sulfuretin inhibited UVB-induced MMP-1 and -3 expressions in a dose-dependent manner. UVB-induced MAPK/NF-${\kappa}B$/p50 activation and MMP expression were completely blocked by pretreatment of sulfuretin. Taken together, sulfuretin could prevent UVB-induced MMP expressions through inhibition of MAPK/NF-${\kappa}B$/p50 activation.

• 동의생리병리학회지
• /
• 제19권5호
• /
• pp.1363-1369
• /
• 2005

Previously we have shown that shikonin has strong anti-tumor activities via inducing apoptosis and suppressing metastasis on LLC cells in vivo and in vitro. Here we have investigated anti-angiogenic potential of shikonin and its possible mechanism of action in HSE cells. Shikonin inhibited the proliferation of HSE cells in a concentration-dependent manner. It was shown that this proliferation inhibition was caused by apoptosis induced by shikonin via BrdU incorporation and Western blotting analysis. Shikonin treatment was caused that decrease of activation of caspases and cleavage of PARP. And shikonin induced that the activation of mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38. Moreover, shikonin showed anti-angiogenic activities inhibiting tube-like formation of HSE cells in vitro and vascular formation of LLC cells in vivo. These findings suggest that shikonin may a possible candidate not only anti-metastatic agent but also anti-angiogenic agent.