• Journal of Microbiology and Biotechnology
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• 제28권10호
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• pp.1614-1625
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• 2018

Periodontitis, which is a severe inflammatory disease caused by endotoxins secreted from oral pathogens, destructs gingival tissue and alveolar bone. Curcuma xanthorrhiza, commonly called Java turmeric, has been shown to possess anti-bacterial and anti-inflammatory activities. The present study evaluated the inhibitory effect of C. xanthorrhiza supercritical extract (CXS) standardized with xanthorrhizol on lipopolysaccharide (LPS)-induced periodontitis in an animal model. LPS was topically injected into the periodontium of Sprague-Dawley rats to induce periodontitis and CXS (30 and $100mg{\cdot}kg^{-1}{\cdot}day^{-1}$) was orally administered after day 12. Histologically, CXS inhibited the collapse of gingival tissue by preventing cell infiltration. CXS significantly downregulated the expression of matrix metalloproteases (MMPs) and inflammation-related biomarkers, such as nuclear factor-kappa B ($NF-{\kappa}B$) and interleukin-1 beta ($IL-1{\beta}$) in gingival tissue. CXS also improved bone remodeling by downregulating osteoclastic transcription factors, such as nuclear factor of activated T-cells c1 (NFATc1), tartrate-resistant acid phosphatase (TRAP), and cathepsin K. In addition, CXS upregulated osteoblast differentiation-related markers, alkaline phosphate (ALP) and collagen type I alpha (COLA1). Thus, CXS can ameliorate periodontitis by inhibiting inflammation and improving bone remodeling.

• 한방안이비인후피부과학회지
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• 제30권1호
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• pp.29-42
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• 2017

Objectives : Atopic dermatitis accompanies with severe pruritus and collapse of skin barrier, inflammation. Maifanite could be used as an ointment for skin disease. However, there have been few studies about maifanite uses for atopic dermatitis. We report the anti-inflammatory and promoting skin recovery effects of ionized maifanite on damaged skin barrier with experimentally elicited atopic dermatitis. Methods : Nc/Nga mice were divided into 3 groups: control group(CON), atopic dermatitis elicited group(AE group), ionized maifanite treated group after atopic dermatitis elicitation(MT group). After 5% SDS was applied D. pteronyssinus crude extract also applied for 3 weeks to elicit atopic dermatitis-like skin disease. MT group was treated for 3 weeks with ionized maifanite. Ionized maifanite was applied once a day and voluntarily administrated. AE group and control group were treated with normal saline in the same way. Results : In MT group, skin lesions like eczema were more improved than AE group. p-ERK1/2 positive reaction was reduced in MT group. MMP-9 and substance P positive reaction at dermal papillae was also reduced in MT group. With skin angiogram, capillary vessel decreased in MT group. Also, IL-4 positive reaction cell and STAT-6 positive reaction cell reduced more in MT group than in AE group. $NF-{\kappa}B$ p65 positive reaction cell and iNOS positive reaction cell also declined more in MT group than in AE group. Conclusions : It is supposed that ionized maifanite has anti-inflammatory effects on NC/Nga mice's atopic dermatitis with suppressing IL-4 production and Th2 cell differentiation, and controlling $NF-{\kappa}B$ activation.

• 한국건축시공학회지
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• 제17권3호
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• pp.219-225
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• 2017

콘크리트의 내구성 요인은 오랜기간동안 많은 연구자들에 의하여 다양한 연구가 진행되었다. 특히 화학적 침식과 관련하여서도 산 알칼리, 염, 그중에서도 황산염 침식 등에 대한 연구가 활발히 진행되고 있다. 그런데 화학적 침식 중 유지류의 경우는 모르타르의 팽창을 일으켜 파괴할 수 있다고 보고되어 있지만, 유지류 종류의 영향, 모르타르의 조직구성과는 어떤 관계가 있고, 파괴 패턴 등은 구체적으로 연구된 바가 없다. 그러므로 본 연구에서는 시중에서 유통되는 각종 유지류에 대한 시멘트 모르타르의 배합비별 침지에 따른 열화특성을 분석하고자 하였다. 실험 결과 유지류 종류 중에서는 BI(바이오디젤)가 가장 피해가 크고 모르타르 배합비는 빈배합일수록 비누화 반응에 따른 팽창파괴가 크게 나타남을 알 수 있었다.

• 국제학술발표논문집
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• The 6th International Conference on Construction Engineering and Project Management
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• pp.324-327
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• 2015

Scaffold is the most commonly used equipment in various types of construction works. Since various types of construction works use the same scaffold equipment, it becomes more difficult to be controlled and managed, thus resulting hazard frequently. According to the information announced in July 2012 by Council of Labor Affairs Executive Yan, the site collapse or incomplete anti-falling protection has led the site to accident frequently, and this is the main reason that causes construction industry occupational disasters. The labor death occupational hazard ratio rises up to 13% in scaffold activity, and the Council of Labor Affairs Executive Yan has showed that the death ratio is higher when using the scaffold in construction site, the total number of death has reached to 139 from 2005 to 2010. In order to ensure the safety of scaffold user, this study tends to build a wireless sensor monitoring system to detect the reliability and safety of the scaffold. The wireless sensor technique applies in this study is different with the traditional monitoring technique which is limited with wired monitoring. Wireless sensor technique does not need wire, it just needs to consider the power supply for establishing the network and receiving stable information, and it can become a monitoring system. In addition, this study also integrates strain gauge technique in this scaffold monitoring system, to develop a real-time monitoring data transfer mechanism and replace the traditional wired single project monitoring equipment. This study hopes to build a scaffold collapse monitoring system to effectively monitor the safety of the scaffold as well as provide the timesaving installation, low-cost and portable features.

• 한국과 국제사회
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• 제2권1호
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• pp.69-92
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• 2018

북한은 2006년 1차 핵실험을 시작으로 2017년 9월까지 총 6차례의 핵실험을 감행하였다. 북한은 미국의 대북적대시 정책에 대응하기 위한 일환으로 체제수호와 방어적 차원에서 핵무장력 담보 전략을 전개하고 있다. 그러나 북한 핵실험의 전략적 목표가 북미협상을 통해 북한체제 위기를 극복하고 그들의 한반도 사회주의통일을 위한 핵무장력을 완성하는 데 있음은 주지의 사실이다. 북한의 계속된 핵실험은 한반도평화를 위협하는 직접적인 요인이 되고 있으며, 동북아안보 역학구도에 간접적인 요인으로 작용하고 있다. 유엔안보리는 이러한 북한의 무모한 핵실험에 대해 지난 10년 이상 6차례의 유엔안보리 결의로 대북제재조치를 단행해 왔다. 그러나 북한 김정은 정권은 유엔과 미국 등 국제사회의 대북제재 조치에도 불구하고 핵 경제병진노선을 고수하겠다는 입장이다. 유엔과 미국의 대북제재조치가 북한에 대한 효과적인 영향을 주지 못한 것은 북한이 강도높은 핵실험으로 격상시키는데 요인으로 분석된다. 2017년 미국의 트럼프 행정부가 대북제재 조치 수단 가운데 하나인 대북 군사옵션은 한반도에서의 전면전과 국지전 양상으로 예상된다. 미 트럼프 행정부는 이전의 미국 행정부의 대북제재 조치 양상과는 다르게 세컨더리 보이콧이라는 외교압박전술을 시도하고 있다. 그럼에도 불구하고 북한은 유엔과 미국의 대북제재조치에 대해 북 미 간 전면적인 군사대결 입장을 밝히며 '벼랑끝 전술'로 맞서고 있다. 북한은 당분간 체제생존차원에서 핵 경제병진노선을 추진할 것으로 판단된다. 북한체제는 미 중 간의 현실주의적 국가전략 추진으로 체제붕괴 변수가 나타날 수 있다는 점에서 북한의 전략적 선택의 폭은 좁아진다.

• Geomechanics and Engineering
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• 제32권1호
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• pp.111-123
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• 2023

The slope of an open cut tunnel is located above the exit of the Leijia tunnel on the Changgan high-speed railway. During the excavation of the open cut tunnel foundation pit, the slope slipped twice, a large landslide of 92500 m³ formed. The landslide body and unstable slope body not only caused the foundation pit of the open cut tunnel to be buried and the anchor piles to be damaged but also directly threatened the operational safety of the later high-speed railway. Therefore, to study the stability change in the slope of the open cut tunnel under heavy rain and excavation conditions, a 3D numerical calculation model of the slope is carried out by Midas GTS software, the deformation mechanism is analyzed, anti-sliding measures are proposed, and the effectiveness of the anti-sliding measures is analyzed according to the field monitoring results. The results show that when rainfall occurs, rainwater collects in the open cut tunnel area, resulting in a transient saturation zone on the slope on the right side of the open cut tunnel, which reduces the shear strength of the slope soil; the excavation at the slope toe reduces the anti-sliding capacity of the slope toe. Under the combined action of excavation and rainfall, when the soil above the top of the anchor pile is excavated, two potential sliding surfaces are bounded by the top of the excavation area, and the shear outlet is located at the top of the anchor pile. After the excavation of the open cut tunnel, the potential sliding surface is mainly concentrated at the lower part of the downhill area, and the shear outlet moves down to the bottom of the open cut tunnel. Based on the deformation characteristics and the failure mechanism of the landslides, comprehensive control measures, including interim emergency mitigation measures and long-term mitigation measures, are proposed. The field monitoring results further verify the accuracy of the anti-sliding mechanism analysis and the effectiveness of anti-sliding measures.

• 식품저장과 가공산업
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• 제7권1호
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• pp.9-18
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• 2008

The health benefits of garlic (Allium sativum L.) are derived from a wide variety of components and from the different ways it is administered. The known health benefits of garlic include cardiovascular protective effects, stimulation of immune function, reduction of blood glucose level, protection against microbial, viral and fungal infections, as well as anticancer effects. In the present study, it was examined the effects of water extract of A. sativum (WEAS) on the growth of cultured human tumor cells in order to investigate its anti-proliferative mechanism. Treatment of WEAS to tumor cells resulted in the growth inhibition, especially in leukemia cells, which was associated with induction of G2/M arrest of the cell cycle and apoptosis. In order to further explore the critical events leading to apoptosis in WEAS-treated U937 human leukemia cells, the following effects of WEAS on components of the mitochondrial apoptotic pathway were examined: generation of reactive oxygen species (ROS), alteration of the mitochondrial membrane potential (MMP), and the expression changes of Bcl-2 and IAP family proteins. The cytotoxic effect of WEAS was mediated by its induction of apoptosis as characterized by the occurrence of DNA ladders, apoptotic bodies and chromosome condensation in U937 cells. The WEAS-induced apoptosis in U937 cells was correlated with the generation of intracellular ROS, collapse of MMP, activation of caspase-3 and down-regulation of anti-apoptotic proteins. The quenching of ROS generation with antioxidant N-acetyl-L-cysteine conferred significant protection against WEAS-elicited ROS generation, caspase-3 activation, G2/M arrest and apoptosis. In conclusion, the present study reveals that the cellular ROS generation plays a pivotal role in the initiation of WEAS-triggered apoptotic death in U937 cells.

• Biomolecules & Therapeutics
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• 제31권4호
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• pp.446-455
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• 2023

The mechanistic functions of 3-deoxysappanchalcone (3-DSC), a chalcone compound known to have many pharmacological effects on lung cancer, have not yet been elucidated. In this study, we identified the comprehensive anti-cancer mechanism of 3-DSC, which targets EGFR and MET kinase in drug-resistant lung cancer cells. 3-DSC directly targets both EGFR and MET, thereby inhibiting the growth of drug-resistant lung cancer cells. Mechanistically, 3-DSC induced cell cycle arrest by modulating cell cycle regulatory proteins, including cyclin B1, cdc2, and p27. In addition, concomitant EGFR downstream signaling proteins such as MET, AKT, and ERK were affected by 3-DSC and contributed to the inhibition of cancer cell growth. Furthermore, our results show that 3-DSC increased redox homeostasis disruption, ER stress, mitochondrial depolarization, and caspase activation in gefitinib-resistant lung cancer cells, thereby abrogating cancer cell growth. 3-DSC induced apoptotic cell death which is regulated by Mcl-1, Bax, Apaf-1, and PARP in gefitinib-resistant lung cancer cells. 3-DSC also initiated the activation of caspases, and the pan-caspase inhibitor, Z-VAD-FMK, abrogated 3-DSC induced-apoptosis in lung cancer cells. These data imply that 3-DSC mainly increased mitochondria-associated intrinsic apoptosis in lung cancer cells to reduce lung cancer cell growth. Overall, 3-DSC inhibited the growth of drug-resistant lung cancer cells by simultaneously targeting EGFR and MET, which exerted anti-cancer effects through cell cycle arrest, mitochondrial homeostasis collapse, and increased ROS generation, eventually triggering anti-cancer mechanisms. 3-DSC could potentially be used as an effective anti-cancer strategy to overcome EGFR and MET target drug-resistant lung cancer.

• 한국의류산업학회지
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• 제5권5호
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• pp.453-464
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• 2003

This study is to analyze that the pluralism is the main aspect of the modem fashion which examines the definition and the character of the pluralism. This will also consider the pluralism that appeared on the modern fashion which is based on them. The main point of pluralism is that the world is necessarily aware of plural and difference. Also many values which is focused on the previous generation, for instance disorganize of westernism, androcentrictrism, christianism and powerful nationalism, what is called unfamiliar, heterogeneous, the others and the circumference things. As these were rehabilitated, morality, ethics, religion or politics were all became possible to choose for one's taste. The pluralism expressed in modern fashion can be divided as collapse of genre, grafting the lower and higher orders cultivation, variety way of approaching in time, internationalism. The result for the consideration is that the pluralism has candid attitude for everything so that in the modern fashion is importing variety range of artistic definition. Namely, it is not only containing previous pure art, elegance art and element of artistic sublime beauty, but also has aesthetics of ugliness, deconstructive art and anti-fashion so that the definition of the art is getting vagueness and diverse.

• 한국자기학회:학술대회 개요집
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• 한국자기학회 2013년도 임시총회 및 하계학술연구발표회
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• pp.15-16
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• 2013

Magnetization behavior of ultra thin $Fe_xCo_{1-x}$ alloy (where x varies from 0 to 100) has been investigated as functions of composition on Cr (100) substrate by using in situ surface magneto optical Kerr effect (SMOKE). It's always show in plane uniaxial magnetic anisotropy at room temperature (RT) & Low temperature (LT). It is observed that composition dependent coercive force maximum at about 30 at % Co and 70 at % Co atomic ratio and minimum near equiatomic site. The relative magnetic moments as composition variation also show magnetization collapse near equiatomic site. The magnetization behaviors of Fe-Co alloy on Cr (100) due to composition varies are supported the order-disordering as well as structural stability bcc (ferromagnetic)/fcc (anti-ferromagnetic) phase stability magnetism.