• Steel and Composite Structures
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• v.50 no.3
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• pp.265-280
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• 2024

The collapse behavior observed in single-story beam-column assembly (SSBCA) do not accurately represent the actual overall stress characteristic of multi-story frame structure (MSFS) under column loss scenario owing to ignoring the interaction action among different stories, leading to a disconnection between the anti-collapse behaviors of "components" and "overall structures", that is, the anti-collapse performance of frame structures with two different structural scales has not yet formed a combined force. This paper conducts a numerical and theoretical study to explore the difference of the collapse behaviors of the SSBCA and MSFS, and further to reveal the internal force relationships and boundary constraints at beam ends of models SSBCA and MSFS. Based on the previous experimental tests, the corresponding refined numerical simulation models were established and verified, and comparative analysis on the resistant-collapse performance was carried out, based on the validated modeling methods with considering the actual boundary constraints, and the results illustrates that the collapse behaviors of the SSBCA and MSFS is not a simple multiple relationship. Through numerical simulation and theoretical analysis, the development laws of internal force in each story beam under different boundary constraints was clarified, and the coupling relationship between the bending moment at the most unfavorable section and axial force in the composite beam of different stories of multi story frames with weld cover-plated flange connections was obtained. In addition, considering the effect of the yield performance of adjacent columns on the anti-collapse bearing capacities of the SSBCA and MSFS during the large deformation stages, the calculation formula for the equivalent axial stiffness at the beam ends of each story were provided.

• Journal of the Society of Disaster Information
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• v.16 no.1
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• pp.1-9
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• 2020

Purpose: In this study, the safety management method supplementing the field displacement prediction management technique was performed using the numerical analysis. Method: The analysis was performed using MIDAS GTS / NX program based on the finite element method (FEM). Approximating the displacement data and displacement trend as close as possible to the collapse site, the collapse prevention method was applied after estimating the cause of collapse. Result: The cause of the collapse was estimated by soil parametar, one of the results obtained by performing the Back-analysis. As a result, it was confirmed that the free length of the anchor was insufficient, and the free length of the anchor was changed by the collapse prevention method, and the displacement was significantly reduced. Conclusion: If Back-analysis technique is used in field management, estimating the cause of collapse and suggesting a reasonable collapse prevention measure will help to reduce collase.

• Steel and Composite Structures
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• v.39 no.4
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• pp.383-399
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• 2021

In the study, three 1:3-scale unequal span steel-concrete composite substructures with top-seat angle and double web angle connection were designed and identified as specimens GTSDWA-0.6, GTSDWA-1.0, and GTSDWA-1.4. Pseudo-static tests and refined numerical model analysis were conducted to examine the anti-progressive collapse performance of a semi-rigid steel-concrete composite substructure. The results indicated that the failure modes of the three specimens revealed that the fracture occurred in the root of the long leg of the top/seat angle in tension at the connection. With increases in the span ratio of the left and right composite beams, the bearing capacities of the composite substructures decreased, and the corresponding displacement increased. With respect to GTSDWA-0.6 and GTSDWA-1.4, the resistance due to the short composite beam corresponded to 62% and 60%, respectively, and the total resistance provided by the short composite beam exceeded that of the long composite beam. With respect to GTSDWA-1.0, the resistance due to the left and right composite beams was similar. All three specimens underwent the flexure mechanism and flexure-axial mixed mechanism stages. They resisted the external load mainly via the flexure mechanism. Moreover, the addition of stiffeners on both sides of the top and seat angles is advantageous in terms of improving the collapse resistance and ductility of unequal span composite substructures.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.49 no.5
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• pp.594-599
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• 2016

Infection with HIV (Human immunodeficiency virus), over time, develops into acquired immunodeficiency syndrome (AIDS). The development of non-toxic and effective anti-HIV drugs is one of the most promising strategies for the treatment of AIDS. In this study, we investigated the anti-HIV-1 activity of gelatin hydrolysates from Alaska pollack skin. Gelatin hydrolysates were prepared using four enzymes (alcalase, flavourzyme, neutrase, and pronase E). Among these, the pronase E gelatin hydrolysate was found to inhibit HIV-1 infection in the human T cell-line MT4. It exhibited inhibitory activity on HIV-1_IIIB-induced cell lysis, reverse transcriptase activity, and viral p24 production at noncytotoxic concentrations. Moreover, it decreased the activation of matrix metalloproteinase-2 (MMP-2) in vitro. Because HIV infection-induced activation of MMP-2 can accelerate collagen resolution and collapse of the immune system, pronase E gelatin hydrolysate might prevent the activation of MMP-2 in cells, resulting in collagen stabilization and immune cell homeostasis consistent with anti-HIV activation. These results suggest that pronase E gelatin hydrolysate could potentially be incorporated into a novel therapeutic agent for HIV/AIDS patients.

• Composites Research
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• v.19 no.1
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• pp.43-48
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• 2006

High performance fiber reinforced cement composites have better performances than traditional cement based materials, therefore, have been expected as new construction applications such as the materials for construction & bridge structure, repair and rehabilitation applications, anti-collapse applications, anti-noise applications etc. However, they have lots of the problems such as material design, fabrication method and structural analysis. Also, the most serious problems of High performance fiber reinforced cement composites have been expensive initial cost, lack of long-term exposure data. As a result, it is needed that the efforts for lowering the initial cost and accumulation of long-term exposure. There has been hardly assessment results of life cycle cost for HPFRCC in construction field, but some papers showed that total life cycle cost could be profitable if the initial cost could be reduced.

• Geomechanics and Engineering
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• v.20 no.1
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• pp.43-54
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• 2020

The limit analysis and response surfaces method were combined to investigate the reliability of pressurized tunnel faces subjected to seismic force. The quasi-static method was utilized to introduce seismic force into the tunnel face. A 3D horn failure mechanism of pressurized tunnel faces subjected to seismic force was constructed. The collapse pressure of pressurized tunnel faces was solved by the kinematical approach. The limit state equation of pressurized tunnel faces was obtained according to the collapse pressure and support pressure. And then a reliability model of pressurized tunnel faces was established. The feasibility and superiority of the response surfaces method was verified by comparing with the Monte Carlo method. The influence of the mean of soil parameters and support pressure, variation coefficients, distribution type and correlation of c-φ on the reliability of pressurized tunnel faces was discussed. The reasonable safety factor and support pressure required by pressurized tunnel faces to satisfy 3 safety levels were presented. In addition, the effects of horizontal seismic force, vertical seismic force and correlation of k_h-k_v on the reliability of pressurized tunnel faces were also performed. The method of this work can give a new idea for anti-seismic design of pressurized tunnel faces.

• Advances in Traditional Medicine
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• v.7 no.5
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• pp.459-465
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• 2008

The present study was undertaken to investigate the effect of in vivo administration of neem oil intra-peritoneally (i.p.) to mice bearing a progressively growing transplantable T cell lymphoma of spontaneous origin, designated as Daltons lymphoma (DL), on the tumor growth. Mice were administered various doses of neem oil mixed in groundnut oil, which was used as a diluting vehicle or for administration to control DL-bearing mice. Administration of neem oil resulted in an acceleration of tumor growth along with a reduction in the survival time of the tumor-bearing host. Neem oil administered DL-bearing mice showed an augmented apoptosis in splenocytes, bone marrow cells and thymocytes along with an inhibition in the anti-tumor functions of tumor-associated macrophages. Thus this study gives an altogether a novel information that neem oil instead of the popular belief of being anti-tumor and immunoaugmentary may in some tumor-bearing conditions, behave in an opposite way leading to an accelarated tumor progression along with a collapse of the host's anti-tumor machinery. These observations will thus have long lasting clinical significance, suggesting caution in use of neem oil for treatment of cancer.

• Journal of Microbiology and Biotechnology
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• v.27 no.2
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• pp.365-371
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• 2017

Hydrogen has potential for preventive and therapeutic applications as an antioxidant. However, micro- and macroparticles of hydrogen in water disappear easily over time. In order to eliminate reactive oxygen species (ROS) related with the aging process, we used functional water containing nanoparticle hydrogen. Nanoparticle hydrogen does not disappear easily and collapse under water after long periods of time. We used murine embryonic fibroblasts that were isolated from 12.5-day embryos of C57BL/6 mice. We investigated the ability of nanoparticle hydrogen in water to suppress hydroxyurea-induced ROS production, cytotoxicity, and the accumulation of ${\beta}-galactosidase$ (an indicator of aging), and promote cell proliferation. The accumulation of ${\beta}-galactosidase$ in the cytoplasm and the appearance of abnormal nuclei were inhibited by daily treatment of cells with hydrogen water. When the aging process was accelerated by hydroxyurea-induced oxidative stress, the effect of hydrogen water was even more remarkable. Thus, this study showed the antioxidant and anti-senescence effects of hydrogen water. Nanoparticle hydrogen water is potentially a potent anti-aging agent.

• Earthquakes and Structures
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• v.16 no.5
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• pp.575-588
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• 2019

Seismic design method based on bearing capacity has been widely adopted in building codes around the world, however, damage and collapse state of structure under strong earthquake can not be reflected accurately. This paper aims to present a deformation-based seismic design method based on the research of RC component deformation index limit, which combines with the feature of Chinese building codes. In the proposed method, building performance is divided into five levels and components are classified into three types according to their importance. Five specific design approaches, namely, "Elastic Design", "Unyielding Design", "Limit Design", "Minimum Section Design" and "Deformation Assessment", are defined and used in different scenarios to prove whether the seismic performance objectives are attained. For the components which exhibit ductile failure, deformation of components under strong earthquake are obtained quantitatively in order to identify the damage state of the components. For the components which present brittle shear failure, their performance is guaranteed by bearing capacity. As a case study, seismic design of an extremely irregular twin-tower high rise building was carried out according to the proposed method. The results evidenced that the damage and anti-collapse ability of structure were estimated and controlled by both deformation and bearing capacity.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.20 no.5
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• pp.113-120
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• 2020

Safety accidents, called industrial accidents in construction work, are causing a lot of casualties, property damage and social controversy in the event of an accident, causing the construction to lose public confidence. The risk of safety accidents at construction sites may continue to increase as the construction of high-rise, large-scale, and multi-purpose complex buildings has increased in recent years. In particular, the most frequently constructed apartment construction among reinforced concrete buildings is designed and constructed with a wall-like structure with no beams for each floor, while the lower floors are made of lamen with columns and beams. As a result, the transfer beam or transfer slab to withstand the upper load is installed on the upper part of the Ramen structure, so the system Dongbari, which is installed as a temporary material during concrete laying construction, may collapse at any time during plowing and curing. The purpose of this study is to apply IT convergence technology to prevent the collapse of the system Dongbari during concrete installation, and to apply many of the variables that may occur during construction on a case-by-case basis to check the stability of the system Dongbari and to propose a model of the anti-conducting prediction system.