• The Journal of Korean Obstetrics and Gynecology
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• v.27 no.3
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• pp.143-150
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• 2014

Objectives: The purpose of this study is to report a effect of herbal medicine at threatened abortion in the early stages of pregnancy. Methods: A 37-year-old female patient who had the abdomen pain with vaginal bleeding was taken Gyoaesamultang-gami and Antae-eum for 11 days at Dae-gu Haany University Hospital in Pohang. Results: During this treatment period, vaginal bleeding and abdomen pain were relieved. Also after all treatment, the effect had been continuing. Conclusions: Gyoaesamultang-gami is effective on threatened abortion. And the female patient deliver normally.

• The Journal of Korean Obstetrics and Gynecology
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• v.29 no.4
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• pp.24-33
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• 2016

Objectives: The aim of this study was to demonstrate the benefit of Traditional Korean Medicine as an adjuvant therapy in management of early uterine contractions and the prevention of Preterm Birth (PTB). Methods: It is a case report of a 38 year-old-woman hospitalized for irregular uterine contractions and cervical change at 33^+3/7weeks of gestation. After 7 trials of IVF and artificial insemination, conception was successful via IVF with help of traditional Korean medicines. 2 TKMs were prescribed: Gami-danggui-san, and Antae-eum. 120 ml of Gami-danggui-san was given twice a day morning and evening along with same amount of Antae-eum once a day from 31 August 2013 to 28 November 2013. Tocolytics (Ritodrine) was administered as a first aid for maintenance of pregnancy. Information regarding progress until the delivery was collected during the patient’s visit. Results: As of 34^+2/7 weeks of gestation, intermittent uterine contractions appeared (5-12 min) on cardiotocography and vaginal bleeding was also smeared at 34^+3/7 weeks. However, enhanced tocolytics and continuous administration of herbal medicine sustained the pregnancy to term. At 37^+2/7 weeks, no sign of labor with restored cervical length was confirmed. The woman gave a term birth to a healthy infant via vaginal delivery at 39^+3/7 gestational weeks. Conclusions: Our report implies the potential of herbal medicine as a adjuvant therapy for preterm labor treatment. Further studies are needed to assess the safety and efficacy of TKM herbal medicine as a therapeutic alternative for curing preterm birth.

• The Journal of Korean Obstetrics and Gynecology
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• v.34 no.3
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• pp.1-14
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• 2021

Methods: We investigated the ability to induce decidualization of human endometrial stromal cells and invasive ability of human trophoblast cells by water extract of three types herbal medicines (Dangguijakyak-san, Siryung-tang, Antae-eum) and ethanol extract on Scutellariae Radix. Results: In the process of decidualization of endometrial stromal cells, three herbal medicines including Dangguijakyak-san, Siryung-tang, and Scutellariae Radix increased the production of decidual markers such as prolactin (PRL) and insulin-like growth factor-binding protein 1 (IGFBP1). However, Antae-eum increased mRNA levels of PRL and IGFBP and secretion of IGFBP in decidual stromal cells, but not PRL. Four herbal medicines inhibited the invasion of trophoblast cells. Conclusions: Four herbal medicines may play a role in implantation in women with reproductive failures. However, further studies are warranted to elucidate whether these medications are helpful in the maintenance of pregnancy.

• The Journal of Korean Medicine
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• v.21 no.3
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• pp.166-173
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• 2000

Objectives : These experiments were undertaken to evaluate the effect of the administration on Korean herbal medicines, Kyoaekungkue-tang, Bojungykki-tang, Kungso-san, Antae-eum, and Antaegumchul-tang, on the reproductive functions in pregnant mice. Methods : Prepared herbal medicines(Kyoaekungkue-tang, Bojungykki-tang, Kungso-san, Antae-eum, Antaegumchul-tang) were administered to three different pregnant staged mice. We designed 3 experiments as follows; prepared herbal medicine administered from ovulation to embryo implantation (Experiment I), or administered after implantation to fetal organogenesis (Experiment II) and lastly administered from end of organogenesis to parturition (Experiment III). At day 14 of pregnancy, the whole uteri of half of the treated mice were retrieved from the Experiment I and in the Experiment II the implantation and mean weight of the fetuses were examined. The mean numbers of offspring, sex ratio and mean birth weight were examined in the other half of the mice. Results : The results from these studies were summarized as followed; 1. From the experiment I (administered from ovulation to embryo implantation), the no. of implantation between control and herbal medicine treated groups were shown similar results. Litter size after parturition was significantly decreased in the herbal medicine treated groups, except for Antaegumchul-tang. However, the mean weight of offspring after parturition showed a tendency to increase in the three herbal medicine treated groups. 2. From the experiment II (administered after implantation to fetal organogenesis), the implantation rates from the herbal medicine treated groups increased more significantly than that of the control Also, litter size and birth weight in the herbal medicine groups, except Antaeeum, increased more significantly than that of the control group. 3. From the experiment III group (administered after organogenesis to parturition), the mean number of offspring in Kyoaekungkue-tang and Antaegumchul-tang treated groups were significantly increased than that of control However, the litter size of the Kungso-san treated mice was significantly decreased compared with that of the control group. Compared with the control and other herbal treated groups, the mean weight of fetuses after parturition in the Kyoaekungkue-tang and Antaegumchul-tang treated groups increased significantly. Conclusions : From these results, it can be concluded that Antaegumchul-tang showed more beneficial effects on the reproductive functions, implantation, maintenance of pregnancy, litter size and mean weight than other herbs.

• The Journal of Korean Obstetrics and Gynecology
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• v.30 no.4
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• pp.203-212
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• 2017

Objectives: To report the efficacy of traditional Korean medicine to an infertile patient who repeatedly failed in vitro fertilization. Methods: The patient was diagnosed with adenomyosis and failed in vitro fertilization 9 times. Her dysmenorrhea and physical symptoms were improved through traditional Korean medicine and she was pregnant with the 10th attempt of in vitro fertilization. She had bleeding during pregnancy due to adenomyosis and took herbal medicines to maintain stable condition. Results: During the treatment period, the uterine thickness due to adenomyosis was reduced and her dysmenorrhea was improved. She was pregnant by in vitro fertilization and gave birth to a healthy child by Caesarean section. Conclusions: This case report shows that traditional Korean medical treatments work to improve the success rate of in vitro fertilization.