• 지질공학
• /
• 제32권1호
• /
• pp.41-57
• /
• 2022

본 연구는 부산 기장지역에 분포하는 백악기 흑운모 화강암에 대한 사례연구를 통하여 DFN(discrete fracture network) 유동해석 기반의 REV(representative elementary volume) 크기 및 삼차원 수리전도텐서 추정을 위한 워크플로우를 제시하였다. 연구지역을 대표하는 이차원 DFN에 대하여 절리텐서의 일차불변량을 이용하여 절리의 빈도 및 길이가 보정되었다. 현장수압시험을 수행하여 선형의 등가유로관으로 취급된 현장의 절리에 대한 유효수리간극이 추정되었다. 연구지역의 이차원 DFN 블록에 대한 REV의 크기는 블록 크기에 따른 지향적 블록수리전도도의 변화를 분석하여 20 m × 20 m으로 결정하였다. 연구지역의 이차원 DFN에 대하여 산정된 지향적 블록수리전도도는 현장의 수리적 거동과 관련하여 강한 이방성을 지시한다. 다양한 방향으로의 이차원 DFN에서 산정된 지향적 블록수리전도도를 바탕으로 연구지역의 절리성 암반에 대한 삼차원 수리전도텐서가 추정되었다. 삼차원 수리전도텐서의 주성분 방향은 현장에서 구분된 주 절리군의 방향과 일치한다.

• Journal of Korean Neurosurgical Society
• /
• 제59권3호
• /
• pp.306-309
• /
• 2016

Using diffusion tensor tractography (DTT), we demonstrated injury of the arcuate fasciculus (AF) in the nondominant hemisphere in two patients who showed subfalcine herniation after intracerebral hemorrhage (ICH) in the dominant hemisphere. Two patients (patient 1 and patient 2) with ICH and six age-matched control patients who have ICH on the left corona radiata and basal ganglia without subfalcine herniation were recruited for this study. DTT was performed at one month after onset in patient 1 and patient 2. AFs of both hemispheres in both patients were disrupted between Wernicke's and Broca's areas. The fractional anisotropy value and tract numbers of the right AFs in both patients were found to be more than two standard deviations lower than those of control patients. In contrast, the apparent diffusion coefficient value was more than two standard deviations higher than those of control patients. Using the configuration and parameters of DTT, we confirmed injury of the AF in the nondominant hemisphere in two patients with subfalcine herniation following ICH in the dominant hemisphere. Therefore, DTT would be a useful tool for detection of underlying injury of the AF in the nondominant hemisphere in patients with subfalcine herniation.

• 터널과지하공간
• /
• 제21권3호
• /
• pp.174-180
• /
• 2011

횡등방성 암석의 강도해석에 활용할 목적으로 이방성 Mohr-Coulomb 파괴조건식을 제안하였다. 제안된 파괴조건식에서는 Pietruszczak & Mroz(2001)가 제안한 조직텐서를 도입하여 마찰각과 점착력을 조직텐서의 스칼라함수로 정의하였다. 두 강도정수의 이방성은 주응력좌표계와 재료 주좌표계의 상대적 회전을 바탕으로 계산된다. 이방성 파괴조건식을 최대로 하는 임계면을 찾는 방법이 Lagrange 승수법에 기초하여 제안되었다. 수치삼축압축 시험을 실시한 후 삼축압축강도와 파괴면 경사각 분석을 통하여 제안된 이방성 파괴함수의 성능을 검증하였다.

• The Journal of Korean Physical Therapy
• /
• 제35권6호
• /
• pp.190-194
• /
• 2023

Purpose: Traumatic brain injury (TBI) refers to brain damage caused by external forces or trauma. TBIs can vary in severity and result from accidents, falls, sports injuries, assaults, or other forms of physical trauma. The prefrontal cortex (PFC) is known have roles in various cognitive functions. We report on a patient with traumatic brain injury who showed prefrontal symptoms after injury of thalamocortical connections between mediodorsal nuclei (MD) of thalamus and PFC. Methods: A 54-year-old, male patient suffered a TBI as a result of a heavy object falling on his head. After onset of TBI, he showed typical symptoms of prefrontal lobe injury, including personality changes, memory impairment, and general cognition problem. The thalamocortical connections between MD and PFC (ventrolateral prefrontal cortex (VLPFC), dorsolateral prefrontal cortex (DLPFC), and obrbitofrontal cortex (OFC)) were reconstructed using diffusion tensor tractography. In terms of fractional anisotropy value, the right thalamocortical connections to the OFC were significantly lower than those of control subjects. Results: The value of mean diffusivity in the right thalamocortical connections to the DLPFC was significantly higher than that of control subjects. By contrast, both VLPFC and left OFC showed significant decrement in the tract volume of thalamocortical connections compared with that of control subjects. Conclusion: We reported on a patient who showed cognitive and neuropsychiatric impairment due to global injury of the thalamocoritcal connections between MD and PFC following TBI.

• 한국방사선학회논문지
• /
• 제16권5호
• /
• pp.575-583
• /
• 2022

AUDIT(Alcohol Use Disorders Identification Test)에서 정상 음주자, 위험 음주자 및 알코올 사용 장애자로 분류하여 뇌 백질 영역의 ROI(Region Of Interest)에 대한 FA 측정값을 분석하였다. TBSS(Tract-Based Spatial Statics) 도구를 사용하여 ROI의 FA 값을 추출하였다. TBSS라는 도구는 뇌 회백질보다는 백질에 대한 FA값과 MD 값의 민감도가 더 높고 뇌 신경섬유의 비등방도를 정량적으로 도출해 낼 수 있는 장점이 있고 백질에 더 특화된 프로그램이라 할 수 있다. 특히 양쪽 맥락총 평균 차이가 높았고 정상 음주자에서는 FA의 평균값이 0.2831과 0.2872로 나타났으며, 알코올 사용 장애자의 경우 0.1972와 0.1936로 나타났다. 즉, AUDIT 척도에서 점수가 높을수록 뇌 백질의 계측한 모든 ROI 영역에서 FA 값이 더 낮게 측정되는 것을 알 수 있었으며 뇌 백질에 신경 섬유로의 손상에 대한 미세구조 변화를 확인할 수 있었다. AUDIT 척도를 사용하여 DTI의 FA 값에 대한 지침을 제시할 수 있으며 혈액학적 인자의 가이드인 처럼 FA 값을 산정한다면 알코올 사용 장애자의 선별 및 진단에 유용한 검사법이라 사료 된다.

• Journal of Korean Neurosurgical Society
• /
• 제38권5호
• /
• pp.331-337
• /
• 2005

Objective : The purpose of this study is to identify correlations between diffusion tensor imaging[DTI] and motor improvement by quantifying and visualizing the corticospinal tract on DTI to predict motor impairment in patients with hypertensive intracerebral hemorrhage[ICH]. Methods : Fifteen normal subjects and 7 patients with hypertensive ICH were examined and the latter were treated surgically. DTI was performed with a 3.0 T MRI. The region of interest[ROI] from the posterior limbs of both internal capsules was measured on a fractional anisotropy[FA] map, and the ratios of ROIs were calculated. Tractography, 3-dimensional DTI was then constructed. Motor impairment was assessed on admission and 2weeks after stroke by the Motricity Index[MI]. The FA ratio, tractography and score on MI were analyzed for correlations. Results : The FA ratio from the initial DTI did not show a linear correlation with motor impairment. However, after 2weeks, patients with high FA ratios showed high degrees of motor recovery, regardless of the initial severity, and patients with low FA ratios showed low recovery rates. Otherwise, a relationship between the amount of hematoma and the degree of motor recovery could not be determined. On tractography, injury of the corticospinal tract could be visualized and estimated 3-dimensionally. Conclusion : FA ratio analysis and tractography constructed from DTI may be useful in understanding corticospinal tract injury and in predicting the recovery from motor impairment in patients.

• 지질공학
• /
• 제10권1호
• /
• pp.13-25
• /
• 2000

단열암반의 수리전도도 텐서를 계산하고 이방성에 대한 정량적인 평가를 수행하기 위해서 단열의 수리적, 기하학적 통계 특성에 근거하여 3차원 단열연결망 모델을 구성하였다. 현장에서 수행된 단정주입시험의 수치모델링을 통해 계산된 수리전도도는 현장시험 결과와 비교적 잘 일치하였다. 따라서 구성된 3차원 단열 연결망 모델이 해석대상 암반의 수리 특성을 구현할 수 있음을 확인하였다. 대상암반의 대표요소체적 규모에서 계산된 블록 수리전도도는 단정주입시험에서 구한 수리전도도의 산술과 조화 평균 사이의 값이며, 2차원 수평단면상에서 남-북 방향의 수리전도도는 동-서 방향에 비해서 약 1.4 배로써 이방성은 크지 않았다. 블록 수리전도도와 단정 주입시험 모델링을 통해 구한 수리전도도의 상관성은 낮게 나타났다. 이는 단정 주입시험 모델링을 통한 암반의 수리전도도는 시추공의 패커구간과 교차하는 단열의 수와 투수량계수에 큰 영향을 받기 때문인 것으로 분석된다.

• The Korean Journal of Pain
• /
• 제33권3호
• /
• pp.275-283
• /
• 2020

Background: Previous studies showed neurography and tractography of the greater occipital nerve (GON). The purpose of this study was determining diffusion tensor imaging (DTI) parameters of bilateral GONs and dorsal root ganglia (DRG) in unilateral cervicogenic headache as well as the grading value of DTI for severe headache. The correlation between DTI parameters and clinical characteristics was evaluated. Methods: The fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values in bilateral GONs and cervical DRG (C2 and C3) were measured. Grading values for headache severity was calculated using a receiver operating characteristics curve. The correlation was analyzed with Pearson's coefficient. Results: The FA values of the symptomatic side of GON and cervical DRG (C2 and C3) were significantly lower than that of the asymptomatic side (all the P < 0.001), while the ADC values were significantly higher (P = 0.003, P < 0.001, and P = 0.003, respectively). The FA value of 0.205 in C2 DRG was considered the grading parameter for headache severity with sensitivity of 0.743 and specificity of 0.999 (P < 0.001). A negative correlation and a positive correlation between the FA and ADC value of the GON and headache index (HI; r = -0.420, P = 0.037 and r = 0.531, P = 0.006, respectively) was found. Conclusions: DTI parameters in the symptomatic side of the C2 and C3 DRG and GON were significantly changed. The FA value of the C2 DRG can grade headache severity. DTI parameters of the GON significantly correlated with HI.

• The Korean Journal of Pain
• /
• 제32권4호
• /
• pp.271-279
• /
• 2019

Background: We utilized diffusion tensor imaging (DTI) to evaluate the cerebral white matter changes that are associated with phantom limb pain in patients with unilateral arm amputation. It was anticipated that this would complement previous research in which we had shown that changes in cerebral blood volume were associated with the cerebral pain network. Methods: Ten patients with phantom limb pain due to unilateral arm amputation and sixteen healthy age-matched controls were enrolled. The intensity of phantom limb pain was measured by the visual analogue scale (VAS) and depressive mood was assessed by the Hamilton depression rating scale. Diffusion tensor-derived parameters, including fractional anisotropy, mean diffusivity, axial diffusivity (AD), and radial diffusivity (RD), were computed from the DTI. Results: Compared with controls, the cases had alterations in the cerebral white matter as a consequence of phantom limb pain, manifesting a higher AD of white matter in both hemispheres symmetrically after adjusting for individual depressive moods. In addition, there were associations between the RD of white matter and VAS scores primarily in the hemispheres related to the missing hand and in the corpus callosum. Conclusions: The phantom limb pain after unilateral arm amputation induced plasticity in the white matter. We conclude that loss of white matter integrity, particularly in the hemisphere connected with the missing hand, is significantly correlated with phantom limb pain.

• Korean Journal of Radiology
• /
• 제21권12호
• /
• pp.1367-1373
• /
• 2020

Objective: To assess diffusion tensor imaging (DTI) parameters of the hepatic parenchyma for the differentiation of biliary atresia (BA) from Alagille syndrome (ALGS). Materials and Methods: This study included 32 infants with BA and 12 infants with ALGS groups who had undergone DTI. Fractional anisotropy (FA) and mean diffusivity (MD) of the liver were calculated twice by two separate readers and hepatic tissue was biopsied. Statistical analyses were performed to determine the mean values of the two groups. The optimum cut-off values for DTI differentiation of BA and ALGS were calculated by receiver operating characteristic (ROC) analysis. Results: The mean hepatic MD of BA (1.56 ± 0.20 and 1.63 ± 0.2 × 10^-3 mm²/s) was significantly lower than that of ALGS (1.84 ± 0.04 and 1.79 ± 0.03 × 10^-3 mm²/s) for both readers (r = 0.8, p = 0.001). Hepatic MD values of 1.77 and 1.79 × 10^-3 mm²/s as a threshold for differentiating BA from ALGS showed accuracies of 82 and 79% and area under the curves (AUCs) of 0.90 and 0.91 for both readers, respectively. The mean hepatic FA of BA (0.34 ± 0.04 and 0.36 ± 0.04) was significantly higher (p = 0.01, 0.02) than that of ALGS (0.30 ± 0.06 and 0.31 ± 0.05) for both readers (r = 0.80, p = 0.001). FA values of 0.30 and 0.28 as a threshold for differentiating BA from ALGS showed accuracies of 75% and 82% and AUCs of 0.69 and 0.68 for both readers, respectively. Conclusion: Hepatic DTI parameters are promising quantitative imaging parameters for the detection of hepatic parenchymal changes in BA and ALGS and may be an additional noninvasive imaging tool for the differentiation of BA from ALGS.