• 한국식품위생안전성학회지
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• 제20권2호
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• pp.83-88
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• 2005

1 혈액 중 중금속 분석방법을 확립하기 위하여 GF-hAS를 이용하여 microwave digestion 방법과 혈액희석법의 검출한계 및 회수율을 비교 검토한 결과 혈액희석법이 검출한계 및 회수율이 우수하였으며, 표준시료(CRM)를 이용한 시험방법에 대한 검증에서 만족스런 결과를 나타내었음. 2.중학생 300명을 대상으로 혈액 중 중금속함량을 GF-AhS를 이용하여 측정한 결과 납과 아연에서 남학생이 여학생에 비해 유의적으로 높은 수치를 보였으며,납의 함량은 남학생 약 4 ug/dL, 여학생 약 3 u즈d트으_로 WHO의 권고치 20 uUdL, 미국질병관리센터의 어린이에 대한 권고치 10 ug/dL에 미달하는 수준이었음. 3. 카드윰은 남, 여 모두 평균 0.06 ug/dl으로 WHO의 일반인 권고치 0.5 ug/dL보다 훨씬 낮은 수치를 나타내었음. 4. 또한 아연의 경우 남학생 약 106 ug/dL, 여학생 약 93 ug/dL으로 혈청 정상치인 64-118 ug/dL에 해당하는 수치이었음 5. 구리는 남 $\cdot$ 여학생 모두 약 99 ufdL로 혈청 정상치인 80-121 ug/dL범위내로 나타났음. 6. 남$\cdot$녀 학생 중 빈혈집단과 정상인과의 중금속함량을 분석한 결과 여학생의 빈혈 집단에서 정상집단 보다 납 함량이 다소 높게 나타났음(P>0.05). 7. 혈액 중 납과 철분 간에 음의 상관관계가, 납과 아연간에는 양의 상관관계가 관찰되었음(P<0.001).

• 대한영양사협회학술지
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• 제21권4호
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• pp.308-319
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• 2015

The purpose of this study was to assess risk factors associated with food insecurity in the Korean elderly aged over 65 years using data from the Korea National Health & Nutrition Examination Survey 2013 (KNHANES VI). A total of 1,200 subjects were analyzed among the participants of the KNHANES 2013 by using SPSS statistics complex samples (ver. 21.0). Food insecurity was measured by using the modified US Household Food Security/Hunger Survey Module. Thirteen percent of subjects lived in food insecure households. There were differences in the prevalence of food insecurity according to sex, educational level, income level, and household structure. Mean age of the food insecurity group was significantly higher than that of the food security group. The results of logistic regression analysis showed that food insecurity was significantly associated with alcohol intake (OR: 1.82), prevalence of melancholy (OR: 2.07) and suicidal thoughts (OR: 2.67), and intake deficiency of energy (OR: 1.60), calcium (OR: 1.97), iron (OR: 1.97), potassium (OR: 1.96), riboflavin (OR: 1.76), and niacin (OR: 1.64), while not with smoking, physical activity, chronic diseases including obesity, anemia, diabetes, and osteoarthritis, and deficiency of protein, vitamin A, thiamin and vitamin C. These findings suggest that food insecurity is strongly related to mental health and certain nutrient intakes. Prospective research is needed to establish the effects of food insecurity on chronic diseases.

• Clinical and Experimental Pediatrics
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• 제52권4호
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• pp.435-440
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• 2009

서 론 : 수용성 트랜스페린 수용체(sTfR)는 적혈구 조혈 및 철분 상태를 나타내는 지표로 이용된다. 본 연구는 급성 염증물질과 sTfR 농도와의 관계를 밝히고, 철분 부족 상태와 염증으로 인한 빈혈을 감별하는데 sTfR 농도가 유용한지를 알아보고자 한다. 방 법 : 2000년 1월부터 2006년 6월까지 경상대학교 병원 소아청소년과를 내원한 2세 미만의 영유아 144명을 대상으로 이들의 Hb, MCV, 페리틴, 수용성 트랜스페린 수용체, 염증인자[CRP, IL-6, ANC]를 측정하였다. Hb 11 g/dL 미만이고 페리틴 12 ug/L 미만인 철결핍 빈혈 환아는 조사에서 제외하였다. 결 과 : 전체 환자군에서 sTfR 농도는 Hb, 페리틴, MCV, ANC와 유의한 음의 상관관계를 보였고 CRP, IL-6 와는 상관관계를 보이지 않았다. 다중 선형 회귀 분석 시 IL-6 (r=0.078, P=0.043)는 sTfR 농도와 양의 상관관계를 보였고, ANC (r=-0.117, P=0.033), MCV (r=-0.027, P=0.009)는 음의 상관관계를 보였다. 결 론 : 영유아에서 sTfR 농도는 염증 상태에 따라 영향을 받을 수 있으므로 급성 감염에 의한 빈혈과 철결핍성 빈혈의 감별진단을 위해서 sTfR 농도를 단독으로 사용하는데 제한점이 있다.

• 혜화의학회지
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• 제25권1호
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• pp.45-52
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• 2016

Objectives : The purpose of this study is to report the clinical effects of Hominis Placenta Pharmacopunture(HPP) on Vertigo. Methods : A 82-year-old female patient whose chief complaint was Vertigo was treated with Placenta Pharmacopunture at CV6 and GB21, twelves times for a month. Acupuncture and herbal medicine were added depending on the symptoms. Laboratory test was taken and Korean Version of Dizziness Handicap Inventory was examined before and after each treatment. Results : After the treatments, the symptoms were improved. Conclusions : Hominis Placenta Pharmacopuncture may be an efficacious therapy for Iron Deficiency Anemia.

• 대한치과의사협회지
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• 제42권6호통권421호
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• pp.414-421
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• 2004

Sjogren syndrome is a chronic systemic autoimmune disorder that chiefly involves the salivary gland and the lacrimal gland, resulting in xerostomia and xerophthalmia. Although the exact cause of the disease is not early diagnosis, treatment and observation must be emphasized because of its poor prognosis, such as the high occurrence of malignant lymphoma and other autoimmune disease that may be accompanied. In the present case, a twenty-year-old woman whose chief complaint was multiple dental hard tissue loss and xerostomia, which was misdiagnosed as iron deficiency anemia at first, but through re-evaluation and differential diagnosis it was Sjogren syndrome. the diagnosis approach was discussed in this report, suggesting that Sjogren syndrome should be considered as a differential diagnosis in a with xerostomia.

• Journal of Chest Surgery
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• 제35권6호
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• pp.495-499
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• 2002

Plummer-Vinson(Paterson-Kelly) 증후군은 임상적으로 상부식도 혹은 하인두의 막양구조(web)와 이로 인한 연하곤란, 철분결핍성 빈혈, 그리고 구강점막의 위축성 변화를 동반하는 질환으로, 식도암을 유발하는 전암성 병변으로, 일반적으로 경구 철분 투여만으로 증상을 호전시키거나 내시경을 이용한 풍선확장술이나 전기소작술 치료가 주로 시행되고 있다. 본 병원에서는 63 세 여자환자에게서 나타난 상부식도의 협착을 유발한 병변에 대하여 공장 이식편을 이용한 유리이식술 치료한 후, 병리조직학적인 검사에서 상피내암종으로 진행한 Plummer-Vinson 증후군으로 판명되었기에 이를 보고하고자 한다.

• Journal of Microbiology and Biotechnology
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• 제18권2호
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• pp.299-307
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• 2008

Soybean seed ferritin is essential for human iron supplementation and iron deficiency anemia prevention because it contains abundant bioavailable iron and is frequently consumed in the human diet. However, it is poorly understood in regards its several properties, such as iron mineralization, subunit assembly, and protein folding. To address these issues, we decided to prepare the soybean seed ferritin complex via a recombinant DNA approach. In this paper, we report a rapid and simple Escherichia coli expression system to produce the soybean seed ferritin complex. In this system, two subunits of soybean seed ferritin, H-2 and H-1, were encoded in a single plasmid, and optimal expression was achieved by additionally coexpressing a team of molecular chaperones, trigger factor and GroEL-GroES. The His-tagged ferritin complex was purified by $Ni^{2+}$ affinity chromatography, and an intact ferritin complex was obtained following His-tagged enterokinase (His-EK) digestion. The purified ferritin complex synthesized in E. coli demonstrated some reported features of its native counterpart from soybean seed, including an apparent molecular weight, multimeric assembly, and iron uptake activity. We believe that the strategy described in this paper may be of general utility in producing other recombinant plant ferritins built up from two types of subunits.

• 정보와 통신
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• 제24권4호
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• pp.27-35
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• 2007

음성 통신을 할 때 배경 잡음이 존재하게 되면 일반적으로 음질이 저하된다. 이것은 잡음 자체가 듣기 싫다거나 음성을 더 작게 들리게 만들기 때문이기도 하고 음성 코덱이 잡음이 섞이지 않은 깨끗한 음성에 최적화되어 있어서 잡음이 섞인 음성에 대한 코딩 효율이 떨어지기 때문이기도 하다. 이 논문에서는 잡음에 의한 음성 통신의 품질 저하를 막기 위한 방법으로서 음성 향상(speech enhancement) 기술과 음성 강화(speech reinforcement) 기술에 대해 소개한다. 음성 향상 기술이란 전송부의 마이크에서 녹음된 잡음과 음성이 섞인 입력 음성으로부터 깨끗한 음성을 추정하는 기술을 말한다. 음성 향상 기술은 상당히 오랜 기간 동안 연구되어 온 기술이며, 최근에는 각 파라미터의 분포에 의존하는 방법보다 확률 모델에 기반한 방법이 각광을 받고 있으며 인간의 청각 특성을 고려한 음성 향상 방법도 제안되고 있다. 음성 강화 기술이란 수신단에서 주변 잡음에 따라 전송되어 온 음성을 주파수별로 증폭하여 더 잘 들리도록 만드는 기술이다. 음성 향상이 내 주위의 잡음이 상대방에게 들리는 음성에 미치는 영향 혹은 상대방 주변의 잡음이 나에게 들리는 소리에 미치는 영향을 줄여주는 기술이라면 음성 강화는 내 주위의 잡음이 나에게 들리는 음성에 미치는 영향을 상쇄해 주는 기술이다. 이 경우 주변 잡음은 어떤 전자 시스템도 거치지 않고 귀로 직접 들어오기 때문에 잡음 자체를 줄여 주는 것은 힘들고 전송되어 온 음성을 적절히 증폭 혹은 변형함으로써 귀에 들리는 음질 또는 명료성을 개선하게 된다. 이 논문에서는 통계 모델을 기반으로 한 음성 향상 기법과 인간의 청각 특성을 고려한 음성 향상 기법, 그리고 음성 강화 기법에 대해 설명한다.을 시도한 결과 안정적이고 반복 가능한 급성 심부전 모델을 얻을 수 있었다. bench scale실험결과와 같이 AOC는 배수관망에서의 박테리아 증식과 크게 상관관계를 갖고 있는 것으로 밝혀졌다.)', 'have a headache (2.10±0.79)', 'poor memory (2.09±0.83)', 'no appetite (1.99±0.85)', As for the correlation between iron parameter and clinical symptoms related to anemia, the hematocrit rate was negatively correlated with 'get a cold easily', 'pale face', 'feeling blue', 'difficult digestion' (p<0.05). The level of iron was negatively correlated with 'tired out easily', 'get a cold easily' (p<0.05) and TS (%) were negatively correlated with 'tired out easily (p<0.05)', 'get a cold easily (p<0.01). Our study resulted that the prevalence of a iron deficiency of a middle school girl is very high, therefore the guidelines for iron supplementation and nutritional education to improve their iron status should be provided.한 질소제거를 N-balance로부터

• Journal of Nutrition and Health
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• 제13권2호
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• pp.82-91
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• 1980

The aim of this study was to define the range of the menstrual blood loss(MBL), and the upper limit of the MBL associated with iron deficiency anemia in Korean women, For this purpose, healthy unmarried women between the age of 15 to 26 years were selected from July to September, 1979 and results obtained were used for determining baseline MBL and its relationship to iron nutriture. One houndred forteen women were tested for their MBL and hematological and biochemical data such as hemoglobin(Hb) concentration, hematocrit, mean corpuscular hemoglobin concentration(MCHC), and serum iron and ferritin concentration. This study was partly supported by World Health Organization. The results of this study are summarized as follows: 1) The mean values and standard error of mean of MBL were $30.7{\pm}2.19ml$ for total subjects, $30.4{\pm}3.14ml$ for sutjects below 20 years of age and $30.3{\pm}2.49ml$ for subjects aged more than 20 years. No significant variation was noted for amount of MBL between two age groups. 2) The median value and 95th percentile value of MBL were 26.5ml and 69.0ml respectively for total subjects. Maximum number (24.6%) of the subjects fell in group with 10-20ml of MBL while 10.5% showed MBL above 50m1. 3) Mean value of the duration of menstruation for total subjects was 4.34 days. 4) It was observed that mean values of Hb concentration, hematocrit and MCHC were decreased slightly in subjects showing MBL more than 40m1. Serum iron and ferritin levels were markedly decreased in women with MBL above 40m1 and 20-30ml, respectively. 5) In subject population showing MBL above 50ml, the frequency of subjects with hematological and biochemical data below anemia criteria were remarkably increased. 6) Although the number of subjects tested was small and the subject selection was not done by random stratified sampling from a population group, this study suggested that the upper normal limit of MBL of Korean women seems to be in the range of 40-50ml.

• Journal of Community Nutrition
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• 제5권1호
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• pp.44-50
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• 2003

The iron status and its relations with nutrient intake, coffee drinking, and cigarette smoking were evaluated through the blood analysis and 3-day dietary recalls in 102 apparently healthy Korean adults (48 males, 54 menstruating females) aged 20-49 years and living in Daejeon City. Mean values of hemoglobin (Hb) in males and females were 15.5g/dL and 13.2g/dL, mean corpscular hemoglobin concentration (MCHC) 36.0% and 36.8 %, serum iron (SI) 135 $\mu\textrm{g}$/dL and 97 $\mu\textrm{g}$/dL, transferrin saturation (TS) 39.4% and 29.2%, and serum ferritin (Ft) 88.1 $\mu\textrm{g}$/L and 23.4 $\mu\textrm{g}$/L, respectively. For males the prevalences of abnormal values of iron status indicators were 4.2% in Hb, 2.1% in TS, and 4.2% in Ft, and for females 16.7% in Hb, 25.9% in TS, and 35.2% in Ft. Among females 9.3% had abnormal Ft, TS, and Hb, which was considered as iron-defeciency anemia, and 14.8% had abnormal Ft and TS. As a whole, the impaired iron status prevalences were estimated to be 2.1 - 4.2% for males and 9.3 - 35.2% for females. Mean daily intakes of iron and heme-iron were 13.7mg and 1.51mg in males, and 12.3mg and 1.45mg in females. Ft was positively correlated with dietary energy, protein, iron, and vitamin A, Hb with energy and iron, and MCHC with iron and heme iron. Vitamin A also tended to show positive correlations with Hb, SI, and TS. Coffee drinkers taking 3 cups per day or more had higher levels of Hb, MCHC, and Ft in males and MCHC in females, compared to non-coffee drinkers. Higher levels of Hb and MCHC were found in male smokers than in non-smokers. Coffee drinkers took more energy and vitamin A in males and MPF protein in females than non-coffee drinkers. From the above results, it was suggested that the iron status of men was much better than that of women, and the intakes of energy, iron, heme iron, and especially vitamin A were positively associated with the iron status. Cigarette smoking elevated Hb and MCHC, but the effect of coffee drinking on iron staus was not clear. (J Community Nutrition 5(1) : 44∼50, 2003)