• 대한암한의학회지
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• 제16권1호
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• pp.41-53
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• 2011

Background and Objectives: Iodine is an essential constituent of the thyroid hormones associated with the growth and development of humans and animals as an inorganic nutrition. This element may be accumulated in human blood, tissues and body through the intake of foodstuffs, a beverage, a nutritional supplement and a medicine, among others. The aim of the research is to find out a better medicinal stuff for the thyroid cancer patient who required a low level of iodine diet. Methods: Neutron activation analysis (NAA) used for the iodine analysis is one of nuclear analytical techniques using radiation and radioisotopes and very useful as sensitive analytical technique for performing both qualitative and quantitative multi-elemental non-destructive analysis of major, minor and trace components in variety of environmental and biological materials. In this study, iodine contents in ten kinds of oriental herb medicinal products, which is frequently used to cancer patients are determined by using instrumental neutron activation analysis (INAA) at the HANARO research reactor. The samples prescribed are manufactured as powdered form for taking medicine easily. The analytical quality control is performed to assure an uncertainty of the measurement and to compensate the measured data using a biological certified reference material, NIST SRM 1572, Citrus Leaves. The measured value is $1.89{\pm}0.35mg/kg$, and the relative error is 2.88%, and relative standard deviation is 19 % due to high counting error by small counts of gamma ray spectrum. The standard deviations for other elements such as Cl, K, Mn and Na were in the range of 2 to 8%. Result: The level of iodine contents of Biki-huan, Chungryong-huan and Chungcho-huan, samples detected is less than 6 mg/kg except Hangam Plus sample (more than 210 mg/kg) and six samples were not detected. Iodine in the samples of Shoxiho-tang, Shopunghualhyl-tang, Shocungryong-tang, Banhasaxim-tang, Insampaedox-san and Myunyuk Plus were not measured, but possible level of content can be estimated from the detection limits. In addition, the concentrations of some major elements like Cl, K, Mn, Na, in the samples were determined with the detection limits. Conclusions: Most of samples showed low iodine contents of less than 6 mg/kg but it turned out that most of testing samples can be used to classify the level of iodine diet samples considering the recommended low level of iodine diet 50 ${\mu}g$/day, and a better medicinal stuff for the thyroid cancer patient can be found.

• 대한화학회지
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• 제55권1호
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• pp.63-69
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• 2011

이 작업은 수송체로서 N,N'-bis(2-hydroxybenzyl)-1,3-diaminopropane (L1)과 N,N'-bis(2-hydroxybenzyl)-2,2-dimethyl-1,3-diaminopropane (L2)에 기초한 $Ag^+$ 이온-선택 전극의 제조, 개발 그리고 전압반응에 대해 토의한다. $Ag^+$에 대하여 L1에 기초한 전극은 58.7 mV/dec에 도달하는 안정한 Nernst에 가까운 기울기와 $1.0{\times}10^{-6}M$의 검출한계를 갖는 등급의 최소 다섯가지 순서의 선형범위에서 최적의 전압 반응 특징을 보이는 것을 나타낸다. 제안된 전극은 다른 테스트한 양이온과 비교하여 $Ag^+$에 우위의 선택성을 보였다. 훌륭한 전압 분석적 특징은 중요한 진짜 샘플에서 은의 순도분석의 성공적인 응용을 이끌 것이다. 그리고 그것은 제안된 $Ag^+$-ISE가 측정 능력의 중요한 진보를 보여준다는 것을 나타내고 있다. 그러나 L2에 기초한 전극에 대해서는, 약한 전압 반응 특징들이 전체 실험 과정에서 관측되었다.

• 한국구조물진단유지관리공학회 논문집
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• 제25권6호
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• pp.50-59
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• 2021

현재 공용중인 교량에 대한 재하시험으로 계측한 응답과 초기해석모델의 해석 응답을 비교하여 응답보정계수를 계산하고, 이 모델을 사용하여 내하율과 내하력을 평가하는 방법을 적용하고 있다. 그러나 이러한 응답보정계수는 계측 위치와 하중 조건에 따라 변동하는 값을 준다. 특히 초기해석모델이 교량의 거동에 합당하지 않은 경우, 그 변동 폭이 크며 보정된 모델에 의한 해석 응답이 계측된 응답과 동떨어진 결과를 줄 수 있다. 본 연구에서는 저속으로 주행하는 차량의 다양한 하중 조건에서 동적 성분을 제거한 정적 응답을 얻기 위해 의사정적재하시험법을 적용하였다. 두 개의 유사한 PSC-I 거더교에서 정적 응답을 계측하고, 두 교량 각각에 대한 변위와 변형률에 대한 응답보정계수를 계산하였다. 초기해석모델이 제대로 설정되어 있지 않다면, 평균적으로 구한 응답보정계수로 보정한 모델의 해석 응답이 계측 응답과 오차범위 내에 들어오는지 않음을 확인하였다.

• 한국해양환경ㆍ에너지학회지
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• 제14권3호
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• pp.205-211
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• 2011

해수 중의 수소이온농도(pH)와 총알칼리도(TA) 측정 방법에 대한 선상 비교 연구가 동해 표층에서 저층에 이르는 약 550개의 실제 해수 시료에 대해 이루어졌다. 분광광도법과 전위차법에 대한 pH의 비교가 이루어졌으며, 두 방법에 의한 해수의 pH는 전반적으로 잘 일치하였으나, pH가 낮은 심층의 경우 피펫을 사용한 분광법에 의한 값이 전위차법 보다 높은 값을 보였다. 그러나 피펫을 사용하지 않은 분광법과는 두 방법의 정밀도 내에서 동일한 값을 보였다. 이는 피펫에 의해 해수 내의 이산화탄소가 제거되면서 시료 내의 pH를 증가시키는 것으로 판단된다. TA 측정법의 비교를 위해 폐쇄 용기를 이용한 전위차법과 개방 용기를 이용한 전위차법이 사용되었으며, 개방형 용기를 사용했을 때의 값이 폐쇄형 용기를 사용했을 때의 값에 비해 약 5~10 ${\mu}mol\;kg^{-1}$ 작은 값을 보인다. 이는 폐쇄형 용기를 사용했을 때, 적정 도중에 발생하는 이산화탄소가 용액 속에 남아 적정액인 염산 이외의 산을 용액 속에 추가하는 효과를 내기 때문으로 판단된다. 따라서 pH혹은 TA의 분석에 있어서 본 연구에서 비교한 어느 방법을 사용할 수도 있지만 각각의 방법에 대해 특별히 요구되는 주의를 기울일 때 만족할 만한 분석결과를 얻을 수 있다.

• 대한의용생체공학회:의공학회지
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• 제41권2호
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• pp.67-74
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• 2020

Brain tumors or gliomas are fatal cancer species with high recurrence rates due to their strong invasiveness. Therefore, the goal of surgery is complete tumor resection. However, the surgery is difficult to distinguish the border because tumors and blood vessels have the same color tone and shape. The fluorescein sodium is used as a fluorescence contrast agent for boundary separation. When the external light source is irradiated, yellow fluorescence is expressed in the tumor, which helps distinguish between blood vessels and tumor boundaries. But, the fluorescence expression of fluorescence sodium depends on the concentration of fluorescein sodium and such analytical data is insufficient. The unclear fluorescence can obscure the boundaries between blood vessels and tumors. In addition, reduce the efficiency of fluorescence sodium use. This paper proposes a protocol of concentration range for fluorescence expression conditions. Fluorescent expression was observed using a near-infrared (NIR) color camera with corresponding dilution using normal saline in 1 ml microtube. The flunoresence emission density range is 1.00 mM to 0.15 mM. The fluorescence emission begin to 1.00 mM and the 0.15 mM discolor. The discolor is difficult to fluorescence emission condition obserbation. Thus, the maximum density range of the bright fluoresecein is 0.15 mM to 0.30 mM. When the concentration range of fluorescein sodium is analyzed based on the gradient of fluorescence expression and the power measurement, the brightest fluorescence is expected to facilitate the complete resection of the tumor. For the concentration range protocol, setting concentration ranges and analyzing fluorescence expression image according to saturation and brightness to find optimal fluorescence concentration are important. Concentration range protocols for fluorescence expression conditions can be used to find optimal concentrations of substances whose expression pattern varies with concentration ranges. This study is expected to be helpful in the boundary classification and resection of brain tumors and glioma.

• Structural Engineering and Mechanics
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• 제46권2호
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• pp.245-267
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• 2013

During preliminary design of a RC building located in a seismic area, having quick but reliable analytical measurement of interstory drifts and storey stiffnesses might be helpful in order to check the fulfillment of damage limit state and stiffness regularity in elevation required by seismic design codes. This paper presents two approximate methods, strongly interrelated each other, and addressed to achieve each of these two purposes for frame buildings. A brief description of some already existing methods addressed to the same aims is included to compare the main differences in terms of general approaches and assumptions. Both new approximate methods are then applied to 9 'ideal' frames and 2 'real' buildings designed according to the Italian seismic code. The results are compared with the 'exact' values obtained by the code-based standard calculation, performed via FEM models, showing a satisfactory range of accuracy. Compared with those by the other methods from literature, they indicate the proposed procedures lead to a better approximation of the objective structural parameters, especially for those buildings designed according to the modern 'capacity design' philosophy.

• Macromolecular Research
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• 제15권4호
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• pp.330-336
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• 2007

Luminescent CdSe/ZnS QDs, with emission in the red region of the spectrum, were synthesized and encapsulated in poly(ethylene glycol)-poly(D,L-lactide) diblock copolymer micelles, to prepare water-soluble, bio-compatible QD micelles. PEG-PLA diblock copolymers were synthesized by ring opening polymerization of D,L-lactide, in the presence of methoxy PEG as a macro initiator. QDs were encapsulated with PEG-PLA polymers using a solid dispersion method in chloroform. The resultant polymer micelles, with encapsulated QDs, were characterized using various analytical techniques, such as UV- Vis measurement, light scattering, fluorescence spectroscopy, transmission electron microscopy (TEM) and atomic forced microscopy (AFM). The polymer micelles, with encapsulated QDs, were spherical and showed diameters in the range of 20-150 nm. The encapsulated QDs were highly luminescent, and have high potential for applications in biomedical imaging and detection.

• 한국공간구조학회논문집
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• 제16권1호
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• pp.35-42
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• 2016

Until recently, almost all ETFE film structures that have been erected is the cushion type because there are problems at lower allowable strength under elastic range and viscosity behaviour such as creep and relaxation of ETFE films under long-term stresses. But the number of tension type structures is currently increasing. This paper proposes the stretch fabrication of ETFE film to verify the applicability of ETFE films to tensile membrane structures. First of all, to investigate the possibility of application on tensile membrane structures, the stretch fabrication test is carried out, and it is verified that it is possible to increase the yield strength of the film membrane structures. After simulating the experiment also carries out an analytical investigation, and the effectiveness of the elasto-plastic analysis considering the viscous behavior of the film is investigated. Finally, post-aging tension measurement is conducted at the experimental facilities, and the viscosity behavior resulting from relaxation is investigated with respect to tensile membrane structures.

• 한국해양공학회지
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• 제19권6호통권67호
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• pp.58-63
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• 2005

The estimation of springing responses for recent ships is carried out, and application to a ship design is described. To this aim, springing effects on hull girder were re-evaluated, including non-linear wave excitations and torsional vibrations of the hull. The Timoshenko beam model was used to calculate stress distribution on the hull girder, using the superposition method. The quadratic strip method was employed to calculate the hydrodynamic forces and moments on the hull. In order to remove the irregular frequencies, we adopted 'rigid lid' on the hull free surface level, and addedasymptotic interpolation along the high frequency range. Several applications were carried out on the following existing ships: The Bishop and Price's container ship, S-175 container ship, large container, VLCC, and ore carrier. One of them is compared with the ship measurement result, while another with that of the model test. The comparison between the analytical solution and the numerical solution for a homogeneous beam-type artificial ship shows good agreement. It is found that Most springing energy comesfrom high frequency waves for the ships having low natural frequency and North Atlantic route etc. Therefore, the high frequency tail of the wave spectrum should be increased by $\omega$$\^{-3}$ instead of $\omega$$\^{-4}$ or $\omega$$\^{-5}$ for the springing calculation.

• 대한수의학회지
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• 제50권1호
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• pp.11-17
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• 2010

Linear and non-linear regressions were used to derive the calibration function for the measurement of roxithromycin plasma concentration. Their results were compared with weighted least squares regression by usual weight factors. In this paper the performance of a non-linear calibration equation with the capacity to account empirically for the curvature, y = ax$^{b}$ + c (b $\neq$ 1) is compared with the commonly used linear equation, y = ax + b, as well as the quadratic equation, y = ax$^{2}$+ bx + c. In the calibration curve (range of 0.01 to 10 ${\mu}g/mL$) of roxithromycin, both heteroscedasticity and nonlinearity were present therefore linear least squares regression methods could result in large errors in the determination of roxithromycin concentration. By the non-linear and weighted least squares regression, the accuracy of the analytical method was improved at the lower end of the calibration curve. This study suggests that the non-linear calibration equation should be considered when a curve is required to be fitted to low dose calibration data which exhibit slight curvature.