• Title/Summary/Keyword: Analytical Techniques

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Comparison of Expression Profiling of Gastric Cancer by O1igonucleotide and cDNA Microarrays (O1igonucleotide Microarray와 cDNA Microarray를 이용한 위암조직의 대단위 유전자 발현 비교)

  • Jung, Kwang-Hwa;Kim, Jung-Kyu;Noh, Ji-Heon;Eun, Jung-Woo;Bae, Hyun-Jin;Lee, Sug-Hyung;Park, Won-Sang;Yoo, Nam-Jin;Lee, Jung-Young;Nam, Suk-Woo
    • YAKHAK HOEJI
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    • v.51 no.3
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    • pp.179-185
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    • 2007
  • Gastric cancer is one of the most common malignancies in Korea, but the predominant molecular event underlying gastric carcinogenesis remain unknown. Recently, DNA microarray technology has enabled the comprehensive analysis of gene expression level, and as such has yielded great insight into the molecular nature of cancer, However, despite the powerful approach of this techniques, the technical artifacts and/or bias in applied array platform limited the liability of resultant tens of thousand data points from microarray experiments. Therefore, we applied two different any platforms, such as olignucleotide microarray and cDNA microarray, to identify gastric cancer related large-scale molecular signature of the same human specimens. When thirty sets of matched human gastric cancer and normal tissues subjected to oligonucleotide microarray, total 623 genes were resulted as differently expressed genes in gastric cancer compared to normal tissues, and 252 genes for cDNA microarray analysis. In addition, forty three outlier genes which reflect the characteristic expression signature of gastric cancer beyond array platform and analytical protocol was recapitulated from two different expression profile. In conclusion, we were able to identify robust large-scale molecular changes in gastric cancer by applying two different platform of DNA microarray, this may facilitate to understand molecular carcinogenesis of gastric cancer.

A Study on the Safety Assessment of Elementary School Environment in Korea (우리나라 신도시 초등학교의 통학로 안전환경 비교분석에 관한 연구)

  • Yoon, Yong-Gi
    • The Journal of Sustainable Design and Educational Environment Research
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    • v.14 no.2
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    • pp.26-36
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    • 2015
  • The new town was assumed that there is a difference between the country's elementary school environment. First, given the important elements of the school safety plan in order to verify this, and we plan to set up each of these elements by safety criteria. In the second chapter in order to achieve the objective of this study was to develop indicators to evaluate the safety of the school environment influences the safety of the school environment through the theoretical consideration. In Chapter 3, the difference in safety through the new elementary school survey of metropolitan areas was given a score per item per item depending on the evaluation criteria. The fourth section is the difference between safety school environment can be summarized as the following analytical results that the difference between the new city. The results of this study as follows: First, the characteristics of the elementary school environment showed a significant difference between the new town. Second, school location, terrain characteristics, bike paths and pedestrian to the installation, the safety of landscape installations, installing median barriers, traffic safety facilities, speed bumps, separation of pedestrian and vehicle circulation in the front door, scores of elements of the plan such as parking scheme there is a difference between the new town. Third, the introduction of elements of the plan such as Traffic calming or Traffic Island installation techniques was found lacking.

An Investigation on Expanding Co-occurrence Criteria in Association Rule Mining (온라인 연관관계 분석의 장바구니 기준에 대한 연구)

  • Kim, Mi-Sung;Kim, Nam-Gyu
    • CRM연구
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    • v.4 no.2
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    • pp.19-29
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    • 2011
  • There is a large difference between purchasing patterns in an online shopping mall and in an offline market. This difference may be caused mainly by the difference in accessibility of online and offline markets. It means that an interval between the initial purchasing decision and its realization appears to be relatively short in an online shopping mall, because a customer can make an order immediately. Because of the short interval between a purchasing decision and its realization, an online shopping mall transaction usually contains fewer items than that of an offline market. In an offline market, customers usually keep some items in mind and buy them all at once a few days after deciding to buy them, instead of buying each item individually and immediately. On the contrary, more than 70% of online shopping mall transactions contain only one item. This statistic implies that traditional data mining techniques cannot be directly applied to online market analysis, because hardly any association rules can survive with an acceptable level of Support because of too many Null Transactions. Most market basket analyses on online shopping mall transactions, therefore, have been performed by expanding the co-occurrence criteria of traditional association rule mining. While the traditional co-occurrence criteria defines items purchased in one transaction as concurrently purchased items, the expanded co-occurrence criteria regards items purchased by a customer during some predefined period (e.g., a day) as concurrently purchased items. In studies using expanded co-occurrence criteria, however, the criteria has been defined arbitrarily by researchers without any theoretical grounds or agreement. The lack of clear grounds of adopting a certain co-occurrence criteria degrades the reliability of the analytical results. Moreover, it is hard to derive new meaningful findings by combining the outcomes of previous individual studies. In this paper, we attempt to compare expanded co-occurrence criteria and propose a guideline for selecting an appropriate one. First of all, we compare the accuracy of association rules discovered according to various co-occurrence criteria. By doing this experiment we expect that we can provide a guideline for selecting appropriate co-occurrence criteria that corresponds to the purpose of the analysis. Additionally, we will perform similar experiments with several groups of customers that are segmented by each customer's average duration between orders. By this experiment, we attempt to discover the relationship between the optimal co-occurrence criteria and the customer's average duration between orders. Finally, by a series of experiments, we expect that we can provide basic guidelines for developing customized recommendation systems.

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Stability Analysis and Reliability Evaluation of the Pretensioned Soil Nailing System (프리텐션 쏘일네일링 시스템의 안정해석 및 신뢰도 분석)

  • 김홍택;강인규;박사원;고용일;권영호
    • Journal of the Korean Geotechnical Society
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    • v.15 no.2
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    • pp.105-127
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    • 1999
  • Application of the soil nailing method is continuously extended in maintaining stable excavations and slopes. Occasionally, however, ground anchor support system may not be used because of space limitations in urban excavation sites nearby the existing structures. In this case, soil nailing system with relatively short length of nails could be efficiently adopted as an alternative method. The general soil nailing support system, however, may result in excessive deformations particularly in an excavation zone of the existing weak subsoils. Pretensioning the soil nails then, could play important roles in reducing deformations mainly in an upper part of the nailed-soil excavation system as well as improving local stability. In the present study, the analytical procedure and design technique are proposed to evaluate maximum pretension force and stability of the pretensioned soil nailing system. Also proposed are techniques to determine the required thickness of a shotcrete facing and to estimate probability of a failure against the punching shear. The predicted results are compared with the limited measurements obtained from the excavation site constructed by using the pretensioned soil nails. Based on the proposed procedure and technique, effects of the radius of a influence circle and dilatancy angle on the thickness of a shotcrete facing, bonded length and safety factors are analyzed. In addition, effects of the reduction of deformations expected by pretensioning of the soil nails are examined in detail throughout an illustrative example and FLAC$^{2D}$ program analysis.s.

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Structure of Data Fusion and Nonlinear Statistical Track Data Fusion in Cooperative Engagement Capability (협동교전능력을 위한 자료융합 구조와 비선형 통계적 트랙 융합 기법)

  • Jung, Hyoyoung;Byun, Jaeuk;Lee, Saewoom;Kim, Gi-Sung;Kim, Kiseon
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.39C no.1
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    • pp.17-27
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    • 2014
  • As the importance of Cooperative Engagement Capability and network-centric warfare has been dramatically increasing, it is necessary to develop distributed tracking systems. Under the development of distributed tracking systems, it requires tracking filters and data fusion theory for nonlinear systems. Therefore, in this paper, the problem of nonlinear track fusion, which is suitable for distributed networks, is formulated, four algorithms to solve the problem of nonlinear track fusion are introduced, and performance of introduced algorithms are analyzed. It is a main problem of nonlinear track fusion that cross-covarinaces among multiple platforms are unknown. Thus, in order to solve the problem, two techniques are introduced; a simplification technique and a approximation technique. The simplification technique that help to ignore cross-covariances includes two algorithms, i.e. the sample mean algorithm and the Millman formula algorithm, and the approximation technique to obtain approximated cross-covariances utilizes two approaches, by using analytical linearization and statistical linearization based on the sigma point approach. In simulations, BCS fusion is the most efficient scheme because it reduces RMSE by approximating cross-covariances with low complexity.

Present and Future of Thermoplastic Elastomers As Environmentally Friendly Organic Materials (친환경 유기 소재로서 열가소성 탄성체의 오늘과 내일)

  • Choi, Eun-Ji;Yoon, Ji-Hwan;Jo, Jung-Kyu;Shim, Sang-Eun;Yun, Ju-Ho;Kim, Il
    • Elastomers and Composites
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    • v.45 no.3
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    • pp.170-187
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    • 2010
  • Much interest on the thermoplastic elastomers (TPEs) has recently been attracted in commercial fields as well as scientific and applied researches. The TPEs have their own characteristic area especially in relation with block copolymers as well as many other polymeric materials, since they show interesting features displayed by the conventional vulcanized rubber, and at the same time, by the thermoplastics. In addition, they are characterized by a set of interesting properties inherent to block and graft copolymers, variety of blends and vulcanized materials. The importance of TPE as organic materials can be evaluated by the number of published reports (papers, patents, technical reports, etc). The input of the concept 'thermoplastic elastomer' to SciFinderScholar yields 18,508 results between 1939 and July 10, 2010, and the number increased exponentially after the mid of 1990. For the suitable introduction of the TPE, historic, scientific, technical and commercial considerations should be taken into account. This review article starts with a brief discussion on historical considerations, followed by a introduction of the main preparations and analytical techniques utilized in chemical, structural, and morphological studies. The properties, processing tools, the position among organic materials, and applications of TPEs are also briefly reviewed. Finally, the most probable trends of their future development are discussed in a short final remarks.

Suitability evaluation of magnesium substituted biphasic calcium phosphates prepared by coprecipitation method (공침법을 이용한 마그네슘이 첨가된 biphasic calcium phosphate의 적합성 평가)

  • Lee, Hyoung-Sin;Kim, Tae-Wan;Kim, Dong-Hyun;Park, Hong-Chae;Yoon, Seog-Young
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.20 no.5
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    • pp.237-242
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    • 2010
  • Magnesium-substituted BCP (biphasic calcium phosphate) powders were prepared by incorporating small amounts of magnesium into the structure of different hydroxyapatite (HAp)/${\beta}$-tricalcium phosphate (${\beta}$-TCP) ratios through coprecipitation method. A series of magnesium substitutions ranging from 0, 0.5, and 1.0 wt%, which are comparable to the measured magnesium contents, were performed. The obtained powders were characterized by the following analytical techniques: X-ray diffraction analysis (XRD), Thermo Gravimetric Analyzer (TGA) and Fourier transform infrared spectroscopy (FT-IR). The results have shown that substitution of magnesium in the calcium-deficient apatites resulted in the formation of biphasic mixtures of different HAP/${\beta}$-TCP ratios after heating above $1000^{\circ}C$. The 1.0 wt% magnesiumsubstituted-BCP were soaked in Hank's solutions after 2 weeks to observe the morphology of the biocement, especially needle-like hydroxyapatite crystals and to estimate the length and diameter of nanoneedle crystals.

Development of FURA Code and Application for Load Follow Operation (FURA 코드 개발과 부하 추종 운전에 대한 적용)

  • Park, Young-Seob;Lee, Byong-Whi
    • Nuclear Engineering and Technology
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    • v.20 no.2
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    • pp.88-104
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    • 1988
  • The FUel Rod Analysis(FURA) code is developed using two-dimensional finite element methods for axisymmetric and plane stress analysis of fuel rod. It predicts the thermal and mechanical behavior of fuel rod during normal and load follow operations. To evaluate the exact temperature distribution and the inner gas pressure, the radial deformation of pellet and clad, the fission gas release are considered over the full-length of fuel rod. The thermal element equation is derived using Galerkin's techniques. The displacement element equation is derived using the principle of virtual works. The mechanical analysis can accommodate various components of strain: elastic, plastic, creep and thermal strain as well as strain due to swelling, relocation and densification. The 4-node quadratic isoparametric elements are adopted, and the geometric model is confined to a half-pellet-height region with the assumption that pellet-pellet interaction is symmetrical. The pellet cracking and crack healing, pellet-cladding interaction are modelled. The Newton-Raphson iteration with an implicit algorithm is applied to perform the analysis of non-linear material behavior accurately and stably. The pellet and cladding model has been compared with both analytical solutions and experimental results. The observed and predicted results are in good agreement. The general behavior of fuel rod is calculated by axisymmetric system and the cladding behavior against radial crack is used by plane stress system. The sensitivity of strain aging of PWR fuel cladding tube due to load following is evaluated in terms of linear power, load cycle frequency and amplitude.

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A Modeling Optimization for Numerical Analysis of GPR in Multi-Grounding Systems (다중 접지계 GPR 수치 해석을 위한 최적 모델링 기법)

  • Lee, Jae-Bok;Chang, Sug-Hun;Myung, Sung-Ho;Cho, Yeon-Gyu
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.17 no.11 s.114
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    • pp.1120-1131
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    • 2006
  • This paper describes the numerical analysis techniques using the Combined Integration/Matrix Method to calculate ground potential rise which can be occurred in the various grounding systems. Combined Integration/Matrix Method is used to reduce the error and computation time with the analytical integration equation and the proper segmentaion of earth embedded conductor. To do it, optimal segmentaion method for the buried conductors is presented through error analysis which is capable of applying the practical scaled various grounding systems. The optimum length of segmented element is much co-related with the buried depth of grounding electrode and the maximum length of buried electrode. As a result, less 3 precent errors was obtained by proposed model. The proposed model is applied to verify an effect of multi-grounding problems which was aroused much controversy with separated or common grounding between the high power grounding system and low power grounding system such as signal and telecommunication grounding.

Hydrothermally Synthesis Nanostructure ZnO Thin Film for Photocatalysis Application (수열합성법으로 합성된 산화아연 나노 구조 박막의 광촉매적 응용)

  • Shinde, N.M.;Nam, Min Sik;Patil, U.M.;Jun, Seong Chan
    • KEPCO Journal on Electric Power and Energy
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    • v.2 no.1
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    • pp.97-101
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    • 2016
  • ZnO has nanostructured material because of unique properties suitable for various applications. Amongst all chemical and physics methods of synthesis of ZnO nanostructure, the hydrothermal method is attractive for its simplicity and environment friendly condition. Nanostructure ZnO thin films have been successfully synthesized on fluorine doped tin oxide (FTO) substrate using hydrothermal method. A possible growth mechanism of the various nanostructures ZnO is discussed in schematics. The prepared materials were characterized by standard analytical techniques, i.e., X-ray diffraction (XRD) and Field-emission scanning electron microscopy (SEM). The XRD study showed that the obtained ZnO nanostructure thin films are in crystalline nature with hexagonal wurtzite phase. The SEM image shows substrate surface covered with nanostructure ZnO nanrod. The UV-vis absorption spectrum of the synthesized nanostructure ZnO shows a strong excitonic absorption band at 365 nm which indicate formation nanostructure ZnO thin film. Photoluminescence spectra illustrated two emission peaks, with the first one at 424 nm due to the band edge emission of ZnO and the second broad peak centered around 500 nm possibly due to oxygen vacancies in nanostructure ZnO. The Raman measurements peaks observed at $325cm^{-1}$, $418cm^{-1}$, $518cm^{-1}$ and $584cm^{-1}$ indicated that nanostrusture ZnO thin film is high crystalline quality. We trust that nanostructure ZnO material can be effectively will be used as a highly active and stable phtocatalysis application.