• Title/Summary/Keyword: Analysis and evaluation

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Simultaneous determination of illegal galactagogue adulterants in supplement diets by LC-MS/MS

  • Lee, Ji Hyun;Cho, So-Hyun;Park, Han Na;Park, Hyoung Joon;Kim, Nam Sook;Park, Sung Kwan;Kang, Hoil
    • Analytical Science and Technology
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    • v.31 no.4
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    • pp.171-178
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    • 2018
  • Recently, for successful lactation, many breastfeeding mothers seek various products, including herbal medicine, dietary supplements, and prescribed medicines, to improve milk production. As demand for galactogogues grows, it is highly possible that pharmaceutical galactogogues may be adulterated with illegal products to maximize their efficacy. For continuous control and supervision of illegal products, we developed and validated a simple and sensitive LC-MS/MS method capable of simultaneously determining five galactogogues. Chromatographic separation was conducted using an Agilent Poroshell $120SB-C_{18}$ column with a mobile phase consisting of 20 mM ammonium formate (pH 5.4) and 100 % acetonitrile. The total run time was 13 min per analyte. The proposed method was performed according to the guidelines of the International Conference of Harmonization and it produced reliable results. This method showed high sensitivity and specificity, with a limit of detection (LOD) and limit of quantitation (LOQ) of 0.01-0.82 ng/mL and 0.02-2.45 ng/mL, respectively, for the solid- and liquid-type samples. Specificity was evaluated by analyzing matrix-blank samples spiked with the target compounds at LOQ levels, which provided a good separation of all peaks without interference. Additionally, the repeatability and intermediate precision were typically <15 %, whereas the recovery was 80-120 % of the values obtained using blank samples. Thus, we concluded that this method could be used for the identification and quantification of galactogogues in food or herbal products.

Study on Comparison of Industrial Static Analysis Tools to Verify the Design Principles for Software Unit Design and Implementation of ISO 26262 (ISO 26262의 소프트웨어 설계원리 적용에 대한 검증 도구의 비교 연구)

  • Heo, Jeho;Lee, Hongseok;Ko, Byeonggak
    • IE interfaces
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    • v.25 no.4
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    • pp.416-421
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    • 2012
  • One of the activities to improve software quality in ISO 26262 is to apply the design principles for software unit design and implementation mentioned in ISO 26262-6, including the evaluation activity. Before evaluation activity, the tool is compared and selected for evaluation. Because the results of the tool a company selected might have an effect on product quality. In this paper, we suggest the method to compare industrial static analysis tools with some of "MISRA C : 2004 Exemplar Suite" and all lessons learned from comparing tools are described. The result on comparison shows that we just couldn't rely on a result of Static Analysis Tool and need to have another appropriate processes and guidelines to evaluate a software.

A Priority Analysis on Influential Factors for Software Bid Evaluation in Public Sectors based on Analytic Hierarchy Process(AHP) (AHP 기법을 활용한 소프트웨어 제안평가요인의 상대적 중요도에 관한 연구 : 발주자와 수주자 비교를 중심으로)

  • Kim, Hong Jin;Jo, Dong Hyuk;Ahn, Tae Ho
    • Journal of Information Technology Services
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    • v.16 no.1
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    • pp.41-53
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    • 2017
  • Recently, due to the economic recession and increase of ITO (IT Outsourcing), bidding in software industry has been recognized as more competitive and the importance of software bid evaluation for corporate selection is being increased. This study aims to analyze and prioritize influential factors in the software bid evaluation criteria which is adopted as the main evaluation model of national software businesses by Ministry of Science. The priority was developed by AHP (Analytic Hierarchy Process) through pair-wise comparison. For the analysis, this study developed analysis model for AHP and conducted survey of experts who have work experience for more than 10 years in the IT industry. As the result of analysis, weighted factors in the evaluation criteria were deduced and differences of priority factors between purchaser and bidder were investigated. The analysis showed differences of view point in the bidding process. With these results, this study suggests how to write a proposal strategically and effectively in perspective of the purchaser. It is expected that priority factors will be adopted in strategic proposals in both bidder and purchaser. For purchaser, the priority will be adopted to select reliable bidder. So, we expect that the priority factors will be used to get more values for both bidder and purchaser in their business atmosphere.

A Development of Evaluation System on Technological Information Analysis by Retired Scientists & Engineers (고경력/퇴직 과학기술자의 기술정보분석 실적평가 방안)

  • 김석진;조흥곤;유영복;민완기
    • Journal of Korea Technology Innovation Society
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    • v.5 no.3
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    • pp.307-320
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    • 2002
  • The purpose of this paper was to design evaluation process on technological information analysis done by re-tired scientists and engineers. Existing studies on evaluation system and methodology were analyzed and their implications are as follows. To provide useful feedback to the retired scientists, indicators of evaluation should be simplified and method of evaluation confined to the quantitative one. And the results of evaluation need to be utilized in direction to encourage the old scientists and engineers.

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A Scheme of the defence project analysis and evaluation using a systems engineering process (시스템 엔지니어링 프로세스를 적용한 사전/사후분석 방안)

  • Min, Seong-Gi;Gwon, Yong-Su;Lee, Im-Su
    • 시스템엔지니어링워크숍
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    • s.1
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    • pp.32-39
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    • 2003
  • This work describes a study of analysis and evaluation activities applied systems engineering approach. It is presented technique of derivation and management requirement. A scheme of the defence project analysis and evaluation using a systems engineering process is described.

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Two-Dimensional Qualitative Asset Analysis Method based on Business Process-Oriented Asset Evaluation

  • Eom, Jung-Ho;Park, Seon-Ho;Kim, Tae-Kyung;Chung, Tai-Myoung
    • Journal of Information Processing Systems
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    • v.1 no.1 s.1
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    • pp.79-85
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    • 2005
  • In this paper, we dealt with substantial asset analysis methodology applied to two-dimensional asset classification and qualitative evaluation method according to the business process. Most of the existent risk analysis methodology and tools presented classification by asset type and physical evaluation by a quantitative method. We focused our research on qualitative evaluation with 2-dimensional asset classification. It converts from quantitative asset value with purchase cost, recovery and exchange cost, etc. to qualitative evaluation considering specific factors related to the business process. In the first phase, we classified the IT assets into tangible and intangible assets, including human and information data asset, and evaluated their value. Then, we converted the quantitative asset value to the qualitative asset value using a conversion standard table. In the second phase, we reclassified the assets using 2-dimensional classification factors reflecting the business process, and applied weight to the first evaluation results. This method is to consider the organization characteristics, IT asset structure scheme and business process. Therefore, we can evaluate the concrete and substantial asset value corresponding to the organization business process, even if they are the same asset type.

A New Model for Effectiveness Analysis of Government- supported R&D Institutes Evaluation System (정부출연연구기관 기관평가시스템 유효성 분석 모형: 유효성 분석을 위한 새로운 접근방법)

  • 이민형
    • Journal of Technology Innovation
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    • v.13 no.3
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    • pp.175-196
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    • 2005
  • This Paper examines analytic studies of the evaluation system used for evaluating government-supported R&D Institutes (GSRIs), and designs a new model for analyzing the evaluation system's effectiveness. The analytic models in existing studies use the meta evaluation and balanced scorecard (BSC) models. However, theses studies focused on the structure and elements of the evaluation system for examples, the appropriateness of the elements within the evaluation system and the balance of the evaluation index. Accordingly, the effectiveness of the GSRI evaluation system, that is, the evaluation's influence on GSRI performance improvement was not analyzed. This study uses the institution theory and contingency theory perspectives as related to government organization management to develop an analytical model of GSRI evaluation system effectiveness. The new model proposes an analytical approach for improving the effectiveness of the GSRI evaluation system in an institutionalized environment.

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Bearing Performance Evaluation Based on Rigid Body Dynamic Analysis Considering Rotation and Loads Over Time (시간에 따른 회전 및 하중을 고려한 강체 동역학 해석에 기반한 베어링 성능 평가)

  • Seungpyo Lee
    • Tribology and Lubricants
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    • v.39 no.2
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    • pp.35-42
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    • 2023
  • Bearing is a mechanical component that supports loads and transmits rotation. As the application of high-value-added products such as semiconductors, aviation, and robots have recently become diverse and more precise, an accurate bearing performance prediction and evaluation technology is required. Bearing performance evaluation can be divided into evaluations based on bearing theory and on numerical analysis. An evaluation based on numerical analysis is a technique that has been highlighted because the problems that remained unsolved owing to time problems can be solved through recent developments in computers. However, current studies have the disadvantage of not considering the essential changes over time and bearing rotation. In this study, bearing performance evaluation based on rigid body dynamic analysis considering rotation and load over time is performed. Rigid body dynamic analysis is performed for deep groove ball bearing to calculate the load applied by the ball. The reliability of the analysis is verified by comparing it with the results calculated using bearing theory. In addition, rigid body dynamic analysis is performed for automotive wheel bearings to calculate the contact angle and load applied by the ball for cases where axial load and radial load are applied, respectively. The effect of rotation and load over time is evaluated from these results.

Evaluation of the Effectiveness of the Air Force LVC Training System Using AHP (AHP를 활용한 공군 LVC 합성전장훈련체계 효용성 평가)

  • Jaehong Lee;Byungho Jung;Namkyu Lim
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.46 no.4
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    • pp.209-217
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    • 2023
  • In this study, the evaluation items related to the effectiveness evaluation of the LVC (Live, Virtual, Constructive) training system of the Air Force were derived and the weights of each item were analyzed. The LVC training system evaluation items for AHP (Analytic Hierarchy Process) analysis were divided into three layers, and according to the level, 3 items were derived at level 1, 11 items at level 2, and 33 items at level 3. For weight analysis of evaluation items, an AHP-based pairwise comparison questionnaire was conducted for Air Force experts related to the LVC training system. As a result of the survey, related items such as (1) Achievement of education and training goals (53.8%), (1.2) Large-scale mission and operational performance (25.5%), and (1.2.1) Teamwork among training participants (19.4%) was highly rated. Also, it was confirmed that the weights of evaluation items were not different for each expert group, that is, the priority for importance was evaluated in the same order between the policy department and the working department. Through these analysis results, it will be possible to use them as evaluation criteria for new LVC-related projects of the Air Force and selection of introduction systems.

Screening and detection of methylisothiazolinone and chloromethylisothiazolinone in cosmetics by UPLC-MS/MS

  • Lee, Ji Hyun;Paek, Ji Hyun;Park, Han Na;Park, Seongsoo;Kang, Hoil
    • Analytical Science and Technology
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    • v.33 no.3
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    • pp.125-133
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    • 2020
  • Methylisothiazolinone (MIT) and chloromethylisothiazolinone (CMIT) cause allergic contact dermatitis and are banned cosmetics ingredients, except in rinse-off products. However, their presence has been detected in cosmetics. We report a UPLC-tandem MS/MS screening method for their simultaneous determination in cosmetics. To facilitate extraction from various matrices, pretreatment methods were developed for each sample type. The method was optimized through a series of assessments, including specificity, LOD, LOQ, linearity, recovery, stability, precision, and accuracy. The LODs and LOQs for MIT ranged from 0.054 and 0.163 ㎍ mL-1 whereas those for CMIT ranged from 0.040 and 0.119 ㎍ mL-1. The linear correlation coefficients (r2) were higher than 0.999. Relative standard deviations (RSDs) for both intra- and inter-day measurements ranged from 0.3 ~ 13.6 %. Recoveries at three different concentrations were within 87.9 ~ 118.9 %. The RSD for stability measurements of spiked samples was within 7 %. These results confirm the suitability of the developed method for the simultaneous quantitation of MIT and CMIT in cosmetics. Samples of 320 color cosmetics, including eyeshadows, solid lipsticks, liquid lipsticks, and nail polishes were analyzed using the developed method, and two of them were found to contain both MIT and CMIT and one of them was found to contain only MIT. This data and the method will aid the regulation of ingredients used in cosmetics.