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Prediction of Amyloid β-Positivity with both MRI Parameters and Cognitive Function Using Machine Learning (뇌 MRI와 인지기능평가를 이용한 아밀로이드 베타 양성 예측 연구)

  • Hye Jin Park;Ji Young Lee;Jin-Ju Yang;Hee-Jin Kim;Young Seo Kim;Ji Young Kim;Yun Young Choi
    • Journal of the Korean Society of Radiology
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    • v.84 no.3
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    • pp.638-652
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    • 2023
  • Purpose To investigate the MRI markers for the prediction of amyloid β (Aβ)-positivity in mild cognitive impairment (MCI) and Alzheimer's disease (AD), and to evaluate the differences in MRI markers between Aβ-positive (Aβ [+]) and -negative groups using the machine learning (ML) method. Materials and Methods This study included 139 patients with MCI and AD who underwent amyloid PET-CT and brain MRI. Patients were divided into Aβ (+) (n = 84) and Aβ-negative (n = 55) groups. Visual analysis was performed with the Fazekas scale of white matter hyperintensity (WMH) and cerebral microbleeds (CMB) scores. The WMH volume and regional brain volume were quantitatively measured. The multivariable logistic regression and ML using support vector machine, and logistic regression were used to identify the best MRI predictors of Aβ-positivity. Results The Fazekas scale of WMH (p = 0.02) and CMB scores (p = 0.04) were higher in Aβ (+). The volumes of hippocampus, entorhinal cortex, and precuneus were smaller in Aβ (+) (p < 0.05). The third ventricle volume was larger in Aβ (+) (p = 0.002). The logistic regression of ML showed a good accuracy (81.1%) with mini-mental state examination (MMSE) and regional brain volumes. Conclusion The application of ML using the MMSE, third ventricle, and hippocampal volume is helpful in predicting Aβ-positivity with a good accuracy.

Analysis of the linkage between the three categories of content system according to the 2022 revised mathematics curriculum and the lesson titles of mathematics textbooks for the first and second-grade elementary school (2022 개정 수학과 교육과정에 따른 내용 체계의 세 범주와 초등학교 1~2학년 수학 교과서 차시명의 연계성 분석)

  • Kim, Sung Joon;Kim, Eun kyung;Kwon, Mi sun
    • Communications of Mathematical Education
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    • v.38 no.2
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    • pp.167-186
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    • 2024
  • Since the 5th mathematics curriculum, the goals of mathematics education have been presented in three categories: cognitive, process, and affective goals. In the 2022 revised mathematics curriculum, the content system was also presented as knowledge-understanding, process-skill, and value-attitude. Therefore, in order to present lesson goals to students, it is necessary to present all three aspects that are the goals of mathematics education. Currently, the lesson titles presented in mathematics textbooks are directly linked to lesson goals and are the first source of information for students during class. Accordingly, this study analyzed how the three categories of lesson titles and content system presented in the 2015 revised 1st and 2nd grade mathematics textbook are connected. As a result, most lesson titles presented two of the three categories, but the reflected elements showed a tendency to focus on the categories of knowledge-understanding and process-skill. Some cases of lesson titles reflected content elements of the value-attitude category, but this showed significant differences depending on the mathematics content area. Considering the goals of mathematics lessons, it will be necessary to look at ways to present lesson titles that reflect the content elements of the value-attitude categories and also explore ways to present them in a balanced way. In particular, considering the fact that students can accurately understand the goals of the knowledge-understanding categories even without presenting them, descriptions that specifically reflect the content elements of the process-skill and value-attitude categories seem necessary. Through this, we attempted to suggest the method of presenting the lesson titles needed when developing the 2022 revised mathematics textbook and help present effective lesson goals using this.

Effect of the Ayres Sensory Integration Intervention on the Motor Skills and Occupation Participation of Preschool Children with Attention-Deficit/Hyperactivity Disorder (Ayres의 감각통합중재가 학령전기 주의력결핍 과잉행동장애(ADHD) 성향 아동의 운동기능 및 작업참여에 미치는 영향)

  • Jung, Yun-Jin;Kang, Je-wook;Chang, Moon-young;Kim, Kyeong-Mi
    • The Journal of Korean Academy of Sensory Integration
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    • v.22 no.1
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    • pp.1-14
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    • 2024
  • Objective : This study aimed to investigate the impact of Ayres' sensory integration (ASI) intervention on motor skills and occupational participation of preschool children with attention-deficit/hyperactivity disorder (ADHD). Method : Children with ADHD aged between 4 and 6 years who met the inclusion and exclusion criteria were randomly recruited through screening tests. The subjects were divided into an experimental group (10 subjects) and a control group (8 subjects). The instruments used were the Bruininks-Oseretsky test of motor proficiency-2 (BOT-2), Pediatric Evaluation of Disability Inventory (PEDI), and Goal Attainment Scale (GAS) to evaluate occupational participation. The subjects in the experimental group underwent individual sensory integration therapy according to the ASI principles for 40 minutes twice a week in a total of 16 sessions over eight weeks. The control group did not receive the ASI intervention. Data analysis was performed using the Mann-Whitney U test, chi-squared test, Wilcoxon signed-rank test, and Cohen's d test in SPSS 20.0. Results : The ASI experimental group had significantly higher scores in total motor composite, manual coordination, body coordination, strength, and agility in motor function than the control group (p<.05). The two groups did not differ significantly in terms of occupational participation (PEDI), but GAS scores for individual target activities were significantly higher in the experimental group than in the control group (p<.05). Conclusion : This study shows that the ASI intervention has positive effects on motor skills and occupation participation among preschool children with ADHD.

Analysis of Applicability of RPC Correction Using Deep Learning-Based Edge Information Algorithm (딥러닝 기반 윤곽정보 추출자를 활용한 RPC 보정 기술 적용성 분석)

  • Jaewon Hur;Changhui Lee;Doochun Seo;Jaehong Oh;Changno Lee;Youkyung Han
    • Korean Journal of Remote Sensing
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    • v.40 no.4
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    • pp.387-396
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    • 2024
  • Most very high-resolution (VHR) satellite images provide rational polynomial coefficients (RPC) data to facilitate the transformation between ground coordinates and image coordinates. However, initial RPC often contains geometric errors, necessitating correction through matching with ground control points (GCPs). A GCP chip is a small image patch extracted from an orthorectified image together with height information of the center point, which can be directly used for geometric correction. Many studies have focused on area-based matching methods to accurately align GCP chips with VHR satellite images. In cases with seasonal differences or changed areas, edge-based algorithms are often used for matching due to the difficulty of relying solely on pixel values. However, traditional edge extraction algorithms,such as canny edge detectors, require appropriate threshold settings tailored to the spectral characteristics of satellite images. Therefore, this study utilizes deep learning-based edge information that is insensitive to the regional characteristics of satellite images for matching. Specifically,we use a pretrained pixel difference network (PiDiNet) to generate the edge maps for both satellite images and GCP chips. These edge maps are then used as input for normalized cross-correlation (NCC) and relative edge cross-correlation (RECC) to identify the peak points with the highest correlation between the two edge maps. To remove mismatched pairs and thus obtain the bias-compensated RPC, we iteratively apply the data snooping. Finally, we compare the results qualitatively and quantitatively with those obtained from traditional NCC and RECC methods. The PiDiNet network approach achieved high matching accuracy with root mean square error (RMSE) values ranging from 0.3 to 0.9 pixels. However, the PiDiNet-generated edges were thicker compared to those from the canny method, leading to slightly lower registration accuracy in some images. Nevertheless, PiDiNet consistently produced characteristic edge information, allowing for successful matching even in challenging regions. This study demonstrates that improving the robustness of edge-based registration methods can facilitate effective registration across diverse regions.

Analysis of Private Road Toll Discounts and Subsidy Payment Plan for Sunset-type Vehicles (민자도로의 통행료 할인 현황과 일몰형 통행차량의 보조금 지급 방안)

  • Kim, Ji-Myong;Lim, Kwangk-kyun
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.44 no.4
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    • pp.519-529
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    • 2024
  • Vehicle toll discounts on private roads are categorized into two types: non-sunset and sunset. Sunset types refer to provisions in which all or part of a law loses its effect upon a specific legislator-set deadline. Vehicles eligible for 'sunset' discounts include cargo vehicles operating late at night and eco-friendly vehicles powered by electricity or hydrogen. Korean government has subsidized all reduced toll fees for vehicles classified as non-sunset types on private roads to operators, but no subsidies have been provided for toll reductions on sunset vehicles. The rapid increase in electric hydrogen vehicles escalates the burden of reduced toll revenue on private road operators. This study analyzed traffic volume and toll reduction data from eight private road operators nationwide as of the end of 2023 to propose the necessity and method of supporting sunset-type toll reduction subsidies. In 2022, the subsidy for non-sunset types amounted to 87.5 billion won, or 18.6 % of total traffic revenue. The toll exemption and reduction ratio under the concession agreement ranged from 4.0 % to 5.65 % of total traffic volume for each operator. Although the proportion of vehicles exempted from sunset traffic increased from 0.85 % in 2017 to 2.79 % in 2022, the reduction amount ratio reached 4.2 % (KRW 25.5 billion) of total traffic revenue in 2022. The escalating number of registered eco-friendly vehicles is gradually causing operating profit losses on private roads. In alignment with the government's policy to expand eco-friendly vehicles, it is imperative to consider including vehicles eligible for toll reductions listed under the sunset category for subsidy payments. The study established a minimum ratio for toll reduction assistance at 4.0 %, agreed upon between the road authorities and private operators. Three policy alternatives were proposed to ensure preservation of amounts exceeding this threshold for sustaining adequate toll revenue for private road operators.

A Study of the New Positioning Guide Based on the Correlation between the Orbit Meatus Line and Mandibular Body Angle in Paranasal Sinus Parietoacanthial Projection(Water's Method) (코곁굴 두정비극방향 검사 시 안와이공선과 아래턱뼈 몸통각도의 상관관계를 이용한 새로운 자세잡이 기준에 관한 연구)

  • Yong-Min Son;Han-Yong Kim;Young-Cheol Joo
    • Journal of the Korean Society of Radiology
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    • v.18 no.4
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    • pp.335-344
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    • 2024
  • In this study, we aim to investigate the correlation between the lateral images of Korean skulls and the angle between the OML and the Body of the Mandible. Additionally, we seek to provide criteria for the ease of positioning in clinical settings and establish standardized imaging procedures for the PNS Water's view examination. This study was conducted on a total of 202 patients who visited the radiology department of a general hospital and examined the skull lateral radiography. In addition to the patient images, skull phantoms were also utilized, and images were obtained using GC85A and EOS equipment. In this research, abbreviations related to the angle of the Body of Mandible were defined using PACS on lateral images. Measurements were taken for various angles, including ramus of mandible angle(RIA), accurate OML angle(TIA), OML and IR Angle(OIA), total mandibular length(TML), ramus height(RH), the angle between the pogonion, gonion, and condylion(MA). The validity of these measurements was confirmed using the skull phantom in the study. The age-specific average range for RIA was 22.67° to 26.04°, with measurements of 23.14° for males and 24.78° for females. The age-related mean ranges for TIA and OIA were 35.98° to 38.31° and 72.27° to 75.25°, respectively. For males, TIA was 36.74° and OIA was 72.73°, while for females, TIA was 36.43° and OIA was 73.38°. The age-dependent measurements for TML and RH ranged from 85.73 mm to 89.60 mm and 62.60 mm to 70.87 mm, respectively. Male values were 90.54 mm and 70.78 mm, while female values were 85.13 mm and 61.54 mm for TML and RH, respectively. The age-specific average range for MA was 55.95° to 58.63°, with measurements of 57.96° for males and 57.76° for females. Correlation analysis revealed a positive correlation between RIA and OIA, as well as between RIA and TIA. Based on the results of this study, which indicate a positive correlation between the angle of the Body of Mandible and the OML, it can be inferred that adjusting the mandible vertically to align with the imaging receptor may contribute to more accurate image acquisition during PNS Water's view examination. Therefore, it is believed that there is value in utilizing this relationship as a criterion for establishing new positioning standards, which could enhance the utility of a new positioning guide.

The Relationship between Financial Constraints and Investment Activities : Evidenced from Korean Logistics Firms (우리나라 물류기업의 재무제약 수준과 투자활동과의 관련성에 관한 연구)

  • Lee, Sung-Yhun
    • Journal of Korea Port Economic Association
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    • v.40 no.2
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    • pp.65-78
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    • 2024
  • This study investigates the correlation between financial constraints and investment activities in Korean logistics firms. A sample of 340 companies engaged in the transportation sector, as per the 2021 KSIC, was selected for analysis. Financial data obtained from the DART were used to compile a panel dataset spanning from 1996 to 2021, totaling 6,155 observations. The research model was validated, and tests for heteroscedasticity and autocorrelation in the error terms were conducted considering the panel data structure. The relationship between investment activities in the previous period and current investment activities was analyzed using panel Generalized Method of Moments(GMM). The validation results of the research indicate that Korean logistics firms tend to increase investment activities as their level of financial constraints improves. Specifically, a positive relationship between the level of financial constraints and investment activities was consistently observed across all models. These findings suggest that investment decision-making varies based on the financial constraints faced by companies, aligning with previous research indicating that investment activities of constrained firms are subdued. Moreover, while the results from the model examining whether investment activities in the previous period affect current investment activities indicated an influence of investment activities from the previous period on current investment activities, the investment activities from two periods ago did not show a significant relationship with current investment activities. Among the control variables, firm size and cash flow variables exhibited positive relationships, while debt size and asset diversification variables showed negative relationships. Thus, larger firm size and smoother cash flows were associated with more proactive investment activities, while high debt levels and extensive asset diversification appeared to constrain investment activities in logistics companies. These results interpret that under financial constraints, internal funding sources such as cash flows exhibit positive relationships, whereas external capital sources such as debt demonstrate negative relationships, consistent with empirical findings from previous research.

Exhibition Hall Lighting Design that Fulfill High CRI Based on Natural Light Characteristics - Focusing on CRI Ra, R9, R12 (자연광 특성 기반 고연색성 실현 전시관 조명 설계 - CRI Ra, R9, R12를 중심으로)

  • Ji-Young Lee;Seung-Teak Oh;Jae-Hyun Lim
    • Journal of Internet Computing and Services
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    • v.25 no.4
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    • pp.65-72
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    • 2024
  • To faithfully represent the intention of the work in the exhibition space, lighting that provides high color reproduction like natural light is required. Thus, many lighting technologies have been introduced to improve CRI, but most of them only evaluated the general color rendering index (CRI Ra), which considers eight pastel colors. Natural light provides excellent color rendering performance for all colors, including red and blue, expressed by color rendering index of R9 and R12, but most artificial lighting has the problem that color rendering performance such as R9 and R12 is significantly lower than that of natural light. Recently, lighting technology that provides CRI at the level of natural light is required to realistically express the colors of works including primary colors but related research is very insufficient. Therefore this paper proposes exhibition hall lighting that fulfills CRI with a focus on CRI Ra, R9, and R12 based on the characteristics of natural light. First reinforcement wavelength bands for improving R9 and R12 are selected through analysis of the actual measurement SPD of natural and artificial lighting. Afterward virtual SPDs with a peak wavelength within the reinforcement wavelength band are created and then SPD combination conditions that satisfy CRI Ra≥95, R9, and R12≥90 are derived through combination simulation with a commercial LED light source. Through this, after specifying two types of light sources with 405,630nm peak wavelength that had the greatest impact on the improvement of R9 and R12, the exhibition hall lighting applied with two W/C White LEDs is designed and a control Index DB of the lighting is constructed. Afterward experiments with the proposed method showed that it was possible to achieve high CRI at the level of natural light with average CRI Ra 96.5, R9 96.2, and R12 94.0 under the conditions of illuminance (300-1,000 Lux) and color temperature (3,000-5,000K).

Development of Kimchi Cabbage Growth Prediction Models Based on Image and Temperature Data (영상 및 기온 데이터 기반 배추 생육예측 모형 개발)

  • Min-Seo Kang;Jae-Sang Shim;Hye-Jin Lee;Hee-Ju Lee;Yoon-Ah Jang;Woo-Moon Lee;Sang-Gyu Lee;Seung-Hwan Wi
    • Journal of Bio-Environment Control
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    • v.32 no.4
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    • pp.366-376
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    • 2023
  • This study was conducted to develop a model for predicting the growth of kimchi cabbage using image data and environmental data. Kimchi cabbages of the 'Cheongmyeong Gaual' variety were planted three times on July 11th, July 19th, and July 27th at a test field located at Pyeongchang-gun, Gangwon-do (37°37' N 128°32' E, 510 elevation), and data on growth, images, and environmental conditions were collected until September 12th. To select key factors for the kimchi cabbage growth prediction model, a correlation analysis was conducted using the collected growth data and meteorological data. The correlation coefficient between fresh weight and growth degree days (GDD) and between fresh weight and integrated solar radiation showed a high correlation coefficient of 0.88. Additionally, fresh weight had significant correlations with height and leaf area of kimchi cabbages, with correlation coefficients of 0.78 and 0.79, respectively. Canopy coverage was selected from the image data and GDD was selected from the environmental data based on references from previous researches. A prediction model for kimchi cabbage of biomass, leaf count, and leaf area was developed by combining GDD, canopy coverage and growth data. Single-factor models, including quadratic, sigmoid, and logistic models, were created and the sigmoid prediction model showed the best explanatory power according to the evaluation results. Developing a multi-factor growth prediction model by combining GDD and canopy coverage resulted in improved determination coefficients of 0.9, 0.95, and 0.89 for biomass, leaf count, and leaf area, respectively, compared to single-factor prediction models. To validate the developed model, validation was conducted and the determination coefficient between measured and predicted fresh weight was 0.91, with an RMSE of 134.2 g, indicating high prediction accuracy. In the past, kimchi cabbage growth prediction was often based on meteorological or image data, which resulted in low predictive accuracy due to the inability to reflect on-site conditions or the heading up of kimchi cabbage. Combining these two prediction methods is expected to enhance the accuracy of crop yield predictions by compensating for the weaknesses of each observation method.

An Analytical Study on the Stem-Growth by the Principal Component and Canonical Correlation Analyses (주성분(主成分) 및 정준상관분석(正準相關分析)에 의(依)한 수간성장(樹幹成長) 해석(解析)에 관(關)하여)

  • Lee, Kwang Nam
    • Journal of Korean Society of Forest Science
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    • v.70 no.1
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    • pp.7-16
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    • 1985
  • To grasp canonical correlations, their related backgrounds in various growth factors of stem, the characteristics of stem by synthetical dispersion analysis, principal component analysis and canonical correlation analysis as optimum method were applied to Larix leptolepis. The results are as follows; 1) There were high or low correlation among all factors (height ($x_1$), clear height ($x_2$), form height ($x_3$), breast height diameter (D. B. H.: $x_4$), mid diameter ($x_5$), crown diameter ($x_6$) and stem volume ($x_7$)) except normal form factor ($x_8$). Especially stem volume showed high correlation with the D.B.H., height, mid diameter (cf. table 1). 3) (1) Canonical correlation coefficients and canonical variate between stem volume and composite variate of various height growth factors ($x_1$, $x_2$ and $x_3$) are ${\gamma}_{u1,v1}=0.82980^{**}$, $\{u_1=1.00000x_7\\v_1=1.08323x_1-0.04299x_2-0.07080x_3$. (2) Those of stem volume and composite variate of various diameter growth factors ($x_4$, $x_5$ and $x_6$) are ${\gamma}_{u1,v1}=0.98198^{**}$, $\{{u_1=1.00000x_7\\v_1=0.86433x_4+0.11996x_5+0.02917x_6$. (3) And canonical correlation between stem volume and composite variate of six factors including various heights and diameters are ${\gamma}_{u1,v1}=0.98700^{**}$, $\{^u_1=1.00000x_7\\v1=0.12948x_1+0.00291x_2+0.03076x_3+0.76707x_4+0.09107x_5+0.02576x_6$. All the cases showed the high canonical correlation. Height in the case of (1), D.B.H. in that of (2), and the D.B.H, and height in that of (3) respectively make an absolute contribution to the canonical correlation. Synthetical characteristics of each qualitative growth are largely affected by each factor. Especially in the case of (3) the influence by the D.B.H. is the most significant in the above six factors (cf. table 2). 3) Canonical correlation coefficient and canonical variate between composite variate of various height growth factors and that of the various diameter factors are ${\gamma}_{u1,v1}=0.78556^{**}$, $\{u_1=1.20569x_1-0.04444x_2-0.21696x_3\\v_1=1.09571x_4-0.14076x_5+0.05285x_6$. As shown in the above facts, only height and D.B.H. affected considerably to the canonical correlation. Thus, it was revealed that the synthetical characteristics of height growth was determined by height and those of the growth in thickness by D.B.H., respectively (cf. table 2). 4) Synthetical characteristics (1st-3rd principal component) derived from eight growth factors of stem, on the basis of 85% accumulated proportion aimed, are as follows; Ist principal component ($z_1$): $Z_1=0.40192x_1+0.23693x_2+0.37047x_3+0.41745x_4+0.41629x_5+0.33454x_60.42798x_7+0.04923x_8$, 2nd principal component ($z_2$): $z_2=-0.09306x_1-0.34707x_2+0.08372x_3-0.03239x_4+0.11152x_5+0.00012x_6+0.02407x_7+0.92185x_8$, 3rd principal component ($z_3$): $Z_3=0.19832x_1+0.68210x_2+0.35824x_3-0.22522x_4-0.20876x_5-0.42373x_6-0.15055x_7+0.26562x_8$. The first principal component ($z_1$) as a "size factor" showed the high information absorption power with 63.26% (proportion), and its principal component score is determined by stem volume, D.B.H., mid diameter and height, which have considerably high factor loading. The second principal component ($z_2$) is the "shape factor" which indicates cubic similarity of the stem and its score is formed under the absolute influence of normal form factor. The third principal component ($z_3$) is the "shape factor" which shows the degree of thickness and length of stem. These three principal components have the satisfactory information absorption power with 88.36% of the accumulated percentage. variance (cf. table 3). 5) Thus the principal component and canonical correlation analyses could be applied to the field of forest measurement, judgement of site qualities, management diagnoses for the forest management and the forest products industries, and the other fields which require the assessment of synthetical characteristics.

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