• Analytical Science and Technology
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• v.36 no.1
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• pp.32-43
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• 2023

This study reports for the first time about a stability indicating RP-HPLC method for qualitative and quantitative determination of acalabrutinib in bulk and dosage form and in presence its impurities 1, 2 and 3. The chromatographic separation was carried on Zorbax XDB-C18 (250×4.6 mm; 5 µ id) as stationary phase, Phosphate buffer pH 6.4 and methanol 80:20 (v/v) as mobile phase at a flow rate of 1.0 mL/min, UV detection was carried at wavelength of 238 nm and the analysis was completed with a run time of 15 min. In these conditions the retention time of acalabrutinib and its impurities 1, 2 and 3 was observed to be 3.50, 4.83, 8.40 and 9.93 min respectively. The method was validated for system suitability, range of analysis, precision, specificity, stability and robustness. Spiked recovery at 50 %, 100 % and 150 % was carried for both standard and impurities and the acceptable % recovery of 98-102 was observed for acalabrutinib and both impurities studied and the % RSD in each spiked level was found to be less than 2. Stability tests were done through exposure of the analyte solution to five different stress conditions i.e expose to 1N hydrochloric acid, 1 N sodium hydroxide, 3 % peroxide, 80 ℃ temperature and UV radiation at 254 nm. In all the degradation condition, standard drug acalabrutinib was detected along with both the impurities studied and the degradation products were successfully separated. In the formulation analysis there is no other chromatographic detection of other impurities and formulation excipients. Hence the developed method was found to be suitable for the quantification of acalabrutinib and can separate and analyse impurities 1 and 2.

• The Journal of the Korea Contents Association
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• v.21 no.8
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• pp.571-579
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• 2021

This study aims to identify the relationship between ADHD trait and game addiction among high school students, and to examine the double mediating model of hardiness and emotional use of music on that relationship. Participants were 254 male and female high school students. World Health Organization ADHD Self-Report Scale, Short Form of Hardiness Questionnaire, Use of Music Inventory, and Internet Gaming Use-Elicited Symptom Screen were used for this study. PROCESS Macro 3.5 Model 6 was used to analyse a double mediating effect. Results revealed that ADHD trait was negatively correlated with hardiness of high school students, and positively correlated with emotional use of music and game addiction. And, hardiness of high school students was positively correlated with emotional use of music and negatively correlated with game addiction, whereas emotional use of music was negatively correlated with game addiction. It was found that hardiness and emotional use of music were sequentially mediating ADHD trait and game addiction among high school students. These findings suggest that hardiness and emotional use of music play some special roles in the path in which adolescents' ADHD trait affects game addiction.

• 한국태양에너지학회:학술대회논문집
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• 2009.04a
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• pp.66-71
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• 2009

To reduce the building energy consumption, the major advanced nations are conducting actively many researches on so called a "self-sufficient building(or other words zero energy building)" which can support its required energy by itself. Given this background, KIER(Korea Institute of Energy Research) built full size test-bed of the zero energy solar house in early 2002, and has studied on the self-sufficient heating load up to now. We analyse the sensitivity between the heating load and the solar radiation gain according to the change the effective transmittance of windows. The authors classified 9 cases by solar transmittance of glass. The results demonstrate the solar radiation amount is 0.466 MWh from the eastern zone of Fl.,1(the first floor), 0.332 MWh from Fl.,2(the second floor), 1.194 MWh form the southern zone of F1., and 0.822 MWh from the southern zone of Fl.,2 on the case 1(each cases are classified by window types). On the case 9, the solar radiation amount is 3.127 MWh, 2.662 MWh, 8.799 MWh and 6.078 MWh from the same condition. For the Fl.,1, the amount of Heat Load that is saved per year ranged 10.5 to 48 %, and the reduction was anywhere from 0.2 to 17.9% for Fl.,2

• Journal of the Korean Vacuum Society
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• v.7 no.1
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• pp.11-16
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• 1998

In this study, we prepared a Na$_2$Se/NH$_4$OH solution to investigate a passivation effect of Se on GaAs surface. X-ray photoelectron spectroscopy and photoluminescence (PL) were used to analyse the surface chemical bonding states and the optical properties of GaAs after Se-treatment and a successive exposure to air, respcetively. It was observed that all of the observed selenium bound with arsenic to form As-Se bond and showed only one oxidation state as -2. PL intensity of Se-passivated surface was larger than that of HCI-cleaned surface, and this means that the effective reduction of surface state density of GaAs was successfully obtained by this treatment. However the existence of partial oxide on the Se-passivated surface was seemed to be a major cause to the degradation of Se passivation effcet. PL intensity of Se-passivated surface also decreased according to air-exposure and converged to that of HCI-cleaned surface.

• Journal of the Korean Institute of Gas
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• v.17 no.6
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• pp.67-72
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• 2013

The flash point is the lowest temperature at which there is enough concentration of flammable vapor to form an ignitable mixture with air. The flash point is a major physical property used to analyse the fire and explosion hazards of a flammable liquid solution. The flash point data for pure components are easily available in several literature. But the flash points of the flammable binary solutions appear to be scarce in the literature. The objective of this study is to measure and estimate the flash point of acetic acid-formic acid system. Cleveland open cup tester was used to measure the flash point. The experimental data were compared with the values estimated by the Raoult's law and the optimization methods based on van Laar and Wilson equations. As a result, the estmated values by optimization methods were found to be better than those based on the Raoult's law.

• The Research Journal of the Costume Culture
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• v.24 no.3
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• pp.336-348
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• 2016

This study was executed to deduce the factors affecting eco-friendly behaviors and attitudes, to analyse the difference of eco-friendly behaviors and attitudes between countries, and to draw the variables affecting clothing recycling behavior. The sample comprised people from the UK, China, South Korea. The results were as follows. The four factors related to eco-friendly behaviors and the five factors related to eco-friendly attitudes were derived from the results of factor analysis. In the case of eco-friendly behaviors, four eco-friendly behavior factors showed a significant difference all according to gender and country. In the case of eco-friendly attitudes, saving of natural resources for eco-friendly life, recycling for eco-friendly life, and individual preference for eco-friendly life showed a significant according to gender, also recycling for eco-friendly life, individual preference for eco-friendly life, social awareness for eco-friendly life, and company's awareness for eco-friendly life showed a significant difference according to country. All of the variables related to clothing recycling behaviors showed the significant difference according to gender and countries. It was verified that the stronger the behaviors or attitudes for waste recycling and environmental protection, individual preference for eco-friendly life, saving of natural resources, buying eco-friendly products, and separate collection for recycling, the more positive the action to clothing recycling. The results of this study will be helpful to establish a marketing strategy for each country and to deduce a plan to attract clothing recycling form people.

• International Commerce and Information Review
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• v.16 no.3
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• pp.465-486
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• 2014

This paper intends to analyse some legal issues on US-Orange Juice Case. Brazil's WTO challenge is to the methods undertaken by US in calculating antidumping duties in administrative reviews of Brazilian Orange Juice. Panel resulted that conforms with earlier Appellate Body decision outlawing the use of 'weighted average to transaction zeroing. This paper note that panel's stance was driven from 'stability and predictability' within the DSB system. There was a de facto form of stare decisis. However, Panel in US-Orange Juice recognized that Appellate Body decision is wrong about finding zeroing to be violation of the fair comparison requirement of the Article 2.4 of the WTO Anti-Dumping agreement. Zeroing dispute of WTO Anti-Dumping Agreement will be continued that because this matter. Fortunately, the American government announced it would be stop zeroing system of administrative reviews. As result, Carefully, We anticipate that US-Orange Juice's decision is the end of zeroing method on the WTO Anti-Dumping Agreement.

• Transactions of the Korean Society of Mechanical Engineers
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• v.13 no.4
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• pp.780-788
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• 1989

An experimental study has been performed to investigate the process from nonequilibrium state to equilibrium state in redeveloping turbulent boundary layer beyond separation-reattachment using pitot tube and hot-wire anemometer. The model sued in the experiment has the form of a backward facing step which is assembled by a two-dimensional 4:1 half elipse and a plate. Measurements are carried out up to a distance of about 50 step height downstream of the step, where the reattachment observed at about x/h=6.5. The profiles of the shape factor H the Clauser parameter G and the coefficient of friction $C^{f}$ exhibited the characteristics similar to those of the equilibrium turbulent boundary layer from x/h=25, and the profiles of the trubulent quantities did from x/h=35. However, the wake region of the boundary layer does not seem to recover the equilibrium turbulent boundary layer even at x/h=50. By considering the distributions of the intermittency factor it has been noted that the turbulence structure changes gradually from a mixing layer to a turbulent boundary layer along downstream direction after reattachment. This becomes clearer as we analyse the one-dimensional energy spectra and the dissipation energy spectra which are measured and caculated at various downstream positions after the backward facing step.p.

• Journal of the Korea Society of Computer and Information
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• v.10 no.3 s.35
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• pp.173-182
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• 2005

In this paper, we propose a landmark recognition method which is irrelevant to the camera viewpoint on the navigation for localization. Features in previous research is variable to camera viewpoint, therefore due to the wealth of information, extraction of visual landmarks for positioning is not an easy task. The proposed method in this paper, has the three following stages; first, extraction of features, second, learning and recognition, third, matching. In the feature extraction stage, we set the interest areas of the image. where we extract the corner points. And then, we extract features more accurate and resistant to noise through statistical analysis of a small eigenvalue. In learning and recognition stage, we form robust feature models by testing whether the feature model consisted of five corner points is an invariant feature irrelevant to viewpoint. In the matching stage, we reduce time complexity and find correspondence accurately by matching method using similarity evaluation function and Graham search method. In the experiments, we compare and analyse the proposed method with existing methods by using various indoor images to demonstrate the superiority of the proposed methods.

• Journal of rehabilitation welfare engineering & assistive technology
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• v.10 no.3
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• pp.185-197
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• 2016

This study purposed to analyse smartphone addiction characteristics of people with disabilities and suggested to establish related prevention policies for them. The analysis of 20-50 aged 494 disabled people resulted, that the smartphone addiction rate of the disabled people was 12.55%. Smartphone use-, mobile messenger-, SNS- and game time were nearly the same or higher than the potential and high risk group from the survey on internet overdependence 2015. In the question about the awareness of smartphone addiction they answered the smartphone addiction is severe in the society, and they are aware of smartphone addiction counseling center. But they will not get a service form the centers. That suggests, that the government should promote the policy of smartphone addiction for the disabled. It should provide institutional strategy and structural change for prevention of smartphone addiction for the disabled.