• Korean Journal of Microbiology
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• v.29 no.1
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• pp.25-33
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• 1991

Antiviral activities of papaverine and nucleoside analogs, 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine (DHPG) and acyclovir, against human cytomegalovirus (HCMV) infection were compared in vitro. Papaverine and DHPG were effective in reducing infectious HCMV yields with $ED_{50}{\s}$ (effective dose 50: the concentraion at which 50% of virus yields was obtained) of approximately 1.02 and $0.45{\mu}{\M}$, respectively; while acyclovir was less effective with an $ED_{50}$ of about $10.4{\mu}{\M}$The relative cytotoxicity of these drugs was evaluated under the same conditions used to measure infectious HCMV yields. Papaverine and DHPG demonstrated little cellular toxicity as measured by their effect on the viability of confluent cells at concentrations in the range of those demonstrating potent inhibition of HCMV replication. Similarly, protein synthesis was largely unaffected by these drugs in stationary mock-infected cells as measured by the incorporation of isotopically labelled amino acids. In contrast, cellular DNA synthesis was invariably reduced in the presence of either drug. HCMV-specific DNA synthesis was also strongly inhibited by papaverine and DHPG.

• Journal of the Korean Institute of Intelligent Systems
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• v.22 no.5
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• pp.646-655
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• 2012

First, we prove a number of results about interval-valued fuzzy groups involving the notions of interval-valued fuzzy cosets and interval-valued fuzzy normal subgroups which are analogs of important results from group theory. Also, we introduce analogs of some group-theoretic concepts such as characteristic subgroup, normalizer and abelian groups. Secondly, we prove that if A is an interval-valued fuzzy subgroup of a group G such that the index of A is the smallest prime dividing the order of G, then A is an interval-valued fuzzy normal subgroup. Finally, we show that there is a one-to-one correspondence the interval-valued fuzzy cosets of an interval-valued fuzzy subgroup A of a group G and the cosets of a certain subgroup H of G.

• Honam Mathematical Journal
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• v.27 no.3
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• pp.369-388
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• 2005

First, we prove a number of results about intuitionistic fuzzy groups involving the notions of intuitionistic fuzzy cosets and intuitionistic fuzzy normal subgroups which are analogs of important results from group theory. Also, we introduce analogs of some group-theoretic concepts such as characteristic subgroup, normalizer and Abelian groups. Secondly, we prove that if A is an intuitionistic fuzzy subgroup of a group G such that the index of A is the smallest prime dividing the order of G, then A is an intuitionistic fuzzy normal subgroup. Finally, we show that there is a one-to-one correspondence the intuitionistic fuzzy cosets of an intuitionistic fuzzy subgroup A of a group G and the cosets of a certain subgroup H of G.

• Bulletin of the Korean Chemical Society
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• v.10 no.5
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• pp.448-452
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• 1989

NADH analogs, 1-benzyl-3-substituted (X)-1,4-dihydropyridines 1-4 (1: X = $CONH_2$; 2: X = $CSNH_2$; 3: X = $COOCH_3$; 4: X = $COCH_3$) were synthesized. The second order rate constants for hydration reaction and oxidation reactions by $Cu^{2+}$, $Fe(CN)_6^{3-}$ or methylacridinium iodide (MAI) of the compounds were determined. For all reactions investigated, the rate constants increased with decreasing electronegative character of the 3-substituents of 1,4-dihydropyridines : the decreasing order of the reaction rates was 2>1>3>4. However, the sensitivity of the reaction rates on the 3-substituents differed among the reactions. This was explained in view of mechanisms of the reactions.

• Bulletin of the Korean Chemical Society
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• v.17 no.7
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• pp.599-604
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• 1996

The synthesis is reported of p-nitrophenyl glycosides of D-galactose modified at C-4 with azido- (5), amino- (6) group and fluorine (13). 4-Azido-2,3,6-tri-O-benzoyl-4-deoxy-α-D-galactopyranosyl chloride and 2,3,6-tri-O-benzoyl-4-deoxy-4-fluoro-α-D-galactopyranosyl bromide were coupled with potassium p-nitrophenoxide in the presence of 18-crown-6 giving the corresponding p-nitrophenyl 4-azido-and 4-fluoro-4-deoxy-β-D-galactopyranoside derivatives. p-Nitrophenyl 4-amino-4-deoxy-β-D-galactopyranoside (6) was obtained by selective reduction of p-nitrophenyl 4-azido-4-deoxy-β-D-galactopyranoside (5) using 1,3-propane dithioltriethylamine. These galactoside analogs were slowly hydrolyzed in the increasing rate order of 5, 6 and 13 by β-galactosidase from Escherichia coli.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.298.2-298.2
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• 2002

Bioflavonoids are semi-essential food components that are ubiquitously present in nature. It has been reported that flavonoids act as anti-oxidant as well as anti-cancer agents. Quercetin is one of the most widely distributed bioflavonoids in the plant kingdom. The goal of this study was to investigate effects of quercetin analogs extracted from Lindera erythrocarpa, quercetin 3-O-${\alpha}$-arabinofuranoside and quercetin 3-O-${\alpha}$-L -rhamnoside, on oxidatie stress-induced cell death. (omitted)

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.312.1-312.1
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• 2002

Previous studies have demonstrated that 2,3',4,5' -tetramethoxystilbene (TMS) and 3,3',4',5,5'-pentamethoxystilbene (PMS) showed selective inhibition of human cytochrome P450 1 Bl and 1A1 in vitro., respectively, In the present study, the effects of synthetic stilbene analogs on the expression of cytochrome P450 1Al or lBl were investigated in human tumor cell lines such as HepG2, MCF-7 and MCF-l0A, TCDD caused a dramatic increase in the amount of P450 1A1 or 1B1 proteins and mRNA levels. (omitted)

• Proceedings of the Korean Society for Applied Microbiology Conference
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• 2005.06a
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• pp.274-275
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• 2005

• Bulletin of the Korean Chemical Society
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• v.25 no.12
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• pp.1755-1756
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• 2004

• Bulletin of the Korean Chemical Society
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• v.19 no.11
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• pp.1274-1276
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• 1998