• KSBB Journal
• /
• 제30권5호
• /
• pp.239-244
• /
• 2015

Bacterial vaginosis (BV) is caused by microbial imbalance of the vaginal ecosystem and overgrowth of anaerobic bacteria. The antibiotic treatment often results in very high recurrence of BV because it disturbs the vaginal ecosystem. The high recurrence rates suggest a need for alternative therapeutic methods and probiotics are being recognized as alternative or additional treatment method for BV. The purpose of this study was to investigate how human vaginal isolates of Lactobacillus spp. inhibit the BV-associated pathogen Gardnerella vaginalis. Results show that selected strains significantly reduced the viability of G. vaginalis. Among these selected strains KLB410 and KLB416 were further selected based on acid/bile tolerance and identified through 16S rRNA gene sequencing being Lactobacillus plantarum. Further studies are underway to demonstrate that the selected strain can be applied as potential probiotics for recovering vaginal ecosystem.

• 한국의류학회지
• /
• 제41권3호
• /
• pp.548-555
• /
• 2017

This study focuses on how clothing can increase in the age of the shared economy and as an alternative to the capitalist economy of the 21st century. This study investigates how infants and children use clothes as they undergo many changes based on physical growth, identifies use and disposal methods for surplus clothing from the perspective of a shared economy and explores plans to foster an environment for the healthy use of clothes. The objectives of this study are as follows. First, identify the need for new clothes based on physical changes in the human body; second, propose an alternative to permanent disposal by making used clothes appropriate for temporary disposal (renting and leasing). In sharing services, the condition and quality of the product were found to be the most important factors. The condition and quality of the product (70.0%) were the most important factors in sharing services. The sharing services for clothes and goods of infants and children could become popular quickly if there was a reliability guarantee offered by such sharing services. In addition, providing trial services and aggressive publicity for sharing services is urgent for the expansion of opportunities for general consumers.

• 품질경영학회지
• /
• 제41권2호
• /
• pp.249-260
• /
• 2013

Purpose: The main objective of this paper is to propose an RD method by developing a neural network (NN)-based estimation approach in order to provide an alternative aspect of response surface methodology (RSM). Methods: A specific modeling procedure for integrating NN principles into response function estimations is identified in order to estimate functional relationships between input factors and output responses. Finally, a comparative study based on simulation is performed as verification purposes. Results: This simulation study demonstrates that the proposed NN-based RD method provides better optimal solutions than RSM. Conclusion: The proposed NN-based RD approach can be a potential alternative method to utilize many RD problems in competitive manufacturing nowadays.

• 한국에너지공학회:학술대회논문집
• /
• 한국에너지공학회 1998년도 추계 학술발표회 논문집
• /
• pp.3-8
• /
• 1998

The present work proposes the potential fuzzy framework, based on fuzzy set theory, for supporting decision-making problems, especially, selection problems of a best design in the area of nuclear energy system. The framework proposed is composed of the hierarchical structure module, the assignment module, the fuzzification module, and the defuzzification module. In the structure module, the relationship among decision objectives, decision criteria, decision sub-criteria, and decision alternatives is hierarchically structured. In the assignment module, linguistic or rank scoring approach can be used to assign subjective and/or vague values to the decision analyst's judgment on decision variables. In the fuzzification module, fuzzy numbers are assigned to these values of decision variables. Using fuzzy arithmetic operations, for each alternative, fuzzy preference index as a fuzzy synthesis measure is obtained. In the defuzzification module, using one of methods ranking fuzzy numbers, these indices are defuzzified to overall utility values as a cardinality measure determining final scores. According these values, alternatives of interest are ranked and an optimal alternative is chosen. To illustrate the applicability of the framework proposed to selection problem, as a case example, the best option choice of four design options under five decision criteria for primary containment wall thickening around large penetrations in an advanced nuclear energy system is studied.

• Applied Microscopy
• /
• 제47권2호
• /
• pp.77-83
• /
• 2017

Drastic development of ubiquitous devices requires more advanced batteries with high specific capacitance and high rate capability. Large-area microstructure characterization across the stacks of cathode, electrolyte and anode might reveal the origin of the instability or degradation of batteries upon cycling charge. In this study, sample preparation methods to observe the cross-section view of the electrodes for battery in SEM and several imaging tips are reviewed. For an accurate evaluation of the microstructure, ion milling which flats the surface uniformly is recommended. Pros and cons of cross-section polishing (CP) with Ar ion and focused ion beam (FIB) with Ga ion were compared. Additionally, a modified but new cross-section milling technique utilizing precision ion polishing system (PIPS) which can be an alternative method of CP is developed. This simple approach will make the researchers have more chances to prepare decent large-area cross-section electrode for batteries.

• Biomolecules & Therapeutics
• /
• 제3권3호
• /
• pp.242-244
• /
• 1995

In vitro cell culture system has been proposed as a promising alternative model to in vivo skin irritation test. These studies were performed to screen the cytotoxicity effects of surfactants using normal human skin fibroblasts. Cell membrane integrity assessed by the leakage of lactate dehydrogenase (LDH) and mitochondrial integrity by MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromides reduction test were affected in a dose dependent manner. The irritation potential of surfactants to human skin patch test, and the changes of capillary permeability by rabbit intradermal safety test were assessed as in vivo methods. Our results suggest that LDH leakage assay and MTT reduction test using cultured human fibroblasts could be predictive for the irritancy of various surfactants in human, and LDH assay is superior correlated with in vivo test (r=0.886) to MTT test with in vivotest (r=0.757).

• 한국산업보건학회지
• /
• 제28권2호
• /
• pp.158-165
• /
• 2018

Objectives: We analyzed the problems that work environment measurement results don't lead to workplace improvement in the Work Environment Measurement System to propose an alternative. Methods: We reviewed reports and articles written by the Korea Occupational Safety and Health Agency and academic circles to identify the problems in the current Work Environment Measurement System and suggest an alternative. Results: One of the reasons that the Work Environment Measurement has not resulted in workplace improvement is that there were no proper regulating systems for managing the workplace improvement plans or improvement results. Moreover, there are not enough professional manpower in ministry of labor to evaluate the improvement plans and results from the Work Environment Measurement. Therefore, all of the workplace whose Work Environment Measurement results exceed the occupational exposure limit (OEL) should be managed by regional ministry of labor, and outside experts and new system for verifying improvement are needed. Conclusions: To accomplish the purpose of Work Environment Measurement, it is necessary to improve the work environment according to the results of Work Environment Measure. For this, it is necessary for the government to manage the fulfillment of workplace improvement plans and for measurement agencies to secure expertise.

• 대한후두음성언어의학회지
• /
• 제26권2호
• /
• pp.97-100
• /
• 2015

Benign vocal fold lesions, such as vocal nodules, polyps and Reinke's edema, usually result from chronic voice overuse. Conservative management such as voice therapy and pharmacotherapy are used as the primary treatment techniques. The main purpose of voice therapy is to identify and reduce voice misuse to achieve the optimal voice. But complete resolution may not be possible in all patients after voice therapy. Furthermore, some patients with voice-related occupations, voice rest and voice therapy are sometimes difficult, which makes it hard to carry out the treatment. When conservative therapy is ineffective, laryngeal microsurgery can be performed under general anesthesia. However, potential complications following laryngeal suspension and violation of the layered structure of the vocal fold during surgery should be considered before surgery. In recent decades, emerging literatures have demonstrated the potential usefulness of vocal fold steroid injection as an alternative treatment option for benign vocal fold lesions. The most advantageous feature of vocal fold steroid injection is the maintenance of regional anti-inflammatory effects while preventing the potential systemic adverse effects of the steroid. Many non-surgical treatment methods can be conducted using different approaches in the office setting. It can be applied as an alternative treatment modality for the management of various benign vocal fold lesions.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제42권3호
• /
• pp.151-156
• /
• 2016

Objectives: To assess submental route intubation as an alternative technique to a tracheostomy in the management of the airway in cranio-maxillofacial trauma, along with an assessment of its morbidity and complications. Materials and Methods: Submental intubation was performed in 17 patients who had maxillofacial panfacial trauma and management was done under general anesthesia during a period of one year from 2013 to 2014 at Departments of Oral and Maxillofacial Surgery and Dentistry, the Malankara Orthodox Syrian Church Medical College, Kochi, India. Results: In all 17 cases, the technique of submental intubation was found to be simple and reliable. Hypertrophic scars were noted in three cases, orocutaneous fistula and mucocele in one case each. All these complications were managed comfortably without significant morbidity to the patient. Conclusion: Submental intubation is a good technique that can be used regularly in the management of the airway in cranio-maxillofacial trauma, but with some manageable complications.

• 디지털콘텐츠학회 논문지
• /
• 제6권3호
• /
• pp.163-168
• /
• 2005

전산구조와 기술이 분산환경으로 옮겨가고 있고 인수합병 및 프로세스 아웃소싱 둥의 증가로 인해 혹은 조직내의 다양한 시스템이 신규 개발 또는 증설됨에 따라 이기종 플랫폼간의 상호연계미비, 유지보수의 난이함, 데이터 중복성과 일관성 결여 등의 문제점들이 발생되면서 EAI환경의 도입에 대한 요구가 증가하고 있으나, 많은 비용과 솔루션 선정의 어려움으로 그 적용이 쉽지 않다. 따라서 본 연구에서는 분산시스템 환경에서 이기종 간의 데이터 및 응용프로그램 통합을 위한 효율적인 대안으로 메시지미들웨어를 적용한 시스템통합방안을 제시하였다. 본 논문에서 밝힌 시스템간의 메시지 미들웨어를 이용한 데이터 통합방안은 비용과 성능 측면에서 소규모 시스템간의 인터페이스를 구축할 수 있는 효율적 대안이 될 것으로 기대한다.