• Journal of Life Science
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• v.32 no.2
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• pp.175-188
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• 2022

Relaxin has been demonstrated to have regulatory functions on both the smooth muscle and extracellular matrix (ECM) of blood vessels and fibrotic organs. The diverse mechanisms by which relaxin acts on small resistance arteries and fibrotic organs, including the bladder, are reviewed here. Relaxin induces vasodilation by inhibiting the contractility of vascular smooth muscles and by increasing the passive compliance of vessel walls through the reduction of ECM components, such as collagen. The primary cellular mechanism whereby relaxin induces arterial vasodilation is mediated by the endothelium-dependent production of nitric oxide (NO) through the activation of RXFP1/PI3K, Akt phosphorylation, and eNOS. In addition, relaxin triggers different alternative pathways to enhance the vasodilation of renal and mesenteric arteries. In small renal arteries, relaxin stimulates the activation of the endothelial MMPs and EtB receptors and the production of VEGF and PlGF to inhibit myogenic contractility and collagen deposition, thereby bringing about vasodilation. Conversely, in small mesenteric arteries, relaxin augments bradykinin (BK)-evoked relaxation in a time-dependent manner. Whereas the rapid enhancement of the BK-mediated relaxation is dependent on IK_Ca channels and subsequent EDH induction, the sustained relaxation due to BK depends on COX activation and PGI₂. The anti-fibrotic effects of relaxin are mediated by inhibiting the invasion of inflammatory immune cells, the endothelial-to-mesenchymal transition (EndMT), and the differentiation and activation of myofibroblasts. Relaxin also activates the NOS/NO/cGMP/PKG-1 pathways in myofibroblasts to suppress the TGF-β1-induced activation of ERK1/2 and Smad2/3 signaling and deposition of ECM collagen.

• Advances in concrete construction
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• v.6 no.4
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• pp.387-405
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• 2018

Geopolymer concrete is a fastest developing field of research for utilizing industrial and agro waste materials as an alternative for Portland cement based concrete. Geopolymers are formed by the alkaline activation of aluminosilicates rich materials termed as geopolymerization. The process of geopolymerization requires elevated temperature curing which restricts its application to precast industry. This review summarizes the work carried out on developing the geopolymer concrete with the addition of various mineral admixtures at ambient curing temperature conditions. An overview of studies promoting the geopolymer concrete in general building construction is presented. Literature study revealed that geopolymer concrete with the addition of admixtures can exhibit desirable properties at ambient temperature conditions.

• Journal of Global Scholars of Marketing Science
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• v.7
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• pp.55-69
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• 2001

This article focuses on subject of the present question to traditional market. These days traditional markets have systemic problems due to deterioration of the outer market circumstance and the inner defect and the inner frailty. In this situation, from the SangNam market case analysis, was traced the alternative activation strategies. Issued the 6 inner competency competition strategies for traditional market and issued 7 functional frame for organization system construction. Struggle strategies is built up of the inner organization solidarity and effective management system. So as to build struggle strategies, suggested and issued the 4 phase organization frame to strength stage of traditional market organization operating.

• Proceedings of the Korea Concrete Institute Conference
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• 2004.05a
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• pp.108-111
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• 2004

The polypropylene(PP) fiber is poised as a low cost alternative for reinforcement in structural applications in comparison with other high performance fibers, such as the polyvinyl-alcohol(PVA), polyethylene, carbon and aramid fiber. The mechanical properties of the composite are strongly determined by the interfacial behavior of fiber and cementitious matrix. The crack bridging mechanism contribute to composite toughness from activation of the fiber-matrix interface where energy is dissipated through debonding of the interface and fiber pullout. In this study, therefore, the pullout behavior of PP fibers is investigated. Experimental work includes the investigation of the interfacial properties, and the composite property. The quantification of interfacial properties, the frictional bond is achieved through single fiber pullout test. A study on the effect of inclination angle on fiber pullout behavior is also conducted.

• Journal of Korean Society for Atmospheric Environment
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• v.21 no.6
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• pp.625-630
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• 2005

This study was focused on the catalytic activity for the combustion of low-concentration methane using various commerical catalysts (six transition metal catalysts in Russia and one rare earth metal (Honeycomb) catalyst in Korea). Catalytic activity was strongly influenced by the type and loading content of metal supported in catalyst. Catalytic performance showed the highest activity in Honeycomb catalyst including rare earth metal, which was the most expensive catalyst, while the next was the catalyst supported Cu with high content (AOK-78-52) and also that supported Cr and Co (AOK-78-56). However, both AOK-78-52 and AOK-78-56 catalysts that were very cheap had lower activation energy than Honeycomb catalyst. In the economical field, both AOK-78-52 and AOK-78-56 catalysts with transition metals showed a good alternative catalyst on the combustion of methane.

• Journal of the Korean Society for information Management
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• v.22 no.2 s.56
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• pp.253-273
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• 2005

The study investigated the 7 problems of journal publishing based scholarly communication and suggested that the open access scholarly communication could be an alternative to that scholarly communication. To understand the status of open access scholarly communication in Korea, the study investigated open access journal or archive, open access license and softwares in Korea, and suggested the expected role of library to be the herb in scholarly communication.

• Knowledge Management Research
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• v.18 no.4
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• pp.159-180
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• 2017

The rapid development of information technology has affected many industries, and made consumers receive new services that are completely different from those of the past. In the financial industry, various changes are taking place, such as providing the payment system which is easy to use and offering differentiated services. This study examined the factors affecting the intention to use mobile payment system. In particular, we considered both practical and emotional factors that affect the intentions. The mobile payment system, which is a new form of payment, is rapidly developing in China. In Korea, it is still in the beginning stage due to the legal regulations and the activation of alternative payment methods. This study, therefore, compared the differences in factors that affect the intention to use mobile payment system between Korea and China.

• Carbon letters
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• v.1 no.3_4
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• pp.154-157
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• 2001

Composite adsorbents were prepared by mixing water plant sludge with phenolic resin having the ratio of 1 : 1, 1 : 2, and 1 : 3 respectively, curing from $100^{\circ}C$ to $170^{\circ}C$ under $N_2$ atmosphere, and then activating with $N_2$ at $700^{\circ}C$. Thermal property, specific surface area and morphology of the composite adsorbents as well as their precursors were measured by TGA, BET and SEM respectively. Removal efficiency of the composite adsorbents to ${NH_4}^+$ and TOC was compared with those of commercial zeolite and activated carbon. The adsorbents presented very promising TOC removal efficiency of 98%, which was identical level to that of commercial activated carbon while they displayed removal efficiency, only 32%, of ${NH_4}^+$. Therefore, this composite adsorbent considered as the alternative material of commercial activated carbon, used as an expensive removal agent of organic substances and THM in water treatment plant and it also suggested a possibility of practical application in other processes.

• Toxicological Research
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• v.26 no.1
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• pp.61-66
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• 2010

Retinoids have many beneficial effects on dermatological applications. But, retinoids cause skin irritation. In this study, the safety of retinoids was clarified via both primary skin irritation test in rabbits and sensitization study using an integrated model for the differentiation of chemical-induced allergic and irritant skin reaction (IMDS), an alternative method to sensitization test. The effects of retinoids on the change of ultraviolet A (UVA)-induced matrix metalloproteinase-1 (MMP-1) in human skin fibroblasts and the modulation of type-1 pN collagen synthesis in hairless mice were examined to clarify the anti-wrinkle effects. Alltrans retinol (t-ROL) and its derivative, all-trans retinoic acid (t-RA), showed mild skin irritation but did not induce the sensitization. t-ROL and t-RA exerted anti-wrinkle effects by inhibiting the UVA-induced MMP-1 in human skin fibroblasts and increasing the type-1 pN collagen synthesis in hairless mice. These findings suggest that retinoids do not induce the allergy, and show anti-wrinkle effects by decreasing MMP-1 activation and increasing collagen synthesis.

• Proceedings of the Korean Society for Quality Management Conference
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• 2004.04a
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• pp.556-563
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• 2004

For the activation of the Sanhakyeon Consortium, the role of local universities is critical. It is necessary for the university professionals to bring forth detailed alternative plans to upgrade the technological power of the inferior local small & medium enterprises. This means that the local self-governing bodies must database local universities and professional personnel. As a result, the professionals that are needed by enterprises must be designated to those businesses. Also, the regional small and medium enterprises must develop research personnel to enhance their power of technology. To make this possible, the participating companies of Sanhakyeon Consortium should support the students who are participating in the Consortium with research funds, and also should consider how these students can work for those companies after graduation. Finally, the local self-governing bodies must support Sanhak's cooperative research on locally specialized Industries, by forming a technology-human power network between local universities and small Sl medium enterprises.