• Asia pacific journal of information systems
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• v.24 no.4
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• pp.473-491
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• 2014

There is a growing interest for 'Cloud computing' to cut costs, and help the users focus on their core business instead of being impeded by IT obstacles. As it became IT version 3.0 which represents the era of cloud services and the dominance of a new kind of IT service provider, cloud service providers (CSPs)' role is more critical as a trusted IT advisor to include cloud migration and integration expertise. However, previous literatures related to cloud computing service have mainly analyzed from customers, although it is hard for customers to totally understand the complex and diverse cloud ecosystem. Therefore, it is an urgent task to mitigate the inhibitory factors in providing the cloud services for activating cloud industry. This study, an exploratory research based on interviews, has derived factors of promoting and hindering the activation of cloud computing from the provider's perspective, and has analyzed a sequence of cause and effect for each factor. For this, the casual loop diagram was developed to deduce key issues, and propose an alternative. The results of this study are expected to help activate 'Cloud computing' in Korea by minimizing the potential negative effects of activating 'Cloud computing' industry.

• Experimental and Molecular Medicine
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• v.50 no.12
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• pp.6.1-6.10
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• 2018

Bmal1 is one of the key molecules that controls the mammalian molecular clock. In humans, two isoforms of Bmal1 are generated by alternative RNA splicing. Unlike the extensively studied hBmal1b, the canonical form of Bmal1 in most species, the expression and/or function of another human-specific isoform, hBmal1a, are poorly understood. Due to the lack of the N-terminal nuclear localization signal (NLS), hBMAL1a does not enter the nucleus as hBMAL1b does. However, despite the lack of the NLS, hBMAL1a still dimerizes with either hCLOCK or hBMAL1b and thereby promotes cytoplasmic retention or protein degradation, respectively. Consequently, hBMAL1a interferes with hCLOCK:hBMAL1b-induced transcriptional activation and the circadian oscillation of Period2. Moreover, when the expression of endogenous hBmal1a is aborted by CRISPR/Cas9-mediated knockout, the rhythmic expression of hPer2 and hBmal1b is restored in cultured HeLa cells. Together, these results suggest a role for hBMAL1a as a negative regulator of the mammalian molecular clock.

• Proceedings of the KSR Conference
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• 2008.11b
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• pp.458-464
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• 2008

The objective of this paper is to seek an alternative to figure out appropriate ways since difficulties lie in the introduction of LRT system to be operated by governments and self-governing local governments in the country. This situation can act as a main cause of breakdown in domestic railway industry by deepening of outflow of national wealth and technological dependency. Policy makers are required to get awareness of justification and necessity of Project management such as project strategy, goals, operating budgets, risks, investment revenue prior to preparing the outline of the introduction of LRT system shall consider securing budget in light of performance, reliability, and safety withe the help of system engineering activities during the entire project cycle such as design, construction, quality management, and commissioning before mapping out the basic plans for LRT project. In view of the current domestic conditions, the first time within the country, Seoulmetro is training professional as trust education of specialist training about LRT system, SE and PM education. This study leads to participating in PM/SE business by human power who finished from education of domestic specialist for LRT introduction corporation and businesses, it is published for introduction of specialist education and business revitalization.

• Nuclear Engineering and Technology
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• v.51 no.2
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• pp.424-431
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• 2019

The aim of the present study was to develop model for detonation cell sizes prediction based on a deep artificial neural network of hydrogen, methane and propane mixtures with air and oxygen. The discussion about the currently available algorithms compared existing solutions and resulted in a conclusion that there is a need for a new model, free from uncertainty of the effective activation energy and the reaction length definitions. The model offers a better and more feasible alternative to the existing ones. Resulting predictions were validated against experimental data obtained during the investigation of detonation parameters, as well as with data collected from the literature. Additionally, separate models for individual mixtures were created and compared with the main model. The comparison showed no drawbacks caused by fitting one model to many mixtures. Moreover, it was demonstrated that the model may be easily extended by including more independent variables. As an example, dependency on pressure was examined. The preparation of experimental data for deep neural network training was described in detail to allow reproducing the results obtained and extending the model to different mixtures and initial conditions. The source code of ready to use models is also provided.

• Journal of Applied Biological Chemistry
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• v.63 no.4
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• pp.457-462
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• 2020

Pancreatic cancer is among the most difficult-to-treat tumors. More than half of patients with this cancer have very few symptoms at the early stages, allowing the development of distant metastases and resistance to cancer treatment. In this study, we found that Juniperus chinensis extract (JCX) decreased the cell viability and migration activity of PANC-1 and SNU-213 pancreatic cancer cells in a dose-dependent manner. JCX increased caspase-3 activation and generation of reactive oxygen species (ROS). N-acetylcysteine treatment blocked JCX-induced ROS generation and the negative effects on pancreatic cancer cell viability. In addition, JCX down-regulated the levels of phospho-focal adhesion kinase (p-FAK) and phospho-extracellular signal-regulated kinase (p-ERK). Together, these results indicate that JCX induces apoptosis in human pancreatic cancer cell lines through ROS production, downregulating FAK/ERK signaling and activating caspase-3. We propose that JCX-derived compounds represent candidates for the development of alternative medicines for the treatment of pancreatic cancer.

• The Journal of the Korea institute of electronic communication sciences
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• v.17 no.5
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• pp.783-790
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• 2022

The development of SNS and video platforms provided an opportunity to explode the activation of content production and consumption. However, in the legacy system, due to the host-based location-oriented data transmission, there are inherent limitations in efficient operation and management. As an alternative to this, a Contents Centric Network (CCN) was studied. In this paper, when intermediate nodes located between the information provider and the information requester between the real-time streaming services in the CCN environment move or restrict their use, failure through monitoring of wireless reception strength to solve problems like disconnection of transmission quality at the information consumer. We propose a stable intermediate node management mechanism through active response before occurrence.

• Mycobiology
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• v.50 no.1
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• pp.1-11
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• 2022

The ascomycete fungus Cordyceps militaris infects lepidopteran larvae and pupae and forms characteristic fruiting bodies. Owing to its immune-enhancing effects, the fungus has been used as a medicine. For industrial application, this fungus can be grown on geminated soybeans as an alternative protein source. In our study, we performed a comprehensive transcriptomic analysis to identify core gene sets during C. militaris cultivation on germinated soybeans. RNA-Seq technology was applied to the fungal cultures at seven-time points (2, 4, and 7-day and 2, 3, 5, 7-week old cultures) to investigate the global transcriptomic change. We conducted a time-series analysis using a two-step regression strategy and chose 1460 significant genes and assigned them into five clusters. Characterization of each cluster based on Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases revealed that transcription profiles changed after two weeks of incubation. Gene mapping of cordycepin biosynthesis and isoflavone modification pathways also confirmed that gene expression in the early stage of GSC cultivation is important for these metabolic pathways. Our transcriptomic analysis and selected genes provided a comprehensive molecular basis for the cultivation of C. militaris on germinated soybeans.

• The Korean Journal of Physiology and Pharmacology
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• v.26 no.5
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• pp.377-387
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• 2022

Benzimidazole anthelmintic agents have been recently repurposed to overcome cancers resistant to conventional therapies. To evaluate the anti-cancer effects of benzimidazole on resistant cells, various cell death pathways were investigated in 5-fluorouracil-resistant colorectal cancer cells. The viability of wild-type and 5-fluorouracil-resistant SNU-C5 colorectal cancer cells was assayed, followed by Western blotting. Flow cytometry assays for cell death and cell cycle was also performed to analyze the anti-cancer effects of benzimidazole. When compared with albendazole, fenbendazole showed higher susceptibility to 5-fluorouracil-resistant SNU-C5 cells and was used in subsequent experiments. Flow cytometry revealed that fenbendazole significantly induces apoptosis as well as cell cycle arrest at G2/M phase on both cells. When compared with wild-type SNU-C5 cells, 5-fluorouracil-resistant SNU-C5 cells showed reduced autophagy, increased ferroptosis and ferroptosis-augmented apoptosis, and less activation of caspase-8 and p53. These results suggest that fenbendazole may be a potential alternative treatment in 5-fluorouracil-resistant cancer cells, and the anticancer activity of fenbendazole does not require p53 in 5-fluorouracil-resistant SNU-C5 cells.

• Proceedings of the Korean Society of Crop Science Conference
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• 2022.10a
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• pp.332-332
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• 2022

Ginseng has been traditionally used in Asia including Korea, for health care and to treat verities of different diseases such as immune disease, liver disease, and cancer. The current study was aim to unveal the most efficient method such heating, prethanol-A and ultrasound, for cured extraction of ginseng with higher antioxidant activity. The current results shows a significant improvement in the inhibition of H₂O₂ by the ultrasound method than the HT and Pre-A method. Thus this inhibition in free redical is possible through the increase in the antioxidant activity. Therefore in this study the CAT, APX and phenolic and flavonoid content was increased in ginseng seed and germinated ginseng sprouts by the US method, while the POD, SOD and GSH activity was increased in HT method. This suggest that the different extraction method in different stage of ginseng growth show a different biochemical and metabolites activation. Thereby the Ultrasound and Heat extraction was a feasible alternative method for extracting interested ingredients from biological materials.

• Journal of Arbitration Studies
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• v.33 no.4
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• pp.69-87
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• 2023

This study recognizes that consumers are becoming important as a subject of commerce as they change from the existing e-commerce market to the consumer-led e-commerce market, and proposes the use of consumer intervention as a remedy for consumer damage in international e-commerce disputes. In Korea, there is no separate regulation on consumer arbitration, so we will analyze the U.S. arbitration judgment, which is the most active in consumer arbitration, and examine it through the U.S. arbitration judgment so that arbitration can become active as a remedy for consumer disputes in Korea. In summary, in the event of a dispute between consumers and companies through e-commerce, consumers' preference for arbitration was confirmed through repeated collection of opinions without coercion. It is necessary to revitalize arbitration in Korea to protect consumers through arbitration rather than litigation and to resolve disputes through active alternative dispute resolution as a solution to disputes in e-commerce, which is rapidly increasing through U.S. consumer arbitration cases. The topic of the activation of arbitration has been mentioned a lot before, but the preference for arbitration is still lower than that of litigation. However, from now on, as the appearance of existing commerce has changed to consumer-led e-commerce, it has proposed a plan to use arbitration to rescue consumers from damage as consumers as buyers grow in the market.