• Journal of Acupuncture Research
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• 제22권2호
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• pp.71-81
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• 2005

Objective : Dear antler (Cervus korean TEMMINCK var. mantchuricus Swinhoe) used for traditional immunosuppressive and immuno-activating action. The effect of deer antler herbal-acupuncture(DAH) solution, prepared by water extract method, on cathepsin activities in bone tissues (cartilage and synovial) cells from mouse rheumatoid arthritis (RA) model was studied. The cysteine endoprotease cathepsin mediates degradation of the MHC class II invariant chain (Ii) in human and mouse antigen-presenting cells. The studies described here examine the functional significance of cathepsin inhibition on autoantigen presentation and organ-specific autoimmune diseases in a murine model for RA. Methods : An animal model for RA in BALB/c mice thymectomized 3 days after birth (3d-Tx) was constructed All 3d-Tx BALB/c mice developed autoimmune lesions in the bone tissue cells, starting at 3 weeks of age, and the disease mediated by CD4+ T cells was chronic and progressive. Significant inhibitory effects of DAH solution on cathepsin S and L were observed in each organ in a dose-dependent manner. Moreover, we confirmed that cathepsin S and L activity in each organ were clearly inhibited by DAB solution. When we examined the inhibitory effects of DAH solution against autoantigen-specific T cell responses in vitro, in regional lymph node cells, but not in spleens, from model mice, a significant inhibitory effect of DAB solution was observed in a dose-dependent manner. DAH solution do not block T cell proliferation to Con A, indicated that the dose of DAB solution 10 to $20\;{\mu}g/m{\ell}$ was sufficient to inactivate the autoantigen-specific T cell responses in vitro. In vivo therapeutic effects of DAB solution were examined in a murine model for RA, autoantigen-specific (C-II-specific) T cell response were significantly inhibited in LNCs from DAH solution-treated mice. Results : Iinhibition of cathepsin S and L in vivo alters autoantigen presentation and development of organ-specific autoimmunity in RA model. Conclusion : These data identify selective inhibition of cysteine protease cathepsin S and L as a potential therapeutic strategy for autoimmune disease process such RA. Thus, DAH solution will served as a potent anti-inflammatory and anti-arthritic agents for treatment of human RA.

• 산업경영시스템학회지
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• 제39권1호
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• pp.130-139
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• 2016

The purpose of this paper is to analyze the problems and the sources of defective products and draw improvement plans in a small plastic boat manufacturing process using TOC (Theory Of Constraints) and statistical analysis. TOC is a methodology to present a scheme for optimization of production process by finding the CCR (Capacity Constraints Resource) in the organization or the all production process through the concentration improvement activity. In this paper, we found and reformed constraints and bottlenecks in plastic boat manufacturing process in the target company for less defect ratio and production cost by applying DBR (Drum, Buffer, Rope) scheduling. And we set the threshold values for the critical process variables using statistical analysis. The result can be summarized as follows. First, CCRs in inventory control, material mix, and oven setting were found and solutions were suggested by applying DBR method. Second, the logical thinking process was utilized to find core conflict factors and draw solutions. Third, to specify the solution plan, experiment data were statistically analyzed. Data were collected from the daily journal addressing the details of 96 products such as temperature, humidity, duration and temperature of heating process, rotation speed, duration time of cooling, and the temperature of removal process. Basic statistics and logistic regression analysis were conducted with the defection as the dependent variable. Finally, critical values for major processes were proposed based on the analysis. This paper has a practical importance in contribution to the quality level of the target company through theoretical approach, TOC, and statistical analysis. However, limited number of data might depreciate the significance of the analysis and therefore it will be interesting further research direction to specify the significant manufacturing conditions across different products and processes.

• 청정기술
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• 제13권2호
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• pp.109-114
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• 2007

본 연구에서는 반도체 제조공정 내의 습식 대기공조 정화설비에 사용될 화학수용액의 선정과 이를 이용한 대기오염물 정화 모사시험을 수행하였다. 50 ppm의 $NH_3$, SOx, NOx의 제거에 있어서 0.5 M의 이산화망간($KMnO_4$) 수용액은 99% 이상의 제거율을 보였다. $O_3$의 제거율은 $22{\sim}30%$ 수준에서 머물러, 별도의 건식 제거 장치가 필요한 것으로 판단된다. 또한 모든 화학수용액들에 있어 NOx의 제거효율은 $O_3$가 공존할 경우, $NO_2$ 농도 증가로 인해 보다 증가될 수 있었다. 마지막으로 액상분사 시스템을 구성하여 화학수용액들이 공기압 분사식 노즐을 통해 $60\;{\mu}m$ 수준의 미세 액적 형태로 분사됨에 따라, 기-액상간의 반응면적이 증가되어 기상 오염물의 제거효율이 보다 향상될 수 있었다.

• 소성∙가공
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• 제32권2호
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• pp.81-86
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• 2023

The hot stamping process is widely used for high strength of vehicle parts, with heating 900 ℃ or higher in a furnace and in-die quenching to achieve strength above 1.5 GPa of the quenchable boron alloyed steel 22MnB5. First of all, the hot stamping process consisted of heating, forming, quenching and trimming. In the trimming process case, the laser method has been conventionally adopted. For laser trimming process, it has the problems pertaining to low productivity and high cost while the hot stamping process, accordingly the trimming process need to investigate the research for alternative method. In order to overcome these issues, many research groups have studied the mechanical trim solution on the hot stamped parts at high temperature. In this study, the mechanical piercing was performed during the hot stamping process at the high temperature for overcome the disadvantages of laser cutting. Also, the process parameters such as piercing time after die closing, clearances of between die and punch were controlled for obtaining the reasonable shear characteristics.

• 한국기계가공학회지
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• 제7권3호
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• pp.87-95
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• 2008

The purpose of this study is to provide a decision support to select an appropriate rapid prototyping(RP) machine that suits the application of a part. Selection factors include concept model, form/fit/functional model, pattern model for molding, material property, build time and part cost that greatly affect the performance of RP machines. However, the selection of a RP is not an easy decision because they are uncertain and vague. For this reason, the aim of this research is to propose hybrid multiple attribute decision making approaches to effectively evaluate RP machines. In addition, because subjective considerations are relevant to selection decision, a fuzzy logic approach is adopted. The proposed selection procedure consists of several steps. First, we identify RP machines that the users consider. After constructing the evaluation criteria, we calculate the weights of the criteria by applying the fuzzy Analytic Hierarchy Process(AHP) method. Finally, we construct the fuzzy Technique of Order Preference by Similarity to Ideal Solution(TOPSIS) method to achieve the ranking order of all machines providing the decision information for the selection of RP machines.

• 한국정보통신학회논문지
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• 제15권11호
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• pp.2439-2443
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• 2011

태양전지를 제작하는데 실리콘기판 표면에서의 광 흡수를 증가시키기 위한 표면조직화를 위해서 염기 용액을 이용한 습식방법을 이용하여 샘플을 제작하였다. 이렇게 준비된 염기성 에칭용액을 이용한 실리콘 웨이퍼의 표면 상태를 관찰하여 광학적 특성과의 연관성을 조사하였다. 표면조직화가 표면 전체적으로 고르게 이루어진 샘플에서 반사도가 낮았으며, 광학적 특성이 좋게 나타났다. 에칭이 과도하게 일어난 샘플에서는 오히려 반사도가 증가하여 광학적 특성이 떨어지는 것을 확인 하였다.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2015년도 추계 학술논문 발표대회
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• pp.181-182
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• 2015

The production technologies of free-form concrete panels are emerging to satisfy the need of modern complex shaped in architectural design. This study aims for introducing and improvising the innovative technique called Rod type mold that overcomes the difficulties in some extent by enabling the mold to be used many times, making the shape of the mold adjustable in a flexible way and describing its production process to provide the alternative solution for the construction of free-form mold with considering the features including reusability and optimization cost across its production process. In this study, the freeform concrete panel shape was designed and experiment was done using computerized numeric control machine and rod type mold. The problems appeared on achieving desired shape while operating on rod type mold. The process of identifying all the root causes and contributing causes that may have generated an undesirable condition were done. Consequently, the conical or semicircular shaped was proposed for the end of Numerical control rod and replaced it with the existing flat shaped end to avoid the detachable problem and to improve rod type mold performance.

• 한국전기전자재료학회논문지
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• 제13권12호
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• pp.1063-1068
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• 2000

Water treeing in underground distribution power cable is not easy to observe by nondestructive method and it has very complex patterns. This study describes the principles and practices of a continuous observation of initiation and growth of tree in polymeric insulation material using an image measurement technique. Using this technique we could observe water tree and the growing process of electrical tree due to the water tree and the growing process of electrical tree due to the water tree. All of these growing process is analyzed quantitatively by image measurement program composed of borland c++. We fabricated the thin film type specimen to observe water tree easier and also the needle electrode was prepared by etching method using electrolytes. Initiation and the growth of three was observed somewhat different depending on the applied voltage and the water electrode. AgNO$_3$solution electrode accelerates the initiation and the growth of water tree, compared to those of distilled water electrode. The water and the electrical tree occurred by water tree has discontinuous growth characteristic.

• Journal of applied mathematics & informatics
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• 제15권1_2호
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• pp.511-525
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• 2004

we model communication and computer systems that process interactive and several and several types of background jobs. The scheduling policy in use is to share the processor among all interactive jobs and, at most, one background job of each type at a time according to the process sharing discipline. Background jobs of each type are served on a first-come-first-served basis. Such scheduling policy is called Processor Sharing with Background jobs (PSBJ). In fact, the PSBJ policy is commonly used on many communication and computer systems that allow interactive usage of the systems and process certain jobs in a background mode. In this paper, the stability conditions for the PSBJ policy are given and proved. Since an exact analysis of the policy seems to be very difficult, an approximate analytic model is proposed to obtain the average job sojourn times. The model requires the solution of a set of nonlinear equations, for which an iterative algorithm is given and its convergence is proved. Our results reveal that the model provides excellent estimates of average sojourn times for both interactive and background jobs with a few percent of errors in most of the cases considered.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2007년도 춘계학술대회 논문집
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• pp.1187-1192
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• 2007

Recently, many organizations such as, including government, railroad operational, railroad facilities managemental and research authorities have made a lot of efforts to identify and prevent hazards from leading to accidents and solve them all over the railroad industry. Railroad total safety technology development project conducted as one of national R&D projects has established business formation structure based on system engineering as an effort to define and give a solution to facing problems in the field of railroad. This paper is building procedures to verify the outcomes derived from this project. The verification process is the one for verifying the outcome produced in the final stage of the project or during the project. It makes sure that the system is satisfying the system requirements through verification of the outcomes produced after conducting the project for verification. We've made verification plan for technically reasonable verification using verification process developed through this research, and established master verification plan in the level of 15 detailed projects for interim and final outcomes produced.