• Journal of Life Science
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• v.5 no.3
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• pp.145-150
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• 1995

Alcoholic liver disease is defined by the development of three types of liver damage following chronic heavy alcohol consumption, namely, alcoholic fatty liver, alcoholic hepatitis, and alcoholic cirrhosis, The clinical features and laboratory tests often do not distinguish among these types of liver injuries. In addition, a considerable number of the patients who have clinical and laboratory features compatible with alcoholic liver disease are diagnosed on liver biopsy to have chronic viral hepatitis or other lesion. Because of these factors, liver biopsy is frequently needed to arrive a definite diagnosis of the disease, its activity, and its chronicity. Fatty liver is usually a benign and reverible condition that disappears on abstinence from alcohol. However, alcoholic hepatitis is usually regarded as a precursor of cirrhosis. The principle factors in the development of alcoholic hepatitis and cirrhosis are the quantity and length of ingestion of alcohol. women are much more susceptible than men to hepatic injuries. Since only 10 - 20% of alcoholics develop cirrhosis, however, it is conceivable that other factors, either genetic, environmental, or nutritional may contribute in the genesis of liver injuries. The most important factor in the treatment of alcoholic liver disease is prolonzed abstinence from alcohol, since abstinence by itself improves clinical status and survival, Nutritional support in patients with nutritional deficiency, and specific drug therapies such as corticosteroid or anabolic steroids for hospitaliged patients with severe alcoholic hepatitis also play an important role in devreasing morbidity and improving survival. Liver transplantation is a newer treatment modality in the patients with advanced cirrhosis, not responsible to medical treatment.

• Journal of Korean Public Health Nursing
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• v.16 no.2
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• pp.400-411
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• 2002

This study was performed to identify the drug use and reuse relating characteristics and reuse relating factors in illegal drug users. Subjects consisted of 88 illegal drug users. Some of them were confined in a mental hospital or National Forensic Psychiatric Hospital located in Chung-nam province, others on attending a drug abuse prevention program in Seoul Probational Institute. Data were collected during the period from February 1, 2002 to February 25, 2002, and analyzed by SAS program. version 6.12. for Wilcoxon rank sum test, Pearson Correlation, Multiple regression. Results were as follows; 1. Drug use characteristics were as follows. $19.3\%$ was has drug family history and $20.7\%$ was has alcohol family history. Main drug was Phillopon$44.3\%$, inhalants $35.2\%$, LSD et al $22.7\%$. Drug use rate of months was everyday $31.2\%$, every other day $24.4\%$. 2. $100\%$ has experienced abstinence and reuse. Abstinence period was less than 12 months in $49.4\%$ and reuse period was less than 6 months in $58.6\%$. 3. Drug use and reuse characteristics related to general characteristics was identified as below. Abstinence period of male was longer than that of female. Person who have drug family history experienced more drugs and person who have family alcohol history started earlier. 4. Reuse periods was correlated with abstinence periods, age. And abstinence period was correlated with age and outcome that following reuse. 5. The multiple regression was used to identify the relating factors that influence reuse period and abstinence period. At the state of controlling abstinence period. inhalants users have 10.07 days shorter reuse period than others. And abstinence period had lengthened age, bad health status, early initiate age, and long reuse period.

• Research in Community and Public Health Nursing
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• v.18 no.3
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• pp.363-372
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• 2007

Purpose: This study is to examine the effects of the drinking-reduction program that utilizes transtheoretical model and leisure ability model on the problem drinking behavior, alcohol outcome expectancy, and abstinence self-efficacy of. problem drinkers at workplaces. Method: The subjects consisted of 54 male problem drinkers who scored over 12 points in the AUDIT-K with 23 persons in the experimental group and 31 persons in the control group. The research results were analyzed using the SAS program with Chi-square test, t-test, repeated ANOVA, and post-hoc comparison. Results: 1) The experimental group showed a significantly lower score in problem drinking behavior than the control group. 2) The experimental group showed a significantly lower score in alcohol outcome expectancy than the control group. 3) The experimental group showed a significantly higher score in abstinence self-efficacy than the control group. Conclusion: These results demonstrate that the drinking-reduction program effectively reduces the drinking behavior of problem drinkers at workplaces, reduces alcohol outcome expectancy, and enhances abstinence self-efficacy. Accordingly, it is considered that a drinking-reduction program can be a useful nursing intervention method for problem drinkers at workplaces to reduce drinking and improve the quality of life.

• Korean Journal of Social Welfare
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• v.58 no.4
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• pp.291-312
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• 2006

Incentive-Therapy approach on substance abuser has a solid theoretical base in Behavior Psychology and shows the effectiveness empirically in US. The purpose of this exploratory study was to evaluate the effectiveness of Incentive-Therapy on two alcohol abusers using ABA Single System Design in a community welfare agency, Korea. It proceeded for 12 week-baseline stage, 6-week intervention stage and 4-week postintervention stage through scanning whether alcohol abuser drinks or not by the alcohol analyzer as a target behavior. As a results, this study showed that two abusers' drinking were decreased in the middle of intervention stage in incentive-therapy but they showed differently in the postintervention stage : One sustained his abstinence and the other recurred to drink. Thus, we concluded Incentive-Therapy had better adaptability in community welfare agency in that alcohol abusers were driven to motivate for abstinence and then had an opportunity for psycho-social counseling and social welfare intervention consistently.

• Korean Journal of Social Welfare Studies
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• no.39
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• pp.57-81
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• 2008

Motivation has been identified as an important factor predicting long-term outcomes of alcohol abuse treatment. Whether a patient agreed on his/her inpatient treatment at time of hospitalization could be an indicator of their motivation for treatment. This study focused on this aspect of treatment motivation and examined whether this factor predicts post-discharge abstinence. A sample of 145 individuals who were hospitalized for alcohol abuse treatment participated in the baseline data collection, of which only 66 successfully completed the 8 month follow-up telephone interview. The findings of survival analysis suggest that voluntarily admitted individuals had significantly longer duration of post-discharge abstinence compared to their counterparts. A Cox proportional hazards regression model revealed that voluntary admission and family support were significant predictors for post-discharge relapse of drinking, after controlling for the effects of marital status, living alone, and working status. Implications for social work practice are discussed.

• The Journal of the Korea Contents Association
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• v.15 no.12
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• pp.304-313
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• 2015

The purpose of this study was to identify the significant predictors of drinking problem among college students attending health and welfare department. A total of 538 college students attending health and welfare department were selected through convenient sampling. Data were collected using self-reporting questionnaires, which were constructed to include depression, anxiety, abstinence self-efficacy, and drinking behavior. SPSS 18.0 was used for data analysis and descriptive statistics, t-test, ANOVA, Scheffe's test, Pearson Correlation coefficients, and multiple regression were done. Drinking problem was positively correlated to the depression and anger while negatively correlated to the abstinence self-efficacy. The significant predictors of drinking behavior were sex, grade, anxiety, and abstinence self-efficacy. The result of this study suggest that drinking problem prevention program should consider improving self management skills by effective management of negative emotions along with enhancing self-efficacy as a cognitive strategy.

• Korean Journal of Biological Psychiatry
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• v.14 no.3
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• pp.161-166
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• 2007

Objectives:Recent studies have raised the possibility that nerve growth factor(NGF) is abnormally regulated in the central nervous system(CNS) of animal models with alcohol dependence. The possible alteration of NGF by prolonged alcohol intake may play an important role in alcohol-induced neurotoxicity. Carbohydrate-deficient transferrin(CDT) is regarded as a reliable biological marker of alcohol dependence. The goal of this study was to estimate the changes of %CDT and serum NGF level according to the duration of alcohol abstinence, and to identify whether %CDT level is associated with the serum NGF level in the patients with alcohol dependence. Methods:The subjects were 24 patients with alcohol dependence. We used the Axis-Shield ASA to measure the %CDT level and the enzyme-linked immunosorbent assay(ELISA) to measure the serum NGF level. %CDT and NGF levels were measured immediately after the admission and at 2 weeks after the admission. Results:Decreased %CDT were observed during the period of 2 weeks after the admission. NGF level was not significantly different after 2 weeks. The NGF levels were not correlated with %CDT. The possibility of %CDT as a predictor of alcohol-induced neurotoxicity was not confirmed. Conclusion:Serum NGF levels is not a reliable indicator of abstinence state in the patients with alcohol dependence. Further studies are needed to evaluate the relation between two indicators in regard to hematological and neurological changes in alcohol dependence.

• The Journal of the Korea Contents Association
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• v.20 no.1
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• pp.505-518
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• 2020

This study is a life history on self-realization of woman in the abstinence of alcohol process. The purpose of the study is to explore the circumstance of female alcoholism, to expand the prospect of discussion for treatment and recovery, and to suggest social welfare intervention measures. The study involved a female alcoholic who had been recovering for more than seven years, and the text for life history analysis was divided into 'dimension of life', 'turning point' and 'adaptation' based on the life history analysis framework proposed by Mandelbaum. As a result of the data analysis, 'dimension of life' was analyzed into three areas, such as the personal level of life, the family level of life, and the social dimension. 'Turning point' is to escape from a father who drinks alcohol and uses violence, to give up his job to avoid boss's abuse, and to proceed one's own way of healing. 'Adaptation' was derived into good at studying, relieving anger by drinking alcohol, and referring to AA and self-realization. Based on these findings, this study presented the social welfare practice and policy discussion focused on self-realization.

• 한국HCI학회:학술대회논문집
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• 2006.02b
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• pp.639-645
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• 2006

During abstinence from alcohol, craving is elicited by the cues and contexts previously associated with alcohol, and contributes to relapse. To prevent the craving and relapse experienced by alcoholics, cue-exposure therapy (CET) has been used to extinguish the association between alcohol and alcohol-related cues and contexts. This study applied CET, using a virtual reality (VR) system, to eight members of an Alcoholics Anonymous group, in eight sessions. Cues and contexts most likely to elicit an urge to drink were selected through a preliminary survey in order to compose VR-CET scenarios: a glass, bottle, food, and a bar were judged to be the most tempting for people in alcohol dependence and abstinence. By these cues and contexts, a Japanese style pub and a western bar were composed. Each session was administered for 30 minutes by a psychiatrist and included an introduction, immersion, VR navigation, interviews about feelings, and self-report questionnaires about cravings. The eight sessions consisted of initial and closing sessions, and six cue- and context-focused sessions. As a result, a reduction in cue-elicited craving after VR-CET was reported. A mean score of 15.75 (SD = 10.91) on the Alcohol Urge Questionnaire in the first session decreased to 11.57 (SD = 6.88) in the final session.

• Korean Journal of Biological Psychiatry
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• v.24 no.4
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• pp.219-224
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• 2017

Objectives This study sought to investigate the relationship between age, sex and alterations in levels of % carbohydrate-deficient transferrin (%CDT) and gamma-glutamyl transferase (GGT) in patients admitted with alcohol dependence. Methods The study retrospectively enrolled 187 patients who were diagnosed with alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-Fourth edition (DSM-IV) and were admitted into a closed ward in Hallym University Hangang Sacred Heart Hospital from 2009 to 2012 and Hallym University Kangnam Sacred Heart Hospital from 2012 to 2017. Demographic factors (age, sex) and biochemical markers [%CDT, GGT, mean corpuscular volume (MCV), aspartate transferase (AST), alanine transferase (ALT)] were collected by reviewing medical records. Alterations in the levels of %CDT and GGT in different groups for each demographic factor were compared after correcting for confounding variables (age, initial %CDT, GGT, MCV, AST, ALT). Results Decreased %CDT and GGT were observed during the period of abstinence after admission. The normalization period for %CDT increased with age, while the normalization period for GGT was longer in female patients. Conclusions These results suggest that alcohol-dependent patients that vary in age have different alterations in %CDT, while different sexes have different alterations in GGT. Age and sex can be potential indicators of treatment response after abstinence in patients with alcohol dependence. Further studies are needed to evaluate the relationship between these factors with regards to physiological and hematological changes in alcohol dependence.