• International Journal of Advanced Culture Technology
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• 제12권3호
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• pp.262-270
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• 2024

In modern society, with the growing emphasis on health and fitness, the need for education on proper exercise methods is increasingly highlighted. The purpose of this study is to develop a 3D anatomical exercise encyclopedia application optimized for Korean users, enabling them to clearly understand the anatomical structure of exercises and easily learn proper exercise methods. In this study, a user-friendly interface was developed using Flutter and Unity, and a feature was added that allows users to intuitively check muscle activation through 3D models. Users can easily understand the anatomical structure of the exercise areas through 3D models that can be zoomed in, out, and rotated, and can easily access information such as exercise definitions, exercise sequences, agonist muscles, and synergist muscles. As a result of the study, most of the 21 users who used the application showed high satisfaction with the intuitiveness of the interface and the accuracy of the information, suggesting improvements such as the addition of exercise items and muscle highlighting effects, confirming the potential for developing an exercise encyclopedia application optimized for users.

• 대한의생명과학회지
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• 제18권4호
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• pp.355-361
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• 2012

We investigated to verify whether the $PPAR{\alpha}$ agonist fenofibrate regulates adipose tissue metabolism and to determine the molecular mechanism involved in this regulation. After male mice (C57BL/6J) received a high fat diet with or without fenofibrate for 6 weeks, the effects of fenofibrate on not only adipose tissue weight, visceral adipocyte size, serum lipid and glucose levels, but also the expression of uncoupling proteins (UCPs). Mice given a fenofibrate-supplemented high fat diet showed reduced both visceral and subcutaneous adipose tissue weights versus high fat diet-fed animals. The size of visceral adipocytes was significantly decreased by fenofibrate treatment. The administration of fenofibrate resulted in decreased serum levels of triglycerides, free fatty acids, and glucose. Moreover, fenofibrate up-regulated mRNA levels of visceral adipose tissue UCP2 and skeletal muscle UCP3. Therefore, our results suggest that the increases in the expression of UCPs by fenofibrate seem to suppress diet-induced visceral adiposity as well as severe hypertriglyceridemia and hyperglycemia in male mice.

• 약학회지
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• 제43권5호
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• pp.659-664
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• 1999

To investigate the difference of contractile mechanism between KCI and phenylephrine-induced contraction, we observed effects of $Ca^{2+}$ antagonists and protein kinase inhibitors on aorta contraction of rats. Verapamil dose-dependently inhibited the contraction induced by KCI and phenylephrine, the inhibitory effect of verapamil was more potent in KCI-induced contraction than phenylephrine-induced contraction. Econazole and TMB-8 significantly inhibited CKI-induced contraction but did not inhibit phenylephrine-induced contraction. Staurosporine dose-dependently inhibited both KCI and phenylephrine-induced contraction. Genistein and calmodulin antagonists (W-7 and trifluoperazine) also inhibited both contraction in a dose dependent manner. However, the inhibitory effects of genistein and calmodulin antagonists were more potent in phenylephrine-induced contraction than KCI-induced contraction. These results suggest that involvements of $Ca^{2+}$ channel and protein kinase in rat aorta contraction were dependent on agonist causing aorta smooth muscle contraction.

• 수산해양교육연구
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• 제28권3호
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• pp.799-807
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• 2016

The objective of research was to explore the effects of Kinesic taping treatment on Kayaker's athletic performance and muscle fatigue variable. In order to accomplish such study objective, this study employed 8 ordinary university students and 8 university kayaker's as study subjects. The athletic performance records and blood lactate were analyzed before and after Kinesic taping treatment (KTT). Kinesic taping treatment was applied to the regions of agonist such as vastus medialis muscle, Latissimus dorsi muscle, Trapezius muscle, Biceps brachii muscle, and Triceps brachii muscle, which are major muscles for Kayaker's. Records for rest heart rate, athletic performance and blood lactate were measured upon 200m and 500m distance exercise using kayak ergometer. Data were analyzed by SPSS 19.0 using paired t-test and one-way repeated ANOVA at significant level of a = .05. First, performance records of 200m paddling kayak showed that the ordinary university students had a mean score of 60.13 second before and 58.75 second after kinesic taping treatment. University kayakers had a mean score of 58.75 second before and 53.0 second after kinesic taping treatment. Both groups had significant differences between before and after KTT in the athletic performance. In addition, levels of blood lactate showed that the ordinary university students had a mean score of 5.89mM before and 8.90mM after KTT and university kayaker's had a mean score of 5.79mM before and 8.48mM after KTT. The ANOVA showed that the level of ordinary university students' blood lactate was significantly higher than university kayakers only after KTT. Second, performance records of 500m paddling kayak showed that the ordinary university students had a mean score of 2.90 minute before and 2.77 minute after KTT and university kayaker's had a mean score of 2.30 minute before and 2.20 minute after KTT. Both groups had significant differences between before and after KTT in the athletic performance. Moreover, only university kayaker's had a significantly higher performance record than the counterpart. Levels of blood lactate showed that the ordinary university students had a mean score of 7.71mM before and 8.85mM after KTT and university kayakers had a mean score of 8.09mM before and 8.45mM after KTT. However, such a level of increase had no significant difference between the groups

• 재활복지공학회논문지
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• 제10권4호
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• pp.295-303
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• 2016

편마비 환자의 상지 운동 기능 재활 치료에 대한 지속적인 관심과 훈련의 정량적인 평가를 위한 다양한 장치가 요구되고 있다. 이러한 문제를 해결하기 위해서 본 논문에서는 거치대와 핸들, 밸런스 볼을 결합한 밸런스 핸들 장치를 개발하였다. 피험자 7명을 대상으로, 개발된 상지 훈련 장치를 기울일 때 주요 상지 근육에 대한 근전도 신호의 변화를 측정하여 재활 훈련 장치로 사용이 가능한지에 대한 유효성을 검토하였다. 밸런스 핸들 장치를 앞뒤로 기울였을 때의 상지 신전 굴곡 운동 동작과 좌우 기울임을 이용한 상지 운동 동작에서 근 수축과 이완이 기준이 되는 주동근과 길항근에서 근 활성화 신호를 분석하였다. 실험결과, Fugl-Meyer Assessment(FMA)의 신전 굴곡 운동 평가 항목에서 편마비 환자의 상지 운동 기능 평가에 이용되는 이두근, 삼두근, 삼각근에서 근 활성화 경향을 보였다. 이러한 결과를 바탕으로 개발된 장치를 활용하여 편마비 환자의 상지 재활 훈련에 도움이 될 수 있다고 볼 수 있다.

• BMB Reports
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• 제43권5호
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• pp.337-343
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• 2010

Fenofibrate, an agonist of $PPAR{\alpha}$, plays an important role in activating many proteins catalyzing lipid metabolism, and it also has a considerable effect on improvement of insulin sensitivity in the diabetic condition. To investigate fenofibrate-dependent expression of peripheral tissue proteins in diabetes, we analyzed whole muscle or fat proteins of fenofibrate-fed OLETF rats, an animal model of type II diabetes, using 2-dimensional gel electrophoresis. We found that many proteins were specifically expressed in a fenofibrate-dependent manner in these diabetic rats. In particular, a functionally unknown C11orf59 protein was differentially expressed in the muscle tissues (about 5-fold increase) in fenofibrate-fed OLETF rats as compared to control rats. Additionally, the signal proteins phosphatidylethanolamine binding protein and IkB interacting protein were differentially regulated in the fenofibrate-treated adipose tissues. We suggest here that these proteins might be involved in controlling lipid or carbohydrate metabolism in diabetes via $PPAR{\alpha}$ activation.

• 대한인간공학회지
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• 제29권3호
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• pp.347-356
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• 2010

The purpose of this study is to analyze the spine stability by comparing muscle activation in various scaffold working conditions. The independent working conditions were designed by two levels of working height, existence and absence of safety handrail, and the two levels of expertise. The corresponding activities of the agonist and antagonist muscles of spine were simultaneously recorded by using EMG. As results, novice worker showed increased muscle activity while doing the task on the 2nd floor, absence of handrail. And expert showed the increase of co-contraction while working on the 2nd floor without handrail. Such co-contraction was found to increase the spine stability when the working condition become risky. On the other hand, the co-contraction was prolonged, the spine muscle fatique and disc pressure could be increased, which would increase the risk of musculo-skeletal disorder. The results of co-contraction in this study indicates that the motor control system responds to maintain the stability of the spine particularly when workers cognitively recognize the danger of falling or imbalance. This study also quantitatively accounted for the biomechanical cause of LBP among workers who has to prevent themselves from falling. Therefore, if can be said that safe environment preventing falling can also prevent workers from MSDs as well. Such knowledge can be applied to design ergonomic workplace environment as well as movable scaffold.

• 한국운동역학회지
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• 제30권3호
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• pp.275-283
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• 2020

Objective: The purpose of this study was to investigate the effect pf flexibility of hip flexor muscles on a conventional deadlift movement. Method: Eighteen healthy male were participated in this study and were divided into normal group (NG: age: 24.0±1.8 yrs, height: 174.5±2.37 cm, body mass: 74.4±5.5 kg, 1RM: 138.0±23.8 kg) and restricted group (RG: age: 24.6±1.7 yrs, height: 171.5±5.3 cm, body mass: 74.0±5.7 kg, 1RM: 137.5±18.3 kg) by Thomas test, which measure flexibility of hip flexor muscles. A 3-dimensional motion analysis with 8 infrared cameras and 3 channels of EMG was performed in this study. A two-way ANOVA (group x load) with repeated measure was used for statistical verification. The significant level was set at α=.05. Results: RG revealed significantly increased muscle activation in erector spinae on 70% and 90% of 1RM and decreased muscle activation in gluteus maximus on 90% of 1RM compared to NG (p<.05). For the muscle activation ratio for agonist to synergist, erector spinae showed the difference in 90% of 1RM while hamstring was observed differences in all loads (p<.05). Conclusion: Our results indicated that hip flexibility affects conventional deadlift movement. Therefore, it is necessary to assess the flexibility of the hip flexor muscles before performing the movement and, as needed, to train to address the lack of flexibility.

• The Korean Journal of Physiology and Pharmacology
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• 제9권5호
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• pp.305-314
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• 2005

Diabetes mellitus is associated with vascular complications, including an impairment of vascular function and alterations in the reactivity of blood vessels to vasoactive substances in various vasculature. In the present study, the authors have observed endothelin-B ($ET_B$) receptor agonist-induced relaxation in precontracted mesenteric arterial segments from streptozotocin (STZ)-induced diabetic rats, which was not shown from control rats or in other arterial segments from diabetic rats. Accordingly, the goal of this study was to investigate in what way STZ-induced diabetes altered reactivity of the mesenteric arterial bed and to examine the causal relaxation, if any, between this $ET_B$ receptor-mediated relaxation and endothelial paracrine function, especially nitric oxide (NO) production. The relaxation induced by $ET_B$ agonists was not observed in mesenteric arteries without endothelium. The relaxation to $ET_B$ agonists was completely abolished by pretreatment with BQ788, but not by BQ610. $N_{\omega}-nitro-L-arginine$ methyl ester and soluble guanylate cyclase inhibitors, methylene blue or LY83583 significantly attenuated the relaxant responses to $ET_B$ agonists, respectively. When the expression of eNOS and iNOS was evaluated on agarose gel stained with ethidium bromide, the expression of eNOS mRNA in diabetic rats was significantly decreased, but the expression of iNOS was increased compared with control rats. Furthermore, the iNOS-like immunostaining was densely detected in the endothelium and slightly in the arterial smooth muscle of diabetic rats, but not in control rats. These observations suggest that $ET_B$ receptor may not play a role in maintaining mesenteric vascular tone in normal situation. However, the alterations in $ET_B$ receptor sensitivity were found in diabetic rats and lead to the $ET_B$ agonist-induced vasorelaxation, which is closely related to NO production. In the state of increased vascular resistance of diabetic mesenteric vascular bed, enhanced NO production by activation of iNOS could lead to compensatory vasorelaxation to modulate adequate perfusion pressure to splanchnic area.

• Biomolecules & Therapeutics
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• 제21권1호
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• pp.84-88
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• 2013

High risk of cardiovascular diseases caused by existing PPAR-${\gamma}$ agonists such as rosiglitazone and pioglitazone has been recently reported. CKD-501 is a novel selective PPAR-${\gamma}$ agonist as a potential target to reduce cardiovascular risk in non-insulin dependent diabetes mellitus (NIDDM). In this study, We investigated potential cardiotoxicity of CKD-501 and compared its toxicity with that of rosiglitazone or pioglitazone using db/db mice. After 12-week repeated administration of CKD-501 at doses of 3, 10 and 30 mg/kg/day or rosiglitazone at doses of 10 and 30 mg/kg/day or pioglitazone at doses of 200 and 540 mg/kg/day, animals were sacrificed for investigation of potential toxicities. Diameters of left ventricles and areas of cardiomyocytes were measured. And lipid accumulation and apoptosis in heart muscle were examined by oil red O staining and TUNEL staining, respectively. Diameters of left ventricles were significantly increased in high dose treatment group of pioglitazone compared to control (p<0.05), while other groups showed a tendency for an increase. All test articles induced significantly the increase of area of cardiomyocytes in heart compared to control (p<0.01), in regular order as pioglitazone > CKD-501 ${\geq}$ rosiglitazone. However, lipid accumulation and apoptotic changes in heart were not observed in all dosing groups. Taken together, the myocardial cell hypertrophy of CKD-501 are relatively lower than that of pioglitazone and similar to rosiglitazone. And it is suggested that the myocardial cell hypertrophy of CKD-501 are less adverse in clinical use for the management of the NIDDM.