• The Korea Journal of Herbology
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• v.22 no.4
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• pp.219-225
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• 2007

Objectives : We investigated the anti-aging effects on skin with Saccharomyces fermented modified Kyungohkgo extract (SFKE). Methods : Fermented modified Kyungohkgo extracts by 14 different kinds of microorganism were prepared and most effective Saccharomyces fermented modified Kyungohkgo extract among these was selected for anti-aging agent. We measured various effects related to skin such as scavenging activity against free radical, cell proliferation, collagen synthesis and toxicity of SFKE were evaluated and compared with modified Kyungohkgo extract (KE). Results : Free-radical scavenging activity and cell proliferating ratio of SFKE were 2 and 8 times higher than those of KE. The SFKE could significantly increase the collagen synthetic ratio compared with KE treated group. SFKE showed no toxicity at all tested concentrations. Conclusions : The results of our study propose that SFKE have good anti-aging effects on skin.

• Food Science of Animal Resources
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• v.36 no.2
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• pp.237-243
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• 2016

Many researchers revealed that collagen contribute to maintaining the skin’s elasticity and inhibit wrinkling of skin. Korean native cattle (Hanwoo) bone (leg bone, foot and tail) infusion contains the various inorganic materials, collagen and chondroitin sulfate. All of this, a large quantity of collagen is included in Hanwoo infusion. Therefore, this study emphasized on the effects of collagen in the Hanwoo bone infusion. For the first time, Hanwoo bone infusions were directly added to the media of Human Dermal Fibroblast (NHDF-c) to test anti-aging effects. First, it was identified that growth rate of skin fibroblast was increased. Furthermore, the Hanwoo bone infusion increased a 50% of fibroblast collagen synthesis. Also, suppression of skin fibroblast aging was confirmed by treatment Hanwoo bone infusion. In conclusion, this study demonstrates the effects of infusion made from Hanwoo leg bone, foot and tail on anti-aging, wrinkle inhibiting and skin fibroblast elasticity maintaining. Therefore, this study identified that traditional infusion has effects that are good for skin elasticity.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.23 no.1
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• pp.135-148
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• 2010

Recently, the demands for the effective and safe depigmentating and anti-aging agents of the skin have increased due to the medical, pharmaceutical and cosmetic reasons. The aim of this study is to search Galla Rhois (GR) inhibitory activity against aging process of skin in vitro. GR was screened for their inhibitory activity against elastase. GR (final concentration 1 mg/ml) appeared over 40% of inhibition of elastase activity. So we investigated anti wrinkle effects of GR look through MMP-1 inhibition activity. Also Extracts of GR showed higher anti-tyrosinase activity than arbutin (final concentration 1 mg/ml). These results suggest that GR could be potential sources of anti-aging and whitening effects for the skin. Objective : Galla Rhois extracts, Elastase (pancreatic from porcine pancreas), N-Succinyl-(Ala)3-p-nitroanilide, Ursolic acid, mushroom tyrosinase, L-tyrosine, arbutin, Amicon Ultra, Hand Hold UV lamp, MMP-1 primary antibody, MMP-1 secondary antibody Result : 1. GR appeared over 40% of elastase inhibitory activity. 2. GR had MMP-1 inhibition activity. 3. GR showed higher anti-tyrosinase activity than arbutin. Conclusion : According to above results, it is supposed that Galla Rhois could be strong potential sources of anti-aging and whitening effects for the skin.

• The Journal of the Korea Contents Association
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• v.18 no.10
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• pp.575-583
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• 2018

The purpose of this study is to examine Mediating effects of aging anxiety on the relationship between social activities and successful aging and Moderating effects of social support in relation to aging anxiety and successful aging. A total of 513 respondents participated in the questionnaire, 450 of which were used for the analysis. The analysis used mediating effect and regulatory effect test using regression analysis. The results showed that social activities lowered aging anxiety and helped to improve successful aging. Aging anxiety showed a mediating effect on the relationship between social activity and successful aging and confirmed the moderating effect of social support on the relationship between aging anxiety and successful aging. On the basis of this, the social activity providers diversify the social activity programs, reorganize the business system so that aging anxiety can be mitigated, and establish a mutual support system among the participants, so that successful aging through social activities will be more effective It is necessary to be managed so that.

• Food Science of Animal Resources
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• v.39 no.4
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• pp.655-667
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• 2019

The present study aimed at investigating the effects of dry- and wet-aging methods on flavor compounds and sensory properties of low fat Hanwoo beef muscles. All the beef samples were obtained from 2-grade carcasses of Hanwoo cows. The beef samples used in the dry- and wet-aging methods were prepared in the forms of quarter beef (bone-in) and cuts (boneless), respectively. The dry-aging was carried out at $2^{\circ}C-4^{\circ}C$ and humidity of 65%-85%, while the wet-aging was done at $1^{\circ}C$ for 0, 20, 40, and 60 d. At each aging time, three muscles: longissmus thoracis (LT), glutaeusmedus (GM) and semimembranosus (SM) were taken from the corresponding quarters and cuts, and used for the flavor compounds and sensory analyses. Results showed that both aging methods significantly increased the concentrations of flavor compounds and total amount of all classes of the flavor compounds as the aging time increased (p<0.05). In the dry-aging method, the GM and SM muscles presented significantly higher total amounts of pyrazines and sulfur-containing compounds compared to the LT muscle (p<0.05). Both the aging methods improved the eating quality attributes, indicating by increased scores of sensorial attributes with increased aging time for all the muscles studied (p<0.05). However, compared to the wet-aging, the dry-aging method resulted in significantly higher scores of tenderness and flavor for the GM and SM muscles after 40 to 60 d. Thus, postmortem aging, especially the dry-aging method could be used to improve eating quality attributes (tenderness and flavor) of low fat beef muscles such as GM and SM.

• The Journal of the Korea Contents Association
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• v.18 no.7
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• pp.194-206
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• 2018

The purpose of this research is to take a look at the factors that influence the successful aging of the elderly with disability as the aging population grows. For this purpose, psychological and social concepts were defined for successful aging of the elderly with disability. It was also verified that the effects of emotional & social preparation for aging on successful aging of the elderly with disability and mediating effects of social support. The subjects of this study are 506 elderly people with disability who are over the age of 50. They were originally extracted from the 4th main survey and 3rd, 4th additional survey of Korean Retirement and Income Study. For data analysis purposes, SPSS 23.0 and SPSS PROCESS macro v2.16 were used. The results of this study are as followed. Firstly, emotional & social preparation for aging turned out to have a significant direct influence on successful aging the elderly with disability. Secondly, emotional & social preparation for aging has a indirect effect on successful aging through social support. On the basis of the results, this study provided the social welfare policy and practical suggestions to enhance the preparation for aging and social support.

• The Journal of the Convergence on Culture Technology
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• v.4 no.4
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• pp.47-56
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• 2018

The purpose of this research is to take a look at the factors that influence the successful aging as the aging population grows. For this purpose, psychological and social concepts were defined for successful aging of the elderly with disability. It was also verified that the effects of emotional & social preparation for aging on successful aging and mediating effects of social support. The subjects of this study are 3,910 who are over the age of 65. They were originally extracted from the 4th main survey and 3rd, 4th additional survey of Korean Retirement and Income Study. For data analysis purposes, SPSS 25.0 and SPSS PROCESS macro v2.16 were used. The results of this study are as followed. Firstly, emotional & social preparation for aging turned out to have a significant direct influence on successful aging. Secondly, emotional & social preparation for aging has a indirect effect on successful aging through social support. On the basis of the results, this study provided the social welfare policy and practical suggestions to enhance the preparation for aging and social support.

• Nutrition Research and Practice
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• v.14 no.3
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• pp.188-202
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• 2020

BACKGROUND/OBJECTIVES: Brain aging is a major risk factor for severe neurodegenerative diseases. Conversely, L-histidine and L-carnosine are known to exhibit neuroprotective effects. The aim of this study was to examine the potential for L-histidine, L-carnosine, and their combination to mediate anti-brain aging effects in neuronal cells subjected to D-galactose-induced aging. MATERIALS/METHODS: The neuroprotective potential of L-histidine, L-carnosine, and their combination was examined in a retinoic acid-induced neuronal differentiated SH-SY5Y cell line exposed to D-galactose (200 mM) for 48 h. Neuronal cell proliferation, differentiation, and expression of anti-oxidant enzymes and apoptosis markers were subsequently evaluated. RESULTS: Treatment with L-histidine (1 mM), L-carnosine (10 mM), or both for 48 h efficiently improved the proliferation, neurogenesis, and senescence of D-galactose-treated SH-SY5Y cells. In addition, protein expression levels of both neuronal markers (β tubulin-III and neurofilament heavy protein) and anti-oxidant enzymes, glutathione peroxidase-1 and superoxide dismutase-1 were up-regulated. Conversely, protein expression levels of amyloid β (1-42) and cleaved caspase-3 were down-regulated. Levels of mRNA for the pro-inflammatory cytokines, interleukin (IL)-8, IL-1β, and tumor necrosis factor-α were also down-regulated. CONCLUSIONS: To the best of our knowledge, we provide the first evidence that L-histidine, L-carnosine, and their combination mediate anti-aging effects in a neuronal cell line subjected to D-galactose-induced aging. These results suggest the potential benefits of L-histidine and L-carnosine as anti-brain aging agents and they support further research of these amino acid molecules.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.3
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• pp.855-864
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• 2013

The dynamic characteristics of natural rubber bearings, which are used as isolator, are dependent on the main rubber's dynamic behaviors and nonlinear properties. Rubber materials tend to undergo an aging process under the influence of mechanical or environmental factors, so they inevitably end up facing damage. A main cause of aging like this is known to be oxidization, which occurs through the heat of reaction at high temperatures. Accordingly, in this study an accelerated thermal aging test was carried out in order to compare the characteristic values of the bearings before and after thermal aging occurs. As a result of this experiment, it was found that a thermal aging phenomenon could have some effects on shear stiffness, energy absorption, and equivalent damping coefficients of the bearings. Furthermore, a deterioration in the dynamic properties of the natural rubber bearings caused by the thermal aging was applied to an actual bridge and then the effects of such thermal aging on the seismic performance of the bridge were also compared and analyzed based on numerical analysis. As a result of this analysis, it was found that the changes in the basic properties of the natural rubber bearings caused by the thermal aging bring only a minor effect on the seismic performance of bridges.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.6
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• pp.440-446
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• 2018

This study examines the contrasting effects of an aging workforce on organizational innovation and the moderating role of age diversity. By utilizing a knowledge-based view, this study asserts that an aging workforce can contribute to organizational innovation to some degree due to accumulated firm-specific knowledge and experiences as well as various social networks within and outside the firm. On the contrary, as the portion of an aging workforce increases, the negative effect of the aging workforce on organizational innovation can overwhelm the positive effects because of the limitations of new knowledge creation. In addition, this study explores the effect of age diversity to moderate the relationship between aging workforce and organizational innovation.Empirical findings showed that an aging workforce and organizational innovation had an inverted-U relationship, and age diversity moderated this curvilinear relationship as this study predicted. These theoretical arguments and empirical findings highlight the necessity to explore the complex effects of an aging workforce on organizational innovation as well as additional factors influencing the relationship between aging workforce and firm innovation.