• Investigative Magnetic Resonance Imaging
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• 제15권2호
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• pp.139-145
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• 2011

목적 : 단일기관에서 발생한 가돌리니움 기반의 자기공명영상 경정맥 조영제의 급성 부작용의 빈도 및 종류, 조영제 별 차이를 알아보았다. 대상 및 방법 : 병원정보시스템의 부작용 보고체계를 분석하여, 2008년 10월부터 2010년 12월 사이에 증례를 검색하였다. 부작용은 경증, 중등도, 중증으로 분류되었고 서로 다른 조영제간에 빈도의 차이가 있는지를 분석하였다. 결과 : 총 33,600건의 조영제가 투여되었고, Gd-BT-DO3A 20,824건 (62%), Gd-DTPA 10,417건 (31%), Gd-EOB-DTPA 2,359건 (7%)이었다. 부작용은 총 39예가 발생하여 빈도는 0.1161%였고, Gd-BT-DO3A 0.1248% (26/39,67%), Gd-DTPA 0.0768% (8/39, 21%), Gd-EOB-DTPA 0.2120% (5/39,13%) 였으며, 조영제 간에 유의한 차이는 없었다. 대부분 (89.7%) 이 경증 부작용이었으며 중등도 및 중증 부작용은 각각 2명에서 발생하였다. 결론 : 한국인에서의 자기공명영상 검사용 경정맥 조영제에 의한 부작용의 빈도는 드물었으며, 특히 중등도 혹은 중증 부작용은 매우 드물었다. 세가지 조영제 사이에 부작용 발생 빈도는 차이는 없었다.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제10권11호
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• pp.465-472
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• 2021

본 논문에서는 약물의 시판 후 이상 반응을 모니터링하기 위해 약물 리뷰 데이터로부터 약물 이상 반응을 탐지할 수 있는 방법을 제시하였다. 부정적인 약물 리뷰는 주로 약물 이상 반응을 언급하고 있다는 점을 고려하여 약물 리뷰들을 감성 분석하여 부정 리뷰를 추출하고, 부정 리뷰에 사전 기반 추출과 개체명 인식 기법을 적용하여 약물 이상 반응을 탐지하였다. 제안하는 BERT+ 알고리즘으로 부정 리뷰를 판별한 다음, MedDRA 표준 의학 용어 사전을 활용해 이상 반응 단어를 찾고, 개체명 인식 기법을 사용하여 구로 표현된 이상 반응 표현을 탐지하였다. 실험을 위해 비스테로이드성 소염진통제 세 종류의 약물 리뷰를 약물 리뷰 사이트로부터 수집하여 테스트하였으며, 실험 결과는 약물 리뷰를 통한 약물 이상 반응 탐지가 현재의 약물 감시 체계의 한계점을 보완할 수 있음을 보여준다.

• 대한임상약리학회:학술대회논문집
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• 대한임상약리학회 2002년도 제11차 추계학술대회
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• pp.11-11
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• 2002

• Clinical and Experimental Vaccine Research
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• 제12권1호
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• pp.60-69
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• 2023

Purpose: Although the fast development of safe and effective messenger RNA (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 has been a success, waning humoral immunity has led to the recommendation of booster immunization. However, knowledge of the humoral immune response to different booster strategies and the association with adverse reactions is limited. Materials and Methods: We investigated adverse reactions and anti-spike protein immunoglobulin G (IgG) concentrations among health care workers who received primary immunization with mRNA-1273 and booster immunization with mRNA-1273 or BNT162b2. Results: Adverse reactions were reported by 85.1% after the first dose, 94.7% after the second dose, 87.5% after a third dose of BNT162b2, and 86.0% after a third dose of mRNA-1273. They lasted for a median of 1.8, 2.0, 2.5, and 1.8 days, respectively; 6.4%, 43.6%, and 21.0% of the participants were unable to work after the first, second, and third vaccination, respectively, which should be considered when scheduling vaccinations among essential workers. Booster immunization induced a 13.75-fold (interquartile range, 9.30-24.47) increase of anti-spike protein IgG concentrations with significantly higher concentrations after homologous compared to heterologous vaccination. We found an association between fever, chills, and arthralgia after the second vaccination and anti-spike protein IgG concentrations indicating a linkage between adverse reactions, inflammation, and humoral immune response. Conclusion: Further investigations should focus on the possible advantages of homologous and heterologous booster vaccinations and their capability of stimulating memory B-cells. Additionally, understanding inflammatory processes induced by mRNA vaccines might help to improve reactogenicity while maintaining immunogenicity and efficacy.

• The Korean Journal of Pain
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• 제31권2호
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• pp.73-79
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• 2018

All drugs have both favorable therapeutic and untoward adverse effects. Conventional opioid analgesics possess both analgesia and adverse reactions, such as nausea, vomiting, and respiratory depression. The opioid ligand binds to ${\mu}$ opioid receptor and non-selectively activates two intracellular signaling pathways: the G protein pathway induce analgesia, while the ${\beta}$-arrestin pathway is responsible for the opioid-related adverse reactions. An ideal opioid should activate the G protein pathway while deactivating the ${\beta}$-arrestin pathway. Oliceridine (TRV130) has a novel characteristic mechanism on the action of the ${\mu}$ receptor G protein pathway selective (${\mu}$-GPS) modulation. Even though adverse reactions (ADRs) are significantly attenuated, while the analgesic effect is augmented, the some residual ADRs persist. Consequently, a G protein biased ${\mu}$ opioid ligand, oliceridine, improves the therapeutic index owing to increased analgesia with decreased adverse events. This review article provides a brief history, mechanism of action, pharmacokinetics, pharmacodynamics, and ADRs of oliceridine.

• 척추신경추나의학회지
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• 제2권2호
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• pp.161-170
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• 2007

Objectives : This report was performed to report the present situation of the adverse reactions of chuna manipulation in Korea. Methods : Searches were conducted on Internet based field. We investigated the cases reported from Korea Consumer Agency and the "Minwon Baekseo" published by Korean Oriental Medicine Society. Results & Conclusions : The relevant cases and papers were of small number. The most adverse reaction of chuna manipulation was disc herniation. The serious adverse reactions were Cauda equina syndrome(CES) and Cerebral infarction. Most of serious adverse reaction cases were performed by non proffesional therapist. We should give chuna treatment to patients after sufficient education. We expect more case reports and systemic studies about adverse reaction and effect of chuna manipulation.

• Genomics & Informatics
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• 제11권4호
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• pp.254-262
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• 2013

The multidrug resistance protein 2 (MRP2, ABCC2) gene may determine individual susceptibility to adverse drug reactions (ADRs) in the central nervous system (CNS) by limiting brain access of antiepileptic drugs, especially valproic acid (VPA). Our objective was to investigate the effect of ABCC2 polymorphisms on ADRs caused by VPA in Korean epileptic patients. We examined the association of ABCC2 single-nucleotide polymorphisms and haplotype frequencies with VPA related to adverse reactions. In addition, the association of the polymorphisms with the risk of VPA related to adverse reactions was estimated by logistic regression analysis. A total of 41 (24.4%) patients had shown VPA-related adverse reactions in CNS, and the most frequent symptom was tremor (78.0%). The patients with CNS ADRs were more likely to have the G allele (79.3% vs. 62.7%, p=0.0057) and the GG genotype (61.0% vs. 39.7%, p=0.019) at the g.-1774delG locus. The frequency of the haplotype containing g.-1774Gdel was significantly lower in the patients with CNS ADRs than without CNS ADRs (15.8% vs. 32.3%, p=0.0039). Lastly, in the multivariate logistic regression analysis, the presence of the GG genotype at the g.-1774delG locus was identified as a stronger risk factor for VPA related to ADRs (odds ratio, 8.53; 95% confidence interval, 1.04 to 70.17). We demonstrated that ABCC2 polymorphisms may influence VPA-related ADRs. The results above suggest the possible usefulness of ABCC2 gene polymorphisms as a marker for predicting response to VPA-related ADRs.

• 한국콘텐츠학회논문지
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• 제19권1호
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• pp.598-607
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• 2019

현재 한국의 약사 연수 교육은 연간 8시간으로 대한약사회와 그 산하 지부 및 분회에서 주로 실시하고 있다. 정해진 시간에 다수의 약사들을 대상으로 진행되는 교육은 학습효과가 제한적이며 적극적인 학습 참여를 유도하기 어렵다. 본 연구에서는 약사 제도의 역사가 긴 미국의 약사 연수 교육을 문헌 연구 하여 한국의 약사 연수 교육의 발전 방안을 찾아보았다. 연구의 대상은 한국과 미국의 약사 연수 교육 운용 방식, 평가제도, 교과목 등이었다. 연구 결과 미국의 약사연수 교육은 다양한 방식이었으며 이수 시간이 길며 약사 면허 갱신 제도와 연계되어 있었다. 한국의 약사 연수 교육이 교육 시간의 연장, 교육 내용의 다양화, 자기 주도적 학습 및 현장 실습 교육을 도입 한다면 현재보다 더 발전할 것이다.

• Korean Journal of Radiology
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• 제20권1호
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• pp.148-157
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• 2019

Objective: To evaluate the current status of managing adverse reactions to iodinated contrast media (ICM) for computed tomography in referral hospitals in South Korea compared with hospitals in other countries. Materials and Methods: This survey investigation involved 59 Korean and 15 overseas hospitals using guideline-based questionnaires consisting of 24 items in 7 main categories related to managing adverse reactions to ICM. Results: Informed written consent with risk factor evaluation was appropriately performed in most of the Korean hospitals. There was considerable variability in assessing renal function across the hospitals; serum creatinine level was used as a reference in 76.4% of Korean hospitals. The Korean hospitals preferred a more stringent approach to determining normal renal function (p = 0.01), withholding metformin (p = 0.01), and fasting before ICM exposure (p < 0.001) compared with overseas hospitals. All the Korean hospitals had an emergency protocol and in-hospital system for adverse reactions to ICM. The Korean (87.7%) and overseas hospitals (100%) were similarly equipped with epinephrine (p = 0.332), but only 38.6% of Korean hospitals were equipped with a bronchodilator (p = 0.004). For patients with a previous hypersensitivity reaction to ICM, 62.3% of Korean hospitals pre-medicated with anti-histamine and corticosteroid according to the severity of the previous reaction, and changed the culprit ICM in 52.8%, while skin test was performed in 17%. Conclusion: In general, Korean referral hospitals were well-prepared regarding informed consent, protocol, and an in-hospital system for managing adverse reactions to ICM. Nevertheless, there was considerable variability in details and management, thus requiring standardization by reflecting current guidelines.

• 동의생리병리학회지
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• 제22권6호
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• pp.1600-1605
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• 2008

The objectives of this study were to survey the adverse reactions by Taeeumjowi-tang and to compare the tendency of symptoms by Sasang constitutional type. The clinical data for this study were based on the medical records of 78 cases collected from an oriental clinic. The major results of this survey are following: The 5.8% of Taeeum-in who took Taeeumjowi-tang showed side effects. And the 52.4% of Soeum-in and 41.6% of Soyang-in also showed side effects against Taeeumjowi-tang. They complained of excitation, irritability, restlessness, hypersensitivity, tinnitus, insomnia, upper abdominal discomfort, poor appetite, thirst, perspiration, dizziness, chest pain, tremor and evacuation troubles in common. And these adverse symptoms were similar to that by Ma-hwang. Therefore if we make a suitable medication guide for Ma-hwang based on Sasang constitutional type, it will be able to maximize the efficacy and minimize the adverse effect.