• Title/Summary/Keyword: Advanced development

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Inhibition of Glycation End Products Formation and Antioxidant Activities of Ilex paraguariensis: comparative study of fruit and leaves extracts

  • Laura Cogoi;Carla Marrassini;Elina Malen Saint Martin;Maria Rosario Alonso;Rosana Filip;Claudia Anesini
    • Journal of Pharmacopuncture
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    • v.26 no.4
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    • pp.338-347
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    • 2023
  • Objectives: Ilex paraguariensis (Aquifoleaceae) is cultivated to produce "yerba mate". Due to its nutritional, energizing, hypoglycemic and antioxidant effects, it is used in the elaboration of food, pharmaceuticals, and cosmetics. The oxidative stress related to protein glycation and production of advanced glycation end products (AGEs) leads to the development of several diseases. The objective of this work was to compare the antioxidant and anti-AGEs activity of a decoction of fruits (F) and leaves (L). Methods: The antioxidant activity was assayed by the DPPH assay and the inhibition of egg yolk lipid peroxidation (ILP), and anti-AGEs activity, through the inhibition of the formation of fructosamine (IF), β-amyloid (Iβ), protein carbonylation (IC) and AGEs (IA). Polyphenols were quantified by HPLC. Results: Maximum response ± SEM: For F 0.01 ㎍/mL: IF = 42 ± 4%, IC = 17 ± 2% and for 10 ㎍/mL: IA = 38 ± 4%, Iβ = 67 ± 7%. For L 0.1 ㎍/mL: IF = 35 ± 2%, IC = 19 ± 2% and for 100 ㎍/mL: IA = 26 ± 3%, Iβ = 63.04 ± 2%. The DPPH IC50 = 134.8 ± 14 ㎍/mL for F and 34.67 ± 3 ㎍/mL for L. The ILP IC50 = 512.86 ± 50 ㎍/mL for F and 154.8 ± 15 ㎍/mL for L. By HPLC L presented the highest amounts of flavonoids and caffeoylquinic acids. F and L showed strong anti-AGEs activity, affecting the early stages of glycation at low concentrations and the late stages of glycation at high concentrations. The highest activity for both F and L was seen in the IF and Iβ. F presented the highest anti-AGEs potency. L presented the highest antioxidant potency, which was related to the highest content of polyphenols. Conclusion: The fruits of I. paraguariensis could be a source of antioxidant and anti-AGEs compounds to be used with medicinal purposes or as functional food.

Approaches to Applying Social Network Analysis to the Army's Information Sharing System: A Case Study (육군 정보공유체계에 사회관계망 분석을 적용하기 위한방안: 사례 연구)

  • GunWoo Park
    • The Journal of the Convergence on Culture Technology
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    • v.9 no.5
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    • pp.597-603
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    • 2023
  • The paradigm of military operations has evolved from platform-centric warfare to network-centric warfare and further to information-centric warfare, driven by advancements in information technology. In recent years, with the development of cutting-edge technologies such as big data, artificial intelligence, and the Internet of Things (IoT), military operations are transitioning towards knowledge-centric warfare (KCW), based on artificial intelligence. Consequently, the military places significant emphasis on integrating advanced information and communication technologies (ICT) to establish reliable C4I (Command, Control, Communication, Computer, Intelligence) systems. This research emphasizes the need to apply data mining techniques to analyze and evaluate various aspects of C4I systems, including enhancing combat capabilities, optimizing utilization in network-based environments, efficiently distributing information flow, facilitating smooth communication, and effectively implementing knowledge sharing. Data mining serves as a fundamental technology in modern big data analysis, and this study utilizes it to analyze real-world cases and propose practical strategies to maximize the efficiency of military command and control systems. The research outcomes are expected to provide valuable insights into the performance of C4I systems and reinforce knowledge-centric warfare in contemporary military operations.

Empirical Analysis of the Influence of ICT SMEs' R&D Resources on Corporate Performance (ICT 중소기업의 연구개발 자원이 기업성과에 미치는 영향에 관한 실증연구)

  • Jong Yoon Won;Kun Chang Lee
    • Information Systems Review
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    • v.23 no.3
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    • pp.1-23
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    • 2021
  • The national economic policy paradigm is constantly changing according to the global business environment. Among them, fostering SMEs is a core policy of many developed countries. The growth of SMEs contributes to the creation of jobs and the development of local communities in the era of employment-free growth. In particular, the growth of SMEs is the foundation for growth into mid-sized and large enterprises. Therefore, the growth of SMEs plays an important role in the national economy. Information and communication technology (ICT) became important much more with the emergence of the 4th industrial revolution. Among them, the growth of ICT SMEs is the nation's future asset. Therefore, this study examines and verifies the main factors affecting the performance of ICT SMEs from the view of their R&D resources. On the basis of 1,999 SMEs dataset, empirical analysis was performed to investigate the influence of R&D resources on their corporate performance. Its results are as follows. First, based on theresource-based theory, ICT SMEs' R&D investment, R&D manpower, and government support policies were found to have a positive effect on securing a company's competitive advantage. Second, it was found that the level of product has a positive effect on the company's performance. Finally, it was found that M&A and technology acquisition method strategies differ according to the growth stage of the company. Therefore, in order to achieve technological innovation and corporate performance of ICT SMEs, the government support policy and investment into internal R&D personnel play as main factors. In addition, it was found that technology acquisition strategies differ depending on the growth stage of the company.

Analysis of major issues in the field of Maritime Autonomous Surface Ships using text mining: focusing on S.Korea news data (텍스트 마이닝을 활용한 자율운항선박 분야 주요 이슈 분석 : 국내 뉴스 데이터를 중심으로)

  • Hyeyeong Lee;Jin Sick Kim;Byung Soo Gu;Moon Ju Nam;Kook Jin Jang;Sung Won Han;Joo Yeoun Lee;Myoung Sug Chung
    • Journal of the Korean Society of Systems Engineering
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    • v.20 no.spc1
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    • pp.12-29
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    • 2024
  • The purpose of this study is to identify the social issues discussed in Korea regarding Maritime Autonomous Surface Ships (MASS), the most advanced ICT field in the shipbuilding industry, and to suggest policy implications. In recent years, it has become important to reflect social issues of public interest in the policymaking process. For this reason, an increasing number of studies use media data and social media to identify public opinion. In this study, we collected 2,843 domestic media articles related to MASS from 2017 to 2022, when MASS was officially discussed at the International Maritime Organization, and analyzed them using text mining techniques. Through term frequency-inverse document frequency (TF-IDF) analysis, major keywords such as 'shipbuilding,' 'shipping,' 'US,' and 'HD Hyundai' were derived. For LDA topic modeling, we selected eight topics with the highest coherence score (-2.2) and analyzed the main news for each topic. According to the combined analysis of five years, the topics '1. Technology integration of the shipbuilding industry' and '3. Shipping industry in the post-COVID-19 era' received the most media attention, each accounting for 16%. Conversely, the topic '5. MASS pilotage areas' received the least media attention, accounting for 8 percent. Based on the results of the study, the implications for policy, society, and international security are as follows. First, from a policy perspective, the government should consider the current situation of each industry sector and introduce MASS in stages and carefully, as they will affect the shipbuilding, port, and shipping industries, and a radical introduction may cause various adverse effects. Second, from a social perspective, while the positive aspects of MASS are often reported, there are also negative issues such as cybersecurity issues and the loss of seafarer jobs, which require institutional development and strategic commercialization timing. Third, from a security perspective, MASS are expected to change the paradigm of future maritime warfare, and South Korea is promoting the construction of a maritime unmanned system-based power, but it emphasizes the need for a clear plan and military leadership to secure and develop the technology. This study has academic and policy implications by shedding light on the multidimensional political and social issues of MASS through news data analysis, and suggesting implications from national, regional, strategic, and security perspectives beyond legal and institutional discussions.

Deep Learning-Based Algorithm for the Detection and Characterization of MRI Safety of Cardiac Implantable Electronic Devices on Chest Radiographs

  • Ue-Hwan Kim;Moon Young Kim;Eun-Ah Park;Whal Lee;Woo-Hyun Lim;Hack-Lyoung Kim;Sohee Oh;Kwang Nam Jin
    • Korean Journal of Radiology
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    • v.22 no.11
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    • pp.1918-1928
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    • 2021
  • Objective: With the recent development of various MRI-conditional cardiac implantable electronic devices (CIEDs), the accurate identification and characterization of CIEDs have become critical when performing MRI in patients with CIEDs. We aimed to develop and evaluate a deep learning-based algorithm (DLA) that performs the detection and characterization of parameters, including MRI safety, of CIEDs on chest radiograph (CR) in a single step and compare its performance with other related algorithms that were recently developed. Materials and Methods: We developed a DLA (X-ray CIED identification [XCID]) using 9912 CRs of 958 patients with 968 CIEDs comprising 26 model groups from 4 manufacturers obtained between 2014 and 2019 from one hospital. The performance of XCID was tested with an external dataset consisting of 2122 CRs obtained from a different hospital and compared with the performance of two other related algorithms recently reported, including PacemakerID (PID) and Pacemaker identification with neural networks (PPMnn). Results: The overall accuracies of XCID for the manufacturer classification, model group identification, and MRI safety characterization using the internal test dataset were 99.7% (992/995), 97.2% (967/995), and 98.9% (984/995), respectively. These were 95.8% (2033/2122), 85.4% (1813/2122), and 92.2% (1956/2122), respectively, with the external test dataset. In the comparative study, the accuracy for the manufacturer classification was 95.0% (152/160) for XCID and 91.3% for PPMnn (146/160), which was significantly higher than that for PID (80.0%,128/160; p < 0.001 for both). XCID demonstrated a higher accuracy (88.1%; 141/160) than PPMnn (80.0%; 128/160) in identifying model groups (p < 0.001). Conclusion: The remarkable and consistent performance of XCID suggests its applicability for detection, manufacturer and model identification, as well as MRI safety characterization of CIED on CRs. Further studies are warranted to guarantee the safe use of XCID in clinical practice.

Evaluation of Manufacturing and Biological Properties of Y Zone Care Hydrogel Solution (Y존 케어 하이드로젤솔루션의 제조 및 생물학적 특성 평가)

  • Eun-Ji Kim;In-Kyoung Kim
    • Journal of Advanced Technology Convergence
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    • v.3 no.2
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    • pp.25-31
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    • 2024
  • In recent industrialization and development due to information and communication technology, modern women in modern society are exposed to physical and mental health due to numerous stresses. Popular inflammations are attributable to a decrease in lactic acid bacteria, frequent antibiotic use, and a decrease in immunity. It is necessary to develop products that are helpful and reflected. The inner care gel currently introduced on the market can increase beneficial bacteria and maintain a healthy y-zone. The inner gel contains a hydrogel component. 90% is made up of water, and other components act as support for supporting water and are formed through crosslinking between polymer chains. Hydroxyethyl cellulose (HEC) is a hydroxyethyl ethylenetel of cellulose. The purpose of use is to act as a binder, an emulsion stabilizer, a viscosity enhancer (water-soluble), and a film forming agent. CA (crosslinker) is a crosslinking agent and serves to bind. Hydrogel in the beauty field acts as a film forming agent that gently wraps around the skin by forming a thin film and serves as an emulsion stabilizer that helps to prevent separation of other raw materials. It also acts as a thickener by increasing viscosity in cosmetics. In addition, it is used for glucose monitoring, nursing care, cell transplantation, and wound treatment in the bio field. Currently, it is understood that no products using functional hydrogel have been released, so in this study, a Y zone care hydrogel solution was manufactured to find out the antibacterial properties of the functional hydrogel, and a new solution was developed. As a result, it was confirmed that the appropriate Ph was applied to the Y zone, and after culturing Candida albicans in PDB medium, all three products of the Y zone care hydrogel solution showed an antibacterial effect of 0.5-1.0mm

Scientifically Gifted Students' Views on the Nature of Science (과학영재들의 과학의 본성에 대한 인식)

  • Kim, Kyoung-Dae;Kang, Soon-Min;Lim, Jai-Hang
    • Journal of The Korean Association For Science Education
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    • v.26 no.6
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    • pp.743-752
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    • 2006
  • The purpose of this study is to gain an understanding of scientifically gifted students' views on the nature of science. A multiple-choice format questionnaire was administered to 237 Korean 10th, 11th and 12th graders at the Korea Science Academy. The differences and similarities by gender and experience of R&E program on the students' views of the nature of science were investigated. The questionnaire developed by Lim(2004) was implemented for this investigation. We found that the majority of scientifically gifted students had highly possessed the tentativeness of scientific knowledge. The students who experienced R&E program have relatively high apprehension of scientists' motivation for researches and activities in social context compared to the students who did not experience an R&E program. Scientifically gifted students had relatively high apprehension that government should not control researches of scientists and relatively low apprehension of social responsibilities of scientists comparing to general high school students. The experience on R&E program was identified as a factor to effect changes in the students' views on the nature of science. The study has implications for the development of gifted program and curriculum such as running and assessing R&E program, and also the pre-service preparation of science teacher, teacher education reformat in both the practical and the policy levels.

Progress in Nanofiltration-Based Capacitive Deionization (나노여과 기반 용량성 탈이온화의 진전)

  • Jeong Hwan Shim;Rajkumar Patel
    • Membrane Journal
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    • v.34 no.2
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    • pp.87-95
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    • 2024
  • Recent studies explore a wide array of desalination and water treatment methods, encompassing membrane processes such as reverse osmosis (RO), nanofiltration (NF), and electrodialysis (ED) to advanced capacitive deionization (CDI) and its membrane variant (MCDI). Comparative analyses reveal ED's cost-effectiveness in low-salinity scenarios, while hybrid systems (NF-MCDI, RO-NF-MCDI) show improved salt removal and energy efficiency. Novel ion separation methods (NF-CDI, NF-FCDI) offer enhanced efficacy and energy savings. These studies also highlight the efficiency of these methods in treating complex wastewater specific to various industries. Environmental impact assessments emphasize the need for sustainability in system selection. Additionally, the integration of microfabricated sensors into membranes allows real-time monitoring, advancing technology development. These studies underscore the variety and promise of emerging desalination and water treatment technologies. They provide valuable insights for enhancing efficiency, minimizing energy usage, tackling industry-specific issues, and innovating to surpass conventional method limitations. The future of sustainable water treatment appears bright, with continual advancements focused on improving efficiency, minimizing environmental impact, and ensuring adaptability across diverse applications.

Numerical Analysis of Electrical Resistance Variation according to Geometry of Underground Structure (지하매설물의 기하학적 특성에 따른 전기저항 변화에 대한 수치 해석 연구)

  • Kim, Tae Young;Ryu, Hee Hwan;Chong, Song-Hun
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.44 no.1
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    • pp.49-62
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    • 2024
  • Reckless development of the underground by rapid urbanization causes inspection delay on replacement of existing structure and installation new facilities. However, frequent accidents occur due to deviation in construction design planned by inaccurate location information of underground structure. Meanwhile, the electrical resistivity survey, knowns as non-destructive method, is based on the difference in the electric potential of electrodes to measure the electrical resistance of ground. This method is significantly advanced with multi-electrode and deep learning for analyzing strata. However, there is no study to quantitatively assess change in electrical resistance according to geometric conditions of structures. This study evaluates changes in electrical resistance through geometric parameters of electrodes and structure. Firstly, electrical resistance numerical module is developed using generalized mesh occurring minimal errors between theoretical and numerical resistance values. Then, changes in resistances are quantitatively compared on geometric parameters including burial depth, diameter of structure, and distance electrode and structure under steady current condition. The results show that higher electrical resistance is measured for shallow depth, larger size, and proximity to the electrode. Additionally, electric potential and current density distributions are analyzed to discuss the measured electrical resistance around the terminal electrode and structure.

Analysis of Occupational Therapy Students' Awareness of Adolescent Occupational Therapy: A Comparative Study Between Korea and the United States (청소년 작업치료에 관한 작업치료전공 학생들의 인식도 분석: 대한민국과 미국의 비교 연구)

  • Bae, Su-Bin;Shin, Chae-Rim;Seo, Hyo-Won;Lee, Min-Gyung;Kim, Eun-Taek;Kam, Kyung-Yoon
    • Therapeutic Science for Rehabilitation
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    • v.13 no.1
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    • pp.23-34
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    • 2024
  • Objective : This study aims to compare the awareness of adolescent occupational therapy (AOT) among university students majoring in occupational therapy (OT) in Korea and the United States through an online survey. Methods : This online survey was conducted from January 9 to 13, 2023 to investigate the awareness about AOT among 55 students majoring in OT in Korea and the United States. An online survey was formulated in Korean and English. Data analysis was performed using descriptive statistics and an independent t-test. Results : In response to the question "Have you ever heard of AOT?", 65.5% of Korean students answered yes and 58.2% of the United States students answered no. In both countries, the average score for the question "Can AOT help improve the quality of life of teenagers?" was the highest, while the score for "Is AOT sufficiently advanced in your country?" was the lowest. For "Potential for future development of AOT," the scores for the two countries showed a significant difference (p < .05). Conclusion : Students in both countries acknowledged the necessity and importance of AOT, but there were differences noted in terms of prospects of the therapy.