• Tuberculosis and Respiratory Diseases
• /
• v.77 no.1
• /
• pp.13-17
• /
• 2014

Background: This study analyzed the negative prognostic factors in patients who received second-line chemotherapy for advanced inoperable non-small cell lung cancer (NSCLC). Methods: We retrospectively reviewed the records of 137 patients with inoperable stage III-IV NSCLC who received second-line chemotherapy. The effects of clinical parameters on survival were analyzed and the hazard ratios (HR) for mortality were identified by a Cox regression analysis. Results: Sex, age older than 65 years, smoking history, cell type, T-stage, best response to first-line chemotherapy and first-line chemotherapy regimen were significant negative predictors in univariate analysis. The multivariate analysis showed that patients older than 65 years (HR, 1.530; 95% confidence interval [CI], 1.020-2.297), advanced T stage (T4 vs. T1; HR, 2.273; 95% CI, 1.010-5.114) and non-responders who showed progression with first-line chemotherapy (HR, 1.530; 95% CI, 1.063-2.203) had higher HR for death. Conclusion: The age factor, T stage and responsiveness to first-line chemotherapy were important factors in predicting the outcome of patients with advanced NSCLC who received second-line chemotherapy. The results may help to predict outcomes for these patients in the future.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
• /
• 2000.10a
• /
• pp.131-137
• /
• 2000

No Abstract.See Full-text

• Proceedings of the Korean Institute of Navigation and Port Research Conference
• /
• 2001.02a
• /
• pp.13-1-13-7
• /
• 2001

• Journal of Oral Medicine and Pain
• /
• v.16 no.1
• /
• pp.121-136
• /
• 1991

This study was undertaken to obtain the data for age determination following the calcification degree of the second molar, third molar in the point of forensic odontology. The intraoral panoramic radiograph of 1600 male and 1600 female (100 persons each age) ranging from 7 to 2 years of age were studied. The developmental state of the second molar and third molar were divided into 12 stages following the calcification degree and correlations of second molar developmental stage and statistically analyzed. The results were as follows : 1. There was remarkable correlation between the development of the second molar, the third molar and age. 2. There was no significant developmental differences between the right and left second molar, third molar.(p>0.05) 3. The developmental stages of the lower second molar was more advanced than those of upper second molar. (p<0.05) 4. The developmental stages of upper third molar was more advanced than those of lower third molar. (p<0.05) 5. Both the developmental stages of second, third molars were earlier in the female than in the male. (p<0.001) 6. For the purpose of age estimation according to developmental stages of the second, third molar, linear equations are as follows. (p<0.001) second molar : male upper : Y=1.3927X + 0.2213 (r=0.72) lower : Y=1.4132X + 0.0012 (r=0.78) female upper : Y=1.4914X + 0.2151 (r=0.73) lower : Y=1.5429X - 0.0911 (r=0.78)

• Women's Health Nursing
• /
• v.19 no.4
• /
• pp.230-241
• /
• 2013

Purpose: This study was done to confirm prenatal health management and educational needs for pregnant women with advanced maternal age (AMA) and pregnant women under 35 years of age. Methods: This study was a descriptive research in which self-report questionnaires were used. Participants were 279 pregnant women (83 AMA and 196 less than 35). Results: Only 32.5% of AMA women had received prenatal education and 51.8% reported wanting internet education. AMA women, compared to the under 35 women, had higher levels of self-awareness of health problems and possibility of health problems but lower levels of alcohol experience before pregnancy. For prenatal health management, scores were low for prenatal exercise, prenatal education and nutrition. For prenatal health management education, AMA women reported high levels of need for education on health problems. Conclusion: The results indicate that prenatal health management education must be given considering differences in age-related requirements by emphasizing health care and obstetric complications during pregnancy for AMA women and anemia and information on substance use during pregnancy for women under 35. Reliable internet-based education programs need to be developed using available information and communication technology for the increasing number of employed pregnant women.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.6
• /
• pp.2895-2899
• /
• 2016

Background: Increasing breast cancer (BC) incidence rates have been reported from India; causal factors for this increased incidence are not understood and diagnosis is mostly in advanced stages. Trivandrum exhibits the highest BC incidence rates in India. This study aimed to estimate trends in incidence by age from 2005-2014, to predict rates through 2020 and to assess the stage at diagnosis of BC in Trivandrum. Materials and Methods: BC cases were obtained from the Population Based Cancer Registry, Trivandrum. Distribution of stage at diagnosis and incidence rates of BC [Age-specific (ASpR), crude (CR) and age-standardized (ASR)] are described and employed with a joinpoint regression model to estimate average annual percent changes (AAPC) and a Bayesian model to estimate predictive rates. Results: BC accounts for 31% (2681/8737) of all female cancers in Trivandrum. Thirty-five percent (944/2681) are <50 years of age and only 9% present with stage I disease. Average age increased from 53 to 56.4 years (p=0.0001), CR (per $10^5$ women) increased from 39 (ASR: 35.2) to 55.4 (ASR: 43.4), AAPC for CR was 5.0 (p=0.001) and ASR was 3.1 (p=0.001). Rates increased from 50 years. Predicted ASpR is 174 in 50-59 years, 231 in > 60 years and overall CR is 80 (ASR: 57) for 2019-20. Conclusions: BC, mostly diagnosed in advanced stages, is rising rapidly in South India with large increases likely in the future; particularly among post-menopausal women. This increase might be due to aging and/or changes in lifestyle factors. Reasons for the increased incidence and late stage diagnosis need to be studied.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.10
• /
• pp.4219-4222
• /
• 2015

Background: Hydronephrosis is frequently encountered in advanced stage cervical cancers, and may be associated with mortality. In the present study, we aimed to demonstrate the effect of hydronephrosis on survival in patients with inoperable advanced stage cervical cancer. Materials and Methods: The study data were acquired by retrospective analysis of the patient records belonging to 165 women with FIGO (International Federation of Gynecology and Obstetrics) stage-IIIB or more advanced cervical cancer, which were not surgical candidates. Parameters including patient age, pathological diagnosis, disease stage, pelvic sidewall extension, presence of hydronephrosis and administration of chemoradiation were analyzed. Further, the effects of these variables on survival were assessed. P values less than 0.05 were considered statistically significant. Results: The distribution of the study patients according to disease stage was as follows: 131 (79.4%) had stage-IIIB, 18 (10.9%) had stage-IVB and 16 (% 9.7) patients had stage-IVA disease. Hydronephrosis was not evident in 91 (55.2%) of these patients, whereas 41 (24.8%) had unilateral and 33 (20%) patients had bilateral hydronephrosis. When compared to mean survival in patients who did not have hydronephrosis, survival was significantly shortened in patients who had bilateral and unilateral hydronephrosis (p<0.05). There was no significant survival difference between patients with unilateral and bilateral hydronephrosis (p>0.05). Although patient age, pathological type, pelvic involvement, and chemotherapy treatment rates were similar (p>0.05), radiotherapy requirement rate and disease stage were significantly different among the study groups (p<0.05). Conclusions: Hydronephrosis was found to be a significant predictor of poor survival in patients with advanced stage cervical cancer, irrespective of unilateral or bilateral involvement.While waiting for future studies with larger sample sizes, we believe that the FIGO stages in advanced cervical cancer could further be stratified into subgroups according to presence or absence of hydronephrosis.

• PNF and Movement
• /
• v.16 no.2
• /
• pp.239-248
• /
• 2018

Purpose: This study aimed to examine the elderly physical fitness test for elderly people living in urban areas and to evaluate the physical fitness level according to gender and age groups. Methods: The subjects were 180 elderly people aged 65 and over living in urban areas. The elderly people were classified into early old age, middle old age, and advanced old age groups. Five items of the physical fitness test for the elderly (arm curl, chair stand, 2 min step test, back scratch, and chair sit and reach). Results: In analyzing the average of each item by gender and age, a significant difference was found in the results of each item as age increased in all sports, but no difference was observed according to gender except dumbbell lifting. Conclusion: Although the physical fitness level of all ages decreased from early age to late age, the difference in physical fitness according to gender was not significant except the arm curl test. The results of this study can be used as basic data for a new "age-specific exercise program" for the elderly.

• Asian-Australasian Journal of Animal Sciences
• /
• v.14 no.12
• /
• pp.1696-1700
• /
• 2001

An experiment was conducted to examine the effect of different feeding levels of concentrate (85, 100 and 115%) and age (15, 18 and 24 month) on fatty acid synthetase (FAS) activities in the 4 locations of adipose tissues (intermuscular, ITER; intramuscular, ITRA; kidney, KIDN and subcutaneous, SUBC) of 36 Korean native cattle (Hanwoo) steers. Steers of 100% feeding group were fed the amount of concentrate to meet the daily nutrient requirements, and the steers of second and third groups were fed concentrates at the levels of 85% and 115% of that of control group, respectively, up to 18 month of age. Thereafter, the steers were fed ad libitum up to 24 month of age. Feeding level of concentrates tended to affect the FAS activity of various adipose tissues in Hanwoo steers of each age. The FAS activity of ITER adipose tissue had the decreasing trend as the age of steers advanced while those of ITRA and SUBC adipose tissues had the slightly increasing tendency with age. The FAS activity based on the pooled data increased with the feeding level of concentrates (115%) in which the activities from all 4 adipose depots were higher than those with the lowest (85%) feeding level. Similar trend was observed from the pooled data of feeding level of concentrates by age of steers in which the FAS activities for all 3 ages were increased with feeding levels of concentrates. But the response in the FAS activity to the feeding level varied with age.

• Journal of Home Health Care Nursing
• /
• v.20 no.2
• /
• pp.133-140
• /
• 2013

Purpose: This study examined the demographic and lifestyle differences between women with osteopenia and those with normal bone mineral density (BMD) to identify risk factors for osteopenia. Method: Participants comprised 381 women age 40-64 years. Data were collected using surveys, BMD measures, and anthropometric parameters. Results: Prevalence of osteopenia was 29.1%; significant differences in age group, job, age at menarche, age at menopause, and body mass index were found between women with osteopenia and those with normal BMD. Logistic regression analysis indicated that advanced age, unemployment, lower body mass index, and lack of exercise in women were significantly associated with osteopenia. Conclusion: This study suggests the need for strategies to improve bone health and continuous cohort studies to identify risk factors.