Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Outcomes of Second-Line Chemotherapy for Advanced Non-Small Cell Lung Cancer in One Institution

  • Lee, Seok Jeong (Department of Internal Medicine, Ewha Womans University School of Medicine) ;
  • Kang, Hyun Ju (Department of Internal Medicine, Ewha Womans University School of Medicine) ;
  • Kim, Seo Woo (Department of Internal Medicine, Ewha Womans University School of Medicine) ;
  • Ryu, Yon Ju (Department of Internal Medicine, Ewha Womans University School of Medicine) ;
  • Lee, Jin Hwa (Department of Internal Medicine, Ewha Womans University School of Medicine) ;
  • Kim, Yookyung (Department of Radiology, Ewha Womans University School of Medicine) ;
  • Chang, Jung Hyun (Department of Internal Medicine, Ewha Womans University School of Medicine)
  • Received : 2014.03.06
  • Accepted : 2014.05.21
  • Published : 2014.07.30
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Abstract

Background: This study analyzed the negative prognostic factors in patients who received second-line chemotherapy for advanced inoperable non-small cell lung cancer (NSCLC). Methods: We retrospectively reviewed the records of 137 patients with inoperable stage III-IV NSCLC who received second-line chemotherapy. The effects of clinical parameters on survival were analyzed and the hazard ratios (HR) for mortality were identified by a Cox regression analysis. Results: Sex, age older than 65 years, smoking history, cell type, T-stage, best response to first-line chemotherapy and first-line chemotherapy regimen were significant negative predictors in univariate analysis. The multivariate analysis showed that patients older than 65 years (HR, 1.530; 95% confidence interval [CI], 1.020-2.297), advanced T stage (T4 vs. T1; HR, 2.273; 95% CI, 1.010-5.114) and non-responders who showed progression with first-line chemotherapy (HR, 1.530; 95% CI, 1.063-2.203) had higher HR for death. Conclusion: The age factor, T stage and responsiveness to first-line chemotherapy were important factors in predicting the outcome of patients with advanced NSCLC who received second-line chemotherapy. The results may help to predict outcomes for these patients in the future.

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References

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