• Title/Summary/Keyword: Adult Children

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Cytogenetic Profile of De Novo B lineage Acute Lymphoblastic Leukemia: Determination of Frequency, Distribution Pattern and Identification of Rare and Novel Chromosomal Aberrations in Indian Patients

  • Bhandari, Prerana;Ahmad, Firoz;Dalvi, Rupa;Koppaka, Neeraja;Kokate, Prajakta;Das, Bibhu Ranjan;Mandava, Swarna
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.16
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    • pp.7219-7229
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    • 2015
  • Background: Chromosomal aberrations identified in acute lymphoblastic leukemia (ALL) have an important role in disease diagnosis, prognosis and management. Information on karyotype and associated clinical parameters are essential to physicians for planning cancer control interventions in different geographical regions. Materials and Methods: In this study, we present the overall frequency and distribution patterns of chromosomal aberrations in both children and adult de novo B lineage ALL Indian patients using conventional cytogenetics, interphase FISH and multiplex RT-PCR. Results: Among the 215 subjects, cytogenetic results were achieved in 172 (80%) patients; normal karyotype represented 37.2% and abnormal 62.8% with a distribution as follows: 15.3% hypodiploidy; 10.3% hyperdiploidy; 15.8% t(9;22); 9.8% t(1;19); 3.7% t(12;21); 2.8% t(4;11); 2.8% complex karyotypes. Apart from these, we observed several novel, rare and common chromosomal rearrangements. Also, FISH studies using LSI extra-signal dual-color probes revealed additional structural or numerical changes. Conclusions: These results demonstrate cytogenetic heterogeneity of ALL and confirm that the incidence of chromosomal abnormalities varies considerably. To the best of our knowledge, this is one of the largest reported series of cytogenetic investigations in Indian B-lineage ALL cases. In addition, ongoing cytogenetic studies are warranted in larger groups of B-lineage ALL cases to identify newly acquired chromosomal abnormalities that may contribute to disease diagnosis and management.

Poor Treatment Outcome of Neuroblastoma and Other Peripheral Nerve Cell Tumors May be Related to Under Usage of Radiotherapy and Socio-Economic Disparity: A US SEER Data Analysis

  • Cheung, Rex
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.9
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    • pp.4587-4592
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    • 2012
  • Purpose: This study used receiver operating characteristic curve to analyze Surveillance, Epidemiology and End Results (SEER) neuroblastoma (NB) and other peripheral nerve cell tumors (PNCT) outcome data. This study found under usage of radiotherapy in these patients. Materials and methods: This study analyzed socio-economic, staging and treatment factors available in the SEER database for NB and other PNCT. For the risk modeling, each factor was fitted by a generalized linear model to predict the outcome (soft tissue specific death, yes/no). The area under the receiver operating characteristic curve (ROC) was computed. Similar strata were combined to construct the most parsimonious models. A random sampling algorithm was used to estimate the modeling errors. Risk of neuroendocrine (other endocrine including thymus as coded in SEER) death was computed for the predictors. Results: There were 5261 patients diagnosed from 1973 to 2009 were included in this study. The mean follow up time (S.D.) was 83.8 (97.6) months. The mean (SD) age was 18 (25) years. About 30.45% of patients were un-staged. The SEER staging has high ROC (SD) area of 0.58 (0.01) among the factors tested. We simplified the 4-layered risk levels (local, regional, distant, un-staged/others) to a simpler 3-tiered model with comparable ROC area of 0.59 (0.01). Less than 50% of PNCT patients received radiotherapy (RT) including the ones with localized disease. This avoidance of RT use occurred in adults and children. Conclusion: The high under-staging rate may have precented patients from selecting definitive radiotherapy (RT) after surgery. Using RT for, especially, adult PNCT patients is a potential way to improve outcome.

A study on the task of the Korean traditional skills competitions - focused on the trends of the examination and manufacturing techniques - (한복기능경기대회의 과제에 관한 연구 - 출제 경향과 제작 기법을 중심으로 -)

  • Koo, Mi-Ran
    • Journal of the Korea Fashion and Costume Design Association
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    • v.20 no.1
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    • pp.125-136
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    • 2018
  • This study classified and analyzed the assignments for the Hanbok skill contests between 1998 and 2017 so that the Korean hanbok can be properly passed down. this study proposes a variety of useful values for the Hanbok culture industry by providing basic data on various Hanbok making techniques to the Hanbok artisan. The results of the analysis of 39 assignments for the Hanbok skill contest are as follows. Firstly, The 20 assignments presented in the Local Skills Competitions consisted of 13 tasks (65%) in formal wear and 7 tasks (35%) in casual wear. Formal wear is mainly comprised of men's and children's wear (85.7%). There are Pungcha Baji, Sagusam, Kkachi Durumagi, Jeonbok & Bokgeon, Durumagi, and others on the formal wear of men'schildren's wear. In casual wear, 66.7% of women's wear such as scarves, skirts, jeogori, Hwejang Jeogori & chima were on the list of assignments. Secondly, All of the 19 assignments presented in the National Skills Competitions were in adult suits. Thirteen tasks (68.4%) were in formal wear and 6 tasks (31.6%) were in casual wear. Nine out of the 13 formal wear tasks (69.2%) were men's clothes. In 6 assignments of the casual wear, men's and women's clothes were presented three times each. Formal wear that had many assignments was the men's Chulik, which was presented three times in 2006, 2008 and 2016. Thirdly, Eighteen (90%) of the 20 assignments presented at the Local Skills Competitions were for lined clothes, and the remaining 2 (10%) were for unlined clothes. Eleven tasks (57.9%) out of the 19 assignments presented in the National Skills Competitions were for lined clothes, and 8 tasks (42.1%) were for unlined clothes.

Intergenerational Residential Proximity and Older Parents' Mental and Physical Health (기혼자녀와의 거주근접성과 부모의 정신 및 신체건강)

  • Nam, Boram;Choi, Heejeong
    • Journal of Families and Better Life
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    • v.34 no.6
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    • pp.69-85
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    • 2016
  • This study examined bidirectional associations between intergenerational residential proximity and older parents' mental and physical health. The data were drawn from first three waves of the Korean Longitudinal Study of Ageing (KLoSA, 2006, 2008, 2010), a nationally representative sample of adults 45 years or older and their spouses. The analytic sample consisted of 2,391 parents aged 60 years or older with at least one child who were continuously married between 2006 and 2010. Intergenerational residential proximity was measured with travel time between parental residence and that of the oldest of the continuously married children. For statistical analysis, autoregressive cross-lagged models were estimated using AMOS. Findings suggest that intergenerational residential proximity may have bidirectional associations with functional health, and an unidirectional association with life satisfaction. Specifically, a closer distance to a married son or daughter reported in 2006 was associated with poorer functional health of the parent in 2008. An older parent's greater number of functional limitations in 2006 was also related to a closer residential proximity to the married child in 2008. A greater residential proximity to a son, but not a daughter, reported in 2006 was associated with a higher level of parental life satisfaction in 2008. Overall, results suggest that having nearby a married adult child, particularly a married son, may help maintain parental health.

A Study on the Family Animation in Korea (국내의 가족(Family)용 애니메이션에 관한 연구)

  • Hwang, Hye-Young;Kim, Ji-Hong
    • Proceedings of the Korea Contents Association Conference
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    • 2006.11a
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    • pp.232-234
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    • 2006
  • Main purpose of producing animation is to entertain children, however, it is create for adult as an art form. For commercial animation focus on young generation rather than art animation, to make consume all over the world. To extend usability, animation company divert from child only contents to family animation, Especially, not even Disney animation company but many animation productions changed their policy and more stressed on that recently. It, however, can not be detected any research on this subject, So this study can proved a basic theory of defining term of family animation and contents with to overcome the limitation of viewers range as consumers. Firstly, it is investigated the family animation in domestic and overseas, secondly will be clarified the target for animation and compare to market for other country, it also be a basic analysis of understanding a family animation in the ways of producing and merchandising as goods.

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Nutrient Intake and Related Factors in Middle-Aged Urban Adults (일부 장.중년층의 영양섭취상태와 이에 영향을 미치는 인자에 관한 연구)

  • 이행신;계승희;김복희;김초일
    • Korean Journal of Community Nutrition
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    • v.6 no.3
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    • pp.516-526
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    • 2001
  • Working towards the compression of morbidity, we attempted to find the way to contribute to desirable aging and/or healthy old age. By looking into the factors affecting nutrient intake in middle-aged adults, we sought to find ways to improve their health status, Two hundred and fifty middle-aged adults from 40 to 60 years of age residing in Seoul and its vicinity were recruited for the survey. Subjects were interviewed for general characteristics, dietary habits lifestyle, status and food intake by a trained interviewer. Two -day food record was included in addition to the 1 -day 24 hr recall. Date were analyzed for the relationship among nutrient intake, health status, socio-economic status dietary habits and lifestyle using a statistical program (SAS) Although the mean energy intake of the subjects did not reach the recommenced dietary allowances(RDA), mean protein intake was well above the RAD for both sex groups(111.2% and 129.1% for men and women, respectively) The caloric contribution of fat was 15 to 20 % of total energy intake among different groups. Riboflavin was the most deficient nutrient and its mean intake reached only 71.0% of RDA for mean This seemed to be due to the lower intake of milk and dairy products among middle-aged Koreans who are more accustomed to traditional meals. Income and exercise habit were the most important factors influencing the nutrient intake of middle-age adults. Also, BMI, smoking habit, level of education regularity of meal, and hours of sleeping influenced the nutrient intake, In conclusion, middle-age adults appeared to have similar problems with the elderly in terms of nutrient intake and this age group should to included when considering nutritionally vulnerable groups in addition to the elderly and young children. The improvement in the nutrition status of middle-age adults is even more important because that could lead into the better health the elderly.

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The Morbidity of Respiratory Diseases Related to Air Pollution in Seoul Area (서울시 일부지역의 대기오염 농도와 호흡기계질환 발생 양상에 관한 연구)

  • 최광수
    • Journal of environmental and Sanitary engineering
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    • v.8 no.1
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    • pp.93-105
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    • 1993
  • The major purpose of this study was to determine the effects of air pollution on respiratory diseases. From the analysis of $SO_2$, $NO_2$ and TSP levels measured at two air pollution monitoring stations(K & E area) of Seoul during Jan. 1988-Dec. 1990, pollution level of K area was higher than E area. Insurance out-patient records for the medical fee reimbusement submitted to the National Federation of Medical Insurance from Jan. to Dec. 1990 were used in order to assess the occurrence of respiratory disease. The results were as follows ; 1. The annual mean levels of $SO_2$, $NO_2$ and TSP in K area were 0.08lppm, O.03lppm and 173.4${\mu}g/m^3$, whereas those of E area were 0.044ppm, 0.02lppm and 146.0 ${\mu}g/m^3$ respectively. The mean levels of above three air pollutants between two areas showed difference about 1.2 times-1.8 times by air pollutant. 2. The monthly out-patient incidence rates of chronic obstructive pulmonary diseases, chronic bronchitis and asthma in K area were higher when compared with those of E area. The monthly out-patient incidence rates of above three chronic respiratory disease of two areas studied showed statistically significant difference about 1.3 times, 2.7 times, 1.4 times respectively. No difference were, however, shown in acute respiratory infections. 3. Highest incidence rates of out-patients could be observed among the group of children less than 10 years old, while adult out-patient incidence rates increased as age increased. 4. The relation between air pollution and chronic respiratory disease was obvious especially, the strongly significant correlation was observed between $NO_2$ and chronic bronchitis.

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AIDS Related Knowledge and Attitude of Adult in Chonbuk Province (일부 성인의 AIDS에 관한 지식과 태도)

  • Suh In Sun;Lee Ok Sook
    • Journal of Korean Public Health Nursing
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    • v.11 no.1
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    • pp.128-137
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    • 1997
  • This study was designed to get basic data about AIDS educational program development of Adults. The objective of this study was to identify the level of AIDS relatied Knowledge and Attitude of Adults. The subject for this study consisted of 327 men and women who were living in chonbuk province. Data was colledted by self-reporting questionaire consist of 61 items during the period from 1st. December to 20th, December, 1996. The results were us follow ; 1. AIDS related knowledge ranged from 6 to 32(M;23.13, SD:5.86). Percentage of correctly answered respondents to each catagories ; Risk factors : $\cdot$ Infection through needle : $93.9\%$ $\cdot$ Infection through blood transfusion : $92.4\%$ $\cdot$ Infection of multi-sexuals : $90.5\%$ $\cdot$ Infection of hemophillias patients : $39.4\%$ $\cdot$ Infection of hemosexuals : $23.2\%$ Mode of transmission : $\cdot$ Infection through pubic rest room : $56.3\%$ $\cdot$ Infection through personal materials: $65.1\%$ $\cdot$ Infection through food: $67.6\%$ 2. The relationship between AIDS related knowledge and each of those general characteristics, AIDS related knowledge showed significant difference with age(p=0.0293), marital status(p=0.003). sexual experience(p=0.020) and used contraceptive(p=0.0l5). 3. Among the items regarding attitudes, what has highed level was preventional education of National policy about AIDS$(94.5\%)$. What has lowest level of Attitides was that AIDS carrier could go to school with noncarrier children$(39.1\%)$. 4. The relationship between attitude of AIDS and each of these general characteristics over 30 age group, married women, sexual experience and used contraceptive were higher than others.

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The conservative treatment of mandibular fracture in a child with circummandibular wiring: case report (환악 결찰술을 이용한 소아 하악 골절의 보존적 치료: 증례보고)

  • Kim, Hyung-Mo;Kim, Tae-Wan;Song, Seung-Il;Lee, Jeong-Keun
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.36 no.2
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    • pp.145-148
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    • 2010
  • Maxillofacial injuries are less common in children than in adolescents and adults. This lower incidence is a result of the relatively small size of mandible, the resilient nature of the bones, and a relatively protected environment, which distinguish the treatment principles of pediatric mandibular fractures from those of the adult. The bone of child is malleable, so pediatric fractures tend to be less displaced and rarely comminuted. Moreover, high regeneration potential of the wound allows more conservative treatment modalities for the pediatric mandibular fracture. High risk of damaging unerupted tooth bud renders many clinicians to resort to more conservative treatment modality for the reduction of displaced segments. This case report describes two successful treatment cases using the circummandibular wiring which was applicated to the fracture on parasymphysis of mandible. Circummandibular wiring can protect the tooth buds, and there is no need for intermaxillary fixation so that it prevents the possible complications of intermaxillary fixation such as the temporomandibular joint ankylosis and the facial growth disturbances. The acrylic splint was removed after 3 weeks, which showed clinically good union across the fracture line without complications. They showed complete clinical and radiological bone healing with an optimum occlusion.

The Relationship between the Characteristics of Social Support and Post-Stroke Depression (사회적 지지의 특성에 따른 뇌졸중 환자의 우울)

  • Kim, In-Ja;Suh, Moon-Ja;Kim, Keum-Soon;Cho, Nam-Ok
    • The Korean Journal of Rehabilitation Nursing
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    • v.2 no.2
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    • pp.206-214
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    • 1999
  • The effect s of social support on post-stroke depression were investigated. Social support was classified into three categories : primary caregiver's, significant other's, and professional support. And primary caregiver's and significant other's support were divided into their relation, living state (which means they living together or not), frequency which they met at, and perceived satisfaction about the support, respectively. Professional support was divided into number of professionals who take care of, frequency they met at, and perceived satisfaction. The subjects were 254 stroke patients who had been discharged and were taken follow-up care at the out patient department. The depression was measured using CES-D. Out of the primary caregiver's support, only relation and perceived satisfaction were identified to affect the post-stroke depression. The patients who primarily their spouse takes care of were less depressed than those who their adult children take care of. None of the significant other's support affects the post-stroke depression. Only perceived satisfaction of the professional support was found to affect the post-stroke depression. So it was found that the quality, not the amount, of care was important to post-stroke depression. These results also support the claim that the facilities and teaching programs for primary caregivers are necessary.

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